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Recognition of Reviewers
doi : 10.1210/clinem/dgad038
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 767–774
New Horizons: Artificial Intelligence Tools for Managing Osteoporosis
Hans Peter Dimai
doi : 10.1210/clinem/dgac702
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 775–783
Osteoporosis is a disease characterized by low bone mass and microarchitectural deterioration leading to increased bone fragility and fracture risk. Typically, osteoporotic fractures occur at the spine, hip, distal forearm, and proximal humerus, but other skeletal sites may be affected as well.
Targeting PCSK9 With Antibodies and Gene Silencing to Reduce LDL Cholesterol
Connie B Newman, Jonathan A Tobert
doi : 10.1210/clinem/dgac708
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 784–790
The discovery of PCSK9 and its role in regulating the low-density lipoprotein (LDL) receptor, and the effect of loss-of-function mutations of its gene, identified it as a therapeutic target in 2006. Fully humanized monoclonal antibodies to PCSK9 (alirocumab and evolocumab) proved effective for lowering LDL cholesterol and subsequently for reducing atherosclerotic events in large outcome trials.
The First Compound Heterozygous Mutations of DMP1 Causing Rare Autosomal Recessive Hypophosphatemic Rickets Type 1
Xiaolin Ni, Yiyi Gong, Yan Jiang, Xiang Li, Qianqian Pang, Wei Liu, Yue Chi, Ruizhi Jiajue, Ou Wang, Mei Li, Xiaoping Xing, Weibo Xia
doi : 10.1210/clinem/dgac640
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 791–801
Hereditary hypophosphatemic rickets (HR) consists of a group of inherited hypophosphatemia due to mutations of different genes, which need genetic analysis to make a differential diagnosis.
Altered Intrinsic Brain Activity Related to Neurologic and Motor Dysfunction in Diabetic Peripheral Neuropathy Patients
Haotian Xin, Yajie Fu, Mengmeng Feng, Shengpei Wang, Chaofan Sui, Yian Gao, Nan Zhang, Lingfei Guo, Hongwei Wen, Changhu Liang
doi : 10.1210/clinem/dgac651
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 802–811
Brain functional alterations in type 2 diabetes with diabetic peripheral neuropathy (DPN) related to motor dysfunction remain largely unknown.
Genotype-phenotype Description of Vitamin D–dependent Rickets 1A: CYP27B1 p.(Ala129Thr) Variant Induces a Milder Disease
Marie-Noëlle Méaux, Jérôme Harambat, Anya Rothenbuhler, Juliane Léger, Peter Kamenicky, Sylvie Soskin, Olivia Boyer, Emese Boros, Pascal D’Anella, Brigitte Mignot, Maite Gebhart, Philippe Vic, Nicolas Richard, Béatrice Thivichon-Prince, Bruno Francou, Agnès Linglart, Justine Bacchetta, Arnaud Molin
doi : 10.1210/clinem/dgac639
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 812–826
Vitamin D–dependent rickets type 1A (VDDR1A) is a rare genetic disease associated with loss-of-function variations in the gene encoding the vitamin D–activating enzyme 1α-hydroxylase (CYP27B1). Phenotype-genotype correlation is unclear. Long-term outcome data are lacking.
Comparisons Between Different Anti-osteoporosis Medications on Postfracture Mortality: A Population-Based Study
Chih-Hsing Wu, Chia-Chun Li, Yu-Hsuan Hsu, Fu-Wen Liang, Yin-Fan Chang, Jawl-Shan Hwang
doi : 10.1210/clinem/dgac636
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 827–833
Osteoporosis is becoming a global epidemic in aging societies. Anti-osteoporotic medications can prevent fractures, and their pleiotropic effect on mortality is interesting but not well compared among each other.
Data Mining Framework for Discovering and Clustering Phenotypes of Atypical Diabetes
Hemang M Parikh, Cassandra L Remedios, Christiane S Hampe, Ashok Balasubramanyam, Susan P Fisher-Hoch, Ye Ji Choi, Sanjeet Patel, Joseph B McCormick, Maria J Redondo, Jeffrey P Krischer
doi : 10.1210/clinem/dgac632
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 834–846
Some individuals present with forms of diabetes that are “atypical� (AD), which do not conform to typical features of either type 1 diabetes (T1D) or type 2 diabetes (T2D). These forms of AD display a range of phenotypic characteristics that likely reflect different endotypes based on unique etiologies or pathogenic processes.
