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COVID and the Cornea: From Controversies to Consensus
Aldave, Anthony J. MD*; DeMatteo, Jennifer MCM, CIC†; Chamberlain, Winston D. MD, PhD‡; Philippy, Brian BSChE, BS, CEBT§; Farooq, Asim V. MD¶; Buckman, Natalie CEBT?; Crosson, Andrea CEBT**; Li, Jennifer MD††; Meinecke, Eric CEBT‡‡; Kaufman, Adam H. MD§§
doi : 10.1097/ICO.0000000000002741
July 2021 - Volume 40 - Issue 7 - p 809-816
Association Between Dry Eye Disease and Newly Diagnosed Obsessive-Compulsive Disorder
Eroglu, Fatma Corak MD*; Gediz, Berrak Sekeryapan MD*; Ozturk, Mehmet MD†; Kazanc?, Burcu MD*
doi : 10.1097/ICO.0000000000002724
July 2021 - Volume 40 - Issue 7 - p 817-821
The purpose of this study was to evaluate the association between dry eye disease and patients with newly diagnosed obsessive-compulsive disorder (OCD).
Long-Term Visual Outcomes and Clinical Course of Patients With Peters Anomaly
Elbaz, Uri MD*,†; Strungaru, Hermina MD, PhD‡,§; Mireskandari, Kamiar MBChB, FRCSEd, FRCOphth, PhD¶,?; Stephens, Derek MSc**,††; Ali, Asim MD, FRCSC¶,?
doi : 10.1097/ICO.0000000000002577
July 2021 - Volume 40 - Issue 7 - p 822-830
To present long-term clinical and visual outcomes of patients with Peters anomaly.
Treatment of Severe Infectious Keratitis With Scleral Contact Lenses as a Reservoir of Moxifloxacin 0.5%
Polania-Baron, Eduardo J. MD; Santana-Cruz, Omar OD; Lichtinger, Alejandro MD; Graue-Hernandez, Enrique O. MD, MSc; Navas, Alejandro MD, PhD
doi : 10.1097/ICO.0000000000002482
July 2021 - Volume 40 - Issue 7 - p 831-836
To report the outcomes of using scleral contact lenses as antibiotic reservoirs as a therapeutic approach in a case series of severe infectious keratitis and to discuss the clinical potential.
Cross-Linking Assisted Infection Reduction (CLAIR): A Randomized Clinical Trial Evaluating the Effect of Adjuvant Cross-Linking on Bacterial Keratitis
Prajna, N. Venkatesh*; Radhakrishnan, Naveen*; Lalitha, Prajna*; Rajaraman, Revathi*; Narayana, Shivananda MS*; Austin, Ariana F.†; Liu, Zijun†; Keenan, Jeremy D.†,‡; Porco, Travis C.†,§; Lietman, Thomas M.†,§,‡; Rose-Nussbaumer, Jennifer MD†,‡,¶
doi : 10.1097/ICO.0000000000002510
July 2021 - Volume 40 - Issue 7 - p 837-841
To determine whether there is a benefit to adjuvant corneal cross-linking (CXL) for bacterial keratitis.
Phenotypic Characterization of Corneal Epithelium in Long-Term Follow-Up of Patients Post-Autologous Cultivated Oral Mucosal Epithelial Transplantation
Prabhasawat, Pinnita MD*; Chirapapaisan, Chareenun MD*; Jiravarnsirikul, Anuwat MD*; Ekpo, Pattama PhD†; Uiprasertkul, Mongkol MD‡; Thamphithak, Ranida MD*; Matamnan, Sutthicha BSc§; Boonwong, Chawikan BSc§
doi : 10.1097/ICO.0000000000002498
July 2021 - Volume 40 - Issue 7 - p 842-850
To analyze the phenotype of the corneal epithelium in patients with long-term follow-up who underwent autologous cultivated oral mucosal epithelial transplantation (COMET) using in vivo confocal microscopy (IVCM) and impression cytology with immunofluorescence staining (ICIF).
