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Diagnostic Criteria for Terrien Marginal Degeneration: Nordic Terrien Degeneration Study
Ruutila, Minna MD, FEBO*; Fagerholm, Per MD†; Lagali, Neil PhD†; Hjortdal, Jesper MD‡; Bram, Thue MD‡; Moilanen, Jukka MD, FEBO*; Kivel?, Tero T. MD, FEBO*
doi : 10.1097/ICO.0000000000002427
Cornea: February 2021 - Volume 40 - Issue 2 - p 133-141
To refine the diagnostic criteria for Terrien marginal degeneration (TMD) based on experience in 3 Nordic countries.
Interferon Alfa-2b for Pigmented Ocular Surface Squamous Neoplasia: A Report of 8 Lesions
Kaliki, Swathi MD; Sharma, Abhimanyu MD; Vempuluru, Vijitha S. MD
doi : 10.1097/ICO.0000000000002350
Cornea: February 2021 - Volume 40 - Issue 2 - p 142-146
To study the efficacy of interferon alfa-2b (IFN-a2b) on pigmented ocular surface squamous neoplasia (p-OSSN) and assess the resolution of the pigment to the treatment.
Corneal Crosslinking to Regress Pathologic Corneal Neovascularization Before High-Risk Keratoplasty
Schaub, Friederike MD*; Hou, Yanhong MD, PhD*,†,‡; Zhang, Wei MD*; Bock, Felix PhD*; Hos, Deniz MD, PhD*,§; Cursiefen, Claus MD, PhD*,§
doi : 10.1097/ICO.0000000000002406
Cornea: February 2021 - Volume 40 - Issue 2 - p 147-155
Corneal neovascularization is the main risk factor for graft rejection after high-risk penetrating keratoplasty (PK). Corneal crosslinking (CXL) has been shown to regress pathological corneal blood and lymphatic vessels and to reduce the risk of graft rejection after high-risk PK experimentally in mice. The aim of this work was to analyze whether CXL is also able to regress corneal neovascularization in patients and is a safe procedure in the context of high-risk PK.
Baseline Findings in the Retrospective Digital Computer Analysis of Keratoconus Evolution (REDCAKE) Project
Jiménez-Garc?a, Marta MSc*,†; N? Dhubhghaill, Sorcha MD, PhD*,†; Koppen, Carina MD, PhD*,†; Varssano, David MD‡,¶; Rozema, Jos J. PhD*,†; and The REDCAKE Study Group
doi : 10.1097/ICO.0000000000002389
Cornea: February 2021 - Volume 40 - Issue 2 - p 156-167
To present the baseline data for a large cohort of patients with keratoconus enrolled in the Retrospective Digital Computer Analysis of Keratoconus Evolution (REDCAKE) study.
Long-term Outcomes of Punctal Cauterization in the Management of Ocular Surface Diseases
Wang, Yvonne MD; Carreno-Galeano, Jimena Tatiana MD; Singh, Rohan Bir MD; Dana, Reza MD, MPH, MSc; Yin, Jia MD, PhD, MPH
doi : 10.1097/ICO.0000000000002384
Cornea: February 2021 - Volume 40 - Issue 2 - p 168-171
To evaluate the long-term outcomes of surgical occlusion of lacrimal puncta using thermal cautery in the management of ocular surface diseases.
The Descemet Membrane in Primary Congenital Glaucoma
Gupta, Shikha MD*; Chaurasia, Abadh K. MOptom*; Sen, Seema MD†; Bhardwaj, Mansi PhD†; Mandal, Sohini MD*; Titiyal, Jeewan S. MD‡; Gupta, Viney MD*
doi : 10.1097/ICO.0000000000002472
Cornea: February 2021 - Volume 40 - Issue 2 - p 172-178
To evaluate Descemet membrane (DM) morphology in eyes with primary congenital glaucoma (PCG) in vivo using high-definition anterior segment optical coherence tomography (ASOCT) and on histopathology.
A New Screening Questionnaire to Identify Patients With Dry Eye With a High Likelihood of Having Sj?gren Syndrome
Bunya, Vatinee Y. MD, MSCE*; Maguire, Maureen G. PhD*; Akpek, Esen K. MD†; Massaro-Giordano, Mina MD*; Hennessy, Sean PharmD, PhD‡; Vivino, Frederick B. MD, MS§; Gonzales, John A. MD¶; Baer, Alan N. MD?; Ying, Gui-Shuang PhD*
doi : 10.1097/ICO.0000000000002515
Cornea: February 2021 - Volume 40 - Issue 2 - p 179-187
To develop a screening questionnaire to identify patients with dry eye with a high likelihood of having underlying Sj?gren syndrome (SS).
