Carlos A DÃaz-Balzac, David Pillinger, Steven D Wittlin
doi : 10.1210/clinem/dgac746
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1019–1033
Continuous subcutaneous insulin infusions (CSIIs) and continuous glucose monitors (CGMs) have revolutionized the management of diabetes mellitus (DM).
John P Bilezikian, Neil Binkley, Hector F De Luca, Angelo Fassio, Anna Maria Formenti, Ghada El-Hajj Fuleihan, Annemieke C Heijboer, Andrea Giustina
doi : 10.1210/clinem/dgac719
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1034–1042
This work aims to review and discuss controversial topics in the field of vitamin D, SARS-CoV-2 infection, and COVID-19.
Anders Juul, Philippe Backeljauw, Marco Cappa, Alberto Pietropoli, Nicky Kelepouris, Agnès Linglart, Roland Pfäffle, Mitchell Geffner
doi : 10.1210/clinem/dgac694
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1043–1052
Early initiation of growth hormone (GH) therapy is recommended for short children born small for gestational age (SGA); however, real-world data indicate that treatment is often delayed.
Rana Halloun, Alfonso Galderisi, Sonia Caprio, Ram Weiss
doi : 10.1210/clinem/dgac700
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1053–1060
The “carbohydrate-insulin model� claims that adipose tissue insulin sensitivity explains development of obesity via adipocyte energy storage and/or low postprandial metabolic fuel levels.
Jingxian Pei, Cheng Liu, Zhengxia Yang, Yanxian Lai, Shenghui Zhang, Tianwang Guan, Yan Shen
doi : 10.1210/clinem/dgac709
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1061–1074
Refractory angina pectoris (RAP) is a specific subtype of coronary artery disease (CAD). Lipoprotein(a) [Lp(a)] and its induced coronary microvascular dysfunction (CMD) play an important role in pathogenesis of RAP, but its metabolism was mostly genetically determined. The adenosine triphosphate (ATP)-sensitive potassium channel (KATP) is involved in lipid metabolism and microvascular homeostasis and becomes a promising target for the management of Lp(a) and its related RAP.
Wei Xian, Dide Wu, Boyuan Liu, Shubin Hong, Zijun Huo, Haipeng Xiao, Yanbing Li
doi : 10.1210/clinem/dgac683
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1075–1083
Both Graves disease (GD) and inflammatory bowel disease (IBD) are common autoimmune diseases that severely damage a patient’s quality of life. Previous epidemiological studies have suggested associations between GD and IBD. However, whether a causal relationship exists between these 2 diseases remains unknown.
Majid Mufaqam Syed-Abdul, Priska Stahel, Alyssa Zembroski, Lili Tian, Changting Xiao, Avital Nahmias, Ian Bookman, Kimberly K Buhman, Gary F Lewis
doi : 10.1210/clinem/dgac690
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1084–1092
A portion of ingested fats are retained in the intestine for many hours before they are mobilized and secreted in chylomicron (CM) particles. Factors such as glucagon-like peptide-2 (GLP-2) and glucose can mobilize these stored intestinal lipids and enhance CM secretion.
Jinghao Cai, Qing Yang, Jingyi Lu, Yun Shen, Chunfang Wang, Lei Chen, Lei Zhang, Wei Lu, Wei Zhu, Tian Xia, Jian Zhou
doi : 10.1210/clinem/dgac692
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1093–1100
Previous studies suggest that the complexity of glucose time series may serve as a novel marker of glucose homeostasis.
Andrew S Perry, Jeffrey S Annis, Hiral Master, Matthew Nayor, Andrew Hughes, Aymone Kouame, Karthik Natarajan, Kayla Marginean, Venkatesh Murthy, Dan M Roden, Paul A Harris, Ravi Shah, Evan L Brittain
doi : 10.1210/clinem/dgac695
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1101–1109
Prior studies of the relationship between physical activity and incident type 2 diabetes mellitus (T2DM) relied primarily on questionnaires at a single time point.
Christine Sommer, Kjersti G Vangberg, Gunn-Helen Moen, David M Evans, Sindre Lee-Ødegård, Ingvild K Blom-Høgestøl, Line Sletner, Anne K Jenum, Christian A Drevon, Hanne L Gulseth, Kåre I Birkeland
doi : 10.1210/clinem/dgac699
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1110–1119
Serum soluble leptin receptor (sOb-R) may protect against future type 2 diabetes or serve as a marker for protective features, but how sOb-R is regulated is largely unknown.
Rachana D Shah, Steven D Chernausek, Laure El ghormli, Mitchell E Geffner, Joyce Keady, Megan M Kelsey, Ryan Farrell, Bereket Tesfaldet, Jeanie B Tryggestad, Michelle Van Name, Elvira Isganaitis
doi : 10.1210/clinem/dgac663
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1120–1131
Prenatal exposures, including undernutrition, overnutrition, and parental diabetes, are recognized risk factors for future cardiometabolic disease. There are currently no data on effects of parental diabetes on disease progression or complications in youth-onset type 2 diabetes (T2D).