Comparison of Corneal Biomechanical Properties and Corneal Tomography Between Customized and Accelerated Corneal Crosslinking in Eyes with Keratoconus
Nishida, Tomoya CO*; Kojima, Takashi MD, PhD*,†; Kataoka, Takahiro CO*; Isogai, Naoki CO*; Yoshida, Yoko MD*; Nakamura, Tomoaki MD*
doi : 10.1097/ICO.0000000000002572
July 2021 - Volume 40 - Issue 7 - p 851-858
To compare the changes in corneal biomechanical properties and corneal tomography between transepithelial customized corneal crosslinking (C-CXL) and epithelium-off accelerated corneal crosslinking (A-CXL) in eyes with keratoconus.
Mini-Scleral Lenses Improve Vision-Related Quality of Life in Keratoconus
Kreps, Elke O. MD*,†,‡; Pesudovs, Konrad PhD§; Claerhout, Ilse MD, PhD†,¶; Koppen, Carina MD, PhD‡,?
doi : 10.1097/ICO.0000000000002518
July 2021 - Volume 40 - Issue 7 - p 859-864
To evaluate the effects of mini-scleral lenses on visual acuity (VA) and visual functioning in patients with keratoconus.
Ocular Discomfort and Quality of Life Among Patients in the Dry Eye Assessment and Management Study
Sayegh, Rony R. MD*; Yu, Yinxi MS†; Farrar, John T. MD, PhD‡; Kuklinski, Eric J. BA§; Shtein, Roni M. MD¶; Asbell, Penny A. MD, MBA?; Maguire, Maureen G. PhD†; for the Dry Eye Assessment and Management (DREAM) Study Research Group
doi : 10.1097/ICO.0000000000002580
July 2021 - Volume 40 - Issue 7 - p 869-876
To assess the association of severity of ocular discomfort with measures of quality of life among patients with moderate to severe dry eye disease (DED).
Prevalence and Risk Factors Associated With Corneal Perforation in Chronic Ocular Graft-Versus-Host-Disease
Sinha, Shruti MD, MS; Singh, Rohan Bir MD; Dohlman, Thomas H. MD; Taketani, Yukako MD, PhD; Yin, Jia MD, PhD, MPH; Dana, Reza MD, MPH, MSc
doi : 10.1097/ICO.0000000000002526
July 2021 - Volume 40 - Issue 7 - p 877-882
To determine the prevalence and risk factors associated with corneal perforation in patients with chronic ocular graft-versus-host disease (oGVHD).
Refractive Outcomes After Descemet Membrane Endothelial Keratoplasty + Cataract/Intraocular Lens Triple Procedure: A Fellow Eye Comparison
Augustin, Victor A. MD; Weller, Julia M. MD; Kruse, Friedrich E. MD; Tourtas, Theofilos MD
doi : 10.1097/ICO.0000000000002602
July 2021 - Volume 40 - Issue 7 - p 883-887
Descemet membrane endothelial keratoplasty is often combined with phacoemulsification and intraocular lens implantation (DMEK + cataract/IOL triple procedure) in phakic patients. This procedure results in a refractive shift that is difficult to predict. The aim of this study was to evaluate the hypothesis that the refractive shift in the second eye follows the shift in the first eye.
Improved Outcome of Pythium Keratitis With a Combined Triple Drug Regimen of Linezolid and Azithromycin
Sane, Sayali S. DNB*; Madduri, Bhagyasree MSc†; Mohan, Nitin MD†; Mittal, Ruchi MD‡; Raghava, J. V. DO*; Fernandes, Merle MS*
doi : 10.1097/ICO.0000000000002503
July 2021 - Volume 40 - Issue 7 - p 888-893
To describe the clinical features, microbiological profile, and outcome of a series of cases of Pythium keratitis treated with topical and oral linezolid and topical azithromycin eye drops.
Ink Retention and Endothelial Cell Viability After the Application of an Orientation Stamp Over an Air Bubble During Descemet Membrane Endothelial Keratoplasty Graft Preparation
Straiko, Megan M. W. PhD; Odell, Kelly BS; Dye, Philip K. CEBT; Hikes, Matthew T. BA; Andersen, Allison BS, CEBT; Trolli, Giulia BS; Tsering, Dolkar T. BS; Galloway, Joshua D. BS, CEBT; Tran, Khoa D. PhD
doi : 10.1097/ICO.0000000000002590
July 2021 - Volume 40 - Issue 7 - p 894-898
To investigate stamp visibility and endothelial cell loss (ECL) after the application of an orientation mark to Descemet membrane endothelial keratoplasty (DMEK) grafts supported by an air bubble.
