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In the Literature
Stan Deresinski
doi : 10.1093/cid/ciad140
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages i–ii
Concordance Between Initial Presumptive and Final Adjudicated Diagnoses of Infection Among Patients Meeting Sepsis-3 Criteria in the Emergency Department
Gabriel A Hooper, Carolyn J Klippel, Sierra R McLean, Edward A Stenehjem, Brandon J Webb, Emily R Murnin, Catherine L Hough, Joseph R Bledsoe, Samuel M Brown, Ithan D Peltan
doi : 10.1093/cid/ciad101
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2047–2055
Guidelines emphasize rapid antibiotic treatment for sepsis, but infection presence is often uncertain at initial presentation. We investigated the incidence and drivers of false-positive presumptive infection diagnosis among emergency department (ED) patients meeting Sepsis-3 criteria.
Measuring Diagnostic Accuracy for Infection in Patients Treated for Sepsis: An Important but Challenging Exercise
Chanu Rhee, Michael Filbin, Michael Klompas
doi : 10.1093/cid/ciad105
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2056–2058
Mortality Attributable to Bloodstream Infections Caused by Different Carbapenem-Resistant Gram-Negative Bacilli: Results From a Nationwide Study in Italy (ALARICO Network)
Marco Falcone, Giusy Tiseo, Sergio Carbonara, Andrea Marino, Giovanni Di Caprio, Anna Carretta, Alessandra Mularoni, Michele Fabiano Mariani, Alberto Enrico Maraolo, Riccardo Scotto, Lidia Dalfino, Lorenzo Corbo, Margherita Macera, Alice Annalisa Medaglia, Maria Luca d’Errico, Claudia Gioè, Christian Sgroi, Rosa Fontana Del Vecchio, Giancarlo Ceccarelli, Antonio Albanese, Calogero Buscemi, Simona Talamanca, Giammarco Raponi, Giuseppe Foti, Giulio De Stefano, Antonina Franco, Carmelo Iacobello, Salvatore Corrao, Uccio Morana, Filippo Pieralli, Ivan Gentile, Teresa Santantonio, Antonio Cascio, Nicola Coppola, Bruno Cacopardo, Alessio Farcomeni, Mario Venditti, Francesco Menichetti, Advancing knowLedge on Antimicrobial Resistant Infections Collaboration Network (ALARICO Network)
doi : 10.1093/cid/ciad100
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2059–2069
Our aim was to analyze mortality attributable to carbapenem-resistant (CR) gram-negative bacilli (GNB) in patients with bloodstream infections (BSIs).
Current Pyuria Cutoffs Promote Inappropriate Urinary Tract Infection Diagnosis in Older Women
Manu P Bilsen, Margaretha J Aantjes, Esther van Andel, Janneke E Stalenhoef, Cees van Nieuwkoop, Eliane M S Leyten, Nathalie M Delfos, Martijn Sijbom, Mattijs E Numans, Wilco P Achterberg, Simon P Mooijaart, Martha T van der Beek, Christa M Cobbaert, Simon P Conroy, Leo G Visser, Merel M C Lambregts
doi : 10.1093/cid/ciad099
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2070–2076
Pre-existing lower urinary tract symptoms (LUTS), cognitive impairment, and the high prevalence of asymptomatic bacteriuria (ASB) complicate the diagnosis of urinary tract infection (UTI) in older women. The presence of pyuria remains the cornerstone of UTI diagnosis.
Coronavirus Disease 2019 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization: A Meta-Analysis of Individual Participant Data From 5 Randomized Trials
Adam C Levine, Yuriko Fukuta, Moises A Huaman, Jiangda Ou, Barry R Meisenberg, Bela Patel, James H Paxton, Daniel F Hanley, Bart J A Rijnders, Arvind Gharbharan, Casper Rokx, Jaap Jan Zwaginga, Andrea Alemany, Oriol Mitjà , Dan Ouchi, Pere Millat-Martinez, Valerie Durkalski-Mauldin, Frederick K Korley, Larry J Dumont, Clifton W Callaway, Romina Libster, Gonzalo Perez Marc, Diego Wappner, Ignacio Esteban, Fernando Polack, David J Sullivan
doi : 10.1093/cid/ciad088
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2077–2086
Outpatient monoclonal antibodies are no longer effective and antiviral treatments for coronavirus disease 2019 (COVID-19) disease remain largely unavailable in many countries worldwide. Although treatment with COVID-19 convalescent plasma (CCP) is promising, clinical trials among outpatients have shown mixed results.
