European Heart Journal

David Messika-Zeitoun, Helmut Baumgartner, Ian G Burwash, Alec Vahanian, Jeroen Bax, Philippe Pibarot, Vince Chan, Martin Leon, Maurice Enriquez-Sarano, Thierry Mesana, Bernard Iung

doi : 10.1093/eurheartj/ehad121

European Heart Journal, Volume 44, Issue 21, 1 June 2023, Pages 1862â€“1873

Valvular heart disease (VHD) is the next epidemic in the cardiovascular field, affecting millions of people worldwide and having a major impact on health care systems. With aging of the population, the incidence and prevalence of VHD will continue to increase. However, VHD has not received the attention it deserves from both the public and policymakers.

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Exercise benefits in cardiovascular diseases: from mechanisms to clinical implementation

Pedro L Valenzuela, Luis M Ruilope, Alejandro Santos-Lozano, Matthias Wilhelm, Nicolle KrÃ¤nkel, Carmen Fiuza-Luces, Alejandro Lucia

doi : 10.1093/eurheartj/ehad170

European Heart Journal, Volume 44, Issue 21, 1 June 2023, Pages 1874â€“1889

There is a pandemic of physical inactivity that appears to parallel the widespread prevalence of cardiovascular disease (CVD). Yet, regular physical activity (PA) and exercise can play an important role not only in primary cardiovascular prevention but also in secondary prevention.

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Leveraging electronic health records to streamline the conduct of cardiovascular clinical trials

Muhammad Shahzeb Khan, Muhammad Shariq Usman, Khawaja M Talha, Harriette G C Van Spall, Stephen J Greene, Muthiah Vaduganathan, Sadiya S Khan, Nicholas L Mills, Ziad A Ali, Robert J Mentz, Gregg C Fonarow, Sunil V Rao, John A Spertus, Matthew T Roe, Stefan D Anker, Stefan K James, Javed Butler, Darren K McGuire

doi : 10.1093/eurheartj/ehad171

European Heart Journal, Volume 44, Issue 21, 1 June 2023, Pages 1890â€“1909

Conventional randomized controlled trials (RCTs) can be expensive, time intensive, and complex to conduct. Trial recruitment, participation, and data collection can burden participants and research personnel. In the past two decades, there have been rapid technological advances and an exponential growth in digitized healthcare data.

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Long-term outcomes of phenoclusters in severe tricuspid regurgitation

Vishal N Rao, Anna Giczewska, Karen Chiswell, G Michael Felker, Andrew Wang, Donald D Glower, Jeffrey G Gaca, Kishan S Parikh, Sreekanth Vemulapalli

doi : 10.1093/eurheartj/ehad133

European Heart Journal, Volume 44, Issue 21, 1 June 2023, Pages 1910â€“1923

Severe tricuspid regurgitation (TR) exhibits high 1-year morbidity and mortality, yet long-term cardiovascular risk overall and by subgroups remains unknown. This study characterizes 5-year outcomes and identifies distinct clinical risk profiles of severe TR.

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The synergy between tricuspid regurgitation and machine learning

Ehud Chorin, Yan Topilsky

doi : 10.1093/eurheartj/ehad140

European Heart Journal, Volume 44, Issue 21, 1 June 2023, Pages 1924â€“1926

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Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study

Hao Yu Chen, Christian Dina, Aeron M Small, Christian M Shaffer, Rebecca T Levinson, Anna HelgadÃ³ttir, Romain Capoulade, Hans Markus Munter, Andreas Martinsson, Benjamin J Cairns, Linea C TrudsÃ¸, Mary Hoekstra, Hannah A Burr, Thomas W Marsh, Scott M Damrauer, Line Dufresne, Solena Le Scouarnec, David Messika-Zeitoun, Dilrini K Ranatunga, Rachel A Whitmer, AmÃ©lie Bonnefond, GarÃ°ar Sveinbjornsson, Ragnar DanÃelsen, David O Arnar, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, DanÃel F Gudbjartsson, Hilma HÃ³lm, Jonas Ghouse, Morten Salling Olesen, Alex H Christensen, Susan Mikkelsen, Rikke Louise Jacobsen, Joseph Dowsett, Ole Birger Vesterager Pedersen, Christian Erikstrup, Sisse R Ostrowski, Regeneron Genetics Center, Christopher J Oâ€™Donnell, Matthew J Budoff, Vilmundur Gudnason, Wendy S Post, Jerome I Rotter, Mark Lathrop, Henning Bundgaard, Bengt Johansson, Johan Ljungberg, Ulf NÃ¤slund, Thierry Le Tourneau, J Gustav Smith, Quinn S Wells, Stefan SÃ¶derberg, KÃ¡ri StefÃ¡nsson, Jean-Jacques Schott, Daniel J Rader, Robert Clarke, James C Engert, George Thanassoulis

doi : 10.1093/eurheartj/ehad142

European Heart Journal, Volume 44, Issue 21, 1 June 2023, Pages 1927â€“1939

Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to integrate functional, expression, and cross-phenotype data to identify mechanisms of AS.

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The journey towards identification of actionable molecular pathways in calcific aortic valve stenosis

SÃ©bastien ThÃ©riault, Patrick Mathieu, Yohan BossÃ©

doi : 10.1093/eurheartj/ehad134

European Heart Journal, Volume 44, Issue 21, 1 June 2023, Pages 1940â€“1942

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Mosaic loss of Y chromosome in monocytes is associated with lower survival after transcatheter aortic valve replacement

Silvia Mas-Peiro, Wesley T Abplanalp, Tina Rasper, Alexander Berkowitsch, David M Leistner, Stefanie Dimmeler, Andreas M Zeiher

doi : 10.1093/eurheartj/ehad093

European Heart Journal, Volume 44, Issue 21, 1 June 2023, Pages 1943â€“1952

Mosaic loss of Y chromosome (LOY) in blood cells is the most common acquired mutation, increases with age, and is related to cardiovascular disease. Loss of Y chromosome induces cardiac fibrosis in murine experiments mimicking the consequences of aortic valve stenosis, the prototypical age-related disease.

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