Camilo Jimenez, Junsheng Ma, Alejandro Roman Gonzalez, Jeena Varghese, Miao Zhang, Nancy Perrier, Mouhammed Amir Habra, Paul Graham, Steven G Waguespack
doi : 10.1210/clinem/dgac677
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1132–1142
Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors. Metastases develop in 15% to 20%. The American Joint Committee on Cancer (AJCC) established inaugural guidelines for PPGL tumor-node-metastasis (TNM) staging.
Ana Alice W Maciel, Thais C Freitas, Gustavo F C Fagundes, Janaina Petenuci, Leticia A P Vilela, Luciana P Brito, Tatiana S Goldbaum, Maria Claudia N Zerbini, Felipe L Ledesma, Fabio Y Tanno, Victor Srougi, Jose L Chambo, Maria Adelaide A Pereira, Fernando M A Coelho, Aline C B S Cavalcante, Francisco C Carnevale, Bruna Pilan, Andrea Pio-Abreu, João V Silveira, Fernanda M Consolim-Colombo, Luiz A Bortolotto, Ana Claudia Latronico, Maria Candida B V Fragoso, Luciano F Drager, Berenice B Mendonca, Madson Q Almeida
doi : 10.1210/clinem/dgac679
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1143–1153
Primary aldosteronism (PA) screening relies on an elevated aldosterone to renin ratio with a minimum aldosterone level, which varies from 10 to 15 ng/dL (277-415.5 pmol/L) using immunoassay.
Zora Messner, David Carro Vázquez, Judith Haschka, Johannes Grillari, Heinrich Resch, Christian Muschitz, Peter Pietschmann, Jochen Zwerina, Matthias Hackl, Roland Kocijan
doi : 10.1210/clinem/dgac667
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1154–1165
MicroRNAs (miRNAs)—short, single-stranded, noncoding RNAs—regulate several biological processes, including bone metabolism.
Huan-Huan Yang, Fu-Rong Li, Ze-Kun Chen, Meng-Ge Zhou, Li-Feng Xie, Yuan-Yuan Jin, Zhi-Hui Li, Guo-Chong Chen
doi : 10.1210/clinem/dgac642
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1166–1172
The influences of diabetes duration and glycemic control and their potential interplays on the risk of heart failure (HF) remain unclear.
Ji Eun Jun, Seung-Eun Lee, You-Bin Lee, Gyuri Kim, Sang-Man Jin, Jae Hwan Jee, Jae Hyeon Kim
doi : 10.1210/clinem/dgac662
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1173–1180
Low skeletal muscle mass often accompanies abdominal obesity in the aging process.
Maria Santa Rocca, Giovanni Minervini, Cinzia Vinanzi, Alberto Bottacin, Federica Lia, Carlo Foresta, Maria Pennuto, Alberto Ferlin
doi : 10.1210/clinem/dgac671
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1181–1191
Mutations in the androgen receptor (AR) gene might be associated with infertility mainly because they cause various degrees of androgen insensitivity.
Srilaxmi Kalavalapalli, Eddison Godinez Leiva, Romina Lomonaco, Xiaofei Chi, Sulav Shrestha, Rachel Dillard, Jeffery Budd, Jessica Portillo Romero, Christina Li, Fernando Bril, George Samraj, John Pennington, Petra Townsend, Frank Orlando, Shwetha Shetty, Lydia Mansour, Lorena Rodrigues Silva-Sombra, Pierre Bedossa, John Malaty, Diana Barb, Matthew J Gurka, Kenneth Cusi
doi : 10.1210/clinem/dgac660
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1192–1201
Although type 2 diabetes (T2D) is a risk factor for liver fibrosis in nonalcoholic fatty liver disease (NAFLD), the specific contribution of insulin resistance (IR) relative to other factors is unknown.
Chaojie Ye, Lijie Kong, Yiying Wang, Hong Lin, Shuangyuan Wang, Zhiyun Zhao, Mian Li, Yu Xu, Jieli Lu, Yuhong Chen, Min Xu, Weiqing Wang, Guang Ning, Yufang Bi, Tiange Wang
doi : 10.1210/clinem/dgac658
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1202–1214
Whether diabetes diagnosed at different age groups is causally associated with cardiovascular diseases (CVDs) is unknown.