Coronavirus Disease 2019 Convalescent Plasma Reaches the Slope of Enlightenment in the Gartner Hype Cycle
Shmuel Shoham
doi : 10.1093/cid/ciad092
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2087–2089
Symptoms and Systemic Drug Reactions in Persons Receiving Weekly Rifapentine Plus Isoniazid (3HP) Treatment for Latent Tuberculosis Infection
Claire Sadowski, Robert Belknap, David P Holland, Ruth N Moro, Michael P Chen, Alicia Wright, Joan Pau Millet, Joan A Caylà , Nigel A Scott, Andrey Borisov, Neel R Gandhi
doi : 10.1093/cid/ciad083
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2090–2097
Three months of weekly rifapentine plus isoniazid (3HP) therapy for latent tuberculosis infection (LTBI) is recommended worldwide. The development of symptoms and systemic drug reactions (SDRs) on 3HP have not been fully characterized. We aimed to determine the patterns of symptom development and identify SDRs and associated factors in patients taking 3HP.
Physician Financial Incentives for Use of Outpatient Intravenous Antimicrobial Therapy: An Interrupted Time Series Analysis
John A Staples, Meghan Ho, Dwight Ferris, Guiping Liu, Jeffrey R Brubacher, Mayesha Khan, Daniel Daly-Grafstein, Karen C Tran, Jason M Sutherland
doi : 10.1093/cid/ciad082
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2098–2105
In 2011, policymakers in British Columbia introduced a fee-for-service payment to incentivize infectious diseases physicians to supervise outpatient parenteral antimicrobial therapy (OPAT). Whether this policy increased use of OPAT remains uncertain.
Adherence to Antimicrobial Prophylaxis Guidelines for Elective Surgeries Across 825 US Hospitals, 2019–2020
Stephanie M Cabral, Anthony D Harris, Sara E Cosgrove, Laurence S Magder, Pranita D Tamma, Katherine E Goodman
doi : 10.1093/cid/ciad077
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2106–2115
There are limited US data assessing adherence to surgical antimicrobial prophylaxis guidelines, particularly across a large, nationwide sample. Moreover, commonly prescribed inappropriate antimicrobial prophylaxis regimens remain unknown, hindering improvement initiatives.
Cryptococcal Meningitis and Clinical Outcomes in Persons With Human Immunodeficiency Virus: A Global View
Anna K Person, Brenda Crabtree-Ramirez, Ahra Kim, Valdiléa Veloso, Fernanda Maruri, Gilles Wandeler, Matthew Fox, Richard Moore, M John Gill, Darma Imran, Kinh Van Nguyen, Elizabeth Nalitya, Winnie Muyindike, Bryan E Shepherd, Catherine C McGowan
doi : 10.1093/cid/ciad076
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2116–2125
Cryptococcal meningitis (CM) is a major cause of morbidity and mortality in persons with human immunodeficiency virus (HIV; PWH). Little is known about CM outcomes and availability of diagnostic and treatment modalities globally.
Infection-Induced Immunity Is Associated With Protection Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Decreased Infectivity
Aaron M Frutos, Guillermina Kuan, Roger Lopez, Sergio Ojeda, Abigail Shotwell, Nery Sanchez, Saira Saborio, Miguel Plazaola, Carlos Barilla, Eben Kenah, Angel Balmaseda, Aubree Gordon
doi : 10.1093/cid/ciad074
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2126–2133
The impact of infection-induced immunity on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission has not been well established. Here we estimate the effects of prior infection induced immunity in adults and children on SARS-CoV-2 transmission in households.
Patterns of Infectious Disease Associated With Injection Drug Use in Massachusetts
Gregg S Gonsalves, A David Paltiel, Thomas Thornhill, Alfred DeMaria, Jr, Kevin Cranston, R Monina Klevens, Joshua L Warren
doi : 10.1093/cid/ciad073
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2134–2139
Since 2014, multiple outbreaks of human immunodeficiency virus (HIV) among people who inject drugs have occurred across the United States along with hepatitis C virus (HCV), skin and soft tissue infections (SSTIs), and infective endocarditis (IE), creating a converging public health crisis.
1-Year Outcomes of Lung Transplantation for Coronavirus Disease 2019–Associated End-Stage Lung Disease in the United States
Kenji Okumura, Soma Jyothula, Thomas Kaleekal, Abhay Dhand
doi : 10.1093/cid/ciad072
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2140–2147
Lung transplantation can provide quality of life and survival benefits for patients with coronavirus disease 2019 (COVID-19)–associated end-stage lung disease. Characteristics and outcomes of these lung transplant recipients are limited to mostly single-center experiences or provide a short-term follow-up.
