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Uterine Tumor Resembling Ovarian Sex Cord Tumors: 23 Cases Indicating Molecular Heterogeneity With Variable Biological Behavior.
Bi, Rui MD, PhD *; Yao, Qianlan PhD *; Ji, Gang MD *; Bai, Qianming MD, PhD *; Li, Anqi MD, PhD +; Liu, Zebing MD, PhD ++; Cheng, Yufan MD, PhD *; Tu, Xiaoyu MD *; Yu, Lin MD, PhD *; Chang, Bin MD, PhD *; Huang, Dan MD, PhD *; Ge, Huijuan MD *; Zuo, Ke MD, PhD *; Li, Hui MD, PhD *; Chang, Heng MD *; Cai, Xu MD *; Jiang, Wenhua MD *; Zhou, Xiaoyan MD, PhD *; Yang, Wentao MD, PhD *
doi : 10.1097/PAS.0000000000002046
Volume 47(7) pgs. 739-848 July 2023
AB Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare mesenchymal neoplasm that mainly harbors NCOA1-3 rearrangements with partner genes ESR1 or GREB1.
Mixed Ovarian Neoplasms With Gastrointestinal-type Mucinous and Mullerian Epithelial Components: A Rare Group of Tumors Demonstrating the Phenotypic Plasticity of the Mullerian Epithelial Cell.
Chui, Michael Herman MD; Ellenson, Lora H. MD
doi : 10.1097/PAS.0000000000002045
AB Primary mucinous ovarian neoplasms, gastrointestinal-type (GI-type), are composed of mucin-producing tumor cells resembling intestinal goblet cells or gastric foveolar epithelium. In contrast to seromucinous tumors, which exhibit endocervical-type mucinous differentiation and are thought to be derived from endometriosis, the cell/tissue-of-origin of most GI-type mucinous ovarian tumors is unknown.
Identification and Prognostic Effect of Extramural Venous Invasion in Locally Advanced Esophageal Squamous Cell Carcinoma.
Lin, Zhen MD *,+; Plukker, John T.M. MD, PhD ++; Tian, Dong-ping MD, PhD *; Chen, Shao-bin MD, PhD [S]; Kats-Ugurlu, Gursah MD, PhD +; Su, Min MD, MSc *
doi : 10.1097/PAS.0000000000002048
AB The role of extramural venous invasion (EMVI) in esophageal cancer is still unclear. This study aimed to identify EMVI and assess its impact on survival and recurrences in esophageal squamous cell carcinoma (ESCC).
Sclerosis in Sex Cord-Stromal Tumors Other Than the Sclerosing Stromal Tumor: A Report of 70 Cases.
Devins, Kyle M. MD; Young, Robert H. MD
doi : 10.1097/PAS.0000000000002049
AB Sclerosis is well-known in sclerosing stromal tumors (SSTs), as its name indicates, but has not been evaluated in other ovarian sex cord-stromal tumors (SCSTs).
Diagnostic Utility of Menin Immunohistochemistry in Patients With Multiple Endocrine Neoplasia Type 1 Syndrome.
Verschuur, Anna Vera D. MD *; Kok, Aranxa S.M. MD *; Morsink, Folkert H.M. BS *; de Leng, Wendy W.J. PhD *; van den Broek, Medard F.M MD +; Koudijs, Marco J. PhD ++; Offerhaus, Johan A. MD, PhD *; Valk, Gerlof D. MD, PhD +; Vriens, Menno R. MD, PhD [S]; van Nesselrooij, Bernadette P.M. MD, PhD ++; Hackeng, Wenzel M. MD, PhD *; Brosens, Lodewijk A.A. MD, PhD *
doi : 10.1097/PAS.0000000000002050
AB A clinical diagnosis of multiple endocrine neoplasia type 1 (MEN1) syndrome is usually confirmed with genetic testing in the germline. It is expected that menin protein expression is lost in MEN1-related tumors.
Unique Morphologic Findings in the Liver After Stereotactic Radiation for Cholangiocarcinoma.
Soon, Gwyneth S.T. MBBS *; Yasir, Saba MBBS +; Wu, Tsung-Teh MD, PhD +; Welle, Christopher MD ++; Venkatesh, Sudhakar K. MD ++; Torbenson, Michael S. MD +; Chen, Zongming Eric MD, PhD +
doi : 10.1097/PAS.0000000000002052
AB Newer radiotherapy techniques, such as stereotactic body radiation, have been increasingly used as part of the treatment of cholangiocarcinomas, particularly as a bridge to liver transplantation.
Giant Cell Tumors With HMGA2: NCOR2 Fusion: Clinicopathologic, Molecular, and Epigenetic Study of a Distinct Entity.
