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Evaluation of the angiogenic factors sFlt-1, PlGF, and the sFlt-1/PlGF ratio in preeclampsia and associated features
Marwa Ben Ali Gannoun, Meriem Mehdi, Hedia Zitouni, Manel Boussabah, Ines Zouari, Ali Jlali, Wassim Y. Almawi
doi : 10.1111/aji.13715
Soluble Fms-like tyrosine kinase-1 (sFLT-1) and placental growth factor (PlGF) were previously reported to play a key role in the pathogenesis of preeclampsia (PE). We tested the link between altered PlGF and sFLT-1 levels, and their ratio (sFlt-1/PlGF) with PE and PE-associated featured in Tunisian PE cases and age- and BMI-matched normotensive women.
Th2 shift in pregnancy and labor: An immunological perspective to elucidate the pathogenesis onset of atopy
Yasuhiro Horiuchi
doi : 10.1111/aji.13716
γδ-T cell with high toxic potential was associated with recurrent miscarriage
Huan Xiao, Rong Lin, Cong Chen, Ruochun Lian, Yulian Wu, Lianghui Diao, Tailang Yin, Chunyu Huang
doi : 0.1111/aji.13717
RM is a common clinical disease in reproduction, affecting approximately 1%–3% of women worldwide. Previous studies have shown the role of peripheral blood γδ-T cells during physiological pregnancy. However, the relationship between the immune status of peripheral blood γδ-T cells and RM is still not well defined.
Reduced expression of Il10, Stat3, Hoxa10, and Itgb3 in the embryo implantation site of rat model with prenatal androgen-induced polycystic ovary syndrome
Mostafa Changaei, Moslem Javidan, Fahimeh Ramezani Tehrani, Nariman Mosaffa, Mahsa Noroozzadeh, Ramin Hosseinzadeh, Samira Rajaei
doi : 10.1111/aji.13702
Impaired implantation due to the reduced endometrial receptivity considers an etiology for infertility in polycystic ovary syndrome (PCOS). In this context, we aimed to compare the expression of interleukin 10 (Il10), homeobox A10 (Hoxa10), signal transducer and activator of transcription 3 (Stat3), and β3-integrin (Itgb3) in the embryo implantation site of a prenatally-androgenized rat model of PCOS before and during gestation.
Follicular helper T lymphocytes in the endometria of patients with reproductive failure: Association with pregnancy outcomes and inflammatory status of the endometria
Ye Tian, Qunxiong Zeng, Yanfei Cheng, Xiao-Hui Wang, Dandan Cao, William Shu-Biu Yeung, Qingzhi Liu, Yong-Gang Duan, Yuan-Qing Yao
doi : 10.1111/aji.13708
The phenotypes and functions of B and CD4+ T-helper cell subsets during chronic inflammation of the endometria remain largely unexplored. This study aimed to investigate the characteristics and functions of follicular helper T (Tfh) cells to understand the pathological mechanisms of chronic endometritis (CE).
Predictive value of D-dimer in patients with unexplained recurrent implantation failure during freeze-thaw embryo transfer cycles
Xin Li, Cheng Zeng, Peili Wu, Jing Shang, Qing Xue
doi : 10.1111/aji.13710
This study aimed to evaluate whether D-dimer can predict the clinical outcomes of patients with unexplained recurrent implantation failure (URIF) during freeze-thaw embryo transfer (FET) cycles.
Hyperoside alleviates postmenopausal osteoporosis via regulating miR-19a-5p/IL-17A axis
Hongqiang An, Chu Chu, Zhen Zhang, Yunhong Zhang, Ran Wei, Bin Wang, Ke Xu, Lihua Li, Yonglin Liu, Gang Li, Xia Li
doi : 10.1111/aji.13709
Postmenopausal osteoporosis (PMO) is a common osteoporosis. Hyperoside (Hyp), a natural flavonoid compound, has anti-osteoporotic effects, but the underlying mechanisms remain poorly understood. Inflammatory cytokine IL-17A is upregulated in PMO and plays vital roles in bone loss, but the upstream regulatory factors and mechanisms are still unknown.
Myeloid-derived suppressor cells: Are they involved in gestational diabetes mellitus?
Siyu Hua, Shanshan Wang, Jinyang Cai, Lamei Wu, Yan Cao
doi : 10.1111/aji.13711
Gestational diabetes mellitus (GDM) is currently the most common metabolic complication during pregnancy, with an increasing prevalence worldwide. Maternal immune dysregulation might be partly responsible for the pathophysiology of GDM.
Mechanism of trophoblast cell-derived microparticles mediated immunocontraceptive response
Shao-Yang Lai, Kai-Lun Hu, Xuan Zhou, Xiao-Xue Li, Xiao-Jun Yu, Jing Shi, Jie Zhao
doi : 10.1111/aji.13712
Immunomodulation profoundly affects the process of human implantation. Trophoblast cell-derived microparticles (Tr-MPs) may activate specific T cells to attack trophoblast cells, thus potentially acting as an immunocontraceptive vaccine. The safety and persistence of Tr-MP vaccine are needed to address.
The transcriptional foundations of interferon-λ-mediated endometrial cell to uterine receptivity
Kezhen Yao, Li Fang, Yu Sun
doi : 10.1111/aji.13718
Interferon-λ (IFN-λ) is a novel non-redundant regulator that participates in the fetal–maternal immune interaction, including immune regulation, uterine receptivity, cell migration and adhesion, and endometrium apoptosis. However, the exact transcriptional foundation for endometrial signaling of IFN-λ is not completely understood, and studies regarding IFN-λ to implantation failure in vivo are limited.
Relation of resistin gene variants to resistin plasma levels and altered susceptibility to polycystic ovary syndrome: A case control study
Aminah M. Al-Awadi, Fabiola Lisa Saldhana, Zhansaya Bauyrzhanova, Rita Nemr, Naeema A. Mahmood, Wassim Y. Almawi
doi : 10.1111/aji.13731
A role for resistin in the pathogenesis of polycystic ovarian syndrome (PCOS) and related features were described for various ethnicities. As its expression is partly inherited, a role for RETN polymorphisms in regulating resistin levels and PCOS risk was shown, but with varied results.
