Journal of Clinical Endocrinology and Metabolism : JCEM




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Continuous Subcutaneous Insulin Infusions: Closing the Loop

Carlos A Díaz-Balzac, David Pillinger, Steven D Wittlin

doi : 10.1210/clinem/dgac746

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1019–1033

Continuous subcutaneous insulin infusions (CSIIs) and continuous glucose monitors (CGMs) have revolutionized the management of diabetes mellitus (DM).

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Consensus and Controversial Aspects of Vitamin D and COVID-19

John P Bilezikian, Neil Binkley, Hector F De Luca, Angelo Fassio, Anna Maria Formenti, Ghada El-Hajj Fuleihan, Annemieke C Heijboer, Andrea Giustina

doi : 10.1210/clinem/dgac719

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1034–1042

This work aims to review and discuss controversial topics in the field of vitamin D, SARS-CoV-2 infection, and COVID-19.

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Early Growth Hormone Initiation Leads to Favorable Long-Term Growth Outcomes in Children Born Small for Gestational Age

Anders Juul, Philippe Backeljauw, Marco Cappa, Alberto Pietropoli, Nicky Kelepouris, Agnès Linglart, Roland Pfäffle, Mitchell Geffner

doi : 10.1210/clinem/dgac694

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1043–1052

Early initiation of growth hormone (GH) therapy is recommended for short children born small for gestational age (SGA); however, real-world data indicate that treatment is often delayed.

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Adipose Tissue Insulin Resistance Is Not Associated With Changes in the Degree of Obesity in Children and Adolescents

Rana Halloun, Alfonso Galderisi, Sonia Caprio, Ram Weiss

doi : 10.1210/clinem/dgac700

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1053–1060

The “carbohydrate-insulin model� claims that adipose tissue insulin sensitivity explains development of obesity via adipocyte energy storage and/or low postprandial metabolic fuel levels.

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Association of KATP Variants With CMD and RAP in CAD Patients With Increased Serum Lipoprotein(a) Levels

Jingxian Pei, Cheng Liu, Zhengxia Yang, Yanxian Lai, Shenghui Zhang, Tianwang Guan, Yan Shen

doi : 10.1210/clinem/dgac709

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1061–1074

Refractory angina pectoris (RAP) is a specific subtype of coronary artery disease (CAD). Lipoprotein(a) [Lp(a)] and its induced coronary microvascular dysfunction (CMD) play an important role in pathogenesis of RAP, but its metabolism was mostly genetically determined. The adenosine triphosphate (ATP)-sensitive potassium channel (KATP) is involved in lipid metabolism and microvascular homeostasis and becomes a promising target for the management of Lp(a) and its related RAP.

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Graves Disease and Inflammatory Bowel Disease: A Bidirectional Mendelian Randomization

Wei Xian, Dide Wu, Boyuan Liu, Shubin Hong, Zijun Huo, Haipeng Xiao, Yanbing Li

doi : 10.1210/clinem/dgac683

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1075–1083

Both Graves disease (GD) and inflammatory bowel disease (IBD) are common autoimmune diseases that severely damage a patient’s quality of life. Previous epidemiological studies have suggested associations between GD and IBD. However, whether a causal relationship exists between these 2 diseases remains unknown.

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Glucagon-like Peptide-2 Acutely Enhances Chylomicron Secretion in Humans Without Mobilizing Cytoplasmic Lipid Droplets

Majid Mufaqam Syed-Abdul, Priska Stahel, Alyssa Zembroski, Lili Tian, Changting Xiao, Avital Nahmias, Ian Bookman, Kimberly K Buhman, Gary F Lewis

doi : 10.1210/clinem/dgac690

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1084–1092

A portion of ingested fats are retained in the intestine for many hours before they are mobilized and secreted in chylomicron (CM) particles. Factors such as glucagon-like peptide-2 (GLP-2) and glucose can mobilize these stored intestinal lipids and enhance CM secretion.

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Impact of the Complexity of Glucose Time Series on All-Cause Mortality in Patients With Type 2 Diabetes

Jinghao Cai, Qing Yang, Jingyi Lu, Yun Shen, Chunfang Wang, Lei Chen, Lei Zhang, Wei Lu, Wei Zhu, Tian Xia, Jian Zhou

doi : 10.1210/clinem/dgac692

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1093–1100

Previous studies suggest that the complexity of glucose time series may serve as a novel marker of glucose homeostasis.

