Bipolar Disorders




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Issue Information

doi : 10.1111/bdi.13216

Volume 25, Issue 3

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A Bipolar Learning Health Network: An innovation whose time has come

Andrew A. Nierenberg, Peter Margolis, Stephen Strakowski, Madhukar Trivedi, Lakshmi N. Yatham, Bipolar Disorder Learning Health Network

doi : 10.1111/bdi.13339

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Brain development after intrauterine exposure to lithium: A magnetic resonance imaging study in school-age children

Eline M. P. Poels, Astrid M. Kamperman, Hilmar H. Bijma, Adriaan Honig, Inge L. van Kamp, Steven A. Kushner, Witte J. G. Hoogendijk, Veerle Bergink, Tonya White

doi : 10.1111/bdi.13297

Lithium is often continued during pregnancy to reduce the risk of perinatal mood episodes for women with bipolar disorder. However, little is known about the effect of intrauterine lithium exposure on brain development. The aim of this study was to investigate brain structure in children after intrauterine exposure to lithium.

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Does circadian dysrhythmia drive the switch into high- or low-activation states in bipolar I disorder?

Ian B. Hickie, Kathleen R. Merikangas, Joanne S. Carpenter, Frank Iorfino, Elizabeth M. Scott, Jan Scott, Jacob J. Crouse

doi : 10.1111/bdi.13304

Emerging evidence suggests a role of circadian dysrhythmia in the switch between “activation� states (i.e., objective motor activity and subjective energy) in bipolar I disorder.

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Detailed assessment of suicidal ideation in youth with bipolar disorder versus major depressive disorder

Rebekah S. Huber, Danielle Boxer, Calen J. Smith, Perry F. Renshaw, Deborah A. Yurgelun-Todd, Douglas G. Kondo

doi : 10.1111/bdi.13294

There is a critical need to better understand the factors underlying the increased suicide risk for youth with bipolar disorder (BD) in order to develop targeted prevention efforts. This study aimed to examine differences in characteristics of suicide ideation (SI) in youth with BD compared to youth with major depressive disorder (MDD) that may be associated with increased suicide risk.

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Significant age by childhood trauma interactions on grey matter volumes: A whole brain VBM analysis

Gin S. Malhi, Pritha Das, Tim Outhred, Erica Bell, Danielle Gessler, Richard Bryant, Zola Mannie

doi : 10.1111/bdi.13286

Childhood trauma is deleterious to long term brain development. The changes are variable, and depend on gender, age and the nature of the trauma. In this exploratory analysis, we investigated the effects of exposure to emotional trauma on grey matter (GM) volumes in adolescent females.

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Proof-of-concept randomized controlled trial of single-session nitrous oxide treatment for refractory bipolar depression: Focus on cerebrovascular target engagement

William S. H. Kim, Mikaela K. Dimick, Danielle Omrin, Rachel H. B. Mitchell, Daniel Riegert, Anthony Levitt, Ayal Schaffer, Susan Belo, John Iazzetta, Garfield Detzler, Mabel Choi, Stephen Choi, Nathan Herrmann, Roger S. McIntyre, Bradley J. MacIntosh, Beverley A. Orser, Benjamin I. Goldstein

doi : 10.1111/bdi.13288

There remain few efficacious treatments for bipolar depression, which dominates the course of bipolar disorder (BD).

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Treating bipolar depression with esketamine: Safety and effectiveness data from a naturalistic multicentric study on esketamine in bipolar versus unipolar treatment-resistant depression

Giovanni Martinotti, Bernardo Dell'Osso, Giorgio Di Lorenzo, Giuseppe Maina, Alessandro Bertolino, Massimo Clerici, Stefano Barlati, Gianluca Rosso, Marco Di Nicola, Matteo Marcatili, Giacomo d'Andrea, Clara Cavallotto, Stefania Chiappini, Sergio De Filippis, Giuseppe Nicolò, Pasquale De Fazio, Ileana Andriola, Raffaella Zanardi, Domenica Nucifora, Stefania Di Mauro, Roberta Bassetti, Mauro Pettorruso, Roger S. McIntyre, Stefano L. Sensi, Massimo di Giannantonio, Antonio Vita, the REAL-ESK Study Group

doi : 10.1111/bdi.13296

Bipolar depression accounts for most of the disease duration in type I and type II bipolar disorder (BD), with few treatment options, often poorly tolerated. Many individuals do not respond to first-line therapeutic options, resulting in treatment-resistant bipolar depression (B-TRD). Esketamine, the S-enantiomer of ketamine, has recently been approved for treatment-resistant depression (TRD), but no data are available on its use in B-TRD.

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Neuroimaging as an approach to advancing research on suicide risk among youth with bipolar disorder

Mikaela K. Dimick

doi : 10.1111/bdi.13279

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Ketamine for Treatment-Resistant bipolar depression�A reality check!

Balwinder Singh

doi : 10.1111/bdi.13324

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Valproate prescription among reproductive age women with bipolar disorders�Are regulatory methods the only solution?

Simran Arora, Preethi V. Reddy, Geetha Desai, Muralidharan Kesavan, Prabha S. Chandra

doi : 10.1111/bdi.13314

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Alice in Wonderland syndrome and bipolar depression

Hanna Tu, Eva Pilato, Pascal Sienaert

doi : 10.1111/bdi.13292

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Postpartum-onset obsessive–compulsive disorder: A harbinger of bipolar disorder

Verinder Sharma, Malak Al-Farayedhi

doi : 10.1111/bdi.13303

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