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Editorial. Neurocognition in fetal myelomeningocele closure: "not shunting per se"
Jeffrey P. Blount MD, MPH and Brandon G. Rocque MD, MS
doi : 10.3171/2022.12.PEDS22472
Volume 31: Issue 6 (Jun 2023)
Hydrocephalus and school-age neurodevelopmental outcomes in the management of myelomeningocele prenatal surgery trial: a secondary analysis
Jack M. Fletcher PhD , Amy J. Houtrow MD, PhD, MPH , Cora MacPherson PhD , Nina H. Thomas PhD , Nalin Gupta MD, PhD , N. Scott Adzick MD , and Elizabeth A. Thom PhD
doi : 10.3171/2022.10.PEDS22358
The purpose of this secondary analysis was to assess the role of hydrocephalus on neurodevelopmental outcomes in a cohort of school-age children enrolled in the Management of Myelomeningocele Study (MOMS) clinical trial.
Variability in neurosurgical management and associated comorbidities and complications among preterm patients with posthemorrhagic hydrocephalus in the United States
Erwin Cabacungan MD , Samuel Adams MD , Benjamin Best MD , Andrew B. Foy MD , Avantika Singh MD , and Susan S. Cohen MD
doi : 10.3171/2023.1.PEDS22461
Posthemorrhagic hydrocephalus (PHH) remains a major morbidity of premature birth resulting from intraventricular hemorrhage (IVH).
From fixed-pressure paediGAV to programmable proGAV/proSA serial valves for pediatric hydrocephalus within the 1st year of life: a technical single-center analysis
Fritz Teping MD , Matthias Huelser MD , Christoph Sippl MD , Michael Zemlin MD , and Joachim Oertel MD
doi : 10.3171/2023.1.PEDS22341
Programmable valves have gained increasing popularity in the complex treatment of pediatric hydrocephalus. Over the last decade, adjustable serial valves have gradually replaced fixed-pressure valves in the authors’ department. The present study investigates this development by analyzing shunt- and valve-related outcomes for this vulnerable population.
The natural history of postoperative hydrocephalus after pediatric hemispherectomy for medically refractory epilepsy: an institutional experience
Victor M. Lu MD, PhD , Shelly Wang MD, MPH , and John Ragheb MD
doi : 10.3171/2023.2.PEDS22569
Hemispherectomy is a complex surgical intervention for medically refractory epilepsy, and its surgical sequelae continue to be defined. The incidence, timing, and predictors of postoperative hydrocephalus are not well understood. Correspondingly, the aim of this study was to define the natural history of the development of hydrocephalus after hemispherectomy based on the authors’ institutional experience.
Magnetic resonance imaging–guided stereotactic laser ablation therapy for the treatment of pediatric epilepsy: a retrospective multiinstitutional study
Elsa V. Arocho-Quinones  MD , Sean M. Lew  MD , Michael H. Handler  MD , Zulma Tovar-Spinoza  MD , Matthew D. Smyth  MD , Robert J. Bollo  MD , David Donahue  MD , M. Scott Perry  MD , Michael Levy  MD, PhD , David Gonda  MD , Francesco T. Mangano  DO , Benjamin C. Kennedy  MD , Phillip B. Storm  MD , Angela V. Price  MD , Daniel E. Couture  MD , Chima Oluigbo  MD , Ann-Christine Duhaime  MD , Gene H. Barnett  MD , Carrie R. Muh  MD , Michael D. Sather  MD , Aria Fallah  MD, MSc , Anthony C. Wang  MD , Sanjiv Bhatia  MD , Daniel Eastwood  MS , Sergey Tarima  PhD , Sarah Graber  BA , Sean Huckins  MS , Daniel Hafez  MD, PhD , Kavelin Rumalla  MD , Laurie Bailey  PhD , Sabrina Shandley  PhD , Ashton Roach  MS , Erin Alexander  BS , Wendy Jenkins  BSN , Deki Tsering  MHS , George Price  BS , Antonio Meola  MD, PhD , Wendi Evanoff , Eric M. Thompson  MD , Nicholas Brandmeir  MD , and for the Pediatric Stereotactic Laser Ablation Workgroup
doi : 10.3171/2022.12.PEDS22282
The authors of this study evaluated the safety and efficacy of stereotactic laser ablation (SLA) for the treatment of drug-resistant epilepsy (DRE) in children.