Comparative Analysis of Safety and Efficacy of Topography-Guided Customized Cross-linking and Standard Cross-linking in the Treatment of Progressive Keratoconus
Sachdev, Gitansha Shreyas MS, FICO, MRCSEd; Ramamurthy, Shreyas MS, FICO; B, Soundariya MS, FICO; Dandapani, Ramamurthy MD, FNAMS
doi : 10.1097/ICO.0000000000002492
Cornea: February 2021 - Volume 40 - Issue 2 - p 188-193
To compare the safety and efficacy of topography-guided customized corneal cross-linking (PiXL) with standard cross-linking (CXL) for the treatment of progressive keratoconus.
Scheimpflug Densitometry in Keratoconus: A New Method of Visualizing the Cone
Jiménez-Garc?a, Marta MSc*,†; N? Dhubhghaill, Sorcha MD, PhD*,†; Consejo, Alejandra PhD‡; Hershko, Sarah MD*,†; Koppen, Carina MD, PhD*,†; Rozema, Jos J. PhD*,†
doi : 10.1097/ICO.0000000000002458
Cornea: February 2021 - Volume 40 - Issue 2 - p 194-202
To report an observation made while performing Scheimpflug densitometry analysis on the corneal region affected in keratoconus (KC) that seems to delineate the base of the cone.
Y-27632 Promotes the Repair Effect of Umbilical Cord Blood-Derived Endothelial Progenitor Cells on Corneal Endothelial Wound Healing
Zhang, Weijie MD, PhD; Shao, Chunyi MD, PhD; Yu, Fei MD, PhD; Chen, Junzhao MD, PhD; Fu, Yao MD, PhD; Fan, Xianqun MD, PhD
doi : 10.1097/ICO.0000000000002560
Cornea: February 2021 - Volume 40 - Issue 2 - p 203-214
To investigate the proliferation of umbilical cord blood–derived endothelial progenitor cells (UCB EPCs) and the differentiation efficiency toward corneal endothelial cell (CEC)-like cells induced by rho-associated protein kinase (ROCK) inhibitor Y-27632 and to determine the most effective strategy for repairing corneal endothelium injuries in rabbits.
Age-Related Corneal Transparency Changes Evaluated With an Alternative Method to Corneal Densitometry
Consejo, Alejandra MSc, PhD*; Jiménez-Garc?a, Marta MSc†,‡; Rozema, Jos J. MSc, PhD†,‡
doi : 10.1097/ICO.0000000000002511
Cornea: February 2021 - Volume 40 - Issue 2 - p 215-222
To compare densitometry distribution analysis (DDA), a platform-independent method to assess corneal transparency, with traditional corneal densitometry.
A Cluster of Corneal Donor Rim Cultures Positive for Achromobacter Species Associated With Contaminated Eye Solution
André, Camille BS*; Durand, Marlene L. MD*,†; Buckley, Thomas BS‡; Cadorette, James BS§; Gilmore, Michael S. PhD*,¶; Ciolino, Joseph B. MD*; Bispo, Paulo J. M. MS, PhD*
doi : 10.1097/ICO.0000000000002473
Cornea: February 2021 - Volume 40 - Issue 2 - p 223-227
To investigate a cluster of corneoscleral rim cultures positive for Achromobacter species over a 6-month period at Massachusetts Eye and Ear.
Pediatric Use of Recombinant Human Nerve Growth Factor 20 ?g/mL Eye Drops (Cenegermin) for Bilateral Neurotrophic Keratopathy in Congenital Corneal Anesthesia
Leto, Marco G. MD, PhD*; Toro, Maria E. MD*; Indemini, Patricia E. MD*; Fruttero, Claudia PharmD†; Denina, Marco MD‡; Dalmazzo, Cristina MD§; Sannia, Andrea MD§; Vaiano, Agostino S. MD, PhD*
doi : 10.1097/ICO.0000000000002612
Cornea: February 2021 - Volume 40 - Issue 2 - p 228-231
This study aimed to present the efficacy and safety of cenegermin eye drop (Oxervate; Dompè Farmaceutici, Milan, Italy) treatment in a pediatric patient affected by neurotrophic keratopathy (NK) with Goldenhar syndrome.
Cluster of Post-Operative Endophthalmitis Caused by Acanthamoeba T10 Genotype – A First Report
Rammohan, Ram PhD*; Hajib Naraharirao, Madhavan MD, PhD, FAMS, FIC Path†; Veerappan, Saravanan DO, DNB*; Vijayaraghavan, Prabhu DO, MS*; Rajaraman, Revathi DO, MS*; Manayath, George J. FRCS*; Dsouza, Palmeera DO, DNB*; Radhakrishnan, Shanthi MD (Path)‡; Venkatapathy, Narendran DO, DNB*; Lakshmipathi, Dhanurekha PhD†; Madhuravasal Krishnan, Janani PhD†; Raghavan, Anita DO, FRCS (Glasgow)*
doi : 10.1097/ICO.0000000000002603
Cornea: February 2021 - Volume 40 - Issue 2 - p 232-241
To report a cluster of postoperative Acanthamoeba endophthalmitis after routine cataract surgeries.
