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Prevalence of Left Atrial Thrombus in Anticoagulated Patients With Atrial Fibrillation
Antony Lurie, Jia Wang, Kyra J. Hinnegan, William F. McIntyre, Jorge A. Wong
doi : 10.1016/j.jacc.2021.04.036
Volume 77, Issue 23, 15 June 2021, Pages 2875-2886
The prevalence of left atrial (LA) thrombus in patients with atrial fibrillation (AF) or atrial flutter (AFL) on guideline-directed anticoagulation is not well known, yet this may inform transesophageal echocardiogram (TEE) use before cardioversion or catheter ablation.
Thrombus or No Thrombus: Is That the Embolic Question??
Paulus Kirchhof, Christoph Sinning
doi : 10.1016/j.jacc.2021.04.034
Volume 77, Issue 23, 15 June 2021, Pages 2887-2889
Improved Risk Stratification for Ventricular Arrhythmias and Sudden Death in Patients With Nonischemic Dilated Cardiomyopathy
Andrea Di Marco, Pamela Frances Brown, Joshua Bradley, Gaetano Nucifora, Matthias Schmitt
doi : 10.1016/j.jacc.2021.04.030
Volume 77, Issue 23, 15 June 2021, Pages 2890-2905
Risk stratification for ventricular arrhythmias (VA) and sudden death in nonischemic dilated cardiomyopathy (DCM) remains suboptimal.
Refining the Approach to Risk Stratification in Patients With Dilated Cardiomyopathy?
Anne B. Curtis, Hassan A. Khan
doi : 10.1016/j.jacc.2021.04.031
Volume 77, Issue 23, 15 June 2021, Pages 2906-2908
Changes in Plasma Renin Activity After Renal Artery Sympathetic Denervation
Felix Mahfoud, Raymond R. Townsend, David E. Kandzari, Kazuomi Kario, Michael A. Weber
doi : 10.1016/j.jacc.2021.04.044
Volume 77, Issue 23, 15 June 2021, Pages 2909-2919
The renin-angiotensin-aldosterone system plays a key role in blood pressure (BP) regulation and is the target of several antihypertensive medications. Renal denervation (RDN) is thought to interrupt the sympathetic-mediated neurohormonal pathway as part of its mechanism of action to reduce BP.
Renal Denervation in Hypertension: Barking Up the Wrong Tree??
Franz H. Messerli, Chirag Bavishi, Sripal Bangalore
doi : 10.1016/j.jacc.2021.04.048
Volume 77, Issue 23, 15 June 2021, Pages 2920-2922
AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction
Rabea Hinkel, Sandor Batkai, Andrea B?hr, Tarik Bozoglu, Christian Kupatt
doi : 10.1016/j.jacc.2021.04.028
Volume 77, Issue 23, 15 June 2021, Pages 2923-2935
Pathological cardiac hypertrophy is a result of afterload-increasing pathologies including untreated hypertension and aortic stenosis. It features progressive adverse cardiac remodeling, myocardial dysfunction, capillary rarefaction, and interstitial fibrosis often leading to heart failure.
MicroRNA-132 Inhibition Prevents Myocardial Hypertrophy and Heart Failure in Pigs: Making Sense Out of Antisense?
Gianluigi Condorelli, Giuseppe Ferrante
doi : 10.1016/j.jacc.2021.04.039
Volume 77, Issue 23, 15 June 2021, Pages 2936-2938
The ARIC (Atherosclerosis Risk In Communities) Study: JACC Focus Seminar 3/8
Jacqueline D. Wright, Aaron R. Folsom, Josef Coresh, A. Richey Sharrett, Gerardo Heiss
doi : 10.1016/j.jacc.2021.04.035
Volume 77, Issue 23, 15 June 2021, Pages 2939-2959
ARIC (Atherosclerosis Risk In Communities) initiated community-based surveillance in 1987 for myocardial infarction and coronary heart disease (CHD) incidence and mortality and created a prospective cohort of 15,792 Black and White adults ages 45 to 64 years. The primary aims were to improve understanding of the decline in CHD mortality and identify determinants of subclinical atherosclerosis and CHD in Black and White middle-age adults. ARIC has examined areas including health disparities, genomics, heart failure, and prevention, producing more than 2,300 publications. Results have had strong clinical impact and demonstrate the importance of population-based research in the spectrum of biomedical research to improve health.
Ending Gender Inequality in Cardiovascular Clinical Trial Leadership: JACC Review Topic of the Week
Harriette G.C. Van Spall, Anuradha Lala, Thomas F. Deering, Barbara Casadei, Biykem Bozkurt
doi : 10.1016/j.jacc.2021.04.038
Volume 77, Issue 23, 15 June 2021, Pages 2960-2972
Women are under-represented as leaders of cardiovascular randomized controlled trials, representing 1 in 10 lead authors of cardiovascular trials published in high-impact journals. Although the proportion of cardiovascular specialists who are women has increased in recent years, the proportion of cardiovascular clinical trialists who are women has not. This gap, underpinned by systemic sexism, has not been adequately addressed.
Controlling Hypertension: Our Cardiology Practices Can Do a Better Job
William J. Oetgen, Janet S. Wright
doi : 10.1016/j.jacc.2021.04.037
Volume 77, Issue 23, 15 June 2021, Pages 2973-2977
Implications of Biomarker Discordance After Coronary Artery Revascularization: The EXCEL Trial
Bj?rn Redfors, John Gregson, Ori Ben-Yehuda, Patrick W. Serruys, ... Gregg W. Stone
doi : 10.1016/j.jacc.2021.04.033
Volume 77, Issue 23, 15 June 2021, Pages 2978-2980
Prognostic Value of Coronary Artery Calcium in Symptomatic Young Individuals Age 18 to 45 Years
Martin B?dtker Mortensen, Omar Dzaye, Flemming Hald Steffensen, Hans Erik B?tker, Bjarne Linde N?rgaard
doi : 10.1016/j.jacc.2021.04.032
Volume 77, Issue 23, 15 June 2021, Pages 2980-2982
Transcatheter Mitral Valve Repair: When Is the Last Moment Before Crossing the Styx River?
Micha? Kuzemczak, Janusz Lipiecki, Tomasz Siminiak
doi : 10.1016/j.jacc.2021.03.336
Volume 77, Issue 23, 15 June 2021, Page 2982
Reply: Transcatheter Mitral Valve Repair: When Is the Last Moment Before Crossing the Styx River?
Michael J. Mack, Gregg W. Stone
doi : 10.1016/j.jacc.2021.04.021
Volume 77, Issue 23, 15 June 2021, Pages 2982-2983
Neonates With Symptomatic TOF: The Shorter Path Need Not Always Be the Desirable Path
Balaji Arvind, Shyam S. Kothari
doi : 10.1016/j.jacc.2021.03.337
Volume 77, Issue 23, 15 June 2021, Pages 2983-2984
Reply: Neonates With Symptomatic TOF: The Shorter Path Need Not Always Be the Desirable Path
Bryan H. Goldstein, Christopher J. Petit, Athar M. Qureshi, Courtney E. McCracken, Andrew C. Glatz
doi : 10.1016/j.jacc.2021.04.024
Volume 77, Issue 23, 15 June 2021, Pages 2984-2985
