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Effect of Type and Dose of Exercise on Neuropathic Pain After Experimental Sciatic Nerve Injury: A Preclinical Systematic Review and Meta-Analysis
Luis Matesanz-Garc?a,*,y,z Clement Billerot,x Joel Fundaun,* and Annina B. Schmid*
doi : 10.1016/j.jpain.2023.01.011
Volume 24, Issue 6, June 2023, Pages 921-938
This preclinical systematic review aimed to determine the effectiveness of different types and doses of exercise on pain behavior and biomarkers in preclinical models of focal neuropathic pain.
The Foundations for Chronic Low Back Pain Management may Start in Early Life. Exploring the Role of Caregiver Parental Leave on Future Low Back Pain in the Offspring
Edel T. O’Hagan,* Sarah B. Wallwork,y Emily Callander,z Tasha R. Stanton,y and Richelle Mychasiuk
doi : 10.1016/j.jpain.2023.01.008
Volume 24, Issue 6, June 2023, Pages 939-945
Chronic low back pain is difficult to treat and despite increased spending on health services, clinical outcomes for people with low back pain have not improved. Innovative, large scale initiatives seem necessary to stem the cost of low back pain.
Effectiveness of Different Electrical Stimulation Modalities for Pain and Masticatory Function in Temporomandibular Disorders: A Systematic Review and Meta-Analysis
Diego Serrano-Mu~noz,PhD Hector Beltran-Alacreu,PT, PhD David Mart?n-Caro Alvarez, MsC Juan Jose Fernandez-Perez,MsC Javier Aceituno-Gomez,PhD Ruben Arroyo-Fernandez,PhD and Juan Avenda~no-Coy,PhD
doi : 10.1016/j.jpain.2023.01.016
Volume 24, Issue 6, June 2023, Pages 946-956
Temporomandibular disorders comprise a set of conditions that include alterations of the temporomandibular joint and masticatory muscles. Although different modalities of electric currents are widely used for treating temporomandibular disorders, previous reviews have suggested these are ineffective.
Optimized Electrical Stimulation of C-Nociceptors in Humans Based on the Chronaxie of Porcine C-Fibers
Tobias Schneider,*,ya,b Julia Filip,*,a,b Sabrina Soares,* Kyra Sohns,* Richard Carr,* Roman Rukwied,* and Martin Schmelz
doi : 10.1016/j.jpain.2023.01.009
Volume 24, Issue 6, June 2023, Pages 957-969
Classically, to electrically excite C-nociceptors, rectangular pulses are used with a duration close to the estimated chronaxie of C-fibres (about 2 ms). Recent results using slow depolarizing stimuli suggest longer chronaxies. We therefore set out to optimize C-fiber stimulation based on recordings of single C-nociceptors in-vivo and C-fiber compound-action-potentials (C-CAP) ex-vivo using half-sine shaped stimuli of durations between 1 and 250ms.
Head and Neck Pain Drawing Area Correlates With Higher Psychosocial Burden But Not With Joint Dysfunction in Temporomandibular Disorders: A Cross-Sectional Study
Christopher Herpel,* Armin Drusko,y Franz Sebastian Schwindling,* Peter Rammelsberg,* and Jonas Tesarz
doi : 10.1016/j.jpain.2023.01.010
Volume 24, Issue 6, June 2023, Pages 970-979
Head and neck pain drawings have been introduced as part of the diagnostic gold standard for temporomandibular disorders (TMD). We aimed to quantify the spatial extent of pain in TMD patients and to analyze its association with further clinical findings.