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Association of Longitudinal Activity Measures and Diabetes Risk: An Analysis From the National Institutes of Health All of Us Research Program

Andrew S Perry, Jeffrey S Annis, Hiral Master, Matthew Nayor, Andrew Hughes, Aymone Kouame, Karthik Natarajan, Kayla Marginean, Venkatesh Murthy, Dan M Roden, Paul A Harris, Ravi Shah, Evan L Brittain

doi : 10.1210/clinem/dgac695

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1101–1109

Prior studies of the relationship between physical activity and incident type 2 diabetes mellitus (T2DM) relied primarily on questionnaires at a single time point.

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Insulin and Body Mass Index Decrease Serum Soluble Leptin Receptor Levels in Humans

Christine Sommer, Kjersti G Vangberg, Gunn-Helen Moen, David M Evans, Sindre Lee-Ødegård, Ingvild K Blom-Høgestøl, Line Sletner, Anne K Jenum, Christian A Drevon, Hanne L Gulseth, Kåre I Birkeland

doi : 10.1210/clinem/dgac699

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1110–1119

Serum soluble leptin receptor (sOb-R) may protect against future type 2 diabetes or serve as a marker for protective features, but how sOb-R is regulated is largely unknown.

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Maternal Diabetes in Youth-Onset Type 2 Diabetes Is Associated With Progressive Dysglycemia and Risk of Complications

Rachana D Shah, Steven D Chernausek, Laure El ghormli, Mitchell E Geffner, Joyce Keady, Megan M Kelsey, Ryan Farrell, Bereket Tesfaldet, Jeanie B Tryggestad, Michelle Van Name, Elvira Isganaitis

doi : 10.1210/clinem/dgac663

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1120–1131

Prenatal exposures, including undernutrition, overnutrition, and parental diabetes, are recognized risk factors for future cardiometabolic disease. There are currently no data on effects of parental diabetes on disease progression or complications in youth-onset type 2 diabetes (T2D).

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TNM Staging and Overall Survival in Patients With Pheochromocytoma and Sympathetic Paraganglioma

Camilo Jimenez, Junsheng Ma, Alejandro Roman Gonzalez, Jeena Varghese, Miao Zhang, Nancy Perrier, Mouhammed Amir Habra, Paul Graham, Steven G Waguespack

doi : 10.1210/clinem/dgac677

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1132–1142

Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors. Metastases develop in 15% to 20%. The American Joint Committee on Cancer (AJCC) established inaugural guidelines for PPGL tumor-node-metastasis (TNM) staging.

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Intra-individual Variability of Serum Aldosterone and Implications for Primary Aldosteronism Screening

Ana Alice W Maciel, Thais C Freitas, Gustavo F C Fagundes, Janaina Petenuci, Leticia A P Vilela, Luciana P Brito, Tatiana S Goldbaum, Maria Claudia N Zerbini, Felipe L Ledesma, Fabio Y Tanno, Victor Srougi, Jose L Chambo, Maria Adelaide A Pereira, Fernando M A Coelho, Aline C B S Cavalcante, Francisco C Carnevale, Bruna Pilan, Andrea Pio-Abreu, João V Silveira, Fernanda M Consolim-Colombo, Luiz A Bortolotto, Ana Claudia Latronico, Maria Candida B V Fragoso, Luciano F Drager, Berenice B Mendonca, Madson Q Almeida

doi : 10.1210/clinem/dgac679

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1143–1153

Primary aldosteronism (PA) screening relies on an elevated aldosterone to renin ratio with a minimum aldosterone level, which varies from 10 to 15 ng/dL (277-415.5 pmol/L) using immunoassay.

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Circulating miRNAs Respond to Denosumab Treatment After 2 Years in Postmenopausal Women With Osteoporosis—the MiDeTe study

Zora Messner, David Carro Vázquez, Judith Haschka, Johannes Grillari, Heinrich Resch, Christian Muschitz, Peter Pietschmann, Jochen Zwerina, Matthias Hackl, Roland Kocijan

doi : 10.1210/clinem/dgac667

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1154–1165

MicroRNAs (miRNAs)—short, single-stranded, noncoding RNAs—regulate several biological processes, including bone metabolism.

