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Goldilocks and the Three Rocuronium Reversals: A Sugammadex Dose-finding Study.
Ende, Holly B. 1; Rathmell, James P. 2; Wanderer, Jonathan P. 3
Instructions for Obtaining ANESTHESIOLOGY Continuing Medical Education (CME) Credit.
Sugammadex Is Not a Silver Bullet: Caveats Regarding Unmonitored Reversal.
Todd, Michael M. M.D. 1; Kopman, Aaron F. M.D. 2
Anesthesia and the Merry-go-round of Information in the Brain.
Sleigh, Jamie W. M.D. 1; Voss, Logan Ph.D. 2
A Dose-finding Study of Sugammadex for Reversal of Rocuronium in Cardiac Surgery Patients and Postoperative Monitoring for Recurrent Paralysis.
Bowdle, T. Andrew M.D., Ph.D., F.A.S.E. 1; Haththotuwegama, Kishanee J. B.S. 2; Jelacic, Srdjan M.D., F.A.S.E. 3; Nguyen, Sharon T. B.S. 4; Togashi, Kei M.D., M.P.H. 5; Michaelsen, Kelly E. M.D., Ph.D. 6
doi : 10.1097/ALN.0000000000004578
The dose of sugammadex recommended by the manufacturer for reversal of rocuronium is 2 mg/kg when the train-of-four count is 2 or more and 4 mg/kg when it is less than 2 but there is a posttetanic count of at least 1.
Morphine and Hydromorphone Effects, Side Effects, and Variability: A Crossover Study in Human Volunteers.
Meissner, Konrad M.D. 1; Dahan, Albert M.D., Ph.D. 2; Olofsen, Erik Ph.D. 3; Gopfert, Christine M.D. 4; Blood, Jane R.N., B.S.N. 5; Wieditz, Johannes Ph.D. 6; Kharasch, Evan D. M.D., Ph.D. 7
doi : 10.1097/ALN.0000000000004567
Balancing between opioid analgesia and respiratory depression continues to challenge clinicians in perioperative, emergency department, and other acute care settings.
Patient and Process Outcomes among Pediatric Patients Undergoing Appendectomy during the COVID-19 Pandemic: An International Retrospective Cohort Study.
Matava, Clyde T. M.B.Ch.B., M.Med., M.H.S.C. 1; Tighe, Nathaniel T. G. M.D., M.M. 2; Baertschiger, Reto M.D., Ph.D. 3; Wilder, Robert T. M.D., Ph.D. 4; Correll, Lynnie M.D., Ph.D. 5; Staffa, Steven J. M.S. 6; Zurakowski, David M.S., Ph.D. 7; Kato, Meredith A. M.D. 8; Meier, Petra M. M.D. 9; Raman, Vidya M.D., M.B.A. 10; Reddy, Srijaya K. M.D., M.B.A. 11; Roque, Remigio A. M.D. 12; Peterson, Melissa Brooks M.D. 13; Zhong, John M.D. 14; Edala, Thejovathi M.D. 15; Greer, Timothy J. M.B.B.S. 16; von Ungern-Sternberg, Britta S. M.D, Ph.D. 17; Cravero, Joseph M.D. 18; Simpao, Allan F. M.D., M.B.I. 19; for the PEACOC Collaborators; Ali, Anita Akbar M.D.; Al-Rabbat, Mohamad F. M.D.; Brzenski, Alyssa B. M.D.; Casey, William F. M.D., B.Ch., F.F.A.R.C.S.I.; Chhabada, Surendrasingh M.D.; Collin, Michael M.B.B.S., F.R.A.C.S.; Dhumak, Vipul J. M.D., M.P.H.; D'Mello, Ajay M.D.; Echeverry, Piedad C. M.D.; Ellison, Pavithra R. M.D., M.M.M.; Fernandez, Allison M. M.D., M.B.A.; Fisher, Jake A. M.D.; Fuller, Clinton L. M.D.; Glover, Chris D. M.D.; Guruswamy, Velu M.B.B.S., D.A., F.R.C.A., F.F.A.R.C.S.I., M.B.A.; Hesselink, Emily B. M.D.; Hunyady, Agnes I. M.D.; Lorinc, Amanda N. M.D.; King, Michael M.D.; Mihaila, Lavinia B.A.; Nelson, Jonathon H. M.D.; Ng, Ann S. M.D.; Ramjist, Joshua K. M.D., M.Sc.; Ravula, Nirop R. M.B.B.S., F.R.C.A.; Beel, Elizabeth Rossmann M.D., M.P.H.; Rugnathx, Rahil M.D.; Shaw, Robert E. M.D.; Sheth, Michelle M. M.D.; Sinha, Tripiti M.D.; Sommerfield, Aine B.Sc., Ph.D., M.Sc.; Soneru, Codruta M.D.; Templeton, Thomas W. M.D.; Williams, R.J. M.A.
doi : 10.1097/ALN.0000000000004570
COVID-19 forced healthcare systems to make unprecedented changes in clinical care processes. The authors hypothesized that the COVID-19 pandemic adversely impacted timely access to care, perioperative processes, and clinical outcomes for pediatric patients undergoing primary appendectomy.
