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Future Directions for Adrenal Insufficiency: Cellular Transplantation and Genetic Therapies
Lara E Graves, David J Torpy, P Toby Coates, Ian E Alexander, Stefan R Bornstein, Brigette Clarke
doi : 10.1210/clinem/dgac751
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1273–1289
Primary adrenal insufficiency (PAI) occurs in 1 in 5 to 7000 adults. Leading etiologies are autoimmune adrenalitis in adults and congenital adrenal hyperplasia (CAH) in children. Oral replacement of cortisol is lifesaving, but poor quality of life, repeated adrenal crises, and dosing uncertainty related to lack of a validated biomarker for glucocorticoid sufficiency persists.
Systemic Activation of the Kynurenine Pathway in Graves Disease With and Without Ophthalmopathy
Hans Olav Ueland, Arve Ulvik, Kristian Løvås, Anette S B Wolff, Lars Ertesvåg Breivik, Ann-Elin Meling Stokland, Eyvind Rødahl, Roy Miodini Nilsen, Eystein Husebye, Grethe Åstrøm Ueland
doi : 10.1210/clinem/dgad004
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1290–1297
Graves disease (GD) is one of the most common autoimmune disorders. Recent literature has shown an immune response involving several different inflammatory related proteins in these patients.
Real-life Data on the Effect of Medical Therapy for Amiodarone-induced Thyrotoxicosis on CV Events and Hospitalizations
Daniele Cappellani, Giulia Marconcini, Luca Manetti, Luigi Bartalena, Fausto Bogazzi
doi : 10.1210/clinem/dgac756
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1298–1307
Patients with amiodarone-induced thyrotoxicosis (AIT) often receive initial therapy for thyrotoxicosis in several different medical settings before admission to a referral center.
Body Fat Distribution, Fasting Insulin Levels, and Insulin Secretion: A Bidirectional Mendelian Randomization Study
Eloi Gagnon, Patricia L Mitchell, Benoit J Arsenault
doi : 10.1210/clinem/dgac758
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1308–1317
Hyperinsulinemia and adiposity are associated with one another, but the directionality of this relation is debated.
Association of Urinary Nitrate With Diabetes Complication and Disease-Specific Mortality Among Adults With Hyperglycemia
Wenbo Jiang, Jia Zhang, Ruiming Yang, Xinyi Sun, Huanyu Wu, Jiacheng Zhang, Siyao Liu, Changhao Sun, Lifang Ma, Tianshu Han, Wei Wei
doi : 10.1210/clinem/dgac741
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1318–1329
The hyperglycemia condition disrupts metabolism of nitrate/nitrite and nitric oxide, and dietary nitrate intake can restore nitric oxide homeostasis.
Response to Surgery Assessments for Sparing Radioiodine Remnant Ablation in Intermediate-Risk Papillary Thyroid Cancer
Xin Zhang, Jie-Rui Liu, Zhuan-Zhuan Mu, Xin-Qi Cheng, Yan-Song Lin
doi : 10.1210/clinem/dgac745
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1330–1337
Using response to surgery when tailoring radioiodine (RAI) therapy for papillary thyroid cancer (PTC) is valued but lacks prospective validation.
Difference of Risk of Pancreatic Cancer in New-Onset Diabetes and Long-standing Diabetes: A Population-based Cohort Study
Hee Seung Lee, Wonjeong Chae, Min Je Sung, Jiyoung Keum, Jung Hyun Jo, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Eun-Cheol Park, Chung Mo Nam, Sung-In Jang, Seungmin Bang
doi : 10.1210/clinem/dgac728
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1338–1347
Considering the absence of methods to find pancreatic cancer early, surveillance of high-risk groups is needed for early diagnosis.
Accumulation in Visceral Adipose Tissue Over 6 Years Is Associated With Lower Paraspinal Muscle Density
Ching-Ti Liu, Timothy Tsai, Brett T Allaire, Mary L Bouxsein, Marian T Hannan, Thomas G Travison, Douglas P Kiel
doi : 10.1210/clinem/dgac744
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1348–1354
Visceral adipose tissue (VAT) has been recognized to be a metabolically active fat depot that may have paracrine effects on surrounding tissues, including muscle. Since many adults accumulate VAT as they age, the effect of changes in VAT on muscle is of interest.