Dual Molecular Diagnosis of Microsporidia (Encephalitozoon hellem) Keratoconjunctivitis in an Immunocompetent Adult
Ma, Kevin K. MD*; Kinde, Benyam MD, PhD†; Doan, Thuy MD, PhD†,‡; Jacobs, Deborah S. MD*; Ong Tone, Stephan MDCM, PhD, FRCSC*
doi : 10.1097/ICO.0000000000002466
Cornea: February 2021 - Volume 40 - Issue 2 - p 242-244
To report a case of microsporidia (Encephalitozoon hellem) keratoconjunctivitis acquired through avian transmission in an immunocompetent adult, diagnosed by metagenomic deep sequencing (MDS), and confirmed by polymerase chain reaction.
Bilateral Corneal Perforation in a Patient Under Anti-PD1 Therapy
Ramaekers, Anaïs MD*; Aspeslagh, Sandrine MD, PhD†; De Brucker, Nele MD‡; Van Mierlo, Camille MD§; ten Tusscher, Marcel MD, PhD*; Schauwvlieghe, Pieter-Paul MD¶; Termote, Karolien MD*,§
doi : 10.1097/ICO.0000000000002490
Cornea: February 2021 - Volume 40 - Issue 2 - p 245-247
Immune checkpoint inhibition has improved the clinical outcomes for numerous patients with cancer. However, the downside is a whole new spectrum of immune-related adverse events. We report a 68-year-old man with a history of nonsmall cell lung cancer presenting with a spontaneous corneal perforation in the right eye after 22 cycles of pembrolizumab. In addition, a chronic central nonhealing epithelial defect developed after performing a penetrating keratoplasty. Treatment with autologous serum drops resulted in complete healing of the corneal ulcer, where other conventional therapies had no effect. One month after reinitiating pembrolizumab therapy, our patient presented again with a corneal perforation in the fellow eye. This case describes relapsing sterile ulcerations associated with pembrolizumab use and presents an unexpected cure.
Presumed Herpes Zoster Ophthalmicus Reactivation Following Recombinant Zoster Vaccination
Jabbour, Samir MD, CM, FRCSC; Shekhawat, Nakul S. MD, MPH; Chen, Ariel MD; Woreta, Fasika A. MD, MPH
doi : 10.1097/ICO.0000000000002537
Cornea: February 2021 - Volume 40 - Issue 2 - p 248-250
To report a case of herpes zoster ophthalmicus (HZO) reactivation after recombinant zoster vaccination.
Eye Rubbing and Transient Corneal Ectasia Detected by Topography in a Pediatric Patient
Scotto, Riccardo PhD; Vagge, Aldo MD, PhD; Traverso, Carlo E. MD
doi : 10.1097/ICO.0000000000002497
Cornea: February 2021 - Volume 40 - Issue 2 - p 251-253
We report on a 13-year-old girl undergoing changes in the refraction of her OS associated with eye rubbing. Corneal topography showed a corneal deformation in OS, classified as stage 1 keratoconus according to the Krumeich classification. A significant reduction in eye rubbing led to a normal corneal shape at the 1-year follow-up. Transient and fully reversible corneal ectasia can be caused by eye rubbing in pediatric age. This may have implications when counseling very young patients with eye rubbing.
Graft Edge Reflection of a Tightly Scrolled Roll Using Endoillumination as a Simple Method for Determining Graft Orientation in Descemet Membrane Endothelial Keratoplasty
Kobayashi, Akira MD, PhD; Yokogawa, Hideaki MD, PhD; Mori, Natsuko MD, PhD; Nishino, Tsubasa MD, PhD; Sugiyama, Kazuhisa MD, PhD
doi : 10.1097/ICO.0000000000002459
Cornea: February 2021 - Volume 40 - Issue 2 - p 254-257
To describe a simple finding that can be used to determine donor tissue orientation in Descemet membrane endothelial keratoplasty (DMEK). This involves the appearance of a highly reflective round curved line from an overlapping graft edge within the anterior chamber using light from an endoilluminator. We here name this Kobayashi sign (K-sign).
Systematic Review: Effects of Pterygium and Pingueculum on the Ocular Surface and Efficacy of Surgical Excision
Linaburg, Taylor BSc*; Choi, Daniel MD†; Bunya, Vatinee Y. MD, MSCE†; Massaro-Giordano, Mina MD†; Brice?o, César A. MD†
doi : 10.1097/ICO.0000000000002575
Cornea: February 2021 - Volume 40 - Issue 2 - p 258-267
This systematic review examines the specific effects of pingueculum and pterygium on the ocular surface and evaluates the efficacy of surgical excision in reversing those effects.
