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Access to Biomedical Innovation — Inside the Legal Labyrinth
Arti K. Rai, J.D.
doi : 10.1056/NEJMp2202098
Vol. 388 No. 17
How the FDA Can Improve Public Health — Helping People Stop Smoking
Neal L. Benowitz, M.D., Kenneth E. Warner, Ph.D., Matthew L. Myers, J.D., Dorothy Hatsukami, Ph.D., Micah L. Berman, J.D., Donna Vallone, Ph.D., and Joanna E. Cohen, Ph.D.
doi : 10.1056/NEJMp2301700
Racial Affinity Group Caucusing in Medical Education — A Key Supplement to Antiracism Curricula
Leanna Lewis, M.S.W., Camila Cribb Fabersunne, M.D., M.P.H., Corina L. Iacopetti, M.D., Gabby Negussie-Retta, M.S., Dannielle McBride, M.D., Paul Irving, B.A., and Jyothi Marbin, M.D.
doi : 10.1056/NEJMp2212866
Fifteen-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer
Freddie C. Hamdy, F.R.C.S.(Urol.), F.Med.Sci., Jenny L. Donovan, Ph.D., F.Med.Sci., J. Athene Lane, Ph.D., Chris Metcalfe, Ph.D., Michael Davis, M.Sc., Emma L. Turner, Ph.D., Richard M. Martin, B.M., B.S., Ph.D., Grace J. Young, M.Sc., Eleanor I. Walsh, M.Sc., Richard J. Bryant, Ph.D., F.R.C.S.(Urol.), Prasad Bollina, M.B., B.S., F.R.C.S.(Urol.), Andrew Doble, F.R.C.S.(Urol.),
doi : 10.1056/NEJMoa2214122
Between 1999 and 2009 in the United Kingdom, 82,429 men between 50 and 69 years of age received a prostate-specific antigen (PSA) test. Localized prostate cancer was diagnosed in 2664 men. Of these men, 1643 were enrolled in a trial to evaluate the effectiveness of treatments, with 545 randomly assigned to receive active monitoring, 553 to undergo prostatectomy, and 545 to undergo radiotherapy.
Genomic Diagnosis of Rare Pediatric Disease in the United Kingdom and Ireland
Caroline F. Wright, Ph.D., Patrick Campbell, M.B., B.S., Ruth Y. Eberhardt, Ph.D., Stuart Aitken, Ph.D., Daniel Perrett, M.Phil., Simon Brent, B.Sc., Petr Danecek, Ph.D., Eugene J. Gardner, Ph.D., V. Kartik Chundru, Ph.D., Sarah J. Lindsay, Ph.D., Katrina Andrews, M.B., B.Ch., Juliet Hampstead, B.Sc.,
doi : 10.1056/NEJMoa2209046
Pediatric disorders include a range of highly penetrant, genetically heterogeneous conditions amenable to genomewide diagnostic approaches. Finding a molecular diagnosis is challenging but can have profound lifelong benefits.
Blinatumomab Added to Chemotherapy in Infant Lymphoblastic Leukemia
Inge M. van der Sluis, M.D., Ph.D., Paola de Lorenzo, Ph.D., Rishi S. Kotecha, M.B., Ch.B., Ph.D., Andishe Attarbaschi, M.D., Gabriele Escherich, M.D., Karsten Nysom, M.D., Ph.D., Jan Stary, M.D., Ph.D., Alina Ferster, M.D., Benoit Brethon, M.D., Franco Locatelli, M.D., Ph.D., Martin Schrappe, M.D., Peggy E. Scholte-van Houtem, M.Sc., Maria G. Valsecchi, Ph.D., and Rob Pieters, M.D., Ph.D.
doi : 10.1056/NEJMoa2214171
KMT2A-rearranged acute lymphoblastic leukemia (ALL) in infants is an aggressive disease with 3-year event-free survival below 40%. Most relapses occur during treatment, with two thirds occurring within 1 year and 90% within 2 years after diagnosis. Outcomes have not improved in recent decades despite intensification of chemotherapy.
Randomized Trial of BCG Vaccine to Protect against Covid-19 in Health Care Workers
Laure F. Pittet, Ph.D., Nicole L. Messina, Ph.D., Francesca Orsini, M.Sc., Cecilia L. Moore, Ph.D., Veronica Abruzzo, M.Clin.Epi., Simone Barry, Ph.D., Rhian Bonnici, B.Sc., Marc Bonten, Ph.D., John Campbell, M.D., Julio Croda, Ph.D., Margareth Dalcolmo, Ph.D., Kaya Gardiner, M.P.H.,
doi : 10.1056/NEJMoa2212616
The bacille Calmette–Guérin (BCG) vaccine has immunomodulatory “off-target� effects that have been hypothesized to protect against coronavirus disease 2019 (Covid-19).
Advances in Artificial Intelligence for Infectious-Disease Surveillance
John S. Brownstein, Ph.D., Benjamin Rader, M.P.H., Christina M. Astley, M.D., Sc.D., and Huaiyu Tian, Ph.D.
doi : 10.1056/NEJMra2119215
Dissecting Cellulitis of the Scalp
Salim N. Najjar, M.D., and Alec B. Rezigh, M.D.
doi : 10.1056/NEJMicm2211456
Isolated Ulnar Shaft Fracture
Ting-Han Tai, M.D., and Chih-Yu Chen, M.D., Ph.D.
doi : 10.1056/NEJMicm2211242
Case 13-2023: A 25-Year-Old Woman with Abdominal Pain and Jerking Movements
Leigh H. Simmons, M.D., Mladen Nisavic, M.D., and Amy K. Dickey, M.D.
doi : 10.1056/NEJMcpc2300896
Genomics in Clinical Practice
Jennifer E. Posey, M.D., Ph.D., and James R. Lupski, M.D., Ph.D.
doi : 10.1056/NEJMe2302643
Audio Interview: Preparing for the Next Pandemic
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Quarraisha Abdool Karim, Ph.D., Salim S. Abdool Karim, M.B., Ch.B., Ph.D., Richard P. Wenzel, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2305010
Dietary Sodium Restriction in Patients with Heart Failure
Leslie L. Chang, M.D., Jacqueline T. DesJardin, M.D., Michelle A. Albert, M.D., M.P.H., Justin Ezekowitz, M.B., B.Ch., and Salim Yusuf, M.D., D.Phil.
doi : 10.1056/NEJMclde2215283