Perret, Raul MD, MSc *,+; Malaka, Zaki MD *,++; Velasco, Valerie BSc *; Llamas-Gutierrez, Francisco MD [S]; Ropars, Mickael MD, PhD [//]; Linck, Pierre-Antoine MD [P]; Hostein, Isabelle PhD *; Azmani, Rihab MSc #; Valo, Isabelle MD **; Galmiche, Louise MD, PhD ++; Moreau, Anne MD ++; de Pinieux, Gonzague MD, PhD ++++; Michot, Audrey MD [S][S]; Bochaton, Dorian MSc; Coindre, Jean-Michel MD *; Le Loarer, Francois MD, PhD *,+,++
doi : 10.1097/PAS.0000000000002051
AB Giant cell tumors (GCTs) with high mobility group AT-Hook 2 (HMGA2)::nuclear receptor corepressor 2 (NCOR2) fusion are rare mesenchymal tumors of controversial nosology, which have been anecdotally reported to respond to CSFR1 inhibitors. Here, we performed a comprehensive study of 6 GCTs with HMGA2::NCOR2 fusion and explored their relationship with other giant cell-rich neoplasms.
The Deepest Extent of Acellular Mucin Pools in Resected Locally Advanced Rectal Cancer With Pathological Complete Response After Preoperative Chemoradiotherapy: A Hidden Killer?.
Chen, Mian MM *; Wang, Chao MD +; Liu, Huashan MD, PhD *; Liang, Zhenxing MD, PhD *; Ye, Fujin MM *; Luo, Shuangling MD *; Liu, Zhanzhen MD *; Hu, Huanxin MD *; Lai, Sicong MD *; Hou, Yujie MD *; Kang, Liang MD, PhD *; Huang, Liang MD, PhD *
doi : 10.1097/PAS.0000000000002055
AB For patients with locally advanced rectal cancer (LARC) with pathological complete response (pCR), the clinical significance of the distribution extent of acellular mucin pools (AMP) distribution remains unclear, so this study was conducted to address key unanswered questions.
Hyperplasia of Arachnoid Trabecular Cells: A Hitherto Undescribed Lesion Observed in the Setting of Neurofibromatosis Type 1.
Maehara, Tatsuro MD *; Yamazaki, Ayako MD, PhD *; Kawabata-Iwakawa, Reika PhD +; Fukuoka, Kohei MD, PhD ++; Akazawa, Ayumi MD [S]; Okura, Naoki MD, PhD [//]; Nishiyama, Masahiko MD, PhD [P]; Nassiri, Farshad MD, PhD #,**,++; Wang, Justin Z. MD #; Zadeh, Gelareh MD, PhD #,**,++; Kikuta, Kenichiro MD, PhD [S]; Oka, Hidehiro MD, PhD ++++; Hirato, Junko MD, PhD *,[S][S]; Yokoo, Hideaki MD, PhD *; Nobusawa, Sumihito MD, PhD *
doi : 10.1097/PAS.0000000000002056
AB Central nervous system manifestations, a variety of benign and malignant tumors as well as non-neoplastic abnormalities, are found in over 70% of neurofibromatosis type 1 (NF1) patients.
Mammary Spindle Cell Proliferations on Core Needle Biopsy: Is Excision Always Necessary?.
Pun, Cherry MD *; Turashvili, Gulisa MD, PhD *,+; Mulligan, Anna Marie MBChB *,++; Slodkowska, Elzbieta MD *,[S]
doi : 0.1097/PAS.0000000000002057
AB Mammary spindle cell proliferations (SCPs) encompass a wide range of lesions and can be challenging to accurately diagnose on core needle biopsies (CNBs). Most SCPs are excised for definitive diagnosis. In the era of minimally invasive therapy, some SCP may be followed conservatively.
Mutation-specific Mismatch Repair-deficient Benign Endometrial Glands in Endometrial Biopsies and Curettings Are a Biomarker of Lynch Syndrome and Associate With Endometrial Carcinoma Development.
Hegazy, Shaymaa MD *; Brand, Randall E. MD +; Dudley, Beth MS, MPH +; Karloski, Eve MS +; Lesnock, Jamie L. MD ++; Elishaev, Esther MD *; Pai, Reetesh K. MD *
doi : 10.1097/PAS.0000000000002061
AB Endometrial carcinoma is the most common extraintestinal cancer in Lynch syndrome (LS). Recent studies have demonstrated mismatch repair (MMR) deficiency can be detected in benign endometrial glands in LS.
CSF1R/CD115 is a Helpful Marker for the Distinction of Florid Dermatopathic Lymphadenopathy From Langerhans Cell Neoplasms.
Ozkaya, Neval MD; Lee, Ina MD, PhD; Johnson, Terrica S. BS; Jaffe, Elaine S. MD
Dr Richard L. Kempson: In Memorium.
Longacre, Teri A. MD *; Weiss, Sharon W. MD +; Mills, Stacey E. MD ++