Skeletal Effects of Sleeve Gastrectomy in Adolescents and Young Adults: A 2-Year Longitudinal Study
Deborah M Mitchell, Vibha Singhal, Abisayo Animashaun, Amita Bose, Brian Carmine, Fatima C Stanford, Thomas H Inge, Megan M Kelsey, Hang Lee, Mary L Bouxsein, Elaine W Yu, Miriam A Bredella, Madhusmita Misra
doi : 10.1210/clinem/dgac634
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 847–857
Vertical sleeve gastrectomy (VSG) is an increasingly common tool to achieve weight loss and improve metabolic health in adolescents and young adults with obesity, although it may adversely affect bone health.
Teprotumumab-Related Hyperglycemia
Linus Amarikwa, Abubakr Mohamed, Sun H Kim, Andrea Lora Kossler, Chrysoula Dosiou
doi : 10.1210/clinem/dgac627
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 858–864
Graves orbitopathy (GO) or thyroid eye disease is a potentially sight-threatening and disfiguring autoimmune disease. Teprotumumab is a monoclonal antibody against the insulin-like growth factor-I receptor that was recently approved for GO treatment. Hyperglycemia is a recognized adverse event of teprotumumab, occurring in 10% of patients in 2 recent randomized controlled trials.
The Acute Cytokine Response to 30-Minute Exercise Bouts Before and After 8-Week Endurance Training in Individuals With Obesity
Thomas Goj, Miriam Hoene, Louise Fritsche, Patrick Schneeweiss, Jürgen Machann, Agnese Petrera, Stefanie M Hauck, Andreas Fritsche, Andreas L Birkenfeld, Andreas Peter, Martin Heni, Andreas M Niess, Anja Moller, Cora Weigert
doi : 10.1210/clinem/dgac623
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 865–875
One acute bout of exercise leads to a rapid increase in the systemic cytokine concentration. Regular exercise might alter the cytokine response, in particular in beforehand untrained and obese individuals.
Survivin: A Potential Marker of Resistance to Somatostatin Receptor Ligands
Clarissa G Borba Herkenhoff, Ericka B Trarbach, Rafael Loch Batista, Iberê Cauduro Soares, Fernando Pereira Frassetto, Felipe Barjud Pereira do Nascimento, Isabella Pacetti Pajaro Grande, Paula P B Silva, Felipe H G Duarte, Marcello D Bronstein, Raquel S Jallad
doi : 10.1210/clinem/dgac610
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 876–887
Invasive and somatostatin receptor ligand (SRL)-resistant pituitary tumors represent a challenge in the clinical practice of endocrinologists. Efforts have been made to elucidate reliable makers for both. Survivin and eukaryotic translation initiation factor-binding protein 1 (4EBP1) are upregulated in several cancers and involved in apoptosis and cell proliferation.
Effect of Dapagliflozin on Cardiac Function and Metabolic and Hormonal Responses to Exercise
Roselle A Herring, Iain Parsons, Fariba Shojaee-Moradie, Mary Stevenage, Nicola Jackson, Ralph Manders, A Margot Umpleby, Barbara A Fielding, Melanie Davies, David L Russell-Jones
doi : 10.1210/clinem/dgac617
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 888–896
This work aimed to investigate the effect of the SGLT2 inhibitor, dapagliflozin (DAPA), on cardiac function and the metabolic and hormonal response to moderate exercise in people with type 2 diabetes.
Reproductive Phenotypes and Genotypes in Men With IHH
Andrew A Dwyer, Maria I Stamou, Ella Anghel, Shira Hornstein, Danna Chen, Kathryn B Salnikov, Isabella R McDonald, Lacey Plummer, Stephanie B Seminara, Ravikumar Balasubramanian
doi : 10.1210/clinem/dgac615
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 897–908
Isolated hypogonadotropic hypogonadism (IHH) is phenotypically and genetically heterogeneous.
