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Elevated Liver Enzymes in Patients with COVID-19: Look, but Not Too Hard
Andrew M. MoonA. Sidney Barritt IV
doi : 10.1007/s10620-020-06585-9
66, pages1767–1769 (2021)
Breath Test or Duodenal Aspirate for Small Intestinal Bacterial Overgrowth: Still No Breath of Fresh Air
Eric D. Shah
doi : 10.1007/s10620-020-06556-0
66, pages1770–1771 (2021)
Vedolizumab Dose Escalation: In for a Penny, in for a Pound?
Robin J. Dart . Peter M. IrvingMark A. Samaan
doi : 10.1007/s10620-020-06565-z
66, pages1772–1774 (2021)
Risk Assessment of Pancreatic Cysts: Benign and Malign Entwined
Mar?a-Victoria Alvarez-S?nchezBertrand Napoléon
doi : 10.1007/s10620-020-06555-1
66, pages1775–1777 (2021)
A Healthy Liver After SVR: Food for Thought
Brittany RocqueJeffrey Kahn. Juliet Emamaullee
doi : 10.1007/s10620-020-06547-1
66, pages1778–1779 (2021)
An Update on the Management of Budd–Chiari Syndrome
A. SharmaS. N. Keshava. C. E. Eapen
doi : 10.1007/s10620-020-06485-y
66, pages1780–1790 (2021)
Budd–Chiari syndrome (BCS) is an uncommon condition, caused by obstruction to hepatic venous outflow. It is largely underdiagnosed, and a high index of suspicion is required for any patient with unexplained portal hypertension. The understanding of its etiology and pathology is improving with advances in diagnostic techniques. Recent studies reported an identifiable etiology in?>?80% of cases.
Benign Blockage: Gastric Outlet Obstruction due to a Prolapsing Gastric Pedunculated Polyp—Case Report and Literature Review
N. ZorzettiA. Lauro. R. M. Tranchino
doi : 10.1007/s10620-021-06890-x
66, pages1791–1795 (2021)
Author Spotlight: Noemi Zorzetti
Noemi Zorzetti
doi : 10.1007/s10620-021-06891-w
66, page1796 (2021)
Too Big to Fail: Successful Resection of a Large Hepatocellular Carcinoma with Portal Tumor Thrombus
John R. BergquistAmy Y. Li. Brendan C. Visser
doi : 10.1007/s10620-020-06682-9
66, pages1797–1801 (2021)
Casting a Wider NET: Is It Crohn’s or Is It Neuroendocrine Tumor?
Yejoo JeonDavid Leung. Jonathan D. Kaunitz
doi : 10.1007/s10620-021-06952-0
66, pages1802–1806 (2021)
Motivations, Barriers, and Outcomes of Patient-Reported Shared Decision Making in Eosinophilic Esophagitis
Joy W. ChangJoel H. Rubenstein. Evan S. Dellon
doi : 10.1007/s10620-020-06438-5
66, pages1808–1817 (2021)
Little is known about patient choice in treatment of eosinophilic esophagitis (EoE).
Trends and Outcomes of Hip Fracture Hospitalization Among Medicare Beneficiaries with Inflammatory Bowel Disease, 2000–2017
Fang XuAnne G. Wheaton. Kurt J. Greenlund
doi : 10.1007/s10620-020-06476-z
66, pages1818–1828 (2021)
Patients with inflammatory bowel disease (IBD) have a higher risk of hip fracture, but lower likelihood of having arthroplasties than non-IBD patients in Nationwide Inpatient Sample. Little is known about hip fracture-associated hospitalization outcomes.
Identifying Patient Priorities for Preconception and Pregnancy Counseling in IBD
Aiya AboubakrAlexa Rae RiggsMarla C. Dubinsky
doi : 10.1007/s10620-020-06480-3
66, pages1829–1835 (2021)
Inflammatory bowel disease (IBD) commonly affects women of reproductive age. Many patients lacking knowledge about IBD and reproduction make uninformed decisions, such as voluntary childlessness and medication cessation. Education should be individualized to the patient’s knowledge base and include topics of most importance to the patient. Our study aimed to describe the priority rankings of topics selected by patients seeking preconception and pregnancy counseling.
