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Population-Based Risk Factors for Ascending, Arch, Descending, and Abdominal Aortic Dilations for 60-74–Year-Old Individuals
Lasse M.ObelMDabcAxel C.DiederichsenMD, PhDadFlemming H.SteffensenMD, PhDeLarsFrostMD, PhD, DMScfJessLambrechtsenMD, PhDgMartinBuskMD, PhDeGrazinaUrbonavicieneMD, PhDfKennethEgstrupMD, DMScgMarekKaronMDhLars M.RasmussenDMSciaiOkeGerkeMSc, PhDcjAnders S.BovlingMDabcJes S.LindholtMD, PhD, DMScab
doi : 10.1016/j.jacc.2021.04.094
Volume 78, Issue 3, 20 July 2021, Pages 201-211
Aortic dilations (ectasias and aneurysms) may occur on any segment of the aorta. Pathogenesis varies between locations, suggesting that etiology and risk factors may differ. Despite this discrepancy, guidelines recommend screening of the whole aorta if 1 segmental dilation is discovered.
The Normal Aorta: Characterization Based on 15,000 CT Scans?
John A.ElefteriadesMD, PhD (Hon)aJoshuaBeckmanMD, MSb
doi : 10.1016/j.jacc.2021.05.018
Volume 78, Issue 3, 20 July 2021, Pages 212-215
Predicting In-Hospital Mortality in Patients Undergoing Percutaneous Coronary Intervention
Yulanka S.Castro-DominguezMDabYongfeiWangMSabKarl E.MingesPhD, MPHabRobert L.McNamaraMD, MHSaJohn A.SpertusMD, MPHcGregory J.DehmerMDdJohn C.MessengerMDeKimberlyLavinMSN, RN, MPHfCorneliaAndersonMSN, RN, CPHQfKristinaBlankinshipMSN, FNPfNestorMercadoMD, PhDgJulie M.ClaryMD, MBAhAnwar D.OsborneMD, MPMiJeptha P.CurtisMDabMatthew A.CavenderMD, MPHj
doi : 10.1016/j.jacc.2021.04.067
Volume 78, Issue 3, 20 July 2021, Pages 216-229
Standardization of risk is critical in benchmarking and quality improvement efforts for percutaneous coronary interventions (PCIs). In 2018, the CathPCI Registry was updated to include additional variables to better classify higher-risk patients.
Refinements in Predicting In-Hospital Mortality Following PCI: The Science and Art of Competing Risk Analysis?
Sorin J.BrenerMD
doi : 10.1016/j.jacc.2021.05.016
Volume 78, Issue 3, 20 July 2021, Pages 230-233
Enhanced Assessment of Perioperative Mortality Risk in Adults With Congenital Heart Disease
AndrewConstantineMBBS, MAab?GiuliaCostolaMDa?PaoloBianchiMDcdMassimoChessaMD, PhDeAlessandroGiambertiMDeAleksanderKempnyMD, PhDabIsmaRafiqMBBSabSonya V.Babu-NarayanMBBS, BSc, PhDabMichael A.GatzoulisMD, PhDabAndreasHoschtitzkyMDabDarrylShoreMDabTuan-ChenAwMDcMarcoRanucciMDfKonstantinosDimopoulosMD, PhD, MScab
doi : 10.1016/j.jacc.2021.04.096
Volume 78, Issue 3, 20 July 2021, Pages 234-242
In-hospital mortality is a rare, yet feared complication following cardiac surgery in adult congenital heart disease (ACHD). A risk score, developed and validated in ACHD, can be helpful to optimize risk assessment.
The PEACH Score Points to Benefits of Early Intervention in Adults With Congenital Heart Disease?
Yvesd’UdekemMD, PhD
doi : 10.1016/j.jacc.2021.05.020
Volume 78, Issue 3, 20 July 2021, Pages 243-244
Associations of Cardiac Mechanics With Exercise Capacity: The Multi-Ethnic Study of Atherosclerosis
Ravi B.PatelMD, MScaBenjamin H.FreedMDaLaurenBeussink-NelsonMSaNorrina B.AllenPhDbSuma H.KonetyMD, MScWendy S.PostMD, MSdJosephYeboahMD, MSeDalane W.KitzmanMDeAlain G.BertoniMD, MPHfSanjiv J.ShahMDa
doi : 10.1016/j.jacc.2021.04.082
Volume 78, Issue 3, 20 July 2021, Pages 245-257
Lower exercise capacity, as measured by 6-minute walk distance (6MWD), is associated with incident heart failure (HF). Among those without HF, the associations of measures of cardiac function with 6MWD are unclear, and may provide insight regarding the risk of incident HF.
