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Farewell editorial
Denis Fouque
doi : 10.1093/ndt/gfad045
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1341–1344
SGLT2 inhibitors: new kids on the block to control hyperkalemia
Pierre Gabai, Denis Fouque
doi : 10.1093/ndt/gfad026
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1345–1348
Magnesium: extracellular, intracellular or total magnesium status?
Silverio Rotondi, Sandro Mazzaferro
doi : 10.1093/ndt/gfad059
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1349–1351
Will osteopontin bridge the gap towards clinical application in chronic kidney disease?
Martin H de Borst, Juan-Jesus Carrero
doi : 10.1093/ndt/gfad057
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1352–1354
Steroidal or non-steroidal MRAs: should we still enable RAASi use through K binders?
L Parker Gregg, Sankar D Navaneethan
doi : 10.1093/ndt/gfac284
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1355–1365
Renin–angiotensin–aldosterone system inhibitors (RAASi) and mineralocorticoid receptor antagonists (MRAs) are important interventions to improve outcomes in patients with chronic kidney disease and heart failure, but their use is limited in some patients by the development of hyperkalemia.
AA amyloidosis associated with cancers
Joyita Bharati, Oscar B Lahoud, Kenar D Jhaveri, Hassan Izzedine
doi : 10.1093/ndt/gfac217
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1366–1374
Systemic AA amyloidosis is associated with systemic inflammatory processes such as autoimmune disorders or chronic infections. In addition, AA amyloidosis can develop in a localized or systemic form in patients with malignant neoplastic disorders, and usually involves kidneys impacting renal function.
Clinical application of microRNAs in glomerular diseases
Haresh Selvaskandan, Izabella Pawluczyk, Jonathan Barratt
doi : 10.1093/ndt/gfac230
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1375–1384
RNA interference (RNAi) occurs in all organisms and modulates most, if not all, biological pathways. It is the process by which non-coding RNAs, including microRNAs (miRNAs), regulate gene transcription and post-transcriptional processing of messenger RNA (mRNA)
Targeted nanotherapy for kidney diseases: a comprehensive review
Gianmarco Sabiu, Vivek Kasinath, Sungwook Jung, Xiaofei Li, George C Tsokos, Reza Abdi
doi : 10.1093/ndt/gfac233
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1385–1396
Kidney diseases represent a major public health problem, affecting millions of people worldwide. Moreover, the treatment of kidney diseases is burdened by the problematic effects of conventional drug delivery, such as systemic drug toxicity, rapid drug clearance, and the absence of precise targeting of the kidney.
Treatment of secondary hyperparathyroidism in non-dialysis CKD: an appraisal 2022s
Markus Ketteler, Jordi Bover, Sandro Mazzaferro
doi : 10.1093/ndt/gfac236
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1397–1404
The situation of secondary hyperparathyroidism (SHPT) in chronic kidney disease patients not on dialysis (ND-CKD) is probably best characterised by the Kidney Disease: Improving Global Outcomes Chronic Kidney Disease–Mineral and Bone Disorder Update 2017 guideline 4.2.1 stating that the optimal parathyroid hormone levels are not known in these stages.
Let's get physical: considering and overcoming the barriers to physical activity in CKD
Kate I Stevens, Matt Graham-Brown, Jennifer S Lees
doi : 10.1093/ndt/gfad002
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1405–1407
Fasting influences aquaporin expression, water transport and adipocyte metabolism in the peritoneal membrane
Ines P D Costa, Nicolas Hautem, Gugliemo Schiano, Shinichi Uchida, Tomoya Nishino, Olivier Devuyst
doi : 10.1093/ndt/gfac318
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1408–1420
The water channels aquaporin-1 (AQP1) and AQP7 are abundantly expressed in the peritoneal membrane. While AQP1 facilitates water transport during peritoneal dialysis (PD), the role of AQP7, which mediates glycerol transport during fasting, remains unknown.
The kidney reabsorption-related magnesium depletion score is associated with increased likelihood of abdominal aortic calcification among US adults
Jian Lu, Han Li, Shixiang Wang
doi : 10.1093/ndt/gfac218
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1421–1429
Kidney reabsorption plays a vital role in magnesium homeostasis. This study aimed to determine the relationship between the kidney reabsorption-related magnesium depletion score (MDS) and abdominal aortic calcification (AAC).
Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study
Inga Steinbrenner, Peggy Sekula, Fruzsina Kotsis, Maja von Cube, Yurong Cheng, Jennifer Nadal, Matthias Schmid, Markus P Schneider, Vera Krane, Matthias Nauck, Kai-Uwe Eckardt, Ulla T Schultheiss, the GCKD investigators
doi : 10.1093/ndt/gfac173
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1430–1438
Osteopontin (OPN), synthesized in the thick ascending limb of Henle's loop and in the distal tubule, is involved in the pathogenesis of kidney fibrosis, a hallmark of kidney failure (KF). In a cohort of chronic kidney disease (CKD) patients, we evaluated OPN's association with kidney markers and KF.