Novel Insulin-Like Growth Factor 1 Gene Mutation: Broadening of the Phenotype and Implications for Insulin Resistance
Claudio Giacomozzi, Ayelen Martin, MarÃa Celia Fernández, Mariana Gutiérrez, Maria Iascone, Horacio M Domené, Fernando P Dominici, Ignacio Bergadá, Biagio Cangiano, Luca Persani, Patricia A Pennisi
doi : 10.1210/clinem/dgac738
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1355–1369
Insulin-like growth factor (IGF)1 gene mutations are extremely rare causes of pre- and postnatal growth retardation. Phenotype can be heterogenous with varying degrees of neurosensory deafness, cognitive defects, glucose metabolism impairment and short stature.
Aggressive Subtypes of Papillary Thyroid Carcinoma Smaller Than 1 cm
Jin Seok Lee, Jun Sung Lee, Hyeok Jun Yun, Seok Mo Kim, Hojin Chang, Yong Sang Lee, Hang-Seok Chang, Cheong Soo Park
doi : 10.1210/clinem/dgac739
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1370–1375
Tumor size is important in determining the range of surgery in papillary thyroid carcinomas (PTCs), especially those smaller than 1 cm.
β-Cell Function and Insulin Sensitivity in Youth With Early Type 1 Diabetes From a 2-Hour 7-Sample OGTT
Alfonso Galderisi, Carmella Evans-Molina, Mariangela Martino, Sonia Caprio, Claudio Cobelli, Antoinette Moran
doi : 10.1210/clinem/dgac740
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1376–1386
The oral minimal model is a widely accepted noninvasive tool to quantify both β-cell responsiveness and insulin sensitivity (SI) from glucose, C-peptide, and insulin concentrations during a 3-hour 9-point oral glucose tolerance test (OGTT).
Circulating FGF21 Concentration, Fasting Plasma Glucose, and the Risk of Type 2 Diabetes: Results From the PREVEND Study
Adrian Post, Wendy A Dam, Sara Sokooti, Dion Groothof, Jolein Gloerich, Alain J van Gool, Daan Kremer, Ron T Gansevoort, Jacob van den Born, Ido P Kema, Casper F M Franssen, Robin P F Dullaart, Stephan J L Bakker
doi : 10.1210/clinem/dgac729
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1387–1393
Fibroblast growth factor 21 (FGF21) is a peptide hormone synthesized by several organs and regulates, among others, energy homeostasis. In obesity, insulin resistance and type 2 diabetes (T2D), higher circulating FGF21 concentrations have been found.
Inhibition of Oocyte Maturation by Follicular Extracellular Vesicles of Nonhyperandrogenic PCOS Patients Requiring IVF
Chang Liu, Meng Wang, Haixia Yao, Mengge Cui, Xueqi Gong, Lan Wang, Cong Sui, Hanwang Zhang
doi : 10.1210/clinem/dgac733
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1394–1404
Polycystic ovary syndrome (PCOS) is one of the most common diseases that contribute to subfertility. Recent evidence showed that oocytes of women with PCOS matured in vitro away from the follicular fluid presented better potentials, whereas the reason remained unclear.
Effect of Conventional Treatment on Dental Complications and Ectopic Ossifications Among 30 Adults With XLH
Hajime Kato, Rena Okawa, Toru Ogasawara, Yoshitomo Hoshino, Naoko Hidaka, Minae Koga, Yuka Kinoshita, Hiroshi Kobayashi, Yuki Taniguchi, Seiji Fukumoto, Masaomi Nangaku, Noriko Makita, Kazuto Hoshi, Kazuhiko Nakano, Nobuaki Ito
doi : 10.1210/clinem/dgac732
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1405–1414
Conventional treatment of X-linked hypophosphatemia (XLH) was reported to prevent dental complications, but whether the preventive effect was different among different types of teeth, including anterior teeth and molar teeth, is uncertain. Evidence of the preventive effect of conventional treatment on ectopic ossifications is also limited.
Effect of an Intermittent Calorie-restricted Diet on Type 2 Diabetes Remission: A Randomized Controlled Trial
Xiao Yang, Jiali Zhou, Huige Shao, Bi Huang, Xincong Kang, Ruiyu Wu, Fangzhou Bian, Minghai Hu, Dongbo Liu
doi : 10.1210/clinem/dgac661
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1415–1424
The 2021 consensus report on the definition and interpretation of remission of type 2 diabetes (T2D) has been released. Although intermittent fasting diets (IF) are becoming very popular, no studies have investigated their benefit in diabetes remission.