Wearable Devices Are Well Accepted by Patients in the Study and Management of Inflammatory Bowel Disease: A Survey Study
Robert P. HirtenStephanie StanleyBruce E. Sands
doi : 10.1007/s10620-020-06493-y
66, pages1836–1844 (2021)
Wearable devices are designed to capture health-related and physiological data. They may be able to improve inflammatory bowel disease management and address evolving research needs. Little is known about patient perceptions for their use in the study and management of inflammatory bowel disease.
Endoscopic Retrograde Cholangiopancreatography During the COVID-19 Pandemic: Effects of Enhanced Personal Protective Equipment
Tolga DüzenliHüseyin K?seo?lu
doi : 10.1007/s10620-021-06940-4
66, pages1845–1851 (2021)
Personal protective equipment (PPE) decreases the risk of disease contagion, and because of the COVID-19 pandemic, enhanced PPE (EPPE) is widely used during endoscopic procedures including endoscopic retrograde cholangiopancreatography (ERCP). The aim of this study was to investigate the effects of EPPE on ERCP success parameters compared to standard PPE (SPPE).
Hepatology Consultants Often Disagree on Etiology of Abnormal Liver Biochemistries in COVID-19 but Agree on Management
Patricia P. BloomTrisha S. PasrichaKathleen Viveiros
doi : 10.1007/s10620-020-06495-w
66, pages1852–1854 (2021)
Coronavirus disease 2019 (COVID-19) is associated with elevated liver biochemistries in approximately half of hospitalized patients, with many possible etiologies.
Social Support Does Not Modify the Risk of Readmission for Patients with Decompensated Cirrhosis
Jeremy LouissaintChelsey FosterElliot B. Tapper
doi : 10.1007/s10620-020-06421-0
66, pages1855–1861 (2021)
Patients with decompensated cirrhosis are at high risk of frequent hospitalizations. Whether the level of perceived social support impacts this risk is unknown. We sought to determine the relationship between social support and burden of hospitalization in patients with decompensated cirrhosis.
Specific Smad2/3 Linker Phosphorylation Indicates Esophageal Non-neoplastic and Neoplastic Stem-Like Cells and Neoplastic Development
Shunsuke HoritaniToshiro FukuiKazuichi Okazaki
doi : 10.1007/s10620-020-06489-8
66, pages1862–1874 (2021)
There is little known about stem cells in human non-neoplastic and neoplastic esophageal epithelia. We have demonstrated expression of linker threonine-phosphorylated Smad2/3 (pSmad2/3L-Thr), suggesting presence of stem-like cells in mouse esophageal epithelium, and identified presence of pSmad2/3L-Thr-positive cells that might function as cancer stem cells in mouse model of colorectal carcinoma.
SNHG10/DDX54/PBX3 Feedback Loop Contributes to Gastric Cancer Cell Growth
Yunfei ZhangHongyan GuoHong Zhang
doi : 10.1007/s10620-020-06488-9
66, pages1875–1884 (2021)
The importance of long noncoding RNAs (lncRNAs) has been identified in human cancers, such as emerged as tumor facilitator or tumor suppressor. Small nucleolar RNA host gene 10 (SNHG10) has been reported as an oncogenic lncRNA in hepatocellular carcinoma. However, its functional role and underlying mechanism in gastric cancer (GC) need to be further explored.
LINC01436 Inhibited miR-585-3p Expression and Upregulated MAPK1 Expression to Promote Gastric Cancer Progression
Yongpan XuMing DongMin Jiao
doi : 10.1007/s10620-020-06487-w
66, pages1885–1894 (2021)
Gastric cancer (GC) is a prevalent type of digestion system malignancies. Dysregulation of long non-coding RNAs (lncRNAs) has been proven to be prognostic factors and biological regulators in human cancers.
Interactions Between Vitamin D and Calcium Intake, Vitamin D Receptor Genetic Polymorphisms, and Colorectal Cancer Risk
Xin ZhangYu-Jing FangCai-Xia Zhang
doi : 10.1007/s10620-020-06455-4
66, pages1895–1905 (2021)
Vitamin D has anticarcinogenic properties and acts through vitamin D receptor (VDR) to carry out its functions.
Inhibition of MicroRNA-302c on Stemness of Colon Cancer Stem Cells via the CARF/Wnt/?-Catenin Axis
Yun ZhangHua MengKun Guo
doi : 10.1007/s10620-020-06435-8
66, pages1906–1915 (2021)
Even though the relevance of microRNA (miR)-302c has been studied, little is known about its involvement in colon cancer (CC).