Minghao Li, Yazhi He, Yingxian Pang, Jing Zhang, Yu Feng, Yao He, Xiaowen Xu, Yongbao Wei, Dewen Zhong, Wanglong Deng, Long Wang, Bin Yan, Yazhuo Jiang, Ning Xu, Hai Cai, Yanlin Wen, Jinzhuo Ning, Yujun Liu, Xin Gao, Zhongyan Shan, Longfei Liu, Xiaochun Teng, Susan Richter, Jingjing Jiang
doi : 10.1210/clinem/dgac653
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1215–1223
IDH1 is a pheochromocytoma/paraganglioma (PPGL) susceptibility gene; however, its role, especially in the Chinese population, has not been characterized.
Xiaolin Ni, Wei Liu, Dingding Zhang, Xiang Li, Yue Chi, Juan Feng, Chenxi Jin, Qianqian Pang, Yiyi Gong, Lijia Cui, Ruizhi Jiajue, Wei Yu, Huanwen Wu, Li Huo, Yong Liu, Jin Jin, Xi Zhou, Wei Lv, Lian Zhou, Yu Xia, Ou Wang, Mei Li, Xiaoping Xing, Yan Jiang, Weibo Xia
doi : 10.1210/clinem/dgac650
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1224–1235,
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 (FGF23) by a tumor. Hyperparathyroidism (HPT) including secondary HPT (SHPT) and tertiary HPT (THPT) in TIO patients, which is believed to be associated with phosphate supplementation, has not been well documented.
Ashley H Shoemaker, Jaclyn Tamaroff
doi : 10.1210/clinem/dgac678
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1236–1242
Hypothalamic obesity (HO) is defined as abnormal weight gain due to physical destruction of the hypothalamus. Suprasellar tumors, most commonly craniopharyngiomas, are a classic cause of HO. HO often goes unnoticed initially as patients, families, and medical teams are focused on oncologic treatments and management of panhypopituitarism.
Angelica Lindén Hirschberg
doi : 10.1210/clinem/dgac673
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1243–1253
Postmenopausal hyperandrogenism is a condition caused by relative or absolute androgen excess originating from the ovaries and/or the adrenal glands. Hirsutism, in other words, increased terminal hair growth in androgen-dependent areas of the body, is considered the most effective measure of hyperandrogenism in women.
Chong Boon Teo, Ming Yi Gan, Ryan Yong Kiat Tay, Wann Jia Loh, Ne-Hooi Will Loh
doi : 10.1210/clinem/dgac685
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1254–1271
Preoperative hyponatremia is prevalent in patients undergoing surgical procedures, but it is uncertain if hyponatremia will lead to increased risk of surgical mortality and morbidity.
Ronald J Sigal, Jane E Yardley, Bruce A Perkins, Michael C Riddell, Gary S Goldfield, Lois Donovan, Janine Malcolm, Stasia Hadjiyannakis, Alun L Edwards, Réjeanne Gougeon, George A Wells, Danièle Pacaud, Vincent Woo, Gordon T Ford, Doug Coyle, Penny Phillips, Steve Doucette, Farah Khandwala, Glen P Kenny, the READI Trial Investigators
doi : 10.1210/clinem/dgac682
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e63–e75
Resistance exercise training (strength training) and aerobic exercise training are both recommended for people with type 1 diabetes, but it is unknown whether adding resistance exercise provides incremental benefits in people with this condition who already perform aerobic exercise regularly.
Chun Ho Wong, Eunice Ka Hong Leung, Lawrence Chi Kin Tang, Chi Ho Lee, Carol Ho Yi Fong, Alan Chun Hong Lee, Yu Cho Woo, Kathryn Choon Beng Tan, David Tak Wai Lui
doi : 10.1210/clinem/dgac684
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e76–e88
Reports of thyroid dysfunction following COVID-19 vaccination included cases of relapse of Graves' disease and worsening of pre-existing Graves' disease. Little is known about the thyroid-specific outcomes among patients treated for hyperthyroidism who have received COVID-19 vaccination.
Ze’ev Hochberg, Kerstin Albertsson-Wikland, Florian Privé, Alina German, Anton Holmgren, Lisa Rubin, Michael Shmoish
doi : 10.1210/clinem/dgac665
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e89–e97
Resource trade-off theory suggests that increased performance on a given trait comes at the cost of decreased performance on other traits.
Federico Gatto, Richard A Feelders, Peter M van Koetsveld, Fadime Dogan, Sebastian J C M M Neggers, Aart-Jan van der Lelij, Jessica Amarù, Diego Ferone, Leo J Hofland
doi : 10.1210/clinem/dgac675
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e98–e109
Cabergoline (CAB) is an off-label medical therapy for acromegaly, overshadowed by first-generation somatostatin receptor ligands, eg, octreotide (OCT).
Dana Bliuc, Thach Tran, Weiwen Chen, Dunia Alarkawi, Dima A Alajlouni, Fiona Blyth, Lyn March, Robert D Blank, Jacqueline R Center
doi : 10.1210/clinem/dgac669
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e110–e119
Bisphosphonates have been reported to be cardioprotective in some, but not all, studies. It is unknown whether denosumab (Dmab) use protects against cardiovascular events (CVEs).
