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Combating West Nile Virus Disease — Time to Revisit Vaccination
Carolyn V. Gould, M.D., J. Erin Staples, M.D., Claire Y.-H. Huang, Ph.D., Aaron C. Brault, Ph.D., and Randall J. Nett, M.D.
doi : 10.1056/NEJMp2301816
Vol. 388 No. 18
Beyond the X — Next Steps in Policy Reforms to Address the Overdose Crisis
Sarah E. Wakeman, M.D., and Leo Beletsky, J.D., M.P.H.
doi : 10.1056/NEJMp2301479
Interrupting Endocrine Therapy to Attempt Pregnancy after Breast Cancer
Ann H. Partridge, M.D., M.P.H., Samuel M. Niman, M.S., Monica Ruggeri, Fedro A. Peccatori, M.D., Ph.D., Hatem A. Azim, Jr., M.D., Ph.D., Marco Colleoni, M.D., Cristina Saura, M.D., Ph.D., Chikako Shimizu, M.D., Anna B. Sætersdal, M.D., Judith R. Kroep, M.D., Ph.D., Audrey Mailliez, M.D., Ellen Warner, M.D., Virginia F. Borges, M.D., Frédéric Amant, M.D., Andrea Gombos, M.D., Akemi Kataoka, M.D., Christine Rousset-Jablonski, M.D., Ph.D., Simona Borstnar, M.D., Ph.D., Junko Takei, M.D., Jeong E. Lee, M.D., Ph.D., Janice M. Walshe, M.D., Manuel RuÃz-Borrego, M.D., Halle C.F. Moore, M.D., Christobel Saunders, M.D., Vesna Bjelic-Radisic, M.D., Ph.D., Snezana Susnjar, M.D., Fatima Cardoso, M.D., Karen L. Smith, M.D., M.P.H., Teresa Ferreiro, Ph.D., Karin Ribi, Ph.D., M.P.H., Kathryn Ruddy, M.D., M.P.H., Roswitha Kammler, B.A., Sarra El-Abed, M.D., Giuseppe Viale, Ph.D., Martine Piccart, M.D., Ph.D., Larissa A. Korde, M.D., M.P.H., Aron Goldhirsch, M.D., Richard D. Gelber, Ph.D., and Olivia Pagani, M.D. for the International Breast Cancer Study Group, and the POSITIVE Trial Collaboratorsâ€
doi : 10.1056/NEJMoa2212856
Prospective data on the risk of recurrence among women with hormone receptor–positive early breast cancer who temporarily discontinue endocrine therapy to attempt pregnancy are lacking.
Trifluridine–Tipiracil and Bevacizumab in Refractory Metastatic Colorectal Cancer
Gerald W. Prager, M.D., Julien Taieb, M.D., Ph.D., Marwan Fakih, M.D., Fortunato Ciardiello, M.D., Ph.D., Eric Van Cutsem, M.D., Ph.D., Elena Elez, M.D., Ph.D., Felipe M. Cruz, M.D., Ph.D., Lucjan Wyrwicz, M.D., Ph.D., Daniil Stroyakovskiy, M.D., Ph.D., Zsuzsanna Pápai, M.D., Pierre-Guillaume Poureau, M.D., Gabor Liposits, M.D., Chiara Cremolini, M.D., Ph.D., Igor Bondarenko, M.D., Ph.D., Dominik P. Modest, M.D., Karim A. Benhadji, M.D., Nadia Amellal, M.D., Catherine Leger, M.Sc., Loïck Vidot, M.Sc., and Josep Tabernero, M.D., Ph.D. for the SUNLIGHT Investigators*
doi : 10.1056/NEJMoa2214963
In a previous phase 3 trial, treatment with trifluridine–tipiracil (FTD–TPI) prolonged overall survival among patients with metastatic colorectal cancer. Preliminary data from single-group and randomized phase 2 trials suggest that treatment with FTD–TPI in addition to bevacizumab has the potential to extend survival.
