New England Journal of Medicine




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Toward Comprehensive Care for Long Covid

Janko Ž. Nikolich, M.D., Ph.D., and Clifford J. Rosen, M.D.

doi : 10.1056/NEJMp2304550

Vol. 388 No. 23

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Approving Workplace Accommodations for Patients with Long Covid — Advice for Clinicians

Doron Dorfman, L.L.B., J.S.D., and Zackary Berger, M.D., Ph.D.

doi : 10.1056/NEJMp2302676

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Over-the-Counter Hearing Aids — Using Regulatory Policy to Improve Public Health

Frank R. Lin, M.D., Ph.D., and Shelly Chadha, M.B., B.S., Ph.D.

doi : 10.1056/NEJMp2302355

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Transplantation Outcomes with Donor Hearts after Circulatory Death

Jacob N. Schroder, M.D., Chetan B. Patel, M.D., Adam D. DeVore, M.D., Benjamin S. Bryner, M.D., Sarah Casalinova, B.S., Ashish Shah, M.D., Jason W. Smith, M.D., Amy G. Fiedler, M.D., Mani Daneshmand, M.D., Scott Silvestry, M.D., Arnar Geirsson, M.D., Victor Pretorius, M.B., Ch.B., David L. Joyce, M.D., John Y. Um, M.D., Fardad Esmailian, M.D., Koji Takeda, M.D., Karol Mudy, M.D., Yasuhiro Shudo, M.D., Ph.D., Christopher T. Salerno, M.D., Si M. Pham, M.D., Daniel J. Goldstein, M.D., Jonathan Philpott, M.D., John Dunning, M.D., Lucian Lozonschi, M.D., Gregory S. Couper, M.D., Hari Reddy Mallidi, M.D., Michael M. Givertz, M.D., Duc Thinh Pham, M.D., Andrew W. Shaffer, M.D., Masashi Kai, M.D., Mohammed A. Quader, M.D., Tarek Absi, M.D., Tamer S. Attia, M.D., Ph.D., Bassam Shukrallah, M.D., Ben C. Sun, M.D., Maryjane Farr, M.D., Mandeep R. Mehra, M.D., Joren C. Madsen, M.D., D.Phil., Carmelo A. Milano, M.D., and David A. D’Alessandro, M.D.

doi : 10.1056/NEJMoa2212438

Data showing the efficacy and safety of the transplantation of hearts obtained from donors after circulatory death as compared with hearts obtained from donors after brain death are limited.

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Treatment of Gestational Diabetes Mellitus Diagnosed Early in Pregnancy

David Simmons, M.D., Jincy Immanuel, Ph.D., William M. Hague, M.D., Helena Teede, Ph.D., Christopher J. Nolan, Ph.D., Michael J. Peek, Ph.D., Jeff R. Flack, M.Med., Mark McLean, Ph.D., Vincent Wong, Ph.D., Emily Hibbert, M.Clin.Ed., Alexandra Kautzky-Willer, M.D., Jürgen Harreiter, Ph.D.,

doi : 10.1056/NEJMoa2214956

Whether treatment of gestational diabetes before 20 weeks’ gestation improves maternal and infant health is unclear.

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Dostarlimab for Primary Advanced or Recurrent Endometrial Cancer

Mansoor R. Mirza, M.D., Dana M. Chase, M.D., Brian M. Slomovitz, M.D., René dePont Christensen, Ph.D., Zoltán Novák, Ph.D., Destin Black, M.D., Lucy Gilbert, M.D., Sudarshan Sharma, M.D., Giorgio Valabrega, M.D., Lisa M. Landrum, M.D., Ph.D., Lars C. Hanker, M.D., Ashley Stuckey, M.D., Ingrid Boere, M.D., Ph.D., Michael A. Gold, M.D., Annika Auranen, M.D., Bhavana Pothuri, M.D., David Cibula, M.D., Carolyn McCourt, M.D., Francesco Raspagliesi, M.D., Mark S. Shahin, M.D., Sarah E. Gill, M.D., Bradley J. Monk, M.D., Joseph Buscema, M.D., Thomas J. Herzog, M.D., Larry J. Copeland, M.D., Min Tian, Ph.D., Zangdong He, Ph.D., Shadi Stevens, M.D., Eleftherios Zografos, M.D., Robert L. Coleman, M.D., and Matthew A. Powell, M.D. for the RUBY Investigators*