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Duration of Diabetes, Glycemic Control, and Risk of Heart Failure Among Adults With Diabetes: A Cohort Study

Huan-Huan Yang, Fu-Rong Li, Ze-Kun Chen, Meng-Ge Zhou, Li-Feng Xie, Yuan-Yuan Jin, Zhi-Hui Li, Guo-Chong Chen

doi : 10.1210/clinem/dgac642

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1166–1172

The influences of diabetes duration and glycemic control and their potential interplays on the risk of heart failure (HF) remain unclear.

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Low Skeletal Muscle Mass Accompanied by Abdominal Obesity Additively Increases the Risk of Incident Type 2 Diabetes

Ji Eun Jun, Seung-Eun Lee, You-Bin Lee, Gyuri Kim, Sang-Man Jin, Jae Hwan Jee, Jae Hyeon Kim

doi : 10.1210/clinem/dgac662

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1173–1180

Low skeletal muscle mass often accompanies abdominal obesity in the aging process.

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Mutational Screening of Androgen Receptor Gene in 8224 Men of Infertile Couples

Maria Santa Rocca, Giovanni Minervini, Cinzia Vinanzi, Alberto Bottacin, Federica Lia, Carlo Foresta, Maria Pennuto, Alberto Ferlin

doi : 10.1210/clinem/dgac671

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1181–1191

Mutations in the androgen receptor (AR) gene might be associated with infertility mainly because they cause various degrees of androgen insensitivity.

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Adipose Tissue Insulin Resistance Predicts the Severity of Liver Fibrosis in Patients With Type 2 Diabetes and NAFLD

Srilaxmi Kalavalapalli, Eddison Godinez Leiva, Romina Lomonaco, Xiaofei Chi, Sulav Shrestha, Rachel Dillard, Jeffery Budd, Jessica Portillo Romero, Christina Li, Fernando Bril, George Samraj, John Pennington, Petra Townsend, Frank Orlando, Shwetha Shetty, Lydia Mansour, Lorena Rodrigues Silva-Sombra, Pierre Bedossa, John Malaty, Diana Barb, Matthew J Gurka, Kenneth Cusi

doi : 10.1210/clinem/dgac660

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1192–1201

Although type 2 diabetes (T2D) is a risk factor for liver fibrosis in nonalcoholic fatty liver disease (NAFLD), the specific contribution of insulin resistance (IR) relative to other factors is unknown.

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Causal Associations Between Age at Diagnosis of Diabetes and Cardiovascular Outcomes: A Mendelian Randomization Study

Chaojie Ye, Lijie Kong, Yiying Wang, Hong Lin, Shuangyuan Wang, Zhiyun Zhao, Mian Li, Yu Xu, Jieli Lu, Yuhong Chen, Min Xu, Weiqing Wang, Guang Ning, Yufang Bi, Tiange Wang

doi : 10.1210/clinem/dgac658

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1202–1214

Whether diabetes diagnosed at different age groups is causally associated with cardiovascular diseases (CVDs) is unknown.

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Somatic IDH1 Hotspot Variants in Chinese Patients With Pheochromocytomas and Paragangliomas

Minghao Li, Yazhi He, Yingxian Pang, Jing Zhang, Yu Feng, Yao He, Xiaowen Xu, Yongbao Wei, Dewen Zhong, Wanglong Deng, Long Wang, Bin Yan, Yazhuo Jiang, Ning Xu, Hai Cai, Yanlin Wen, Jinzhuo Ning, Yujun Liu, Xin Gao, Zhongyan Shan, Longfei Liu, Xiaochun Teng, Susan Richter, Jingjing Jiang

doi : 10.1210/clinem/dgac653

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1215–1223

IDH1 is a pheochromocytoma/paraganglioma (PPGL) susceptibility gene; however, its role, especially in the Chinese population, has not been characterized.

