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Highlights from this issue
Keith Barton, James Chodosh, Jost B Jonas
doi : 10.1136/bjophthalmol-2020-318536
11 December, 2020
When gold standards change: time to move on from Goldmann tonometry?
Gus Gazzard, Hari Jayaram, Ana M Roldan, David S Friedman
doi : 10.1136/bjophthalmol-2020-317112
24 September, 2020
Iris and its relevance to angle closure disease: a review
Zhi Da Soh, Sahil Thakur, Shivani Majithia, Monisha Esther Nongpiur, Ching-Yu Cheng
doi : 10.1136/bjophthalmol-2020-316075
19 March, 2020
Glaucoma is a leading cause of irreversible visual impairment, and primary angle closure glaucoma (PACG) affects Asians disproportionately. Whereas advances in ocular imaging have identified several anatomical risk factors, our ability to predict PACG still requires considerable improvement.
Shaped corneal transplantation surgery
Pranita Sahay, Louis Julian Stevenson, Tushar Agarwal, Bhavana Sharma, Namrata Sharma, Rasik B Vajpayee
doi : 10.1136/bjophthalmol-2019-315754
25 March, 2020
Since its inception in 1905, keratoplasty techniques have continuously evolved. Shaped keratoplasty procedures have allowed corneal surgeons to use complex graft–host junctions and non-circular graft designs to optimise wound strength and healing, facilitate early suture removal and expedite visual rehabilitation
Indications and prognosis for keratoplasty in eyes with severe visual impairment and blindness due to corneal disease in India
Anthony Vipin Das, Sayan Basu
doi : 10.1136/bjophthalmol-2019-315361
18 March, 2020
Purpose To describe the indications and prognosis for keratoplasty in eyes with severe visual impairment and blindness due to corneal diseases in India.
Multicentre study: reliability and repeatability of Scheimpflug system measurement in keratoconus
Beatriz de Luis Eguileor, Pedro Arriola-Villalobos, Jose Ignacio Pijoan Zubizarreta, Raquel Feijoo Lera, Alaitz Santamaria Carro, David Diaz-Valle, Jaime Etxebarria
doi : 10.1136/bjophthalmol-2019-314954
26 March, 2020
Purpose To assess the repeatability and reliability of the most important tomographic parameters for characterising keratoconus measured with a Pentacam HR (high resolution).
Four-year outcomes of small incision lenticule extraction (SMILE) to correct high myopic astigmatism
Yuanyuan Zhong, Meng Li, Tian Han, Dan Fu, Xingtao Zhou
doi : 10.1136/bjophthalmol-2019-315619
22 March, 2020
Aims To evaluate the long-term outcomes of small incision lenticule extraction (SMILE) in subjects with myopic astigmatism of ?2.00 dioptres (D).
Prevalence and risk factors for visual impairment among elderly residents in ‘homes for the aged’ in India: the Hyderabad Ocular Morbidity in Elderly Study (HOMES)
Srinivas Marmamula, Navya Rekha Barrenakala, Rajesh Challa, Thirupathi Reddy Kumbham, Satya Brahmanandam Modepalli, Ratnakar Yellapragada, Madhuri Bhakki, Rohit C Khanna, David S Friedman
doi : 10.1136/bjophthalmol-2019-315678
25 March, 2020
Background/Aim To investigate the prevalence, causes and risk factors of visual impairment (VI) among the elderly in ‘home for the aged’ in Hyderabad, India.
Reduced stereoacuity as a predictor for clinically significant convergence insufficiency
Ari Leshno, Chaim Stolovitch, Ofira Zloto, Sharon Blum Meirovitch, Daphna Mezad-Koursh
doi : 10.1136/bjophthalmol-2019-315208
18 March, 2020
Background Stereoacuity relies on accurate binocular alignment. Convergence insufficiency (CI) a binocular motor disorder, interferes with near work.
Naevus of Ota: clinical characteristics and proposal for a new ocular classification and grading system
Vicktoria Vishnevskia-Dai, Iris Moroz, Tal Davidy, Keren Zloto, Yael Birger, Ido Didi Fabian, Guy Ben Simon, Ayelet Priel, Ofira Zloto
doi : 10.1136/bjophthalmol-2019-313984
30 March, 2020
Introduction Naevus of Ota is a congenital condition that may involve the skin, eyeball and even intracranial structures usually in the distribution of the ophthalmic and maxillary divisions of the trigeminal cranial nerve. The purpose of this study was to summarise our experience with the ocular clinical presentation, imaging, outcome, treatment of complications and to offer a new classification of patients with naevus of Ota.