Movement-Evoked Pain Versus Widespread Pain: A Longitudinal Comparison in Older Adults With Chronic Low Back Pain From the Delaware Spine Studies
Patrick J. Knox,* Corey B. Simon,y Ryan T. Pohlig,z,x Jenifer M. Pugliese,* Peter C. Coyle,* Jaclyn M. Sions,* and Gregory E. Hicks*
doi : 10.1016/j.jpain.2023.01.012
Volume 24, Issue 6, June 2023, Pages 980-990
It is currently unknown which pain-related factors contribute to long-term disability and poorer perceived health among older adults with chronic low back pain (LBP). This investigation sought to examine the unique influence of movement-evoked pain (MeP) and widespread pain (WP) on longitudinal health outcomes (ie, gait speed, perceived disability, and self-efficacy) in 250 older adults with chronic LBP.
Modulation of the Inflammatory Response by Pre-emptive Administration of IMT504 Reduces Postoperative Pain in Rats and has Opioid-Sparing Effects
Julia Rubione,* Sandra M. Sbrascini,* ,y Bernardo Miguel,* Candelaria Leiguarda,* Mar?a F. Coronel,* Carly J. McCarthy,* Alejandro Montaner,z Marcelo J. Villar,* and Pablo R. Brumovsky
doi : 10.1016/j.jpain.2023.01.013
Volume 24, Issue 6, June 2023, Pages 991-1008
Despite the available knowledge on underlying mechanisms and the development of several therapeutic strategies, optimal management of postoperative pain remains challenging. This preclinical study hypothesizes that, by promoting an anti-inflammatory scenario, pre-emptive administration of IMT504, a noncoding, non-CpG oligodeoxynucleotide with immune modulating properties, will reduce postincisional pain, also facilitating therapeutic opioid-sparing.
Pain and Disability Transitions Among Older Americans: The Role of Education
Feinuo Sun,* Zachary Zimmer,*,y and Anna Zajacova
doi : 10.1016/j.jpain.2023.01.014
Volume 24, Issue 6, June 2023, Pages 1009-1019
Previous literature has rarely examined the role of pain in the process of disablement. We investigate how pain associates with disability transitions among older adults, using educational attainment as a moderator. Data are from the National Health and Aging Trends Study, NÂ =Â 6,357; 33,201 1 year transitions between 2010 to 2020.
Somatostatin Neurons from Periaqueductal Gray to Medulla Facilitate Neuropathic Pain in Male Mice
Yuehong Zhang,* Xuelin Huang,* Wen-Jun Xin,y Shilang He,z Jie Deng,y and Xiangcai Ruan
doi : 10.1016/j.jpain.2023.01.002
Volume 24, Issue 6, June 2023, Pages 1020-1029
Projections from the periaqueductal gray (PAG) to the rostral ventromedial medulla (RVM) are known to engage in descending pain modulation, but how the neural substrates of the PAG-RVM projections contribute to neuropathic pain remains largely unknown.
“I Refused to Get Addicted to Opioids�: Exploring Attitudes About Opioid Use Disorder in Patients With Advanced Cancer Pain and Their Support People
Hailey W. Bulls,*,y,z Megan Hamm,x Rachel Wasilko,x Flor de Abril Cameron,x Shane Belin,*,y Burel R. Goodin,{ Jane M. Liebschutz,k Antoinette Wozniak, # Lindsay M. Sabik,** Yael Schenker,*,y and Jessica S. Merlin*
doi : 10.1016/j.jpain.2023.01.015
Volume 24, Issue 6, June 2023, Pages 1030-1038
Patients with advanced cancer are commonly prescribed opioids, yet patient attitudes about opioid risks (eg, opioid use disorder, or OUD) are understudied. Our objective was to use in-depth qualitative interviews to understand perceptions of opioid prescribing and OUD in patients with advanced, solid-tumor cancers and their support people.
Extensive Sensorimotor Training Predetermines Central Pain Changes During the Development of Prolonged Muscle Pain
Anna M. Zamorano,* Boris Kleber,y Federico Arguissain,* Shellie Boudreau,* Peter Vuust,y Herta Flor,*,z and Thomas Graven-Nielsen
doi : 10.1016/j.jpain.2023.01.017
Volume 24, Issue 6, June 2023, Pages 1039-1055
Repetitive movements (RM) are a main risk factor for musculoskeletal pain, which is partly explained by the overloading of musculoskeletal structures. However, RM may also drive brain plasticity, leading to maladaptive changes in sensorimotor areas and altered pain processing. This study aimed to understand whether individuals performing extensive RM (musicians) exhibit altered brain processing to prolonged experimental muscle pain.