Pilot Study of Corneal Clearance With the Use of a Rho-Kinase Inhibitor After Descemetorhexis Without Endothelial Keratoplasty for Fuchs Endothelial Corneal Dystrophy
Davies, Emma MD; Jurkunas, Ula MD; Pineda, Roberto II MD
doi : 10.1097/ICO.0000000000002691
July 2021 - Volume 40 - Issue 7 - p 899-902
To investigate corneal clearance time using a topical rho-kinase inhibitor, netarsudil, after descemetorhexis without endothelial keratoplasty (DWEK).
Case Report: Suspected Donor Transmission of Acanthamoeba Keratitis After Deep Anterior Lamellar Keratoplasty
Ward, Matthew S. MD*; Bontu, Sneha MD†; Martheswaran, Tanisha‡; Mamalis, Nick MD†; Moshirfar, Majid MD†,§,¶
doi : 10.1097/ICO.0000000000002517
July 2021 - Volume 40 - Issue 7 - p 903-906
In our report, we present a suspected case of donor-derived Acanthamoeba keratitis after deep anterior lamellar keratoplasty. To the authors' knowledge, there have been no confirmed cases of Acanthamoeba keratitis transmission through corneal transplantation.
Alkali Burn Over a LASIK Flap
Witsberger, Emily M. MD; Patel, Sanjay V. MD, FRCOphth
doi : 10.1097/ICO.0000000000002604
July 2021 - Volume 40 - Issue 7 - p 907-909
To describe the management and outcome of an ocular surface alkali burn in the setting of previous laser in situ keratomileusis (LASIK).
Wound Healing of Descemet Membrane After Penetrating Keratoplasty and Its Relevance for Descemet Membrane Endothelial Keratoplasty Surgeons
Steindor, Friedrich A. MD*; Clemens, Amelie C. MD†; Herwig-Carl, Martina C. MD†; Loeffler, Karin U. MD†; Menzel-Severing, Johannes MD*; Geerling, Gerd MD*
doi : 10.1097/ICO.0000000000002678
July 2021 - Volume 40 - Issue 7 - p 910-913
Compared with penetrating keratoplasty (PK), Descemet membrane endothelial keratoplasty (DMEK) is characterized as lower risk for complications such as immunological graft reaction and faster and better postoperative visual recovery. In patients with endothelial graft failure after PK, DMEK can be used to regenerate PK graft transparency. The surgical technique for DMEK in this specific situation is still under debate, particularly regarding stripping of Descemet membrane (DM) from the failed PK and diameter of the DMEK graft. Here we report a case of a 75-year-old female patient with a failed graft 16 years after PK for Fuchs endothelial dystrophy, who underwent uneventful DMEK surgery. Stripping of DM in this particular case was performed outside the failed PK and demonstrated a biomechanically stable junction between the PK donor and the host DM. Histopathologic analysis of the excised DM showed continuous extracellular matrix connecting the host and donor DM, indicating primary intention wound healing after PK at this tissue level. This case demonstrates that after PK, a biomechanically stable and histologically continuous DM can enable Descemetorhexis outside the failed graft and transplantation of a DMEK graft larger than the previous PK. This may provide more endothelial cells for transplantation.
“Doughnut” Amniotic Membrane Transplantation With Penetrating Keratoplasty for Vernal Keratoconjunctivitis With Limbal Stem Cell Disease
Singh, Aastha MS, DNB*; Murthy, Somasheila I. MS†; Gandhi, Arpan MD‡; Sangwan, Virender S. MS*
doi : 10.1097/ICO.0000000000002553
July 2021 - Volume 40 - Issue 7 - p 914-916
Severe vernal keratoconjunctivitis (VKC) can cause ocular surface disease including partial or complete limbal stem cell deficiency (LSCD), especially in early-onset and severe limbal form of VKC. We report a novel technique of doughnut amniotic membrane transplantation (AMT) along with penetrating keratoplasty (PK) for management of partial LSCD and corneal scarring in a case of severe VKC.