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Hyperparathyroidism in a Large Cohort of Chinese Patients With Tumor-induced Osteomalacia

Xiaolin Ni, Wei Liu, Dingding Zhang, Xiang Li, Yue Chi, Juan Feng, Chenxi Jin, Qianqian Pang, Yiyi Gong, Lijia Cui, Ruizhi Jiajue, Wei Yu, Huanwen Wu, Li Huo, Yong Liu, Jin Jin, Xi Zhou, Wei Lv, Lian Zhou, Yu Xia, Ou Wang, Mei Li, Xiaoping Xing, Yan Jiang, Weibo Xia

doi : 10.1210/clinem/dgac650

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1224–1235,

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 (FGF23) by a tumor. Hyperparathyroidism (HPT) including secondary HPT (SHPT) and tertiary HPT (THPT) in TIO patients, which is believed to be associated with phosphate supplementation, has not been well documented.

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Approach to the Patient With Hypothalamic Obesity

Ashley H Shoemaker, Jaclyn Tamaroff

doi : 10.1210/clinem/dgac678

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1236–1242

Hypothalamic obesity (HO) is defined as abnormal weight gain due to physical destruction of the hypothalamus. Suprasellar tumors, most commonly craniopharyngiomas, are a classic cause of HO. HO often goes unnoticed initially as patients, families, and medical teams are focused on oncologic treatments and management of panhypopituitarism.

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Approach to Investigation of Hyperandrogenism in a Postmenopausal Woman

Angelica Lindén Hirschberg

doi : 10.1210/clinem/dgac673

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1243–1253

Postmenopausal hyperandrogenism is a condition caused by relative or absolute androgen excess originating from the ovaries and/or the adrenal glands. Hirsutism, in other words, increased terminal hair growth in androgen-dependent areas of the body, is considered the most effective measure of hyperandrogenism in women.

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Association of Preoperative Hyponatremia With Surgical Outcomes: A Systematic Review and Meta-analysis of 32 Observational Studies

Chong Boon Teo, Ming Yi Gan, Ryan Yong Kiat Tay, Wann Jia Loh, Ne-Hooi Will Loh

doi : 10.1210/clinem/dgac685

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages 1254–1271

Preoperative hyponatremia is prevalent in patients undergoing surgical procedures, but it is uncertain if hyponatremia will lead to increased risk of surgical mortality and morbidity.

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The Resistance Exercise in Already Active Diabetic Individuals (READI) Randomized Clinical Trial

Ronald J Sigal, Jane E Yardley, Bruce A Perkins, Michael C Riddell, Gary S Goldfield, Lois Donovan, Janine Malcolm, Stasia Hadjiyannakis, Alun L Edwards, Réjeanne Gougeon, George A Wells, Danièle Pacaud, Vincent Woo, Gordon T Ford, Doug Coyle, Penny Phillips, Steve Doucette, Farah Khandwala, Glen P Kenny, the READI Trial Investigators

doi : 10.1210/clinem/dgac682

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e63–e75

Resistance exercise training (strength training) and aerobic exercise training are both recommended for people with type 1 diabetes, but it is unknown whether adding resistance exercise provides incremental benefits in people with this condition who already perform aerobic exercise regularly.

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Effect of Inactivated and mRNA COVID-19 Vaccination on Thyroid Function Among Patients Treated for Hyperthyroidism

Chun Ho Wong, Eunice Ka Hong Leung, Lawrence Chi Kin Tang, Chi Ho Lee, Carol Ho Yi Fong, Alan Chun Hong Lee, Yu Cho Woo, Kathryn Choon Beng Tan, David Tak Wai Lui

doi : 10.1210/clinem/dgac684

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e76–e88

Reports of thyroid dysfunction following COVID-19 vaccination included cases of relapse of Graves' disease and worsening of pre-existing Graves' disease. Little is known about the thyroid-specific outcomes among patients treated for hyperthyroidism who have received COVID-19 vaccination.

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Energy Trade-off and 4 Extreme Human Body Types

Ze’ev Hochberg, Kerstin Albertsson-Wikland, Florian Privé, Alina German, Anton Holmgren, Lisa Rubin, Michael Shmoish

doi : 10.1210/clinem/dgac665

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e89–e97

Resource trade-off theory suggests that increased performance on a given trait comes at the cost of decreased performance on other traits.

