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Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher, Elizabeth D. MD *; Marques-Piubelli, Mario L. MD *; Ramalingam, Preetha MD *; Wistuba, Ignacio MD *; Lawson, Barrett C. MD *; Frumovitz, Michael MD +; Malpica, Anais MD *
doi : 10.1097/PAS.0000000000002039
Volume 47(6) pgs. 635-737 June 2023
AB Extrauterine mesonephric-like carcinoma (ExUMLC) shares histologic, immunohistochemical (IHC), and molecular (MOL) features with endometrial mesonephric-like carcinoma (EnMLC). Its rarity and histologic overlap with Mullerian carcinomas contribute to underrecognition of ExUMLC.
Does "Low-Grade" Dedifferentiated Liposarcoma Exist? The Role of Mitotic Index in Separating Dedifferentiated Liposarcoma From Cellular Well-differentiated Liposarcoma.
Graham, Danielle S. MD, MBA *; Qorbani, Amir MD +,++; Eckardt, Mark A. MD *,[S],[//]; Klingbeil, Kyle D. MD *; Chen, Lucia Y. MS [P]; Chopra, Shefali MD #; Eilber, Fritz C. MD *,**; Dry, Sarah M. MD +,**
doi : 10.1097/PAS.0000000000002037
Subjective, varying criteria identify "low-grade" dedifferentiation in well-differentiated/dedifferentiated liposarcoma (WD/DDLPS). The value of mitotic rate (MR) in defining DDLPS is not confirmed.
Salivary Gland Secretory Carcinoma: Clinicopathologic and Genetic Characteristics of 215 Cases and Proposal for a Grading System.
Baneckova, Martina MD, PhD *,+; Thompson, Lester D.R. MD ++; Hyrcza, Martin D. MD, PhD [S]; Vanecek, Tomas PhD [//]; Agaimy, Abbas MD, PhD [P]; Laco, Jan MD, PhD #; Simpson, Roderick H.W. MD **; Di Palma, Silvana MD ++; Stevens, Todd M. MD ++++; Brcic, Luka MD, PhD [S][S]; Etebarian, Arghavan DDS, MSc [//][//]; Dimnik, Katarina MD [P][P]; Majewska, Hanna MD ##; Starek, Ivo MD, PhD ***; O'Regan, Esther MD, PhD +++; Salviato, Tiziana MD ++++++; Helliwell, Tim MD [S][S][S]; Horakova, Marketa MD, PhD *,+; Biernat, Wojciech MD, PhD [//][//][//]; Onyuma, Timothy MD [P][P][P]; Michal, Michal MD *,+; Leivo, Ilmo MD, PhD ###; Skalova, Alena MD, PhD *,+
Venous Invasion in Pancreatic Neuroendocrine Tumors Is Independently Associated With Disease-free Survival and Overall Survival.
Shi, Chanjuan MD, PhD *; Chen, Wei MD *; Davis, Richard MD *; Morse, Michael A. MD +
doi : 10.1097/PAS.0000000000002038
AB In this study, we evaluated venous invasion and its association with survival in patients with resected pancreatic neuroendocrine tumor (PanNET). Surgical Pathology Archives were searched for pancreatectomies performed for PanNET between October 1, 2005, and December 31, 2019.
A Simplified Version of the IASLC Grading System for Invasive Pulmonary Adenocarcinomas With Improved Prognosis Discrimination.
Bosse, Yohan PhD *,+; Gagne, Andreanne MD, PhD *; Althakfi, Wajd A. MD ++; Orain, Michele *; Couture, Christian MD, MSc *; Trahan, Sylvain MD *; Page, Sylvain MD *; Joubert, David PhD [S]; Fiset, Pierre O. MD, PhD [//]; Desmeules, Patrice MD, MSc *; Joubert, Philippe MD, PhD *
doi : 10.1097/PAS.0000000000002040
AB Tumor grading enables better management of patients and treatment options. The International Association for the Study of Lung Cancer (IASLC) Pathology Committee has recently released a 3-tier grading system for invasive pulmonary adenocarcinoma consisting of predominant histologic patterns plus a cutoff of 20% of high-grade components including solid, micropapillary, and complex glandular patterns.