Polygenic Contributions to Chronic Overlapping Pain Conditions in a Large Electronic Health Record Sample
Lori Schirle,* David C. Samuels,y,z Annika Faucon,z Nancy J. Cox,z,x and Stephen Bruehl
doi : 10.1016/j.jpain.2023.01.018
Volume 24, Issue 6, June 2023, Pages 1056-1068
Chronic overlapping pain conditions (COPCs) are believed to share common etiological mechanisms involving central sensitization. Genetic and environmental factors putatively combine to influence susceptibility to central sensitization and COPCs. This study employed a genome-wide polygenic risk score approach to evaluate genetic influences on 8 common COPCs.
Development and Validation of the Scale for Pain Self-Efficacy (SPaSE) in German and English Languages for Children and Adolescents
Lorin Stahlschmidt,* ,y Meltem Dogan,*,y Bettina H€ubner-M€ohler,*,y Kelsey Jervis,z Edin T. Randall,z,x Dustin P. Wallace,{,? Boris Zernikow,*,y and Julia Wager
doi : 10.1016/j.jpain.2023.01.007
Volume 24, Issue 6, June 2023, Pages 1069-1079
No validated measure for pain self-efficacy in children and adolescents is currently available in the German language, and existing English versions have limitations. This study used a thorough development process to create the Scale for Pain Self-Efficacy (SPaSE) in both German and English languages.
The Importance of the Treatment Rationale for Pain in Animal-Assisted Interventions: A Randomized Controlled Trial in Healthy Participants
Cora Wagner,* Jens Gaab,* and Karin Hediger
doi : 10.1016/j.jpain.2023.01.004
Volume 24, Issue 6, June 2023, Pages 1080-1093
Animal-assisted interventions (AAIs) is a promising treatment approach for pain, but possible mechanisms still need to be elucidated. This study set out to investigate the analgesic effects of an animal provided with a treatment rationale in a randomized controlled trial employing a standardized experimental heat-pain paradigm.
The Problem of Pain in the United States: A Population-Based Characterization of Biopsychosocial Correlates of High Impact Chronic Pain Using the National Health Interview Survey
Titilola Falasinnu,*,y Md Belal Hossain,z Kenneth Arnold Weber,II* Charles G. Helmick,{ Mohammad Ehsanul Karim,z,x and Sean Mackey
doi : /10.1016/j.jpain.2023.03.008
Volume 24, Issue 6, June 2023, Pages 1094-1103
Over 20 million adults in the United States live with high impact chronic pain (HICP), or chronic pain that limits life or work activities for ≥3 months. It is critically important to differentiate people with HICP from those who sustain normal activities although experiencing chronic pain.
Depression, Cognition, and Pain: Exploring Individual, Cultural and Country-Level Effects Across Europe
Richard J.E. James,*,y and Eamonn Ferguson
doi : 10.1016/j.jpain.2023.03.006
Volume 24, Issue 6, June 2023, Pages 1104-1115
The aim of this paper was to investigate the role of economic (eg, GDP per capita), political (eg, healthcare spending), cultural (country-level aggregates norms) and individual correlates (eg, depression) of pain in a secondary analysis of a sample of 76,000 adults in 19 countries across Europe.
Spatial Tuning in Nociceptive Processing Is Driven by Attention
Waclaw M. Adamczyk,* ,y,z,x Michal Katra,x Tibor M. Szikszay,{ James Peugh,y,z Christopher D. King,* ,y,z Kerstin Luedtke,x,{ and Robert C. Coghill
doi : 10.1016/j.jpain.2023.03.005
Volume 24, Issue 6, June 2023, Pages 1116-1125
