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Ensuring a Reliable Platelet Supply in the United States
William Riley, Ph.D., Claudia S. Cohn, M.D., Ph.D., Kailey Love, M.B.A., M.S., and Jeffrey McCullough, M.D.
doi : 10.1056/NEJMp2302523
Vol. 388 No. 22
Supporting Robust Teamwork — Bridging Technology and Organizational Science
Anna T. Mayo, Ph.D., Christopher G. Myers, Ph.D., John C. Bucuvalas, M.D., Sandy Feng, M.D., Ph.D., and Courtney E. Juliano, M.D.
doi : 10.1056/NEJMp2300172
Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion
Wenjie Zi, M.D., Jiaxing Song, M.D., Weilin Kong, M.D., Jiacheng Huang, M.D., Changwei Guo, M.D., Wencheng He, M.D., Yinquan Yu, M.D., Bo Zhang, M.D., Wanjie Geng, M.D., Xiaolin Tan, M.D., Yaoyu Tian, M.D., Zongtao Liu, M.D.,
doi : 10.1056/NEJMoa2214299
The effects of the glycoprotein IIb/IIIa receptor inhibitor tirofiban in patients with acute ischemic stroke but who have no evidence of complete occlusion of large or medium-sized vessels have not been extensively studied.
Five-Year Follow-up after Transcatheter Repair of Secondary Mitral Regurgitation
Gregg W. Stone, M.D., William T. Abraham, M.D., JoAnn Lindenfeld, M.D., Saibal Kar, M.D., Paul A. Grayburn, M.D., D. Scott Lim, M.D., Jacob M. Mishell, M.D., Brian Whisenant, M.D., Michael Rinaldi, M.D., Samir R. Kapadia, M.D., Vivek Rajagopal, M.D., Ian J. Sarembock, M.B., Ch.B., M.D.,
doi : 10.1056/NEJMoa2300213
Data from a 5-year follow-up of outcomes after transcatheter edge-to-edge repair of severe mitral regurgitation, as compared with outcomes after maximal doses of guideline-directed medical therapy alone, in patients with heart failure are now available.
Ultrasonography or Radiography for Suspected Pediatric Distal Forearm Fractures
Peter J. Snelling, M.B., B.S., M.P.H.&T.M., Philip Jones, M.Biostat., David Bade, M.B., B.S., Randy Bindra, M.B., B.S., Joshua Byrnes, Ph.D., Michelle Davison, M.B., B.S., Shane George, M.P.H., Mark Moore, M.Nurs.N.P., Gerben Keijzers, Ph.D., and Robert S. Ware, Ph.D. for the BUCKLED Trial Group*
doi : 10.1056/NEJMoa2213883
Data on whether ultrasonography for the initial diagnostic imaging of forearm fractures in children and adolescents is noninferior to radiography for subsequent physical function of the arm are limited.
Capivasertib in Hormone Receptor–Positive Advanced Breast Cancer
Nicholas C. Turner, M.D., Ph.D., Mafalda Oliveira, M.D., Ph.D., Sacha J. Howell, M.D., Ph.D., Florence Dalenc, M.D., Ph.D., Javier Cortes, M.D., Ph.D., Henry L. Gomez Moreno, M.D., Ph.D., Xichun Hu, M.D., Komal Jhaveri, M.D., Petr Krivorotko, M.D., Ph.D., Sibylle Loibl, M.D., Ph.D., Serafin Morales Murillo, M.D., Meena Okera, M.D., Yeon Hee Park, M.D., Ph.D., Joohyuk Sohn, M.D., Masakazu Toi, M.D., Ph.D., Eriko Tokunaga, M.D., Ph.D., Samih Yousef, M.D., Lyudmila Zhukova, M.D., Ph.D., Elza C. de Bruin, Ph.D., Lynda Grinsted, M.Sc., Gaia Schiavon, M.D., Ph.D., Andrew Foxley, M.F.P.M., and Hope S. Rugo, M.D. for the CAPItello-291 Study Group*
doi : 10.1056/NEJMoa2214131
AKT pathway activation is implicated in endocrine-therapy resistance. Data on the efficacy and safety of the AKT inhibitor capivasertib, as an addition to fulvestrant therapy, in patients with hormone receptor–positive advanced breast cancer are limited.
Adipocyte Regulation of Insulin Sensitivity and the Risk of Type 2 Diabetes
Anna Santoro, Pharm.D., Ph.D., and Barbara B. Kahn, M.D.
doi : 10.1056/NEJMra2216691
Phantom Tumor of the Lung
Enrique M. Baldessari, M.D., and Sara M. Mesquida, M.D.
doi : 10.1056/NEJMicm2214264
Falling-Leaf Motility of Giardia lamblia
Debasish Biswal, M.D., and Bijay Mirdha, M.D.
doi : 10.1056/NEJMicm2211056
A Wrong Turn
Michael S. Bohnen, M.D., Ph.D., Brahmajee K. Nallamothu, M.D., M.P.H., Robert Zilinyi, M.D., Sanjay Saint, M.D., M.P.H., and Emily D. Slater, M.D.
doi : 10.1056/NEJMcps2215388
Expanding Treatment for Acute Ischemic Stroke beyond Revascularization
Jose G. Romano, M.D., and Tatjana Rundek, M.D., Ph.D.
doi : 10.1056/NEJMe2303184
Transcatheter Repair of Secondary Mitral Regurgitation
John J.V. McMurray, M.D., and Marco Metra, M.D.
doi : 10.1056/NEJMe2302924
Pediatric Dosing Errors during a National Shortage of Fever and Pain Medications
doi : 10.1056/NEJMc2300561