Sex Differences in Phosphate Homeostasis: Females Excrete More Phosphate and Calcium After an Oral Phosphate Challenge
Mandy E Turner, Amanda S Paynter, Christine A White, Tom Mazzetti, Emilie C Ward, Patrick A Norman, Jenny Munroe, Michael A Adams, Rachel M Holden
doi : 10.1210/clinem/dgac616
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 909–919
Dietary consumption of phosphate is increasing, and elevated serum phosphate is associated with increased cardiovascular disease (CVD) risk. Sex differences in phosphate homeostasis and response to changes in dietary phosphate intake, which are not captured by clinically measured analytes, may contribute to differences in CVD presentation and bone disease.
Clinical and Safety Outcomes With GLP-1 Receptor Agonists and SGLT2 Inhibitors in Type 1 Diabetes: A Real-World Study
Khary Edwards, Xilong Li, Ildiko Lingvay
doi : 10.1210/clinem/dgac618
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 920–930
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) are used off-label in the management of type 1 diabetes mellitus (T1DM) in real-world practice as adjuvant therapies to insulin. There are few real-world data regarding efficacy and safety of this practice.
Differences in Inflammatory Pathways Between Dutch South Asians vs Dutch Europids With Type 2 Diabetes
Maaike E Straat, Borja Martinez-Tellez, Huub J van Eyk, Maurice B Bizino, Suzanne van Veen, Eleonora Vianello, Rinke Stienstra, Tom H M Ottenhoff, Hildo J Lamb, Johannes W A Smit, Ingrid M Jazet, Patrick C N Rensen, Mariëtte R Boon
doi : 10.1210/clinem/dgac598
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 931–940
South Asian individuals are more prone to develop type 2 diabetes (T2D) coinciding with earlier complications than Europids. While inflammation plays a central role in the development and progression of T2D, this factor is still underexplored in South Asians.
Association Between Systemic Lupus Erythematosus and Primary Hypothyroidism: Evidence from Complementary Genetic Methods
Xue Liu, Jie Yuan, Huizhi Zhou, Yuyao Wang, Guoyu Tian, Xueying Liu, Xinhui Wang, Mulin Tang, Xue Meng, Chunjia Kou, Qingqing Yang, Juyi Li, Li Zhang, Jiadong Ji, Haiqing Zhang
doi : 10.1210/clinem/dgac614
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 941–949
Systemic lupus erythematosus (SLE) and hypothyroidism often coexist in observational studies; however, the causal relationship between them remains controversial.
Autopsy Study of Testicles in COVID-19: Upregulation of Immune-Related Genes and Downregulation of Testis-Specific Genes
Alessio Basolo, Anello Marcello Poma, Elisabetta Macerola, Diana Bonuccelli, Agnese Proietti, Alessandra Salvetti, Paola Vignali, Liborio Torregrossa, Laura Evangelisti, Rebecca Sparavelli, Riccardo Giannini, Clara Ugolini, Fulvio Basolo, Ferruccio Santini, Antonio Toniolo
doi : 10.1210/clinem/dgac608
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 950–961
Infection by SARS-CoV-2 may be associated with testicular dysfunction that could affect male fertility.
The Association of Inflammatory Factors With Peripheral Neuropathy: The Study of Women's Health Across the Nation
Wade M Sanders, Siobán D Harlow, Kelly R Ylitalo, Brittney S Lange-Maia, Aleda M Leis, Daniel S McConnell, Carrie A Karvonen-Gutierrez
doi : 10.1210/clinem/dgac612
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 962–970
Previous work has focused on the role of diabetes in peripheral neuropathy (PN), but PN often occurs before, and independently from, diabetes. This study measures the association of cardiometabolic and inflammatory factor with PN, independent of diabetes.
Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men
Haitham Abdulla, Bethan Phillips, Daniel Wilkinson, Amanda Gates, Marie Limb, Tereza Jandova, Joseph Bass, Johnathan Lewis, John Williams, Kenneth Smith, Iskandar Idris, Philip Atherton
doi : 10.1210/clinem/dgac613
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 971–978
Ageing skeletal muscles become both insulin resistant and atrophic. The hormone glucagon-like peptide 1 (GLP-1) facilitates postprandial glucose uptake as well as augmenting muscle perfusion, independent of insulin action. We thus hypothesized exogenous GLP-1 infusions would enhance muscle perfusion and positively affect glucose metabolism during fed-state clamps in older people.
