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U.S. Law and Discrimination in Health Care
Kimani Paul-Emile, J.D., Ph.D.
doi : 10.1056/NEJMp2202164
Vol. 388 No. 21
Enhancing Regulations to Reduce Exposure to PFAS — Federal Action on “Forever Chemicals�
Joseph M. Braun, Ph.D., R.N., M.S.P.H.
doi : 10.1056/NEJMp2303333
Public Health’s Role in a Post-Dobbs World — The New York City Abortion Access Hub
Tara B. Stein, M.D., M.P.H., and Ashwin Vasan, M.D., Ph.D.
doi : 10.1056/NEJMp2301278
Hydrocortisone in Severe Community-Acquired Pneumonia
Pierre-François Dequin, M.D., Ph.D., Ferhat Meziani, M.D., Ph.D., Jean-Pierre Quenot, M.D., Ph.D., Toufik Kamel, M.D., Jean-Damien Ricard, M.D., Ph.D., Julio Badie, M.D., Jean Reignier, M.D., Ph.D., Nicholas Heming, M.D., Ph.D., Gaëtan Plantefève, M.D., Bertrand Souweine, M.D., Ph.D., Guillaume Voiriot, M.D., Ph.D., Gwenhaël Colin, M.D., Jean-Pierre Frat, M.D., Ph.D., Jean-Paul Mira, M.D., Ph.D., Nicolas Barbarot, M.D., Bruno François, M.D., Guillaume Louis, M.D., Sébastien Gibot, M.D., Ph.D., Christophe Guitton, M.D., Ph.D., Christophe Giacardi, M.D., Sami Hraiech, M.D., Ph.D., Sylvie Vimeux, M.D., Erwan L’Her, M.D., Ph.D., Henri Faure, M.D., Jean-Etienne Herbrecht, M.D., Camille Bouisse, M.D., Aurélie Joret, M.D., Nicolas Terzi, M.D., Ph.D., Arnaud Gacouin, M.D., Charlotte Quentin, M.D., Mercé Jourdain, M.D., Ph.D., Marie Leclerc, M.Sc., Carine Coffre, M.Sc., Hélène Bourgoin, Pharm.D., Céline Lengellé, Pharm.D., Caroline Caille-Fénérol, M.Sc., Bruno Giraudeau, Ph.D., and Amélie Le Gouge, M.Sc. for the CRICS-TriGGERSep Network*
doi : 10.1056/NEJMoa2215145
Whether the antiinflammatory and immunomodulatory effects of glucocorticoids may decrease mortality among patients with severe community-acquired pneumonia is unclear.
Meningococcal ACWYX Conjugate Vaccine in 2-to-29-Year-Olds in Mali and Gambia
Fadima C. Haidara, M.D., Ama Umesi, M.B., B.S., Samba O. Sow, M.D., Magnus Ochoge, M.B., B.Ch., Fatoumata Diallo, M.D., Abdulazeez Imam, M.B., B.S., Youssouf Traore, M.D., Lucy Affleck, M.B., Ch.B., Moussa F. Doumbia, M.D., Bubacarr Daffeh, M.B., Ch.B., Mamoudou Kodio, Pharm.D., Oghenebrume Wariri, M.B., B.S., Awa Traoré, Pharm.D., Edrissa Jallow, B.Sc., Beate Kampmann, Ph.D., Dhananjay Kapse, M.D., Prasad S. Kulkarni, M.D., Asha Mallya, Ph.D., Sunil Goel, Ph.D., Pankaj Sharma, M.Sc., Annamraju D. Sarma, Ph.D., Nikhil Avalaskar, M.Pharm., F. Marc LaForce, M.D., Mark R. Alderson, Ph.D., Abdi Naficy, M.D., Steve Lamola, M.D., Yuxiao Tang, Ph.D., Lionel Martellet, M.A., Nancy Hosken, Ph.D., Evangelos Simeonidis, Ph.D., Jo Anne Welsch, Ph.D., Milagritos D. Tapia, M.D., and Ed Clarke, M.B., Ch.B.
doi : 10.1056/NEJMoa2214924
An effective, affordable, multivalent meningococcal conjugate vaccine is needed to prevent epidemic meningitis in the African meningitis belt. Data on the safety and immunogenicity of NmCV-5, a pentavalent vaccine targeting the A, C, W, Y, and X serogroups, have been limited.
Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia
Floor L.F. van Baarle, M.D., Emma K. van de Weerdt, M.D., Ph.D., Walter J.F.M. van der Velden, M.D., Ph.D., Roelof A. Ruiterkamp, M.Sc., Pieter R. Tuinman, M.D., Ph.D., Paula F. Ypma, M.D., Ph.D., Walter M. van den Bergh, M.D., Ph.D., Astrid M.P. Demandt, M.D., Emile D. Kerver, M.D., A.J. Gerard Jansen, M.D., Ph.D., Peter E. Westerweel, M.D., Ph.D., Sesmu M. Arbous, M.D., Ph.D., Rogier M. Determann, M.D., Ph.D., Walther N.K.A. van Mook, M.D., Ph.D., Mirelle Koeman, M.D., Ph.D., Anja B.U. Mäkelburg, M.D., Ph.D., Krijn P. van Lienden, M.D., Ph.D., Jan M. Binnekade, Ph.D., Bart J. Biemond, M.D., Ph.D., and Alexander P.J. Vlaar, M.D., Ph.D.
doi : 10.1056/NEJMoa2214322
Transfusion guidelines regarding platelet-count thresholds before the placement of a central venous catheter (CVC) offer conflicting recommendations because of a lack of good-quality evidence. The routine use of ultrasound guidance has decreased CVC-related bleeding complications.
Upadacitinib Induction and Maintenance Therapy for Crohn’s Disease
Edward V. Loftus, Jr., M.D., Julian Panés, M.D., Ana P. Lacerda, M.D., Laurent Peyrin-Biroulet, M.D., Ph.D., Geert D’Haens, M.D., Remo Panaccione, M.D., Walter Reinisch, M.D., Edouard Louis, M.D., Ph.D., Minhu Chen, M.D., Hiroshi Nakase, M.D., Jakob Begun, M.D., Brigid S. Boland, M.D., Charles Phillips, M.D., Mohamed-Eslam F. Mohamed, Ph.D., Jianzhong Liu, M.D., Ziqian Geng, Ph.D., Tian Feng, Ph.D., Elena Dubcenco, M.D., and Jean-Frederic Colombel, M.D.
doi : 10.1056/NEJMoa2212728
Upadacitinib, an oral selective Janus kinase (JAK) inhibitor, is under investigation for the treatment of Crohn’s disease.
The Current and Future State of AI Interpretation of Medical Images
Pranav Rajpurkar, Ph.D., and Matthew P. Lungren, M.D., M.P.H.
doi : 10.1056/NEJMra2301725
Medication-Related Osteonecrosis of the Jaw
Yu-Feng Chen, D.D.S., M.D.S., and Hong-Po Chang, D.M.D., Ph.D.
doi : 10.1056/NEJMicm2209172
Case 16-2023: A 13-Year-Old Boy with Depression and Hypotension
Kevin R. Schwartz, M.D., Abigail L. Donovan, M.D., Bryan D. Hayes, Pharm.D., Mai Uchida, M.D., and Joy B. Rosen, M.S.
doi : 10.1056/NEJMcpc2201237
Time to Treat Severe Community-Acquired Pneumonia with Steroids?
Joshua P. Metlay, M.D., Ph.D., and Grant W. Waterer, M.B., B.S., Ph.D.
doi : 10.1056/NEJMe2302544
Audio Interview: The Lasting Effects of Covid-19
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2306166
Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression
doi : 10.1056/NEJMc2304804