Follow-Up of Patients After Total Pancreatectomy and Islet Cell Autotransplantation at Off-Site Islet Isolation Facility
Saloni U Lad, Khawla F Ali, Philip C Johnston, Vicente T San Martin, Rita Bottino, Yu Kuei Lin, R Matthew Walsh, Tyler Stevens, Chao Tu, Betul Hatipoglu
doi : 10.1210/clinem/dgac674
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1425–1431
Total pancreatectomy with islet autotransplantation (TPIAT) is a definitive management for intractable pain in patients with chronic pancreatitis (CP). Islet autotransplantation (IAT) allows for the preservation of beta cells to prevent complications of long-term diabetes.
Causal Association Between Obesity, Circulating Glutamine Levels, and Depression: A Mendelian Randomization Study
Ruixin He, Ruizhi Zheng, Jie Zheng, Mian Li, Tiange Wang, Zhiyun Zhao, Shuangyuan Wang, Hong Lin, Jieli Lu, Yuhong Chen, Yu Xu, Weiqing Wang, Min Xu, Yufang Bi, Guang Ning
doi : 10.1210/clinem/dgac707
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1432–1441
Observational studies indicated obesity and glutamatergic dysfunction as potential risk factors of depression, and reported disturbance of glutamine metabolism in obese state. However, it remains unclear whether the interrelationships between obesity, glutamine, and depression are causal.
Effects of 25-Hydroxyvitamin D Levels on Renal Function: A Bidirectional Mendelian Randomization Study
Manel Adi, Faegheh Ghanbari, Mallory L Downie, Adriana Hung, Cassiane Robinson-Cohen, Despoina Manousaki
doi : 10.1210/clinem/dgac724
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1442–1451
Observational studies investigating the role of vitamin D in renal function have yielded inconsistent results.
Integrating Methylome and Transcriptome Signatures Expands the Molecular Classification of the Pituitary Tumors
Rui M PatrÃcio da Silva-Júnior, Ana Carolina Bueno, Clarissa Silva Martins, Fernanda Coelli-Lacchini, Jorge Guilherme Okanobo Ozaki, Danillo Cunha de Almeida-e-Silva, Junier Marrero-Gutiérrez, Antônio Carlos dos Santos, Carlos Garcia-Peral, Hélio Rubens Machado, Marcelo Volpon dos Santos, Paula Lamparelli Elias, Ayrton C Moreira, Leandro M Colli, Ricardo Z N Vêncio, Sonir R Antonini, Margaret de Castro
doi : 10.1210/clinem/dgac703
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1452–1463
To explore pituitary tumors by methylome and transcriptome signatures in a heterogeneous ethnic population.
Nicotinamide Nucleotide Transhydrogenase Is Essential for Adrenal Steroidogenesis: Clinical and In Vitro Lessons
Aline Faccioli Bodoni, Fernanda Borchers Coeli-Lacchini, Juliana Lourenço Gebenlian, Lays Martin Sobral, Cristiana Bernadelli Garcia, Wilson Araújo Silva, Jr, Kamila Chagas Peronni, Leandra Náira Zambelli Ramalho, Fernando Silva Ramalho, Ayrton C Moreira, Margaret de Castro, Andreia Machado Leopoldino, Sonir Roberto Rauber Antonini
doi : 10.1210/clinem/dgac705
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1464–1474
Nicotinamide nucleotide transhydrogenase (NNT) acts as an antioxidant defense mechanism. NNT mutations cause familial glucocorticoid deficiency (FGD). How impaired oxidative stress disrupts adrenal steroidogenesis remains poorly understood.
Efficacy and Safety of Osilodrostat in Paraneoplastic Cushing Syndrome: A Real-World Multicenter Study in France
Alexandre Dormoy, Magalie Haissaguerre, Géraldine Vitellius, Christine Do Cao, Aurore Geslot, Delphine Drui, Hélène Lasolle, Oceana Vieira-Pinto, Sylvie Salenave, Maud François, Marie Puerto, Hélène Du Boullay, Anne Mayer, Anne Rod, Claire Laurent, Philippe Chanson, Yves Reznik, Frédéric Castinetti, Olivier Chabre, Eric Baudin, Gérald Raverot, Antoine Tabarin, Jacques Young
doi : 10.1210/clinem/dgac691
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1475–1487
Prospective studies have demonstrated the efficacy of osilodrostat in Cushing disease. No study has evaluated osilodrostat in a series of patients with paraneoplastic Cushing syndrome/ectopic adrenocorticotropin syndrome (PNCS/EAS).