New Onset or Deterioration of Thyroid Eye Disease After mRNA SARS-CoV-2 Vaccines: Report of 2 Cases and Literature Review
Abubakr Mohamed, Ploutarchos Tzoulis, Andrea Lora Kossler, Chrysoula Dosiou
doi : 10.1210/clinem/dgac606
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 979–985
Occurrence of Graves’ disease (GD) has been reported following SARS-CoV-2 vaccine administration, but little is known about thyroid eye disease (TED) after SARS-CoV-2 vaccination.
Serum IGF-1 to IGFBP-3 Molar Ratio: A Promising Diagnostic Tool for Growth Hormone Deficiency in Children
Laith M Haj-Ahmad, Muhannad M Mahmoud, Nabil W G Sweis, Isam Bsisu, Ahmad M Alghrabli, Alaa M Ibrahim, Ayman A Zayed
doi : 10.1210/clinem/dgac609
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 986–994
The serum insulin-like growth factor-1 (IGF-1)/insulin-like growth factor binding protein-3 (IGFBP-3) ratio has various potential applications in growth hormone-related disorders. This study aimed to investigate the performance of the IGF-1/IGFBP-3 ratio, independently and in combination with serum IGF-1 and IGFBP-3, in the diagnosis of growth hormone deficiency (GHD) in children with short stature (SS).
Approach to the Patient With Adrenal Hemorrhage
Yasir S Elhassan, Cristina L Ronchi, Piyumi Wijewickrama, Stephanie E Baldeweg
doi : 10.1210/clinem/dgac672
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 995–1006
Adrenal hemorrhage is an uncommon, underrecognized condition that can be encountered in several clinical contexts. Diagnosing adrenal hemorrhage is challenging due to its nonspecific clinical features.
Approach to the Patient With Short Stature: Genetic Testing
Reena Perchard, Philip George Murray, Peter Ellis Clayton
doi : 10.1210/clinem/dgac637
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 1007–1017
The first step in the evaluation of the short child is to decide whether growth parameters in the context of the history are abnormal or a variant of normal. If growth is considered abnormal, system and hormonal tests are likely to be required, followed by more directed testing, such as skeletal survey and/or genetic screening with karyotype or microarray.
Osteoporosis Treatment: Decreased Mortality Too?
Robert A Adler
doi : 10.1210/clinem/dgac723
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages e48–e49
Isolated Hypogonadotropic Hypogonadism: New Insights into Relationships Between Genotype and Reproductive Phenotype
Luca Giovanelli, Richard Quinton
doi : 10.1210/clinem/dgac727
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages e50–e51
GLP-1 Receptor Agonists and SGLT-2 Inhibitors as Adjuncts to Insulin in Type 1 Diabetes: Benefits and Concerns
George D Dimitriadis, Vaia Lambadiari
doi : 10.1210/clinem/dgac704
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages e52–e53
IGF-1/IGFBP-3 Serum Ratio as a Robust Measure to Determine GH Deficiency and Guide Human Recombinant GH Therapy
Nils Lambrecht
doi : 10.1210/clinem/dgac687
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages e54–e55,
Letter to the Editor from Han and Xu: “Association Between DPP4 Inhibitor Use and the Incidence of Cirrhosis, ESRD, and Some Cancers in Patients With Diabetes�
Qianqian Han, Huan Xu
doi : 10.1210/clinem/dgac693
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages e56–e57
Response to Letter to the Editor From Han and Xu: “Association Between DPP4 Inhibitor Use and the Incidence of Cirrhosis, ESRD, and Some Cancers in Patients With Diabetes�
Dae Ho Lee
doi : 10.1210/clinem/dgac697
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages e58–e59
Correction to “Altered Intrinsic Brain Activity Related to Neurologic and Motor Dysfunction in Diabetic Peripheral Neuropathy Patients�
doi : 10.1210/clinem/dgac749
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Page e60
Correction to “Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets�
doi : 10.1210/clinem/dgac713
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Page e61
Correction to: “Cervical MUC5B and MUC5AC are Barriers to Ascending Pathogens During Pregnancy�
doi : 10.1210/clinem/dgac717
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Page e62