Intravascular Imaging–Guided or Angiography-Guided Complex PCI
Joo Myung Lee, M.D., Ph.D., M.P.H., Ki Hong Choi, M.D., Ph.D., Young Bin Song, M.D., Ph.D., Jong-Young Lee, M.D., Ph.D., Seung-Jae Lee, M.D., Ph.D., Sang Yeub Lee, M.D., Ph.D., Sang Min Kim, M.D., Ph.D., Kyeong Ho Yun, M.D., Ph.D., Jae Young Cho, M.D., Ph.D., Chan Joon Kim, M.D., Ph.D., Hyo-Suk Ahn, M.D., Ph.D., Chang-Wook Nam, M.D., Ph.D., Hyuck-Jun Yoon, M.D., Ph.D., Yong Hwan Park, M.D., Ph.D., Wang Soo Lee, M.D., Ph.D., Jin-Ok Jeong, M.D., Ph.D., Pil Sang Song, M.D., Ph.D., Joon-Hyung Doh, M.D., Ph.D., Sang-Ho Jo, M.D., Ph.D., Chang-Hwan Yoon, M.D., Ph.D., Min Gyu Kang, M.D., Ph.D., Jin-Sin Koh, M.D., Ph.D., Kwan Yong Lee, M.D., Ph.D., Young-Hyo Lim, M.D., Ph.D., Yun-Hyeong Cho, M.D., Ph.D., Jin-Man Cho, M.D., Ph.D., Woo Jin Jang, M.D., Ph.D., Kook-Jin Chun, M.D., Ph.D., David Hong, M.D., Taek Kyu Park, M.D., Ph.D., Jeong Hoon Yang, M.D., Ph.D., Seung-Hyuk Choi, M.D., Ph.D., Hyeon-Cheol Gwon, M.D., Ph.D., and Joo-Yong Hahn, M.D., Ph.D. for the RENOVATE-COMPLEX-PCI Investigators*
doi : 10.1056/NEJMoa2216607
Data regarding clinical outcomes after intravascular imaging–guided percutaneous coronary intervention (PCI) for complex coronary-artery lesions, as compared with outcomes after angiography-guided PCI, are limited.
Reappraisal of Idiopathic CD4 Lymphocytopenia at 30 Years
Andrea Lisco, M.D., Ph.D., Ana M. Ortega-Villa, Ph.D., Harry Mystakelis, M.D., M.H.S., Megan V. Anderson, R.N., B.A., Allyson Mateja, M.S.P.H., Elizabeth Laidlaw, P.A.-C., Maura Manion, M.D., Gregg Roby, R.N., B.S., Jeanette Higgins, Ph.D., Safia Kuriakose, Pharm.D., Magdalena A. Walkiewicz, Ph.D., Morgan Similuk, Sc.M., Jennifer W. Leiding, M.D., Alexandra F. Freeman, M.D., Virginia Sheikh, M.D., and Irini Sereti, M.D., M.H.S.
doi : 10.1056/NEJMoa2202348
Idiopathic CD4 lymphocytopenia (ICL) is a clinical syndrome that is defined by CD4 lymphopenia of less than 300 cells per cubic millimeter in the absence of any primary or acquired cause of immunodeficiency. Some 30 years after its original identification, ICL has remained a disease of obscure cause, with limited evidence with respect to its prognosis or management, despite diagnostic and therapeutic innovations.
Sporotrichoid Nodular Lymphangitis from Nocardia brasiliensis
Luca Pipito, M.D., and Antonio Cascio, M.D., Ph.D.
doi : 10.1056/NEJMicm2213996
Lead Poisoning
Siddhartha Dhar, M.D., and Divyani Garg, M.D., D.M., D.N.B.
doi : 10.1056/NEJMicm2210842
A Diagnostic Sequence
Heather M. Giannini, M.D., Clement Lee, M.D., Cameron Baston, M.D., and Daniel Dorgan, M.D.
doi : 10.1056/NEJMcps2214685
POSITIVE Results for Breast Cancer Survivors Who Desire Pregnancy
Sharon H. Giordano, M.D., M.P.H.
doi : 10.1056/NEJMe2301139
Combination Therapy, Including Bevacizumab, for Advanced Colorectal Cancer
Oladapo O. Yeku, M.D., Ph.D., and Dan L. Longo, M.D.
doi : 10.1056/NEJMe2300385
Time to Recovery as Measured on Clinical Assessments after Sport-Related Concussion
doi : 10.1056/NEJMc2301706