Isolated Light Chain-restricted Germinal Centers are Common in Follicular Hyperplasia by Ultrasensitive In Situ Hybridization.
Obiorah, Ifeyinwa E. MD, PhD; Aguilera, Nadine S. MD; Gru, Alejandro MD; Courville, Elizabeth L. MD
doi : 10.1097/PAS.0000000000002035
AB Ultrasensitive bright-field RNA in situ hybridization (BRISH) can be used to detect lower levels of light chain expression than immunohistochemical stains or conventional colorimetric RNA in situ hybridization.
Clinicopathologic Significance of Anterior Prostate Cancer: Comparison With Posterior Prostate Cancer in the Era of Multiparametric Magnetic Resonance Imaging.
Samaratunga, Hemamali MBBS, FRCPA *,+; Egevad, Lars MD, PhD ++; Yaxley, John W. MBChB, FRACS +,[S]; Johannsen, Shulammite MSc *; Le Fevre, Ian K. MBBS, FRCPA *; Perry-Keene, Joanna L. MBBS, FRCPA *; Gianduzzo, Troy MBBS,FRACS +,[S]; Chabert, Charles MBBS, FRACS [S]; Coughlin, Gregory MBBS, FRACS [S]; Parkinson, Robert MBBS, FRACS [S]; Kua, Boon MBBS, FRACS [S]; Yaxley, William MBBS [//]; Delahunt, Brett MD, FRCPA *,[P]
doi : 10.1097/PAS.0000000000002042
AB Anterior prostate cancer (APC) has been considered an indolent tumor, most commonly arising in the transition zone (TZ). More recently, detection of APC has been facilitated through multiparametric magnetic resonance imaging and improved biopsy techniques, enabling earlier detection.
Ossifying Fibromyxoid Tumor of the Genitourinary Tract: Report of 4 Molecularly Confirmed Cases of a Diagnostic Pitfall.
Argani, Pedram MD *,+; Dickson, Brendan C. MD ++; Gross, John M. MD *,+; Matoso, Andres MD *,+,[S]; Baraban, Ezra MD *,+; Antonescu, Cristina R. MD [//]
doi : 10.1097/PAS.0000000000002036
AB Ossifying fibromyxoid tumors (OFMTs) are rare mesenchymal neoplasms which typically present in the superficial subcutaneous tissues and have not been reported to arise in visceral organs.
Uterine Endometrial Stromal Tumors With Pure Low-Grade Morphology Harboring YWHAE: NUTM2 Fusions: Report of a Case Series Emphasizing Potential for High-Grade Transformation and Aggressive Behavior.
Devins, Kyle M. MD *; Attygalle, Ayoma D. FRCPath, PhD +; Croce, Sabrina MD, PhD ++; Vroobel, Katherine MA, FRCPath +; Oliva, Esther MD *; McCluggage, W. Glenn FRCPath [S]
doi : 10.1097/PAS.0000000000002041
AB Uterine endometrial stromal sarcomas (ESS) with YWHAE::NUTM2 gene fusions are typically morphologically high-grade tumors composed of atypical round cells, sometimes associated with a low-grade fibromyxoid component; they are currently included in the category of high-grade ESS (HGESS).
Calcified Chondroid Mesenchymal Neoplasm: Exploring the Morphologic and Clinical Features of an Emergent Entity With a Series of 33 Cases.
Kallen, Michael E. MD *; Michal, Michael MD, PhD +; Meyer, Anders MD ++; Suster, David I. MD [S]; Olson, Nicholas J. MD [//],[P]; Charville, Gregory W. MD, PhD #; Perret, Raul MD, MSc **; Gross, John M. MD, MS ++
doi : 10.1097/PAS.0000000000002044
AB Calcified chondroid mesenchymal neoplasm is a term proposed for tumors with a spectrum of morphologic features, including cartilage/chondroid matrix formation, that frequently harbor FN1 gene fusions.