Approach to the Patient: A Case With an Unusual Cause of Hypopituitarism
Liza Das, Pinaki Dutta
doi : 10.1210/clinem/dgac747
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1488–1504
Hypopituitarism, which refers to insufficiency of one or more hormones of the pituitary, can be due to myriad causes. The clinical and radiological spectrum of the condition is heterogeneous, based on the patient’s age, gender, clinical setting, and/or other past medical history.
Approach to the Patient: Management of Parathyroid Diseases Across Pregnancy
Natasha M Appelman-Dijkstra, Stefan Pilz
doi : 10.1210/clinem/dgac734
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1505–1513
Taking care of patients with parathyroid disorders during pregnancy requires consideration of the physiological fundamental changes in bone and mineral metabolism occurring in these women. Diagnostic and therapeutic procedures regarding primary hyperparathyroidism (PHPT) and hypoparathyroidism significantly differ from the nonpregnant population.
Approach to the Patient With Immune Checkpoint Inhibitor–Associated Endocrine Dysfunction
Jordan J Wright, Douglas B Johnson
doi : 10.1210/clinem/dgac689
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1514–1525
Immune checkpoint inhibitors (ICI) are cancer therapies that are approved for use in at least 19 different cancers. They function by stimulating immune cell responses against cancer, and their toxicities comprise a host of autoinflammatory syndromes that may impact any organ system.
Real-World Performance of the Afirma Genomic Sequencing Classifier (GSC)—A Meta-analysis
Christian E Nasr, Massimiliano Andrioli, Mayumi Endo, R Mack Harrell, Masha J Livhits, Ibitoro Osakwe, Preethi Polavarapu, Allan Siperstein, Shuanzeng Wei, Xingyu Zheng, Ruochen Jiang, Yangyang Hao, J I ng Huang, Joshua P Klopper, Richard T Kloos, Giulia Kennedy, Trevor E Angell
doi : 10.1210/clinem/dgac688
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages 1526–1532
The Afirma® GSC aids in risk stratifying indeterminate thyroid nodule cytology (ITN). The 2018 GSC validation study (VS) reported a sensitivity (SN) of 91%, specificity (SP) of 68%, positive predictive value (PPV) of 47%, and negative predictive value (NPV) of 96%. Since then, 13 independent real-world (RW) postvalidation studies have been published.
Dynamic Risk Stratification for Predicting Long-term Outcomes in Pediatric Differentiated Thyroid Cancers
Althaf K Majeed, Swayamjeet Satapathy, Sanjana Ballal, Chandrasekhar Bal
doi : 10.1210/clinem/dgac731
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e208–e215
The American Thyroid Association (ATA) guidelines recommend Dynamic Risk Stratification (DRS) for predicting long-term outcomes and personalizing management in adult differentiated thyroid cancers (DTCs). However, its applicability in pediatric DTCs needs to be validated.
Proton Pump Inhibitor Use and Risks of Cardiovascular Disease and Mortality in Patients With Type 2 Diabetes
Tingting Geng, Jun-Xiang Chen, Yan-Feng Zhou, Qi Lu, Zhenzhen Wan, Liegang Liu, An Pan, Gang Liu
doi : 10.1210/clinem/dgac750
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e216–e222
Proton pump inhibitors (PPIs) are widely used drugs for gastric acid–related diseases and may affect the gut microbiome.
Prediagnostic Vitamin D Status and Colorectal Cancer Survival by Vitamin D Binding Protein Isoforms in US Cohorts
Hanseul Kim, Chen Yuan, Long H Nguyen, Kimmie Ng, Edward L Giovannucci
doi : 10.1210/clinem/dgac742
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e223–e229
Lower 25-hydroxyvitamin D (25(OH)D) levels have consistently been associated with higher mortality among participants with colorectal cancer (CRC).
Sex-specific Trajectories of Insulin Resistance Markers and Reduced Renal Function During 18 Years of Follow-up: TLGS
Atieh Amouzegar, Mohammadjavad Honarvar, Safdar Masoumi, Maryam Tohidi, Ladan Mehran, Fereidoun Azizi
doi : 10.1210/clinem/dgac735
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e230–e239
The evidence suggest that insulin resistance (IR) complicates chronic kidney disease (CKD); however, the longitudinal association of IR with development of CKD is unknown.