Evaluation of a Statewide Online, At-Home Sexually Transmitted Infection and Human Immunodeficiency Virus Screening Program
David M Higgins, MaShawn Moore, Lucy Alderton, Laura Weinberg, Andrew M Hickok, Andrew Yale, Karen A Wendel
doi : 10.1093/cid/ciad071
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2148–2153
Innovative approaches such as online, at-home programs may address important barriers to sexually transmitted infection (STI) and human immunodeficiency virus (HIV) screening in the United States. This study evaluated the first year of an online, at-home program offering HIV and triple-site (urogenital, rectal, and pharyngeal) gonorrhea (GC) and chlamydia (CT) testing in Colorado.
Antimicrobial for 7 or 14 Days for Febrile Urinary Tract Infection in Men: A Multicenter Noninferiority Double-Blind, Placebo-Controlled, Randomized Clinical Trial
Matthieu Lafaurie, Sylvie Chevret, Jean-Paul Fontaine, Pierre Mongiat-Artus, Victoire de Lastours, Lélia Escaut, Stéphane Jaureguiberry, Louis Bernard, Franck Bruyere, Caroline Gatey, Sophie Abgrall, Milagros Ferreyra, Hugues Aumaitre, Caroline Aparicio, Valérie Garrait, Vanina Meyssonnier, Anne Bourgarit-Durand, Amélie Chabrol, Emilie Piet, Jean-Philippe Talarmin, Marine Morrier, Etienne Canoui, Caroline Charlier, Manuel Etienne, Jerome Pacanowski, Nathalie Grall, Kristell Desseaux, Florence Empana-Barat, Isabelle Madeleine, Béatrice Bercot, Jean-Michel Molina, Agnès Lefort, for the PROSTASHORT Study Group
doi : 10.1093/cid/ciad070
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2154–2162
The optimal duration of antimicrobial therapy for urinary tract infections (UTIs) in men remains controversial.
Relationships Between Patient Race and Residential Race Context With Missed Human Immunodeficiency Virus Care Visits in the United States, 2010–2015
Kaylee B Crockett, Cassandra O Schember, Aihua Bian, Peter F Rebeiro, Jeanne Keruly, Kenneth Mayer, Christopher Mathews, Richard D Moore, Heidi Crane, Elvin Geng, Sonia Napravnik, Bryan E Shepherd, Michael J Mugavero, Bulent Turan, April C Pettit
doi : 10.1093/cid/ciad069
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2163–2170
Racial inequities exist in retention in human immunodeficiency virus (HIV) care and multilevel analyses are needed to contextualize and address these differences. Leveraging data from a multisite clinical cohort of people with HIV (PWH), we assessed the relationships between patient race and residential characteristics with missed HIV care visits.
Risk of Acute Myocardial Infarction Among Patients With Laboratory-Confirmed Invasive Pneumococcal Disease: A Self-Controlled Case Series Study
Andrew D Wiese, Ed Mitchel, Danielle Ndi, Tiffanie M Markus, H Keipp Talbot, William Schaffner, Carlos G Grijalva
doi : 10.1093/cid/ciad065
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2171–2177
Acute myocardial infarction (AMI) events have been reported among patients with certain viral and bacterial infections. Whether invasive pneumococcal disease (IPD) increases the risk of AMI remains unclear. We examined whether laboratory-confirmed IPD was associated with the risk of AMI.
Prospective Cohort Study of Cryptosporidium Infection and Shedding in Infants and Their Households
Poonum Korpe, Zhanmo Ni, Mamun Kabir, Masud Alam, Tahsin Ferdous, Rifat Ara, Rebecca M Munday, Rashidul Haque, Priya Duggal
doi : 10.1093/cid/ciad059
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2178–2186
Cryptosporidium spp. are responsible for significant diarrheal morbidity and mortality in under-5 children. There is no vaccine; thus, a focus on prevention is paramount. Prior studies suggest that person-to-person spread may be an important pathway for transmission to young children.
gyrA Mutations in Mycoplasma genitalium and Their Contribution to Moxifloxacin Failure: Time for the Next Generation of Resistance-Guided Therapy
Gerald L Murray, Erica L Plummer, Kaveesha Bodiyabadu, Lenka A Vodstrcil, Jose L Huaman, Jennifer A Danielewski, Teck Phui Chua, Dorothy A Machalek, Suzanne Garland, Michelle Doyle, Emma L Sweeney, David M Whiley, Catriona S Bradshaw
doi : 10.1093/cid/ciad057
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2187–2195
Although single nucleotide polymorphisms (SNPs) in Mycoplasma genitalium parC contribute to fluoroquinolone treatment failure, data are limited for the homologous gene, gyrA. This study investigated the prevalence of gyrA SNPs and their contribution to fluoroquinolone failure.