Mesenchymal Stem Cell-Derived Exosomal microRNA-3940-5p Inhibits Colorectal Cancer Metastasis by Targeting Integrin ?6
Tao LiYingchun WanChangyu Zhou
doi : 10.1007/s10620-020-06458-1
66, pages1916–1927 (2021)
Exosomes are potential tools for disease control by regulating intercellular communication through carrying proteins and RNAs between cells or remote organs. Exosome activities have aroused wide concerns in cancer biology and malignancy control.
MicroRNA-503 Targets Mothers Against Decapentaplegic Homolog 7 Enhancing Hepatic Stellate Cell Activation and Hepatic Fibrosis
Xia XieCheng-Yun DouHai-Bo Tang
doi : 10.1007/s10620-020-06460-7
66, pages1928–1939 (2021)
The hyper-accumulation of extracellular matrix (ECM) is the leading cause of hepatic fibrosis, and TGF-?-induced activation of hepatic stellate cells (HSCs) is the central event of hepatic fibrosis pathogenesis. The deregulation and dysfunction of miRNAs in hepatic fibrosis have been reported previously.
Gender-Specific Risk Factors for Reflux Esophagitis in a Predominantly Hispanic Population of a Large Safety-Net Hospital
Shida HaghighatCaron ParkAnisa Shaker
doi : 10.1007/s10620-020-06482-1
66, pages1940–1948 (2021)
Defining factors associated with severe reflux esophagitis allows for identification of subgroups most at risk for complications of strictures and esophageal malignancy. We hypothesized there might be unique clinical features in patients with reflux esophagitis in a predominantly Hispanic population of a large, safety-net hospital
Prealbumin and D-dimer as Prognostic Indicators for Rebleeding in Patients with Nonvariceal Upper Gastrointestinal Bleeding
Wenjie YueYi LiuJie Liu
doi : 10.1007/s10620-020-06420-1
66, pages1949–1956 (2021)
Determining the risk stratification of nonvariceal upper gastrointestinal bleeding (NVUGIB) plays a vital role in treating upper gastrointestinal bleeding (UGIB). Traditional scores like Glasgow–Blatchford score (GBS), Rockall score (RS), and AIMS65 score have been widely utilized in UGIB practice, however exhibiting limited practical use due to relative lack of user-friendly characters. Prealbumin as a nutritional indicator and d-dimer as a fibrinolytic activity monitor, are generally used to evaluate the overall nutritional and fibrinolytic condition in UGIB patients.
Dysplasia in Random Biopsies from Barrett’s Surveillance Is an Important Marker for More Severe Pathology
I. C. NoordzijM. C. M. Van Loon van de EndeE. J. Schoon
doi : 10.1007/s10620-020-06463-4
66, pages1957–1964 (2021)
Although endoscopic recognition of dysplasia in Barrett’s esophagus is difficult, experience in recognition of early neoplastic lesions is supposed to increase the detection of early neoplastic lesions. The aim of this study was to assess the significance of dysplasia in random biopsies in Barrett’s esophagus, in the absence of reported visible lesions as well as the difference in final outcome of pathology
Does Risk of Progression from Barrett’s Esophagus to Esophageal Adenocarcinoma Change Based on the Number of Non-dysplastic Endoscopies?
Andrew T. KunzmannHelen G. ColemanAaron P. Thrift
doi : 10.1007/s10620-020-06483-0
66, pages1965–1973 (2021)
There is a large Barrett’s esophagus patient population undergoing endoscopic surveillance. Methods to stratify patients into higher and lower risk groups may enable more varied surveillance intervals for patients with non-dysplastic Barrett’s esophagus that could optimize use of endoscopy resources.
Gastroparesis Following Immune Checkpoint Inhibitor Therapy: A Case Series
Jessica AtiehJordan SackShilpa Grover
doi : 10.1007/s10620-020-06440-x
66, pages1974–1980 (2021)
Immune checkpoint inhibitors (ICI) have improved outcomes in patients with various malignancies; however, they can cause immune-related hepatitis and enterocolitis. Patients on ICI may also develop upper gastrointestinal symptoms and undergo measurement of gastric emptying.
