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COP27 Climate Change Conference: urgent action needed for Africa and the world: Wealthy nations must step up support for Africa and vulnerable countries in addressing past, present and future impacts of climate changeâ€
Lukoye Atwoli, Gregory E Erhabor, Aiah A Gbakima, Abraham Haileamlak, Jean-Marie Kayembe Ntumba, James Kigera, Laurie Laybourn-Langton, Bob Mash, Joy Muhia, Fhumulani Mavis Mulaudzi, David Ofori-Adjei, Friday Okonofua, Arash Rashidian, Maha El-Adawy, Siaka Sidibé, Abdelmadjid Snouber, James Tumwine, Mohammad Sahar Yassien, Paul Yonga, Lilia Zakhama, Chris Zielinski
doi : 10.1093/humrep/deac223
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2725–2727
Live birth numbers undulate as crises come and go
Christian De Geyter
doi : 10.1093/humrep/deac232
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2728–2729
We have reached a dead end for preimplantation genetic testing for aneuploidy
Norbert Gleicher, David H Barad, Pasquale Patrizio, Raoul Orvieto
doi : 10.1093/humrep/deac052
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2730–2734,
The hypothesis of preimplantation genetic testing for aneuploidy (PGT-A) was first proposed 20 years ago, suggesting that during IVF elimination of aneuploid embryos prior to transfer will improve implantation rates of remaining embryos and, therefore, increase pregnancy and live birth rates, while also reducing miscarriages. Subsequently, unvalidated and increasingly unrestricted clinical utilization of PGT-A called for at least one properly randomized controlled trial (RCT) to assess cumulative live birth rates following a single oocyte retrieval, utilizing all fresh and frozen embryos of an IVF cycle.
Limits imposed by the experimental design of a large prospective non-inferiority study on PGT-A invalidate many of the conclusions
Richard T Scott, Jr, Dominique de Ziegler, Paul Pirtea, Chaim Jalas
doi : 10.1093/humrep/deac224
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2735–2742
The New England Journal of Medicine recently published a large study addressing the efficacy of preimplantation genetic testing for aneuploidy (PGT-A).
Cell-free fetal DNA testing performance and fetal fraction estimation are not affected in ART-conceived pregnancies
Nuria Balaguer, Emilia Mateu-Brull, MarÃa Gómez-López, Carlos Simón, Miguel Milán
doi : 10.1093/humrep/deac217
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2743–2756
Pregnancies achieved via ART are increasing, and cffDNA testing is displacing traditional prenatal screening methods due to its high sensitivity and specificity and noninvasive nature. However, conflicting data exist on cffDNA testing performance and FF in ART pregnancies compared with natural pregnancies.
Incubator type affects human blastocyst formation and embryo metabolism: a randomized controlled trial
Alexandra J Kermack, Irina Fesenko, David R Christensen, Kate L Parry, Philippa Lowen, Susan J Wellstead, Scott F Harris, Philip C Calder, Nicholas S Macklon, Franchesca D Houghton
doi : 10.1093/humrep/deac233
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2757–2767
Culture environment is known to be important for the developing preimplantation embryo. TLSs provide a stable milieu allowing embryos to be monitored in situ, whereas embryos cultured in standard benchtop incubators experience environmental fluctuations when removed for morphological assessment.
The cost-effectiveness of transvaginal hydrolaparoscopy versus hysterosalpingography in the work-up for subfertility
M A van Kessel, C T Pham, R Tros, G J E Oosterhuis, W K H Kuchenbecker, M Y Bongers, B W J Mol, C A M Koks
doi : 10.1093/humrep/deac219
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2768–2776
Tubal pathology is a common cause of subfertility and tubal patency testing is one of the cornerstones of the fertility work-up. Both THL and HSG are safe procedures and can be used as a first-line tubal patency test.
Comparison of blastocyst euploidy rates following luteal versus follicular phase stimulation in a GnRH antagonist protocol: a prospective study with repeated ovarian stimulation cycles
Francisca Martinez, Elisabet Clua, Marta Roca, Sandra Garcia, Nikolaos P Polyzos
doi : 10.1093/humrep/deac222
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2777–2786
Starting ovarian stimulation at any time of the cycle (‘random-start’) is commonly used for emergency fertility preservation in cancer patients. A few retrospective studies have been published evaluating LS in women undergoing ovarian stimulation in the context of IVF, but there is a lack of robust data on the comparative efficacy of LS versus FS.