Phil A Hart, Yogish C Kudva, Dhiraj Yadav, Dana K Andersen, Yisheng Li, Frederico G S Toledo, Fuchenchu Wang, Melena D Bellin, David Bradley, Randall E Brand, Kenneth Cusi, William Fisher, Kieren Mather, Walter G Park, Zeb Saeed, Robert V Considine, Sarah C Graham, Jo Ann Rinaudo, Jose Serrano, Mark O Goodarzi
doi : 10.1210/clinem/dgac670
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e120–e128
Pancreatogenic diabetes refers to diabetes mellitus (DM) that develops in the setting of a disease of the exocrine pancreas, including pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). We sought to evaluate whether a blunted nutrient response of pancreatic polypeptide (PP) can differentiate these DM subtypes from type 2 DM (T2DM).
Anne Pourquet, Jordan Teoli, Aurore Bouty, Lucie Renault, Florence Roucher, Delphine Mallet, Chantal Rigaud, Frédérique Dijoud, Pierre Mouriquand, Pierre-Yves Mure, Damien Sanlaville, René Ecochard, Ingrid Plotton
doi : 10.1210/clinem/dgac656
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e129–e138
Determination of steroid levels in the amniotic fluid gives some insight on fetal adrenal and gonadal functions.
Laura Alvarez-Jimenez, Felix Morales-Palomo, Alfonso Moreno-Cabañas, Juan F Ortega, Ricardo Mora-Rodriguez
doi : 10.1210/clinem/dgac668
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e139–e147
Statins blunt cardiorespiratory fitness improvements after exercise training and may affect fat oxidation adaptations to training.
Monica R Gadelha, Murray B Gordon, Mirjana Doknic, Emese Mezősi, Miklós Tóth, Harpal Randeva, Tonya Marmon, Theresa Jochelson, Rosa Luo, Michael Monahan, Ajay Madan, Christine Ferrara-Cook, R Scott Struthers, Alan Krasner
doi : 10.1210/clinem/dgac643
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e148–e159
Paltusotine is a once-daily, oral, nonpeptide small-molecule somatostatin receptor type 2 (SST2) agonist in clinical development for treatment of acromegaly.
Giovanna Rotondo Dottore, Giulia Lanzolla, Simone Comi, Francesca Menconi, Lodovica Cristofani Mencacci, Iacopo Dallan, Claudio Marcocci, Michele Marinò
doi : 10.1210/clinem/dgac645
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e160–e168
A role of DNA methylation in Graves orbitopathy (GO) has been proposed.
Megan N Perez, Stephen Halada, Amber Isaza, Lindsay Sisko, Sogol Mostoufi-Moab, Andrew J Bauer, Lamia P Barakat
doi : 10.1210/clinem/dgac648
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e169–e177
Pediatric thyroid cancer (TC) incidence rates are increasing, yet TC has one of the highest survival rates. Despite increased prevalence, little is known about youth adjustment to TC, particularly compared to other pediatric cancers.
Filippo Ceccato, Mattia Barbot, Alessandro Mondin, Marco Boscaro, Maria Fleseriu, Carla Scaroni
doi : 10.1210/clinem/dgac686
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e178–e188
Diagnostic accuracy of testing currently used for the differential diagnosis of Cushing disease (CD) vs ectopic adrenocorticotropic hormone secretion (EAS) is difficult to interpret.
Justin B Echouffo-Tcheugui
doi : 10.1210/clinem/dgac761
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e189–e190
Tamar Reisman, Joshua D Safer
doi : 10.1210/clinem/dgac757
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e191–e192
David S McLaren, Robert D Murray
doi : 10.1210/clinem/dgac762
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e193–e194
Rosario Pivonello, Cristina de Angelis, Davide Menafra, Annamaria Colao
doi : 10.1210/clinem/dgac730
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e195–e196
Shijie Yang, Meijuan Tan, Feng Gao, Xiequn Xu
doi : 10.1210/clinem/dgac753
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e197
Jee-Hye Choi, Ja Kyung Lee, Woochul Kim, Hyeong Won Yu, Su-jin Kim, Young Jun Chai, June Young Choi, Kyu Eun Lee
doi : 10.1210/clinem/dgac754
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e198–e199
doi : 10.1210/clinem/dgad064
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e200
doi : 10.1210/clinem/dgad065
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e201
doi : 10.1210/clinem/dgad057
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e202
doi : 10.1210/clinem/dgad062
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e203
doi : 10.1210/clinem/dgad012
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e204
doi : 10.1210/clinem/dgad022
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e205
doi : 10.1210/clinem/dgad023
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e206
doi : 10.1210/clinem/dgad056
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e207
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