Prognostic significance of immune checkpoints in the tumour–stromal microenvironment of sebaceous gland carcinoma
Lata Singh, Mithalesh Kumar Singh, Moshahid Alam Rizvi, Neelam Pushker, Sameer Bakhshi, Seema Sen, Seema Kashyap
doi : 10.1136/bjophthalmol-2019-315490
10 April, 2020
Background Immune checkpoint blockade strategies have gained attention in the treatment/prognosis of cancers by targeting the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway alone or in combination with cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) blockade and are currently in clinical trials. The present study investigated the expression of the PD-1, PD-L1, CTLA-4, CD4 and CD8 proteins and their prognostic value in the tumour microenvironment of sebaceous gland carcinoma (SGC).
Effect of plaque brachytherapy dose and dose rate on risk for disease-related mortality in 1238 patients with choroidal melanoma
Maria Fil?, Eric Trocme, Christina Herrspiegel, Stefan Seregard, Gustav St?lhammar
doi : 10.1136/bjophthalmol-2019-315722
19 May, 2020
Background Episcleral brachytherapy is the most common treatment for medium-sized choroidal melanomas. Although controversial, inadequate brachytherapy dose and dose rates have at least a hypothetical implication on patient survival.
Retinoblastoma in Finland, 1964–2014: incidence and survival
Kalle Nummi, Tero T Kivel?
doi : 10.1136/bjophthalmol-2019-315744
25 March, 2020
Aims To determine the incidence of retinoblastoma (Rb) and subsequent survival in the Finnish population during five decades.
Clinical and laboratory characteristics of ocular syphilis and neurosyphilis among individuals with and without HIV infection
Dony Mathew, Derrick Smit
doi : 10.1136/bjophthalmol-2019-315699
27 March, 2020
Background/aims In the era of increasing incidence of syphilis globally, ocular syphilis is re-emerging as an important cause of uveitis. The aim of this study was to determine the clinical and laboratory characteristics of ocular- and neurosyphilis among individuals with and without HIV infection.
Prevalence and clinical features of systemic diseases in Chinese patients with uveitis
Peizeng Yang, Zhenyu Zhong, Liping Du, Fuzhen Li, Zhijun Chen, Ying Zhu, Wanyun Zhang, Fanfan Huang, Xingsheng Ye, Guannan Su, Aize Kijlstra
doi : 10.1136/bjophthalmol-2020-315960
18 March, 2020
Purpose Systemic diseases are frequently associated with uveitis but are often not recognised by clinicians. An estimate of the prevalence in a large-scale uveitis population is essential for understanding the epidemiological profile and may be helpful for clinical practice.
Clinical and genetical features of probands and affected family members with familial exudative vitreoretinopathy in a large Chinese cohort
Shiyuan Wang, Xiang Zhang, Yiqian Hu, Ping Fei, Yu Xu, Jie Peng, Peiquan Zhao
doi : 10.1136/bjophthalmol-2019-315598
1 April, 2020
Aims To explore the clinical and genetical features of families with strictly confirmed familial exudative vitreoretinopathy (FEVR) in a large Chinese cohort.
Prevalence and genetic–phenotypic characteristics of patients with USH2A mutations in a large cohort of Chinese patients with inherited retinal disease
Feng-Juan Gao, Dan-Dan Wang, Fang Chen, Hao-Xiang Sun, Fang-Yuan Hu, Ping Xu, Jiankang Li, Wei Liu, Yu-He Qi, Wei Li, Ming Wang, Shenghai Zhang, Ge-Zhi Xu, Qing Chang, Ji-Hong Wu
doi : 10.1136/bjophthalmol-2020-315878
18 March, 2020
Aims To investigate the frequency of USH2A mutation and the clinical and genetic differences between Usher syndrome type II (USH2) and retinitis pigmentosa (RP) in a large cohort of Chinese patients.
Intraoperative iatrogenic retinal breaks in 23-gauge vitrectomy for stage 3 and stage 4 idiopathic macular holes
Yanping Yu, Biying Qi, Xida Liang, Zengyi Wang, Jing Wang, Wu Liu
doi : 10.1136/bjophthalmol-2019-315579
26 March, 2020
Aims To investigate characteristics of intraoperative iatrogenic retinal breaks in 23-gauge vitrectomy for idiopathic macular hole and classify the breaks based on their causes to analyse the risk factors.
Choriocapillaris flow impairment could predict the enlargement of geographic atrophy lesion
Riccardo Sacconi, Eleonora Corbelli, Enrico Borrelli, Luigi Capone, Adriano Carnevali, Francesco Gelormini, Lea Querques, Francesco Bandello, Giuseppe Querques
doi : 10.1136/bjophthalmol-2019-315800
22 March, 2020
Aim To analyse the choriocapillaris (CC) flow status in the area that subsequently showed geographic atrophy (GA) expansion secondary to age-related macular degeneration (AMD) during 1-year follow-up, matching optical coherence tomography angiography (OCT-A) and fundus autofluorescence (FAF).