Coronary artery calcium and risk of chronic kidney disease in young and middle-aged adults
Yejin Kim, Jeonggyu Kang, Yoosoo Chang, Young Youl Hyun, Kyu-Beck Lee, Hocheol Shin, Sarah H Wild, Christopher D Byrne, Seungho Ryu
doi : 10.1093/ndt/gfac272
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1439–1447
The role of the coronary artery calcium score (CACS) in incident chronic kidney disease (CKD) in asymptomatic young populations remains unclear. The aim of this study was to evaluate the association between CACSs and CKD development in adults.
Design and population of the VALOR-CKD study: a multicenter, randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of veverimer in slowing progression of chronic kidney disease in patients with metabolic acidosis
Vandana S Mathur, David A Bushinsky, Lesley Inker, Gerrit Klaerner, Elizabeth Li, Dawn Parsell, Vlado Perkovic, Yuri Stasiv, Michael Walker, Donald E Wesson, David C Wheeler, Navdeep Tangri
doi : 10.1093/ndt/gfac289
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1448–1458
Whether treating metabolic acidosis slows progression of chronic kidney disease (CKD) has not been established. Veverimer is a novel hydrochloric acid binder that removes acid from the gastrointestinal tract leading to an increase in serum bicarbonate; it is being developed to treat metabolic acidosis with the goal of slowing progression of CKD.
Trimethoprim-sulfamethoxazole and the risk of a hospital encounter with hyperkalemia: a matched population-based cohort study
Y Joseph Hwang, Flory T Muanda, Eric McArthur, Matthew A Weir, Jessica M Sontrop, Ngan N Lam, Amit X Garg
doi : 10.1093/ndt/gfac282
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1459–1468
Trimethoprim-sulfamethoxazole (TMP-SMX) can cause hyperkalemia by reducing renal potassium excretion. We assessed the risk of hyperkalemia after initiating TMP-SMX versus amoxicillin and determined if this risk is modified by a patient's baseline kidney function [estimated glomerular filtration rate (eGFR)].
Total cortical interstitial inflammation predicts chronic kidney disease progression in patients with lupus nephritis
Minh Dien Duong, Shudan Wang, Daniel Schwartz, Wenzhu B Mowrey, Anna Broder, Beatrice Goilav
doi : 10.1093/ndt/gfac286
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1469–1476
End-stage kidney disease (ESKD) from lupus nephritis (LN) is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Kidney biopsy is the gold standard for diagnosis and prognostication of LN.
Metabolic acidosis is undertreated and underdiagnosed: a retrospective cohort study
Reid H Whitlock, Thomas W Ferguson, Paul Komenda, Claudio Rigatto, David Collister, Clara Bohm, Nancy L Reaven, Susan E Funk, Navdeep Tangri
doi : 10.1093/ndt/gfac299
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1477–1486
Guidelines recommend treatment of metabolic acidosis (MA) in patients with chronic kidney disease (CKD), but the diagnosis and treatment rates in real-world settings are unknown. We investigated the frequency of MA treatment and diagnosis in patients with CKD.
Association of chronic kidney disease with total and site-specific cancer incidence in participants of the Japan Public Health Center-based Prospective Study
Yoshihisa Miyamoto, Ryoko Katagiri, Taiki Yamaji, Manami Inoue, Atsushi Goto, Motoki Iwasaki, Mitsuhiko Noda, Shoichiro Tsugane, Norie Sawada
doi : 10.1093/ndt/gfac288
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1487–1496
Although studies have found an association between chronic kidney disease (CKD) and cancer incidence, the results are inconsistent.
Clinical and genetic characteristics of Dent's disease type 1 in Europe
Carla Burballa, Gerard Cantero-Recasens, Larisa Prikhodina, Francesca Lugani, Karlpeter Schlingmann, Petr V Ananin, Martine Besouw, Detlef Bockenhauer, Leire Madariaga, Aurelia Bertholet-Thomas, Francesca Taroni, Mattia Parolin, Peter Conlon, Francesco Emma, Dorella Del Prete, Dominique Chauveau, Linda Koster-Kamphuis, Marc Fila, Andrea Pasini, Isabel Castro, Giacomo Colussi, Marta Gil, Barian Mohidin, Tanja Wlodkowski, Franz Schaefer, Gema Ariceta, for the DENT study group
doi : 10.1093/ndt/gfac310
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1497–1507
Dent's disease type 1 (DD1) is a rare X-linked nephropathy caused by CLCN5 mutations, characterized by proximal tubule dysfunction, including low molecular weight proteinuria (LMWP), hypercalciuria, nephrolithiasis–nephrocalcinosis, progressive chronic kidney disease (CKD) and kidney failure (KF). Current management is symptomatic and does not prevent disease progression. Here we describe the contemporary DD1 picture across Europe to highlight its unmet needs.