Safety of vagus nerve stimulation and responsive neurostimulation used in combination for multifocal and generalized onset epilepsy in pediatric patients
Cameron P. Beaudreault MS , Eris Spirollari BA , Alexandria F. Naftchi BS , Vishad Sukul MD , Ankita Das BS , Sima Vazquez MS , Steven M. Wolf MD , Patricia E. McGoldrick NP , and Carrie R. Muh MD
doi : 10.3171/2023.1.PEDS22486
The aim of this study was to assess the safety and efficacy of combined active responsive neurostimulation (RNS) and vagus nerve stimulation (VNS) therapies in pediatric patients with drug-resistant epilepsy.
Persistent discrepancies in orbital morphology after surgical treatment of unicoronal craniosynostosis: a critical image-based analysis
Hanna M. Lif MD , Johan E. Nysjö PhD , Johan R. Vegelius PhD , Jesper Unander-Scharin MD, PhD , Per Enblad MD, PhD , and Daniel J. Nowinski MD, PhD
doi : 10.3171/2023.1.PEDS22349
Unicoronal craniosynostosis (UCS) is characterized by complex orbital deformity and is typically treated by asymmetrical fronto-orbital remodeling (FOR) during the 1st year of life. The aim of this study was to elucidate to what extent orbital morphology is corrected by surgical treatment.
Association of novel mutation in TRPV4 with familial nonsyndromic craniosynostosis with complete penetrance and variable expressivity
Tenzin Gayden PhD , Gabriel Crevier-Sorbo MD , Wajih Jawhar MSc , Christine Saint-Martin MD , Robert Eveleigh MSc , Mirko S. Gilardino MD, MSc , Natascia Anastasio MD, CM , Yannis Trakadis MD , Angelia V. Bassenden PhD , Albert M. Berghuis PhD , Nada Jabado MD, PhD , and Roy W. R. Dudley MD, PhD
doi : 10.3171/2023.1.PEDS22287
The aim of this study was to characterize a novel pathogenic variant in the transient receptor potential vanilloid 4 (TRPV4) gene, causing familial nonsyndromic craniosynostosis (CS) with complete penetrance and variable expressivity.
Cerebral ischemia: a frequent complication of large traumatic epidural hematoma in infants
Matthieu Landart MD , Sandro Benichi MD , Lelio Guida MD , Marilena Lazarescu MD , Marie Bourgeois MD , Hélène Sauvé-Martin MD , Raphael Levy MD , Charles-Joris Roux MD , Syril James MD , Timothée de Saint-Denis MD , Estelle Vergnaud MD , Giovanna Paternoster MD , Kevin Beccaria MD, PhD , and Thomas Blauwblomme MD, PhD
doi : 10.3171/2023.1.PEDS22324
Epidural hematoma (EDH) has rarely been studied specifically in infants. The objective of this study was to investigate the outcomes of patients aged < 18 months (infants) with EDH.