Differences Between Familial and Sporadic Celiac Disease
Laura AiraksinenLauri Myllym?kiKalle Kurppa
doi : 10.1007/s10620-020-06490-1
66, pages1981–1988 (2021)
It is not known if genetic background, characteristics at diagnosis, physical and psychological well-being, and adherence to a gluten-free diet are comparable between patients with familial or sporadic celiac disease. These issues were investigated in a follow-up study.
Enteric-Release Budesonide May Be Useful in the Management of Non-Responsive Celiac Disease
Amelie TherrienJocelyn A. SilvesterCiaran P. Kelly
doi : 10.1007/s10620-020-06454-5
66, pages1989–1997 (2021)
Non-responsive celiac disease (NRCD) has many aetiologies, including gluten exposure. Budesonide may be used for refractory celiac disease (RCD) and celiac crisis.
Concise Commentary: Budesonide—When Going Gluten-Free Is Not Good Enough
Prashant Singh
doi : 10.1007/s10620-020-06514-w
66, pages1998–1999 (2021)
Superiority of Higher-Volume Fresh Feces Compared to Lower-Volume Frozen Feces in Fecal Microbiota Transplantation for Recurrent Clostridioides Difficile Colitis
Amol AgarwalAnurag MaheshwariSudhir Dutta
doi : 10.1007/s10620-020-06459-0
66, pages2000–2004 (2021)
To compare the clinical outcomes of different protocols for fecal microbiota transplantation (FMT) in two community hospitals with similar patient demographics.
Comorbid Diabetes in Inflammatory Bowel Disease Predicts Adverse Disease-Related Outcomes and Infectious Complications
Anand KumarTatiana TeslovaDana J. Lukin
doi : 10.1007/s10620-020-06439-4
66, pages2005–2013 (2021)
Diabetes mellitus (DM) and inflammatory bowel diseases (IBD) are chronic systemic illnesses associated with chronic inflammation, dysbiosis, impaired immune function, and infection risk. The impact of DM in modifying disease activity in patients with IBD remains largely unknown.
Extraintestinal Manifestations in Patients with Inflammatory Bowel Disease: Study Based on the ENEIDA Registry
Alicia AlgabaIv?n Guerrathe Spanish GETECCU Group (ENEIDA Project)
doi : 10.1007/s10620-020-06424-x
66, pages2014–2023 (2021)
Patients with inflammatory bowel disease (IBD) may present extraintestinal manifestations (EIMs) that affect the joints, skin, eyes, and hepatobiliary area, among others.
Clinician Administered and Self-Report Survey Both Effective for Identifying Fecal Incontinence in Patients with Inflammatory Bowel Disease
Lesley DibleyAilsa HartChristine Norton
doi : 10.1007/s10620-020-06418-9
66, pages2024–2031 (2021)
To test two methods for reporting of fecal incontinence (FI) in people with inflammatory bowel disease.
Trends in Morbidity and Mortality Following Colectomy Among Patients with Ulcerative Colitis in the Biologic Era (2002–2013): A Study Using the National Inpatient Sample
Babatunde OlaiyaBenjamin D. RenelusSumona Saha
doi : 10.1007/s10620-020-06474-1
66, pages2032–2041 (2021)
Total abdominal colectomy (TAC) is a treatment modality of last recourse for patients with severe and/or refractory ulcerative colitis (UC). The goal of this study is to evaluate temporal trends and treatment outcomes following TAC among hospitalized UC patients in the biologic era.
Diagnosing Small Intestinal Bacterial Overgrowth: A Comparison of Lactulose Breath Tests to Small Bowel Aspirates
David J. CangemiBrian E. LacyJourney Wise
doi : 10.1007/s10620-020-06484-z
66, pages2042–2050 (2021)
Duodenal aspiration (DA) and lactulose breath tests (LBT) are commonly performed to diagnose small intestinal bacterial overgrowth (SIBO). There are no data directly comparing these tests.
Vedolizumab Dose Escalation Improves Therapeutic Response in a Subset of Patients with Ulcerative Colitis
Courtney PerryKyle FischerTerrence A. Barrett
doi : 10.1007/s10620-020-06486-x
66, pages2051–2058 (2021)
The Gemini trial failed to detect a significant difference in response rate for patients with ulcerative colitis (UC) randomized to standard (every 8 week) vedolizumab dosing vs escalated (every 4 week) dosing. Subsequent real-world data imply the Gemini trial design may have obscured a benefit of escalated dosing.