Effect of residual kidney function and dialysis adequacy on chronic pruritus in dialysis patients
Robin Lengton, Esmee M van der Willik, Esther N M de Rooij, Yvette Meuleman, Saskia Le Cessie, Wieneke M Michels, Marc Hemmelder, Friedo W Dekker, Ellen K Hoogeveen, for the Netherlands Cooperative Study on the Adequacy of Dialysis-2 (NECOSAD) Study Group
doi : 10.1093/ndt/gfac341
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1508–1518
Serum testosterone concentrations and outcomes in hemodialysis patients enrolled in the EVOLVE trial
Erik Nilsson, Peter Stenvinkel, Sai Liu, Margaret R Stedman, Glenn M Chertow, Jürgen Floege
doi : 10.1093/ndt/gfac278
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1519–1527
Hypogonadism is common in end-stage kidney disease and may contribute to morbidity and mortality.
Trends in kidney transplantation rate across Europe: study from the ERA Registry
Rianne Boenink, Anneke Kramer, Rosalie E Tuinhout, Emilie Savoye, Anders Åsberg, Alma Idrizi, Julia Kerschbaum, Ieva Ziedina, Edita Ziginskiene, Emanuel Farrugia, Liliana Garneata, Elena V Zakharova, Samira Bell, Miha Arnol, Mårten Segelmark, Kyriakos Ioannou, Kristine Hommel, Mai Rosenberg-Ots, Evgueniy Vazelov, Jaakko Helve, Sándor Mihály, Runólfur Pálsson, Maurizio Nordio, Nikola Gjorgjievski, Aiko P J de Vries, Nurhan Seyahi, Winnie A Magadi, Halima Resić, Aleh Kalachyk, Axel O Rahmel, Ana A Galvão, Radomir Naumovic, Torbjörn Lundgren, Mustafa Arici, Johan M de Meester, Alberto Ortiz, Kitty J Jager, Vianda S Stel
doi : 10.1093/ndt/gfac333
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1528–1539
The aim of this study was to identify trends in total, deceased donor (DD) and living donor (LD) kidney transplantation (KT) rates in European countries.
Factors influencing kidney transplantation rates: a study from the ERA Registry
Rianne Boenink, Anneke Kramer, Raymond C Vanholder, Beatriz Mahillo, Ziad A Massy, Mirela Bušić, Alberto Ortiz, Vianda S Stel, Kitty J Jager, Survey Collaborators
doi : 10.1093/ndt/gfad001
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1540–1551
Large international differences exist in kidney transplantation (KT) rates. We aimed to investigate which factors may explain the total, deceased donor and living donor KT rates over the last decade.
Post-transplant diabetes mellitus and renal cell cancer after renal transplantation
Esteban Porrini, Nuria Montero, Juan Manuel DÃaz, Ricardo Lauzurrica, Juana Oramas RodrÃguez, Irene Silva Torres, Francesc Moreso, Josep M Cruzado, RocÃo BenÃtez Ruiz, Meritxel Ibernon Vilaró, Maria Xixiang Molina Lima, Simran Khemlani Ramchand, Juan Carlos Ruiz, Francisco Gainza de los Rios, Carla RodrÃguez Alvarez, MarÃa del Carmen de Gracia Guindo, Manuel MacÃas, David Bonet Vela, Antonio Osuna, Beatriz Bayés-GenÃs, Cristina Aleman Sanchez, MarÃa del Carmen Ruiz, Ana Elena RodrÃguez RodrÃguez, Rosa DomÃnguez Rollán, Federico González Rinne, Alejandro Jiménez Sosa, Patricia Delgado Mallén, Ana González Rinne, Domingo Marrero Miranda, Armando Torres
doi : 10.1093/ndt/gfac291
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1552–1559
Diabetes is a risk factor for cancer in the general population. However, few data are available on the association between post-transplant diabetes mellitus (PTDM) and cancer after transplantation.
Use of kidney injury molecule-1 for sepsis-associated acute kidney injury staging
Luca Molinari, Douglas P Landsittel, John A Kellum, for the ProCESS and ProGReSS-AKI Investigators*
doi : 10.1093/ndt/gfad004
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1560–1563
Serological response to Nuvaxovid (NVX-CoV2373) vaccine given as a fifth dose in non- and low-responder kidney transplant recipients
Alexandra Nowak, Peter Hemmingsson, Marie Evans, Julia Wijkström
doi : 10.1093/ndt/gfad010
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1564–1566
Suppression of thyroid profile during roxadustat treatment in chronic kidney disease patients
Yuan Cheng, Qiong Xiang, Tao Cao, Fei Tang, Jia Chen, Dongli Qi, Haofei Hu, Haiying Song, Zheyi Chang, Ming Ku, Xinglin Chen, Chi Chen, Qijun Wan
doi : 10.1093/ndt/gfad017
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1567–1570
Management of severe hypercalcaemia: results of the French-speaking physicians’ practice survey
Cyril Mousseaux, Romain Arrestier, Khalil Chaibi, Antoine Braconnier, Aldjia Hocine, Antoine Lanot, Justine Serre, Mickaël Bobot
doi : 10.1093/ndt/gfad018
Nephrology Dialysis Transplantation, Volume 38, Issue 6, June 2023, Pages 1571–1573