Prehospital and emergency management of pediatric traumatic brain injury: a multicenter site survey
Gawin Mai BS , Jan Hau Lee MBBS , Paula Caporal MD , Juan D. Roa G. MD, MS , Sebastián González-Dambrauskas MD , Yanan Zhu PhD , Adriana Yock-Corrales MD , Qalab Abbas MBBS , Yasser Kazzaz MPH , Dianna Sri Dewi BS , Shu-Ling Chong MPH , on behalf of PACCMAN and LARed , Deborah M. Turina MD , Jesús A. DomÃnguez-Rojas MD , Francisco J. Pilar-Orive PhD, MD , Chin Seng Gan MPaeds , Qalab Abbas MRCPCH , Willmer E. Diaz Villalobos MBBS , Ivan J. Ardila MD , Rujipat Samransamruajkit MD , Adriana Yock-Corrales MSc , Marisol Fonseca MD , Gabriela Aparicio MD , Juan C. Jaramillo-Bustamante MD , Pei-Chuen Lee MRCPCH , Thelma E. Teran MD , Nicolas Monteverde-Fernandez MD , MarÃa Miñambres RodrÃguez PhD , Juan D. Roa G MD , Chunfeng Liu PhD , Tao Zhang PhD , Meixiu Ming MD , Hongxing Dang MD , Hiroshi Kurosawa PhD, MD , Freddy Israel Pantoja Chamorro MD , Deiby Lasso Noguera MD , Esteban Cerón MD , Natalia Gómez Arriola MD , and Ruben Eduardo Lasso Palomino MD
doi : 10.3171/2023.1.PEDS22456
There is a paucity of information on pediatric traumatic brain injury (TBI) care in Asia and Latin America. In this study, the authors aimed to describe the clinical practices of emergency departments (EDs) participating in the Saline in Asia and Latin-America Neurotrauma in the Young (SALTY) study, by comparing designated trauma centers (DTCs) and nontrauma centers (NTCs) in their networks.
Cerebellar tonsil reduction for surgical treatment of Chiari malformation type I in children
Bruno P. Braga MD , Eric Y. Montgomery BA , Bradley E. Weprin MD , Angela V. Price MD , Brett A. Whittemore MD , Mark N. Pernik MD , Frederick Sklar MD , Rafael De Oliveira Sillero MD , and Dale M. Swift MD
doi : 10.3171/2023.1.PEDS22222
The goal of this study was to review the efficacy and safety of different surgical techniques used for treatment of Chiari malformation type I (CM-I) in children.
Morning glory disc anomaly and its implications in moyamoya arteriopathy: a retrospective case series
Alfred P. See MD , Melissa A. LoPresti MD, MPH , Jeffrey Treiber MD , Brice Thomas MD , Madeline B. Karsten BA , Coleman P. Riordan BS , R. Michael Scott MD , Sandi K. Lam MD, MBA , and Edward R. Smith MD
doi : 10.3171/2023.2.PEDS22470
Morning glory disc anomaly (MGDA), a congenital abnormality of the optic nerve, may be associated with moyamoya arteriopathy, a cerebrovascular abnormality. In this study, the authors aimed to define the temporal evolution of cerebrovascular arteriopathy in patients with MGDA to characterize a rational strategy for screening and management over time.
Efficacy and safety of bevacizumab, irinotecan, and temozolomide combination for relapsed or refractory pediatric central nervous system embryonal tumor: a single-institution study
Yoshiki Shiba MD , Kazuya Motomura MD, PhD , Rieko Taniguchi MD, PhD , Michihiro Kurimoto MD, PhD , Kosuke Mizutani MD , Fumiharu Ohka MD, PhD , Kosuke Aoki MD, PhD , Eiji Ito MD, PhD , Tomohide Nishikawa MD, PhD , Junya Yamaguchi MD , Yuji Kibe MD , Hiroki Shimizu MD , Sachi Maeda PhD , Takuma Nakashima MD , Hiromichi Suzuki MD, PhD , Hideki Muramatsu MD, PhD , Yoshiyuki Takahashi MD, PhD , and Ryuta Saito MD, PhD
doi : 10.3171/2023.1.PEDS22345
This study aimed to evaluate the efficacy and safety of combination therapy with bevacizumab (Bev), irinotecan (CPT-11), and temozolomide (TMZ) in children with central nervous system (CNS) embryonal tumor relapse.
Mental health and substance use disorders in young adults with spina bifida
Bao Y. Sciscent BS , David R. Hallan MD , and Elias B. Rizk MD
doi : 10.3171/2023.2.PEDS22504
Although medical advances have allowed most patients with spina bifida (SB) to survive into adulthood, these patients may have physical impairments, urological complications, infections, and neurocognitive deficits. These factors can cause psychological distress and impact the transition from pediatric to adult care.
Letter to the Editor. The molecular mechanisms of folic acid fortification to prevent spina bifida
Juan Armando MejÃa MD and Luis Garcia Rairan MD
doi : 10.3171/2023.1.PEDS235