Determinants of transplantation success with cryopreserved ovarian tissue: data from 196 women of the FertiPROTEKT network
L Lotz, J Bender-Liebenthron, R Dittrich, L Häberle, M W Beckmann, A Germeyer, M Korell, N Sänger, J S Kruessel, M von Wolff, FertiPROTEKT (Transplantation group)
doi : 10.1093/humrep/deac225
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2787–2796
Live birth rates after ovarian tissue transplantations have been reported to be between around 24% and 41% per patient. Success rates seem to be negatively associated with increasing female age at the time of tissue cryopreservation and with pelvic radiation. Success rates are apparently not reduced after overnight transportation of ovarian tissue before freezing.
Is there an optimal window of time for transferring single frozen-thawed euploid blastocysts? A cohort study of 1170 embryo transfers
Belinda Gia Linh An, Michael Chapman, Liza Tilia, Christos Venetis
doi : 10.1093/humrep/deac227
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2797–2807
There is compelling evidence for maintaining embryo-endometrial synchrony to optimize clinical outcomes following FETs, which could potentially be achieved by matching the transfer time of an embryo post-ovulation to its developmental age post-oocyte retrieval. For modified-natural cycles, ovulation is widely accepted to occur ∼40 h following the hCG trigger, whilst ovulation following spontaneous LH surge onset is thought to vary from 24 to 56 h.
Expectant management versus IUI in unexplained subfertility and a poor pregnancy prognosis (EXIUI study): a randomized controlled trial
J A Wessel, M H Mochtar, D E Besselink, H Betjes, J P de Bruin, A E P Cantineau, E R Groenewoud, A B Hooker, C B Lambalk, J Kwee, E M Kaaijk, L A Louwé, J W M Maas, B W J Mol, M M E van Rumste, M A F Traas, M Goddijn, M van Wely, F Mol
doi : 10.1093/humrep/deac236
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2808–2816
Couples with unexplained subfertility and a poor prognosis are often treated with IUI-OS. In couples with unexplained subfertility and a relatively good prognosis for natural conception (>30% in 12 months), IUI-OS does not increase the live birth rate as compared to 6 months of EM. However, in couples with a poor prognosis for natural conception (<30% in 12 months), the effectiveness of IUI-OS is uncertain.
Health-related quality of life in women with primary ovarian insufficiency: a scoping review of the literature and implications for targeted interventions
Isabella R McDonald, Corrine K Welt, Andrew A Dwyer
doi : 10.1093/humrep/deac200
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2817–2830
Prior studies have reported increased depressive symptoms, diminished sexual function and altered body image/self-concept in women with POI.
Mental health and behavioural problems in adolescents conceived after ART
L A Wijs, D A Doherty, J A Keelan, P Burton, J L Yovich, M Robinson, R J Hart
doi : 10.1093/humrep/deac214
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2831–2844
Health outcomes of ART-conceived offspring may differ from those conceived without ART, and previous studies have reported differences in behaviour and mental health, particularly in childhood.
Effects of trying to conceive using an every-other-day strategy versus fertile window monitoring on stress: a 12-month randomized controlled trial
Mariana V Martins, Joana Fernandes, Juliana Pedro, Alberto Barros, Pedro Xavier, Lone Schmidt, Maria E Costa
doi : 10.1093/humrep/deac228
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2845–2855
Recent findings indicate that time to pregnancy can be significantly shortened by targeting the fertile period, but some reproductive care guidelines recommend instead the practice of intercourse every other day on the basis that it is less stressful to the couple. Evidence to support guidelines on how to preserve well-being and psychosocial adjustment and optimize pregnancy chances is lacking.
Construction of a competing endogenous RNA network to identify drug targets against polycystic ovary syndrome
Tong Wu, Yue-Yue Gao, Xia-Nan Tang, Yan Li, Jun Dai, Su Zhou, Meng Wu, Jin-Jin Zhang, Shi-Xuan Wang
doi : 10.1093/humrep/deac218
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2856–2866
Thus far, no effective drugs are available for treating PCOS. ceRNAs play crucial roles in multiple diseases, and some of them are in current use as prognostic biomarkers as well as for chemo-response and drug prediction.