Risk factors for subretinal fibrosis after anti-VEGF treatment of myopic choroidal neovascularisation
Hu Xiao, Xiujuan Zhao, Songshan Li, Limei Sun, Wen Xin, Zhirong Wang, Aiyuan Zhang, Junyan Zhang, Xiaoyan Ding
doi : 10.1136/bjophthalmol-2019-315763
11 March, 2020
Purpose To assess the incidence, clinical features and predictive risk factors of subretinal fibrosis after treatment of active myopic choroidal neovascularisation (mCNV) with anti-vascular endothelial growth factor (VEGF).
Retinal cavitations in macular telangiectasia type 2 (MacTel): longitudinal structure–function correlations
Cindy X Cai, John Choong, Sina Farsiu, Stephanie J Chiu, Emily Y Chew, Glenn J Jaffe
doi : 10.1136/bjophthalmol-2019-315416
9 March, 2020
Background/aims To quantify retinal cavitation size over time in macular telangiectasia type 2 (MacTel) and to correlate changes with visual acuity and area of ellipsoid zone loss.
RAP study, report 1: novel subtype of macular neovascularisation type III, cilioretinal MNV3
Bilal Haj Najeeb, Gabor G Deak, Ursula Margarethe Schmidt-Erfurth, Bianca S Gerendas
doi : 10.1136/bjophthalmol-2019-315311
11 March, 2020
Purpose To report on patients with macular neovascularisation type III (MNV3) arising from cilioretinal arteries (CRAs) (cilioretinal macular neovascularisation type III (cMNV3)).
Widefield optical coherence tomography angiography for early detection and objective evaluation of proliferative diabetic retinopathy
Hagar Khalid, Roy Schwartz, Luke Nicholson, Josef Huemer, Mohamed Hosny El-Bradey, Dawn A Sim, Praveen J Patel, Konstantinos Balaskas, Robin D Hamilton, Pearse A Keane, Ranjan Rajendram
doi : 10.1136/bjophthalmol-2019-315365
19 March, 2020
Purpose To evaluate the utility of widefield optical coherence tomography angiography (WF-OCTA) compared with clinical examination in grading diabetic retinopathy in patients diagnosed clinically with proliferative diabetic retinopathy (PDR) or severe non-proliferative diabetic retinopathy (NPDR).
Retinal blood flow reduction in normal-tension glaucoma with single-hemifield damage by Doppler optical coherence tomography
Takafumi Yoshioka, Youngseok Song, Motofumi Kawai, Tomofumi Tani, Kengo Takahashi, Satoshi Ishiko, Fabio Lavinsky, Gadi Wollstein, Hiroshi Ishikawa, Joel S Schuman, Akitoshi Yoshida
doi : 10.1136/bjophthalmol-2019-315616
26 March, 2020
Aims To evaluate the associations between retinal blood flow (RBF) and optical coherence tomography (OCT) structural measurements in normal-tension glaucoma (NTG) eyes with single-hemifield visual field (VF) damage by the Doppler OCT.
Evaluation of meridional scans for angle closure assessment with anterior segment swept-source optical coherence tomography
Natalia Porporato, Mani Baskaran, Shamira Perera, Tin A Tun, Rehena Sultana, Marcus Tan, Joanne HuiMin Quah, John C Allen, David Friedman, Ching Yu Cheng, Tin Aung
doi : 10.1136/bjophthalmol-2019-315461
9 March, 2020
Background/aims As swept-source optical coherence tomography (SS-OCT) simultaneously obtains 128 meridional scans, it is important to identify which scans are playing the main role in classifying gonioscopic angle closure to simplify the analysis. We aimed to evaluate the diagnostic performance of every meridional scan in its ability to detect gonioscopic angle closure.
Binocular superior visual field areas associated with driving self-regulation in patients with primary open-angle glaucoma
Tomoyo Yamasaki, Kenya Yuki, Sachiko Awano-Tanabe, Takeshi Ono, Hiroshi Murata, Kazuo Tsubota, Ryo Asaoka
doi : 10.1136/bjophthalmol-2019-315187
25 March, 2020
Background/aims The aim of our study was to investigate the associations between driving self-regulation and glaucoma severity, and between driving self-regulation and glaucomatous visual field (VF) defect patterns.
Tear neuromediators in eyes on chronic topical antiglaucoma therapy with and without BAK preservatives
Vanathi Murugesan, Roopa Dwivedi, Manu Saini, Viney Gupta, Tanuj Dada, S Vivekanandhan
doi : 10.1136/bjophthalmol-2019-314234
5 August, 2019
Purpose To evaluate tear neuropeptides (NPs) (vasoactive intestinal peptide (VIP), neuropeptide Y (NPY), calcitonin gene-related peptide (CGRP), substance P (SP), nerve growth factor (NGF)) in chronic ocular topical hypotensive therapy with and without benzalkonium chloride (BAK) preservative.