Isavuconazole in the Treatment of Chronic Forms of Coccidioidomycosis
Arash Heidari, Rupam Sharma, Qusai Shakir, Madiha Shah, Josh Clement, Monica A Donnelley, Trina Reynolds, Kate Trigg, Jeff Jolliff, Rasha Kuran, Royce Johnson, George R Thompson, III
doi : 10.1093/cid/ciad146
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2196–2199
Coccidioidomycosis is a fungal infection with a range of clinical manifestations. Currently used antifungal agents exhibit variable efficacy and toxicity profiles that necessitate evaluation of additional therapeutic options. Improvement was observed in the majority of patients treated with isavuconazole, with clinical failures observed only in those with coccidioidal meningitis.
Chronic Active Epstein-Barr Virus (EBV) Infection Controlled by Allogeneic Stem Cell Transplantation and EBV-Specific T Cells
Elisabeth Meedt, Daniela Weber, Agnes Bonifacius, Britta Eiz-Vesper, Britta Maecker-Kolhoff, Susanne Delecluse, Henri-Jacques Delecluse, Myriam Lorenz, Klaus Schwarz, Stefan T Meedt, Jan Braess, Wolfgang Herr, Ernst Holler, Matthias Edinger, Daniel Wolff
doi : 10.1093/cid/ciad131
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2200–2202
We report sustained remission of chronic active Epstein-Barr virus (EBV) infection in a 27-year-old female patient treated with third-party EBV-specific T cells followed by allogeneic hematopoietic stem cell transplantation (HSCT). The viremia cleared after administration of anti-T-lymphocyte globulin for graft-versus-host disease (GvHD) prophylaxis. Subsequent expansion of EBV-infected host T cells was controlled by transfusion of donor-derived EBV-specific T cells.
45-Year-Old Male With Dyspnea, Chronic Chough, Significant Weight Loss, and Episodes of Massive Hemoptysis
Ilad Alavi Darazam, Siamak Afaghi, Arash Khameneh Bagheri, Roghayeh Sedaghati, Legha Lotfollahi, Amir Hossein Akbari
doi : 10.1093/cid/ciac729
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2203–2205
The Testing Imperative: Why the US Ending the Human Immunodeficiency Virus (HIV) Epidemic Program Needs to Renew Efforts to Expand HIV Testing in Clinical and Community-Based Settings
Bohdan Nosyk, Anthony Todd Fojo, Parastu Kasaie, Benjamin Enns, Laura Trigg, Micah Piske, Angela B Hutchinson, Elizabeth A DiNenno, Xiao Zang, Carlos del Rio
doi : 10.1093/cid/ciad103
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2206–2208
Data from several modeling studies demonstrate that large-scale increases in human immunodeficiency virus (HIV) testing across settings with a high burden of HIV may produce the largest incidence reductions to support the US Ending the HIV Epidemic (EHE) initiative's goal of reducing new HIV infections 90% by 2030.
Complexity Interactions Between Nirmatrelvir/Ritonavir and Voriconazole in Patients With Coronavirus Disease 2019
Peile Wang, Han Xing, Xiaojian Zhang, Jing Yang
doi : 10.1093/cid/ciad159
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2209–2210
Appropriate Outcome Settings for the Effectiveness of Oral Zinc Treatment for Coronavirus Disease 2019
Nobuaki Mori, Jun Hirai, Nobuhiro Asai, Hiroshige Mikamo
doi : 10.1093/cid/ciad153
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2210–2211
Reply to Mori et al
Khaoula Bel Haj Ali, Adel Sekma, Yosra Mhalla, Asma Zorgati, Semir Nouira
doi : 10.1093/cid/ciad154
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2211–2212
β-Lactam Therapeutic Drug Monitoring in Critically Ill Patients
Teagan Zeggil, Bruce Dalton
doi : 10.1093/cid/ciad150
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2212–2213,
Applying Desirability of Outcome Ranking End Point to Randomized Trial of Sulopenem for the Treatment of Complicated Urinary Tract Infections
Michael W Dunne, Steven I Aronin, Anita F Das, Jayanti Gupta, Karthik Akinapelli, Jeanne Breen, Michael T Zelasky, Sailaja Puttagunta
doi : 10.1093/cid/ciad149
Clinical Infectious Diseases, Volume 76, Issue 12, 15 June 2023, Pages 2213–2215