Atrial Strain: A Piece of the HFpEF Puzzle Found, But Not Yet in Place?
Brage H?yemAmundsenMD, PhD
doi : 10.1016/j.jacc.2021.05.017
Volume 78, Issue 3, 20 July 2021, Pages 258-259
The Coronary Artery Risk Development In Young Adults (CARDIA) Study: JACC Focus Seminar 8/8
Donald M.Lloyd-JonesMD ScMaCora E.LewisMD, MSPHbPamela J.SchreinerPhDcJames M.ShikanyDrPHdStephenSidneyMD MPHeJared P.ReisPhDf
doi : 10.1016/j.jacc.2021.05.022
Volume 78, Issue 3, 20 July 2021, Pages 260-277
The CARDIA (Coronary Artery Risk Development in Young Adults) study began in 1985 to 1986 with enrollment of 5,115 Black or White men and women ages 18 to 30 years from 4 US communities. Over 35 years, CARDIA has contributed fundamentally to our understanding of the contemporary epidemiology and life course of cardiovascular health and disease, as well as pulmonary, renal, neurological, and other manifestations of aging. CARDIA has established associations between the neighborhood environment and the evolution of lifestyle behaviors with biological risk factors, subclinical disease, and early clinical events. CARDIA has also identified the nature and major determinants of Black-White differences in the development of cardiovascular risk. CARDIA will continue to be a unique resource for understanding determinants, mechanisms, and outcomes of cardiovascular health and disease across the life course, leveraging ongoing pan-omics work from genomics to metabolomics that will define mechanistic pathways involved in cardiometabolic aging.
Pathophysiology of the Lymphatic System in Patients With Heart Failure: JACC State-of-the-Art Review
MaximItkinMDaStanley G.RocksonMDbDanielBurkhoffMD, PhDc
doi : 10.1016/j.jacc.2021.05.021
Volume 78, Issue 3, 20 July 2021, Pages 278-290
The removal of interstitial fluid from the tissues is performed exclusively by the lymphatic system. Tissue edema in congestive heart failure occurs only when the lymphatic system fails or is overrun by fluid leaving the vascular space across the wall of the capillaries into the interstitial space. This process is driven by Starling forces determined by hydrostatic and osmotic pressures and organ-specific capillary permeabilities to proteins of different sizes. In this review, we summarize current knowledge of the generation of lymph in different organs, the mechanics by which lymph is returned to the circulation, and the consequences of the inadequacy of lymph flow. We review recent advances in imaging techniques that have allowed for new research, diagnostic, and therapeutic approaches to the lymphatic system. Finally, we review how efforts to increase lymph flow have demonstrated potential as a viable therapeutic approach for refractory heart failure.
Early Feasibility Studies in Evolution
David R.HolmesJr.MDRickGeoffrionMBAAaron V.KaplanMDAndrew A.FarbMDRobert “Chip”HanceBS, MBAMartin B.LeonMDMichael J.MackMDJaimeWalkowiakJDPamelaGoldbergMBAJonHuntPhD
doi : 10.1016/j.jacc.2021.05.014
Volume 78, Issue 3, 20 July 2021, Pages 291-292
Orodispersible Ticagrelor in Acute Coronary Syndromes: The TASTER Study
GuidoParodiMD, PhDGiuseppeTalanasMDEnricoMuraMDMario E.CanonicoMDRobertaSicilianoMDSimonaGuarinoMDAlessandroMariniMDFilippoDossiMDPaoloFrancaMDMarioRaccisMDPier SergioSabaMD, PhDGiuseppe D.SannaMD, PhD
doi : 10.1016/j.jacc.2021.05.015
Volume 78, Issue 3, 20 July 2021, Pages 292-294
Phosphodiesterase-5 Inhibitors in Men With Stable Coronary Artery Disease
ZhiliWenPhDYuliangFengPhDLeiJiangPhD
doi : 10.1016/j.jacc.2021.04.093
Volume 78, Issue 3, 20 July 2021, Pages 294-295
Macrotroponin Probably Contributes to a Difference in Patient Stratification in Suspected Acute Coronary Syndromes
Janet V.WarnerMBBS, PhDLeoLamMBChB
doi : 10.1016/j.jacc.2021.05.013
Volume 78, Issue 3, 20 July 2021, Pages 295-296