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Dissecting the In Vitro Efficacy of Octreotide and Cabergoline in GH- and GH/PRL-Secreting Pituitary Tumors

Federico Gatto, Richard A Feelders, Peter M van Koetsveld, Fadime Dogan, Sebastian J C M M Neggers, Aart-Jan van der Lelij, Jessica Amarù, Diego Ferone, Leo J Hofland

doi : 10.1210/clinem/dgac675

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e98–e109

Cabergoline (CAB) is an off-label medical therapy for acromegaly, overshadowed by first-generation somatostatin receptor ligands, eg, octreotide (OCT).

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Antiresorptive Medication Use Is not Associated With Acute Cardiovascular Risk: An Observational Study

Dana Bliuc, Thach Tran, Weiwen Chen, Dunia Alarkawi, Dima A Alajlouni, Fiona Blyth, Lyn March, Robert D Blank, Jacqueline R Center

doi : 10.1210/clinem/dgac669

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e110–e119

Bisphosphonates have been reported to be cardioprotective in some, but not all, studies. It is unknown whether denosumab (Dmab) use protects against cardiovascular events (CVEs).

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A Reduced Pancreatic Polypeptide Response is Associated With New-onset Pancreatogenic Diabetes Versus Type 2 Diabetes

Phil A Hart, Yogish C Kudva, Dhiraj Yadav, Dana K Andersen, Yisheng Li, Frederico G S Toledo, Fuchenchu Wang, Melena D Bellin, David Bradley, Randall E Brand, Kenneth Cusi, William Fisher, Kieren Mather, Walter G Park, Zeb Saeed, Robert V Considine, Sarah C Graham, Jo Ann Rinaudo, Jose Serrano, Mark O Goodarzi

doi : 10.1210/clinem/dgac670

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e120–e128

Pancreatogenic diabetes refers to diabetes mellitus (DM) that develops in the setting of a disease of the exocrine pancreas, including pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). We sought to evaluate whether a blunted nutrient response of pancreatic polypeptide (PP) can differentiate these DM subtypes from type 2 DM (T2DM).

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Steroid Profiling in the Amniotic Fluid: Reference Range for 12 Steroids and Interest in 21-Hydroxylase Deficiency

Anne Pourquet, Jordan Teoli, Aurore Bouty, Lucie Renault, Florence Roucher, Delphine Mallet, Chantal Rigaud, Frédérique Dijoud, Pierre Mouriquand, Pierre-Yves Mure, Damien Sanlaville, René Ecochard, Ingrid Plotton

doi : 10.1210/clinem/dgac656

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e129–e138

Determination of steroid levels in the amniotic fluid gives some insight on fetal adrenal and gonadal functions.

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Effects of Statins on Fat Oxidation Improvements After Aerobic Exercise Training

Laura Alvarez-Jimenez, Felix Morales-Palomo, Alfonso Moreno-Cabañas, Juan F Ortega, Ricardo Mora-Rodriguez

doi : 10.1210/clinem/dgac668

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e139–e147

Statins blunt cardiorespiratory fitness improvements after exercise training and may affect fat oxidation adaptations to training.

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ACROBAT Edge: Safety and Efficacy of Switching Injected SRLs to Oral Paltusotine in Patients With Acromegaly

Monica R Gadelha, Murray B Gordon, Mirjana Doknic, Emese Mezősi, Miklós Tóth, Harpal Randeva, Tonya Marmon, Theresa Jochelson, Rosa Luo, Michael Monahan, Ajay Madan, Christine Ferrara-Cook, R Scott Struthers, Alan Krasner

doi : 10.1210/clinem/dgac643

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e148–e159

Paltusotine is a once-daily, oral, nonpeptide small-molecule somatostatin receptor type 2 (SST2) agonist in clinical development for treatment of acromegaly.

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Insights Into the Role of DNA Methylation and Gene Expression in Graves Orbitopathy

Giovanna Rotondo Dottore, Giulia Lanzolla, Simone Comi, Francesca Menconi, Lodovica Cristofani Mencacci, Iacopo Dallan, Claudio Marcocci, Michele Marinò

doi : 10.1210/clinem/dgac645

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e160–e168

A role of DNA methylation in Graves orbitopathy (GO) has been proposed.