Low T3 Syndrome on Admission and Response to Nutritional Support in Malnourished Medical Inpatients
Natasha Anouschka Müller, Nina Kaegi-Braun, Mirsada Durmisi, Carla Gressies, Pascal Tribolet, Zeno Stanga, Beat Mueller, Philipp Schuetz
doi : 10.1210/clinem/dgac743
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e240–e248
During illness, deiodination of thyroxine (T4) to triiodothyronine (T3) is downregulated. This is called “low T3 syndrome�, an adaptive metabolic mechanism to reduce energy expenditure and prevent catabolism.
Does the Risk of Embryo Abnormality Increase in PCOS Women? A Secondary Analysis of a Multicenter, Randomized Controlled Trial
Jiahui Wang, Wei Zhou, Zhiyi Song, Tianxiang Ni, Qian Zhang, Zi-Jiang Chen, Junhao Yan
doi : 10.1210/clinem/dgac726
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e249–e257
Some studies have reported the early miscarriage rate is higher in polycystic ovary syndrome (PCOS) women. However, there is a lack of evidence as to whether the risk of embryo abnormalities increases in PCOS women.
Serum Thyrotropin and Triiodothyronine Levels in Levothyroxine-treated Patients
Matthew D Ettleson, Wesley H Prieto, Pedro S T Russo, Jose de Sa, Wen Wan, Neda Laiteerapong, Rui M B Maciel, Antonio C Bianco
doi : 10.1210/clinem/dgac725
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e258–e266
Small adjustments in levothyroxine (LT4) dose do not appear to provide clinical benefit despite changes in thyrotropin (TSH) levels within the reference range. We hypothesize that the accompanying changes in serum total triiodothyronine (T3) levels do not reflect the magnitude of the changes in serum TSH.
Evaluating Disease-specific Survival Prediction of Risk Stratification and TNM Systems in Differentiated Thyroid Cancer
Evert F S van Velsen, Robin P Peeters, Merel T Stegenga, Folkert J van Kemenade, Tessa M van Ginhoven, Mathé van Balkum, Frederik A Verburg, W Edward Visser
doi : 10.1210/clinem/dgac721
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e267–e274
Many countries have national guidelines for the management of differentiated thyroid cancer (DTC), including a risk stratification system to predict recurrence of disease. Studies whether these guidelines could also have relevance, beyond their original design, in predicting survival are lacking.
A Genetic Assessment of Dopamine Agonist-Induced Impulse Control Disorder in Patients With Prolactinoma
Serdar Sahin, Tugce Sudutan, Yasin Kavla, Emre Durcan, Yeliz Yagiz Özogul, Burc Cagri Poyraz, Muge Sayitoglu, Hande Mefkure Ozkaya, Pinar Kadioglu
doi : 10.1210/clinem/dgac718
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e275–e282
Dopamine agonist (DA)–induced impulse control disorder (ICD) represents a group of behavioral disorders that are increasingly recognized in patients with prolactinoma.
A Computed Tomography-based Radiomics Nomogram for Predicting Osteoporotic Vertebral Fractures: A Longitudinal Study
Miaomiao Wang, Xin Chen, Wenjing Cui, Xinru Wang, Nandong Hu, Hongye Tang, Chao Zhang, Jirong Shen, Chao Xie, Xiao Chen
doi : 10.1210/clinem/dgac722
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e283–e294
Fractures are a serious consequence of osteoporosis in older adults. However, few longitudinal studies have shown the role of computed tomography (CT)-based radiomics in predicting osteoporotic fractures.
Association of Obesity and Diabetes With SARS-CoV-2 Infection and Symptoms in the COVID-19 Community Research Partnership
Morgana Mongraw-Chaffin, Ashley Hogan Tjaden, Austin Lyles Seals, Kristen Miller, Naheed Ahmed, Mark A Espeland, Michael Gibbs, Dorey Thomas, Diane Uschner, William S Weintraub, Sharon L Edelstein, Covid-19 Community Research Partnership
doi : 10.1210/clinem/dgac715
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e295–e305
Obesity and diabetes are established risk factors for severe SARS-CoV-2 outcomes, but less is known about their impact on susceptibility to COVID-19 infection and general symptom severity.
