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Xylazine — Medical and Public Health Imperatives
Rahul Gupta, M.D., M.P.H., M.B.A., David R. Holtgrave, Ph.D., and Michael A. Ashburn, M.D., M.P.H., M.B.A.
doi : 10.1056/NEJMp2303120
Vol. 388 No. 24
A Slow-Moving Disaster — The Jackson Water Crisis and the Health Effects of Racism
Richard M. Mizelle, Jr., Ph.D.
doi : 10.1056/NEJMp2212978
Testing for Fentanyl — Urgent Need for Practice-Relevant and Public Health Research
Nora D. Volkow, M.D., Robert M. Califf, M.D., Marta Sokolowska, Ph.D., Lawrence A. Tabak, D.D.S., Ph.D., and Wilson M. Compton, M.D., M.P.E.
doi : 10.1056/NEJMp2302857
Decompressive Craniectomy versus Craniotomy for Acute Subdural Hematoma
Peter J. Hutchinson, Ph.D., F.R.C.S. (SN), Hadie Adams, M.D., Midhun Mohan, M.R.E.S., M.R.C.S., Bhagavatula I. Devi, M.Ch., Christopher Uff, Ph.D., F.R.C.S. (SN), Shumaila Hasan, M.R.C.S., Harry Mee, M.R.C.P., Mark H. Wilson, Ph.D., F.R.C.S. (SN), Deepak K. Gupta, M.Ch., Ph.D., Diederik Bulters, F.R.C.S. (SN), Ardalan Zolnourian, M.R.C.S., Catherine J. McMahon, Ph.D., F.R.C.S. (SN),
doi : 10.1056/NEJMoa2214172
Traumatic acute subdural hematomas frequently warrant surgical evacuation by means of a craniotomy (bone flap replaced) or decompressive craniectomy (bone flap not replaced). Craniectomy may prevent intracranial hypertension, but whether it is associated with better outcomes is unclear.
Dexamethasone versus Surgery for Chronic Subdural Hematoma
Ishita P. Miah, M.D., Ph.D., Dana C. Holl, M.D., Ph.D., Jurre Blaauw, M.D., Hester F. Lingsma, Ph.D., Heleen M. den Hertog, M.D., Ph.D., Bram Jacobs, M.D., Ph.D., Nyika D. Kruyt, M.D., Ph.D., Joukje van der Naalt, M.D., Ph.D., Suzanne Polinder, Ph.D., Rob J.M. Groen, M.D., Ph.D., Kuan H. Kho, M.D., Fop van Kooten, M.D., Ph.D., Clemens M.F. Dirven, M.D., Ph.D., Wilco C. Peul, M.D., Ph.D., Korné Jellema, M.D., Ph.D., Ruben Dammers, M.D., Ph.D., and Niels A. van der Gaag, M.D., Ph.D. for the DECSA Collaborators*
doi : 10.1056/NEJMoa2216767
The role of glucocorticoids without surgical evacuation in the treatment of chronic subdural hematoma is unclear.
Variant STAT4 and Response to Ruxolitinib in an Autoinflammatory Syndrome
Hratch Baghdassarian, B.S., Sarah A. Blackstone, B.S., Owen S. Clay, M.D., Ph.D., Rachael Philips, Ph.D., Brynja Matthiasardottir, M.Sc., Michele Nehrebecky, N.P., Vivian K. Hua, B.S., Rachael McVicar, B.S., Yang Liu, Ph.D., Suzanne M. Tucker, M.D., Davide Randazzo, Ph.D., Natalie Deuitch, M.S., Sofia Rosenzweig, B.S., Adam Mark, M.S., Roman Sasik, Ph.D., Kathleen M. Fisch, Ph.D., Pallavi Pimpale Chavan, M.D., Elif Eren, Ph.D., Norman R. Watts, Ph.D., Chi A. Ma, Ph.D., Massimo Gadina, Ph.D., Daniella M. Schwartz, M.D., Anwesha Sanyal, Ph.D., Giffin Werner, B.S., David R. Murdock, M.D., Nobuyuki Horita, M.D., Ph.D., Shimul Chowdhury, Ph.D., David Dimmock, M.D., Kristen Jepsen, Ph.D., Elaine F. Remmers, Ph.D., Raphaela Goldbach-Mansky, M.D., M.H.S., William A. Gahl, M.D., Ph.D., John J. O’Shea, M.D., Joshua D. Milner, M.D., Nathan E. Lewis, Ph.D., Johanna Chang, M.D., Daniel L. Kastner, M.D., Ph.D., Kathryn Torok, M.D., Hirotsugu Oda, M.D., Ph.D., Christopher D. Putnam, Ph.D., and Lori Broderick, M.D., Ph.D.
doi : 10.1056/NEJMoa2202318
Disabling pansclerotic morphea (DPM) is a rare systemic inflammatory disorder, characterized by poor wound healing, fibrosis, cytopenias, hypogammaglobulinemia, and squamous-cell carcinoma. The cause is unknown, and mortality is high.
Rare Antagonistic Leptin Variants and Severe, Early-Onset Obesity
Jan-Bernd Funcke, Ph.D., Barbara Moepps, Ph.D., Julian Roos, Ph.D., Julia von Schnurbein, M.D., Kenneth Verstraete, Ph.D., Elke Fröhlich-Reiterer, M.D., Katja Kohlsdorf, M.D., Adriana Nunziata, Ph.D., Stephanie Brandt, Ph.D., Alexandra Tsirigotaki, Ph.D., Ann Dansercoer, M.S., Elisabeth Suppan, M.D., Basma Haris, M.D., Klaus-Michael Debatin, M.D., Savvas N. Savvides, Ph.D., I. Sadaf Farooqi, M.D., Ph.D., Khalid Hussain, M.D., Peter Gierschik, M.D., Pamela Fischer-Posovszky, Ph.D., and Martin Wabitsch, M.D., Ph.D.
doi : 10.1056/NEJMoa2204041
Xylazine-Associated Skin Injury
Jessica O’Neil, M.D., and Stephen Kovach, M.D.
doi : 10.1056/NEJMicm2303601
Patella Alta
Yoshitaka Ishiguro, M.D., and Akira Kuriyama, M.D., M.P.H., Ph.D.
doi : 10.1056/NEJMicm2213003
Case 18-2023: A 19-Year-Old Woman with Dyspnea and Tachypnea
Cory A. Perugino, D.O., Eric M. Isselbacher, M.D., Vinit Baliyan, M.D., M.B., B.S., Sebastian H. Unizony, M.D., and Rex N. Smith, M.D., Ph.D.
doi : 10.1056/NEJMcpc2300894
Traumatic Acute Subdural Hematoma — Should the Bone Flap Be Removed or Replaced?
Shankar Gopinath, M.D.
doi : 10.1056/NEJMe2302936
Varieties of Chronic Subdural Hematoma and Glucocorticoid Treatment
Ossama Al-Mefty, M.D.
doi : 10.1056/NEJMe2304797
Audio Interview: Dr. Fauci on Infectious Disease Challenges
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Anthony S. Fauci, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2307011
Dystrophin Immunity after Gene Therapy for Duchenne’s Muscular Dystrophy
doi : 10.1056/NEJMc2212912