Measures of Information Content during Anesthesia and Emergence in the Caenorhabditis elegans Nervous System.
Chang, Andrew S. M.S. 1; Wirak, Gregory S. Ph.D. 2; Li, Duan Ph.D. 3; Gabel, Christopher V. Ph.D. 4; Connor, Christopher W. M.D., Ph.D. 5
doi : 10.1097/ALN.0000000000004579
Suppression of behavioral and physical responses defines the anesthetized state. This is accompanied, in humans, by characteristic changes in electroencephalogram patterns.
TREK-1 and TREK-2 Knockout Mice Are Not Resistant to Halothane or Isoflurane.
Spencer, Kira A. Ph.D. 1; Woods, Christian B. B.S. 2; Worstman, Hailey M. B.A. 3; Johnson, Simon C. Ph.D. 4; Ramirez, Jan-Marino Ph.D. 5; Morgan, Philip G. M.D. 6; Sedensky, Margaret M. M.D. 7
doi : 10.1097/ALN.0000000000004577
A variety of molecular targets for volatile anesthetics have been suggested, including the anesthetic-sensitive potassium leak channel, TREK-1. Knockout of TREK-1 is reported to render mice resistant to volatile anesthetics, making TREK-1 channels compelling targets for anesthetic action.
Hemostatic In Vitro Properties of Novel Plasma Supernatants Produced from Late-storage Low-titer Type O Whole Blood.
Mihalko, Emily P. Ph.D. 1; Srinivasan, Amudan J. M.D. 2; Rahn, Katelin C. B.S. 3; Seheult, Jansen N. M.D. 4; Spinella, Philip C. M.D. 5; Cap, Andrew P. M.D., Ph.D. 6; Triulzi, Darrell J. M.D. 7; Yazer, Mark H. M.D. 8; Neal, Matthew D. M.D. 9; Shea, Susan M. Ph.D. 10
doi : 10.1097/ALN.0000000000004574
The use of low-titer group O whole blood is increasing. To reduce wastage, unused units can be converted to packed red blood cells. Supernatant is currently discarded post-conversion; however, it could be a valuable transfusable product.
Preoperative Evaluation in the 21st Century.
Blitz, Jeanna D. M.D., F.A.S.A., D.F.P.M. 1
Perfect Preparation.
Goldstein, Joseph C. M.D. 1; Goldstein, Heidi V. M.D. 2
Sugammadex Vial Wastage: Implications for the Cost of Anesthesia Care in Children: Research Letter.
Mpody, Christian M.D., Ph.D., M.P.H., M.B.A. 1; Beltran, Ralph M.D.; Hayes, Seth M.D.; Nafiu, Olubukola O. M.D., F.R.C.A., M.S.; Tobias, Joseph D. M.D.
Lack of Association between Diaphragm Thickening Fraction and Transdiaphragmatic Pressure Swing in COVID-19 Pneumonia during Helmet Continuous Positive Airway Pressure: Research Letter.
Lassola, Sergio M.D. 1; Miori, Sara M.D.; Sanna, Andrea M.D.; Umbrello, Michele M.D.; De Rosa, Silvia M.D., F.C.C.N.; Bellani, Giacomo M.D., Ph.D.
Cryoneurolysis: Interest and Caution: Comment.
Ilfeld, Brian M. M.D., M.S. 1; Wagner, Rochelle Ph.D.
Sedation versus General Anesthesia for Intubation: Comment.
Feldman, Jeffrey M. M.D., M.S.E. 1
Sedation versus General Anesthesia for Intubation: Reply.
Fiadjoe, John M.D. 1; Sequera-Ramos, Luis M.D.; Kovatsis, Pete M.D.
Anesthesia and Eye Diseases: Comment.
Priebe, Hans-Joachim M.D. 1
Anesthesia and Eye Diseases: Reply.
Roth, Steven M.D., F.A.R.V.O. 1; Moss, Heather E. M.D., Ph.D.; Vajaranant, Thasarat Sutabutr M.D.; Sweitzer, BobbieJean M.D., F.A.C.P., S.A.M.B.A.-F., F.A.S.A.