Comparative Effectiveness of Commercial Bowel Preparations in Ambulatory Patients Presenting for Screening or Surveillance Colonoscopy
Shashank SarvepalliAri GarberMichael B. Rothberg
doi : 10.1007/s10620-020-06492-z
66, pages2059–2068 (2021)
Inadequate bowel preparation (IBP) is associated with reduced adenoma detection. However, limited research has examined the impact of different commercial bowel preparations (CBPs) on IBP and adenoma detection. We aim to determine whether type of CBP used is associated with IBP or adenoma detection.
Quantification of Structural Heterogeneity Using Fractal Analysis of Contrast-Enhanced CT Image to Predict Survival in Gastric Cancer Patients
Hiroki WatanabeKoichi HayanoHisahiro Matsubara
doi : 10.1007/s10620-020-06479-w
66, pages2069–2074 (2021)
Malignant tumor essentially implies structural heterogeneity. Fractal analysis of medical imaging has a potential to quantify this structural heterogeneity in the tumor
High-Risk Characteristics Associated with Advanced Pancreatic Cystic Lesions: Results from a Retrospective Surgical Cohort
Liqi SunWei WangZhendong Jin
doi : 10.1007/s10620-020-06481-2
66, pages2075–2083 (2021)
The management of pancreatic cystic lesions (PCLs) remains controversial. We performed a retrospective study to determine characteristics associated with advanced PCLs (A-PCLs) and whether these characteristics vary in different pathological types of PCLs. The additional diagnostic value of endoscopic ultrasound (EUS) was also evaluated.
A Novel Score to Predict Esophageal Varices in Patients with Compensated Advanced Chronic Liver Disease
Vikram KotwalChimezie MbachiArvind R. Murali
doi : 10.1007/s10620-020-06456-3
66, pages2084–2091 (2021)
Several criteria have been described to noninvasively predict the presence of high-risk esophageal varices in patients with compensated advanced chronic liver disease (cACLD). However, a recent study showed that treatment with ? blockers could increase decompensation-free survival in patients with clinically significant portal hypertension, thereby making it important to predict the presence of any esophageal varices. We aimed to develop a simple scoring system to predict any esophageal varices.
Fatty Liver Index and Development of Cardiovascular Disease: Findings from the UK Biobank
Biyao ZouYee Hui YeoMindie H. Nguyen
doi : 10.1007/s10620-021-06954-y
66, pages2092–2100 (2021)
Nonalcoholic fatty liver disease is common and is associated with rising morbidity and mortality in the UK. Cardiovascular disease is the main cause of death in people with nonalcoholic fatty liver disease.
Two-Dose Hepatitis B Vaccine (Heplisav-B) Results in Better Seroconversion Than Three-Dose Vaccine (Engerix-B) in Chronic Liver Disease
Waseem AmjadJoseph AlukalPaul J. Thuluvath
doi : 10.1007/s10620-020-06437-6
66, pages2101–2106 (2021)
The efficacy of the two-dose hepatitis B virus (HBV) vaccine (Heplisav-B®) in patients with chronic liver disease (CLD) is unknown.
Sustained Remission After Treatment Withdrawal in Autoimmune Hepatitis: A Multicenter Retrospective Study
Yasmina Ben MerabetCoralie BarbeGérard Thiéfin
doi : 10.1007/s10620-020-06444-7
66, pages2107–2117 (2021)
In patients with autoimmune hepatitis (AIH), relapse rates between 25 and 100% after treatment withdrawal have been reported. The optimal strategy for immunosuppressive treatment withdrawal is controversial.
Lifestyles Associated with Prognosis After Eradication of Hepatitis C Virus: A Prospective Cohort Study in Japan
Satoko OhfujiTomoka MatsuuraWakaba Fukushima
doi : 10.1007/s10620-020-06475-0
66, pages2118–2128 (2021)
Hepatocellular carcinoma develops in some patients with hepatitis C virus (HCV), even after achieving sustained virological response (SVR).
Clinical, Endoscopic, and Pathological Characteristics of Immune Checkpoint Inhibitor-Induced Gastroenterocolitis
Yukie HayashiNaoki HosoeTakanori Kanai
doi : 10.1007/s10620-020-06441-w
66, pages2129–2134 (2021)
Observations on the Effect of Electronic Needle Container on Adherence to Adalimumab
John ArmstrongSharifah Sarhan
doi : 10.1007/s10620-020-06574-y
66, pages2135–2136 (2021)