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Health-Related Quality of Life at Diagnosis for Pediatric Thyroid Cancer Patients

Megan N Perez, Stephen Halada, Amber Isaza, Lindsay Sisko, Sogol Mostoufi-Moab, Andrew J Bauer, Lamia P Barakat

doi : 10.1210/clinem/dgac648

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e169–e177

Pediatric thyroid cancer (TC) incidence rates are increasing, yet TC has one of the highest survival rates. Despite increased prevalence, little is known about youth adjustment to TC, particularly compared to other pediatric cancers.

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Dynamic Testing for Differential Diagnosis of ACTH-Dependent Cushing Syndrome: A Systematic Review and Meta-analysis

Filippo Ceccato, Mattia Barbot, Alessandro Mondin, Marco Boscaro, Maria Fleseriu, Carla Scaroni

doi : 10.1210/clinem/dgac686

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e178–e188

Diagnostic accuracy of testing currently used for the differential diagnosis of Cushing disease (CD) vs ectopic adrenocorticotropic hormone secretion (EAS) is difficult to interpret.

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Does the Duration of Diabetes Matter When Evaluating the Risk of Heart Failure?

Justin B Echouffo-Tcheugui

doi : 10.1210/clinem/dgac761

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e189–e190

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Are Adrenal Androgens Altered by Gender-Affirming Hormone Therapy?

Tamar Reisman, Joshua D Safer

doi : 10.1210/clinem/dgac757

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e191–e192

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Paltusotine, a Novel Oral Somatostatin Receptor Ligand in the Management of Acromegaly

David S McLaren, Robert D Murray

doi : 10.1210/clinem/dgac762

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e193–e194

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Testis-Specific Genes Deregulation in the Testis of COVID-19 Patients: A Potential Driver of Spermatogenesis Disruption?

Rosario Pivonello, Cristina de Angelis, Davide Menafra, Annamaria Colao

doi : 10.1210/clinem/dgac730

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e195–e196

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Letter to the Editor From Yang et al: “Prevalence of Postoperatively Detected High-Risk Features in 2- to 4-cm Papillary Thyroid Cancers�

Shijie Yang, Meijuan Tan, Feng Gao, Xiequn Xu

doi : 10.1210/clinem/dgac753

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e197

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Response to Letter to the Editor From Yang et al: “Prevalence of Postoperatively Detected High-Risk Features in 2- to 4-cm Papillary Thyroid Cancers�

Jee-Hye Choi, Ja Kyung Lee, Woochul Kim, Hyeong Won Yu, Su-jin Kim, Young Jun Chai, June Young Choi, Kyu Eun Lee

doi : 10.1210/clinem/dgac754

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Pages e198–e199

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Correction to “Pheochromocytoma and Paraganglioma: An Endocrine Society Clinical Practice Guideline�

doi : 10.1210/clinem/dgad064

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e200

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Correction to “Diabetes Technology—Continuous Subcutaneous Insulin Infusion Therapy and Continuous Glucose Monitoring in Adults: An Endocrine Society Clinical Practice Guideline�

doi : 10.1210/clinem/dgad065

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e201

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Correction to “Treatment of Hyperthyroidism Reduces Systemic Oxidative Stress, as Measured by Markers of RNA and DNA Damage�

doi : 10.1210/clinem/dgad057

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e202

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Correction to “Low Circulating Levels of miR-451a in Girls with Polycystic Ovary Syndrome: Different Effects of Randomized Treatments�

doi : 10.1210/clinem/dgad062

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e203

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Correction to “Intra-individual Variability of Serum Aldosterone and Implications for Primary Aldosteronism Screening�

doi : 10.1210/clinem/dgad012

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e204

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Correction to: “GLP-1 Receptor Agonists and SGLT-2 Inhibitors as Adjuncts to Insulin in Type 1 Diabetes: Benefits and Concerns�

doi : 10.1210/clinem/dgad022

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e205

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Correction to: “Aldosterone, Renin, and Aldosterone-to-Renin Ratio Variability in Screening for Primary Aldosteronism�

doi : 10.1210/clinem/dgad023

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e206

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Retraction to “Thyroid Cancer Cell Resistance to Gefitinib Depends on the Constitutive Oncogenic Activation of the ERK Pathway�

doi : 10.1210/clinem/dgad056

The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 5, May 2023, Page e207

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