MicroRNAs Associated With Incident Diabetes in the Diabetes Prevention Program
Elena Flowers, Bradley E Aouizerat, Alka M Kanaya, Jose C Florez, Xingyue Gong, Li Zhang
doi : 10.1210/clinem/dgac714
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e306–e312
MicroRNAs (miRs) are short (ie, 18-26 nucleotide) regulatory elements of messenger RNA translation to amino acids.
Dehydroepiandrosterone Sulfate and Mortality in Middle-Aged and Older Men and Women—A J-shaped Relationship
Trasias Mukama, Theron Johnson, Verena Katzke, Rudolf Kaaks
doi : 10.1210/clinem/dgac716
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e313–e325
The relationship between dehydroepiandrosterone sulfate (DHEAS) and mortality is of scientific and public health interest, yet it remains poorly understood.
Combined Detection of Islet Autoantibodies for Clinical Diagnosis of Type 1 Diabetes in the Low-Prevalence Population
Yanyan Qi, Shuang Chen, Heng Chen, Yang Chen, Yun Shi, Yao Qin, Mei Zhang, Tao Yang, Yong Gu
doi : 10.1210/clinem/dgac720
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e326–e333
Single positive islet autoantibodies (IAbs), sometimes detected in healthy individuals and patients with low-risk of developing type 1 diabetes (T1D), are considered to be irrelevant to the development of diabetes, making it difficult to diagnose and classify adult-onset diabetes.
Association of Type 2 Diabetes Subgroups With Cognitive Status Without Modification From Lifestyle Intervention
Michael P Bancks, James Lovato, Ashok Balasubramanyam, Mace Coday, Karen C Johnson, Medha Munshi, Candida Rebello, Lynne E Wagenknecht, Mark A Espeland
doi : 10.1210/clinem/dgac706
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e334–e342
Type 2 diabetes is a risk factor for incident dementia but whether risk and treatment/prevention strategies differ by diabetes subgroup is unknown.
Rates of Pheochromocytoma/Paraganglioma Screening in At-Risk Populations
Seda Grigoryan, Winnie Nhan, Lei Zhang, Caitlin Urban, Lili Zhao, Adina F Turcu
doi : 10.1210/clinem/dgac701
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e343–e349
Pheochromocytomas and paragangliomas (PPGL) are rare causes of secondary hypertension, but when unrecognized, they can lead to serious complications. Data regarding PPGL screening are lacking.
Pheochromocytoma/Paraganglioma Screening: Low Rates in At-Risk Populations
Peter Igaz
doi : 10.1210/clinem/dgad029
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e350–e351
Type 2 Diabetes Remission: Achieving Calorie Restriction and Weight Loss by Any Which Way?
James G Boyle, Michael E J Lean
doi : 10.1210/clinem/dgac755
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e352–e353
Letter to the Editor From Virú-Loza and Chávez-Nomberto: “Safety and Efficacy of Pediatric Growth Hormone Therapy: Results From the Full KIGS Cohort�
Manuel André Virú-Loza, Ruth Elizabeth Chávez-Nomberto
doi : 10.1210/clinem/dgad054
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e354–e355
Response to Letter to the Editor From Virú-Loza and Chávez-Nomberto: “Safety and Efficacy of Pediatric Growth Hormone Therapy: Results From the Full KIGS Cohort�
Mohamad Maghnie, Michael B Ranke, Mitchell E Geffner, Elpis Vlachopapadopoulou, Lourdes Ibáñez, Martin Carlsson, Wayne Cutfield, Raoul Rooman, Roy Gomez, Michael P Wajnrajch, Agnès Linglart, Renata Stawerska, Peter E Clayton, Feyza Darendeliler, Anita C S Hokken-Koelega, Reiko Horikawa, Toshiaki Tanaka, Helmuth-Günther Dörr, Kerstin Albertsson-Wikland, Michel Polak, Adda Grimberg
doi : 10.1210/clinem/dgad055
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Pages e356–e357,
Correction to: “Accumulation in Visceral Adipose Tissue Over 6 Years Is Associated With Lower Paraspinal Muscle Density�
doi : 10.1210/clinem/dgad167
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Page e358
Correction to “Systemic Activation of the Kynurenine Pathway in Graves Disease With and Without Ophthalmopathy�
doi : 10.1210/clinem/dgad067
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 6, June 2023, Page e359