Diffuse Lamellar Keratitis in a Patient Undergoing Collagen Corneal Cross-Linking 18 Years After Laser In Situ Keratomileusis Surgery
Grassmeyer, Justin J. PhD*; Goertz, John G. OD†; Baartman, Brandon J. MD†
doi : 10.1097/ICO.0000000000002653
July 2021 - Volume 40 - Issue 7 - p 917-920
To report a case of diffuse lamellar keratitis (DLK) after corneal collagen cross-linking in an eye with a remote history of laser in situ keratomileusis (LASIK) surgery.
Supra-Descemetic Venting Incision in the Management of Spontaneous Descemet Membrane Detachment in an Old Penetrating Keratoplasty Graft
Ramakrishnan, Seema DO, DNB, FICO*; Devarajan, Sathish DO†; Srinivasan, Muthiah MS†; Karunakaran, Vanishree DNB*
doi : 10.1097/ICO.0000000000002664
July 2021 - Volume 40 - Issue 7 - p 921-925
To report a case of late spontaneous detachment of Descemet membrane (DM) in a donor penetrating keratoplasty (PKP) graft and its successful management using a supra-Descemetic venting incision combined with gas descemetopexy.
Acute Benign Paroxysmal Positional Vertigo After Endothelial Keratoplasty–A Unique Cause of Postoperative Nausea and Headache
Patel, Sachin PhD; Yuan, Amy MD; Pineda, Roberto MD
doi : 10.1097/ICO.0000000000002587
July 2021 - Volume 40 - Issue 7 - p 926-929
To describe a case of new-onset benign paroxysmal positional vertigo (BPPV) after uncomplicated Descemet stripping automated endothelial keratoplasty.
Corneal Donor Characteristics and Descemet Membrane Endothelial Keratoplasty Success: A Scoping Review
Luke, Weinel BSc, BHSc (Hons); Tamme, Golding-holbrook BMSc; Yee Chen, Jern MBBS, M. MED, FRANZCO; Richard, Mills MBBS, FRCOPHTH, FRCS(ED), FRANZCO, PHD
doi : 10.1097/ICO.0000000000002682
July 2021 - Volume 40 - Issue 7 - p 930-935
The purpose of this study was to review published data on donor characteristics and the influence on preoperative Descemet membrane endothelial keratoplasty (DMEK) preparation and intraoperative graft manipulation.
Do Eye Bank Models and Competitive Practice Affect International Cornea Allocation?
Machin, Heather MBA*,†; Sutton, Gerard‡,§; Baird, Paul N. PhD†
doi : 10.1097/ICO.0000000000002693
July 2021 - Volume 40 - Issue 7 - p 936-941
International export and import of corneas is dependent on the stakeholders involved in the process and how those organizations engage to move corneas from one point to another. Our article presents the pathway of corneal donation from the export nation until its use in the import nation. It presents opinion on how aspects, such as competition and promotional behaviors, the use of online systems, and third-party engagement may influence allocation.
Empirical and Normative Research in Ethics in Eye Banking
Weinlander, Eric MD
doi : 10.1097/ICO.0000000000002735
July 2021 - Volume 40 - Issue 7 - p e13
Clinical Metagenomic Next-Generation Sequencing has the Potential to Reduce Costs in the Management of Microbial Keratitis Patients
Borroni, Davide MD
doi : 10.1097/ICO.0000000000002719
July 2021 - Volume 40 - Issue 7 - p e14
COVID-19 Pandemic Impact on Epidemic Keratoconjunctivitis
Khavandi, Siamak MD*; Tabibzadeh, Elsa MD†; Khavandi, Soheila MD‡
doi : 10.1097/ICO.0000000000002750
July 2021 - Volume 40 - Issue 7 - p e14-e15
Beware of Polymegathism
Kivel?, Tero T. MD, FEBO
doi : 10.1097/ICO.0000000000002732
July 2021 - Volume 40 - Issue 7 - p e15