Obese outbred mice only partially benefit from diet normalization or calorie restriction as preconception care interventions to improve metabolic health and oocyte quality
A Smits, W F A Marei, K Moorkens, P E J Bols, D De Neubourg, J L M R Leroy
doi : 10.1093/humrep/deac226
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2867–2884
Maternal obesity is linked with reduced metabolic health and oocyte quality; therefore, infertile obese women are advised to lose weight before conception to increase pregnancy chances.
Basigin is necessary for normal decidualization of human uterine stromal cells
Shuhong Yang, Jiajia Bi, Jenny Drnevich, Kailiang Li, Romana A Nowak
doi : 10.1093/humrep/deac229
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2885–2898
Studies have shown that in the human endometrium, BSG expression is menstrual-cycle dependent and its expression was significantly lower in uterine endometrium during the luteal phase of women experiencing multiple implantation failures after IVF than in women with normal fertility.
Health of singletons born after frozen embryo transfer until early adulthood: a Finnish register study
A M Terho, A Tiitinen, H Martikainen, M Gissler, S Pelkonen
doi : 10.1093/humrep/deac211
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2899–2907
The differences in perinatal outcomes of children born after FET and fresh ET are well known. FET is associated with an increased risk of large-for-gestational-age but diminished risks of preterm birth (PTB), small-for-gestational-age and decreased perinatal mortality compared to fresh ET. However, knowledge on the long-term health after FET is scarce.
The metabolic health of young men conceived using intracytoplasmic sperm injection
S R Catford, J Halliday, S Lewis, M K O’Bryan, D J Handelsman, R J Hart, J McBain, L Rombauts, D J Amor, R Saffery, R I McLachlan
doi : 10.1093/humrep/deac212
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2908–2920
Some studies suggest that IVF-conceived offspring may have poorer cardiovascular and metabolic profiles than SC children. Few studies have examined the metabolic health of ICSI-conceived offspring.
Impact of the first wave of the COVID-19 pandemic on birth rates in Europe: a time series analysis in 24 countries
Léo Pomar, Guillaume Favre, Claire de Labrusse, Agathe Contier, Michel Boulvain, David Baud
doi : 10.1093/humrep/deac215
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2921–2931
Previous pandemics in the 20th and 21st centuries have been associated with a decline in birth rates 9 months after their peak, and a rebound in births over time. Lockdowns were necessary to control the first wave of the COVID-19 pandemic and may have had an impact on subsequent birth rates.
Infertility, pregnancy loss and assisted reproduction in women with asthma: a population-based cohort study
Anna Jöud, Emma Nilsson-Condori, Lone Schmidt, Søren Ziebe, Ditte Vassard, Kristina Mattsson
doi : 10.1093/humrep/deac216
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2932–2941
Reproductive dysfunction has been reported among women with asthma, including longer time to pregnancy, increased risk of pregnancy loss and a higher need of medically assisted reproduction, but their risk of clinical infertility is unknown.
Inactivated Covid-19 vaccine did not undermine live birth and neonatal outcomes of women with frozen-thawed embryo transfer
Mingzhu Cao, Yixuan Wu, Yanshan Lin, Zijin Xu, Zhu Liang, Qing Huang, Sichen Li, Hanyan Liu, Chunyan An, Yiqun Luo, Haiying Liu, Jianqiao Liu
doi : 10.1093/humrep/deac220
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2942–2951
Accumulating reports are now available indicating the safe use of mRNA vaccines against Covid-19 in pregnant and lactating women, and a few reports indicate that they are not associated with adverse effects on ovarian stimulation or early pregnancy outcomes following IVF. Evidence about the safety of inactivated Covid-19 vaccines is very limited.
Persistent Müllerian duct syndrome associated with genetic defects in the regulatory subunit of myosin phosphatase
Jean-Yves Picard, Gilles Morin, Mojgan Devouassoux-Shisheboran, Jasper Van der Smagt, Serge Klosowski, Catherine Pienkowski, Peggy Pierre-Renoult, Cécile Masson, Christine Bole, Nathalie Josso
doi : 10.1093/humrep/deac239
Human Reproduction, Volume 37, Issue 12, December 2022, Pages 2952–2959
Mutations of AMH and AMHR2 are detectable in an overwhelming majority of PMDS patients but in 10% of cases, both genes are apparently normal, suggesting that other genes may be involved.
