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Spatial Transcriptional Mapping Reveals Site-Specific Pathways Underlying Human Atherosclerotic Plaque Rupture
Jiangming Sun, PH D, a Pratibha Singh, P HD, a Annelie Shami, P HD, a Ewelina Kluza, P HD, b,c Mengyu Pan, MS C,a Djordje Djordjevic, PHD, d Natasha Barascuk Michaelsen, P HD, e Cecilia Kennb?ck, f Nicole N. van der Wel, P HD, g Marju Orho-Melander, P HD, a Jan Nilsson, MD, PHD, a Ivan Formentini, PHD, h Karin Conde-Knape, MD, PH D, i Esther Lutgens, MD, PH D, b,j,k,l Andreas Edsfeldt, MD, PHD, a,m,n, * Isabel Gonçalves, MD, PH D
doi : 10.1016/j.jacc.2023.04.008
Volume 81, Issue 23, 13 June 2023, Pages 2213-2227
Atherosclerotic plaque ruptures, triggered by blood flow–associated biomechanical forces, cause most myocardial infarctions and strokes.
Single-Point Vulnerabilities in Atherosclerotic Plaque∗
Chiara Giannarelli, MD, PH D
doi : 10.1016/j.jacc.2023.05.001
Volume 81, Issue 23, 13 June 2023, Pages 2228-2230
Effect of 2022 ACC/AHA/HFSA Criteria on Stages of Heart Failure in a Pooled Community Cohort
Reza Mohebi, MD, a,b, * Dongyu Wang, MS, MPH,b,c,d,e, * Emily S. Lau, MD, MPH,a Juhi K. Parekh, MPH,c,d Norrina Allen, MPH, PHD, f Bruce M. Psaty, MD, PHD, g,h,i,j Emelia J. Benjamin, MD, SC M,k,l,m Daniel Levy, MD, k,l,m,n Thomas J. Wang, MD, o Sanjiv J. Shah, MD, p John S. Gottdiener, MD,q James L. Januzzi, J R, MD, a,b,r Jennifer E. Ho, MD
doi : 10.1016/j.jacc.2023.04.007
Volume 81, Issue 23, 13 June 2023, Pages 2231-2242
The 2022 American College of Cardiology (ACC)/American Heart Association (AHA)/Heart Failure Society of America (HFSA) clinical practice guideline proposed an updated definition for heart failure (HF) stages.
Disrupting the Definition of Heart Failure: A Rose by Any Other Name∗
Lee R. Goldberg, MD, MPH
doi : 10.1016/j.jacc.2023.04.013
Volume 81, Issue 23, 13 June 2023, Pages 2243-2245
Contribution of Migraine to Cardiovascular Disease Risk Prediction
Pamela M. Rist, SCD, a Julie E. Buring, SC D, a Nancy R. Cook, SCD, a, * Tobias Kurth, MD, SCD b
doi : 10.1016/j.jacc.2023.03.429
Volume 81, Issue 23, 13 June 2023, Pages 2246-2254
Migraine with aura (MA) is associated with cardiovascular disease (CVD) independently from traditional vascular risk factors. However, the importance of MA on CVD occurrence relative to existing cardiovascular prediction tools remains unclear.
Are We Sure We Know the Risk Factors for Cardiovascular Disease?∗
Angela A. Stanton, PHD
doi : 10.1016/j.jacc.2023.04.012
Volume 81, Issue 23, 13 June 2023, Pages 2255-2257
Ventricular Arrhythmias Associated With Over-the-Counter and Recreational Opioids
Mori J. Krantz, MD, a,b Todd J. Rudo, MD, a Mark C.P. Haigney, MD, c Norman Stockbridge, MD, PHD, d Robert B. Kleiman, MD,a Michael Klein, P HD, c David P. Kao, MD
doi : 10.1016/j.jacc.2023.04.009
Volume 81, Issue 23, 13 June 2023, Pages 2258-2268
Epidemic increases in opioid deaths prompted policies limiting access to prescription opioids in North America. Consequently, the over-the-counter opioids loperamide (Imodium A-D) and mitragynine, the herbal ingredient in kratom, are increasingly used to avert withdrawal or induce euphoria. Arrhythmia events related to these nonscheduled drugs have not been systematically studied.
The Changing Complexities of Opioid-Related Sudden Death∗
Lee L. Eckhardt, MD, MS, Andrew C. Nickel, MD
doi : 10.1016/j.jacc.2023.04.024
Volume 81, Issue 23, 13 June 2023, Pages 2269-2271
Remote Monitoring for Heart Failure Management at Home: JACC Scientific Statement
Lynne Warner Stevenson, MD, a Heather J. Ross, MD,b Lisa D. Rathman, MSN, CRNP, c John P. Boehmer, MD
doi : 10.1016/j.jacc.2023.04.010
Volume 81, Issue 23, 13 June 2023, Pages 2272-2291
Early telemonitoring of weights and symptoms did not decrease heart failure hospitalizations but helped identify steps toward effective monitoring programs. A signal that is accurate and actionable with response kinetics for early re-assessment is required for the treatment of patients at high risk, while signal specifications differ for surveillance of low-risk patients.
Utility of a Handheld, Single-Lead ECG Device for Diagnosis of Cardiac Arrhythmias
Samual Turnbull, BSc Kartheek Garikapati, MBBS Richard G. Bennett, BSc, MBChB Timothy G. Campbell, BSc Yasuhito Kotake, MD, PhD Rajiv Mahajan, MBBS, PhD Simone Marschner, MSc Karen Byth, PhD Clara K. Chow, MBBS, PhD *Saurabh Kumar, BSc(Med)/MBBS, PhD
doi : 10.1016/j.jacc.2023.03.428
Volume 81, Issue 23, 13 June 2023, Pages 2292-2294