doi : 10.1056/NEJMoa2216334

Dostarlimab is an immune-checkpoint inhibitor that targets the programmed cell death 1 receptor. The combination of chemotherapy and immunotherapy may have synergistic effects in the treatment of endometrial cancer.

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Pembrolizumab plus Chemotherapy in Advanced Endometrial Cancer

Ramez N. Eskander, M.D., Michael W. Sill, Ph.D., Lindsey Beffa, M.D., Richard G. Moore, M.D., Joanie M. Hope, M.D., Fernanda B. Musa, M.D., Robert Mannel, M.D., Mark S. Shahin, M.D., Guilherme H. Cantuaria, M.D., Eugenia Girda, M.D., Cara Mathews, M.D., Juraj Kavecansky, M.D., Charles A. Leath, III, M.D., M.S.P.H., Lilian T. Gien, M.D., Emily M. Hinchcliff, M.D., M.P.H., Shashikant B. Lele, M.D., Lisa M. Landrum, M.D., Floor Backes, M.D., Roisin E. O’Cearbhaill, M.D., Tareq Al Baghdadi, M.D., Emily K. Hill, M.D., Premal H. Thaker, M.D., Veena S. John, M.D., Stephen Welch, M.D., Amanda N. Fader, M.D., Matthew A. Powell, M.D., and Carol Aghajanian, M.D.

doi : 10.1056/NEJMoa2302312

Standard first-line chemotherapy for endometrial cancer is paclitaxel plus carboplatin. The benefit of adding pembrolizumab to chemotherapy remains unclear.

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Posterior Reversible Encephalopathy Syndrome

Romergryko G. Geocadin, M.D.

doi : 10.1056/NEJMra2114482

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Idiopathic Pulmonary Hemosiderosis

Kazuhiro Uda, M.D., and Masato Yashiro, M.D., Ph.D.

doi : 10.1056/NEJMicm2214160

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Posterior Reversible Encephalopathy Syndrome

Saifudheen Kondanath, M.D., and Muhammad Ariwala, M.D.

doi : 10.1056/NEJMicm2213584

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Case 17-2023: A 58-Year-Old Woman with Fatigue, Abdominal Bloating, and Eosinophilia

Natasha S. Hochberg, M.D., M.P.H., Vincent V. Dinculescu, M.D., and Thomas B. Nutman, M.D.

doi : 10.1056/NEJMcpc2201248

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Safely Increasing Heart Transplantation with Donation after Cardiac Death

Nancy K. Sweitzer, M.D., Ph.D.

doi : 10.1056/NEJMe2303928

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Early versus Second-Trimester Screening and Treatment for Diabetes in Pregnancy

Michael F. Greene, M.D.

doi : 10.1056/NEJMe2304543

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Management of Possible Multiple Sclerosis

Clement D. Lee, M.D., Steven L. Galetta, M.D., and Ruth Dobson, Ph.D., F.R.C.P.

doi : 10.1056/NEJMclde2300812

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Antibody-Associated Reversal of ATTR Amyloidosis–Related Cardiomyopathy

doi : 10.1056/NEJMc2304584

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Transcatheter Arterialization of Veins in Chronic Limb-Threatening Ischemia

doi : 10.1056/NEJMc2304972

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Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus

doi : 10.1056/NEJMc2303757

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Hybrid Closed-Loop Control in Young Children with Type 1 Diabetes

doi : 10.1056/NEJMc2304389

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Covid-19 Surveillance Testing in Nursing Homes

doi : 10.1056/NEJMc2304781

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Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer

doi : 10.1056/NEJMx230003

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