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Polygenic risk score for embryo selection—not ready for prime time
Alex Polyakov, David J Amor, Julian Savulescu, Christopher Gyngell, Ektoras X Georgiou, Vanessa Ross, Yossi Mizrachi, Genia Rozen
doi : 10.1093/humrep/deac159
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2229–2236
Numerous chronic diseases have a substantial hereditary component. Recent advances in human genetics have allowed the extent of this to be quantified via genome-wide association studies, producing polygenic risk scores (PRS), which can then be applied to individuals to estimate their risk of developing a disease in question.
The statistical foundation of the reference population for semen analysis included in the sixth edition of the WHO manual: a critical reappraisal of the evidence
Alessio Paffoni, Edgardo Somigliana, Luca Boeri, Paola Viganò
doi : 10.1093/humrep/deac161
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2237–2245
In the most recent version of the ‘WHO Laboratory Manual For The Examination And Processing Of Human Semen’, the updated target population used to infer reference values included 3589 fertile subjects, representative of 12 countries and 5 continents, and 10 studies.
Sperm aminopeptidase N identifies the potential for high-quality blastocysts and viable embryos in oocyte-donation cycles
Marta Gianzo, Itziar Urizar-Arenaza, Iraia Muñoa-Hoyos, Gorka Labaka, Zaloa Larreategui, Nicolás Garrido, Jon Irazusta, Nerea Subirán
doi : 10.1093/humrep/deac170
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2246–2254
The diagnosis of male fertility is one of the major concerns of reproductive medicine. Approximately 30–40% of men with otherwise normal fertility parameters are still unable to achieve pregnancy.
Do studies published in two leading reproduction journals between 2011 and 2020 demonstrate that they followed WHO5 recommendations for basic semen analysis?
A L Vasconcelos, M J Campbell, C L R Barratt, S A Gellatly
doi : 10.1093/humrep/deac173
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2255–2263
A basic semen analysis is currently an integral part of infertility investigations of the male, but method standardization in laboratories remains an issue.
Prospectively assessed perceived stress associated with early pregnancy losses among women with history of pregnancy loss
Karen C Schliep, Stefanie N Hinkle, Keewan Kim, Lindsey A Sjaarda, Robert M Silver, Joseph B Stanford, Alexandra Purdue-Smithe, Torie Comeaux Plowden, Enrique F Schisterman, Sunni L Mumford
doi : 10.1093/humrep/deac172
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2264–2274
Women who have experienced a pregnancy loss may be more vulnerable to stress while trying to become pregnant again.
Embryologist agreement when assessing blastocyst implantation probability: is data-driven prediction the solution to embryo assessment subjectivity?
Daniel E Fordham, Dror Rosentraub, Avital L Polsky, Talia Aviram, Yotam Wolf, Oriel Perl, Asnat Devir, Shahar Rosentraub, David H Silver, Yael Gold Zamir, Alex M Bronstein, Miguel Lara Lara, Jara Ben Nagi, Adrian Alvarez, Santiago Munné
doi : 10.1093/humrep/deac171
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2275–2290
Previous studies have demonstrated significant interobserver variability amongst embryologists when assessing embryo quality. However, data concerning embryologists’ ability to predict implantation probability using TLI is still lacking.
Human blastocyst spontaneous collapse is associated with worse morphological quality and higher degeneration and aneuploidy rates: a comprehensive analysis standardized through artificial intelligence
Danilo Cimadomo, Anabella Marconetto, Samuele Trio, Viviana Chiappetta, Federica Innocenti, Laura Albricci, Itay Erlich, Assaf Ben-Meir, Iris Har-Vardi, Ben Kantor, Anat Sakov, Giovanni Coticchio, Andrea Borini, Filippo Maria Ubaldi, Laura Rienzi
doi : 10.1093/humrep/deac175
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2291–2306
Time-lapse microscopy (TLM) is a powerful tool to observe preimplantation development dynamics. Lately, artificial intelligence (AI) has been harnessed to automate and standardize such observations.
Human 1PN and 3PN zygotes recapitulate all morphokinetic events of normal fertilization but reveal novel developmental errors
Kenji Ezoe, Tsubasa Takahashi, Kiyoe Shimazaki, Tetsuya Miki, Yuko Tanimura, Ayumi Amagai, Ayano Sawado, Hikari Akaike, Mai Mogi, Shigeru Kaneko, Mizuki Kato, Keiichi Kato, Nicoletta Tarozzi, Andrea Borini, Giovanni Coticchio
doi : 10.1093/humrep/deac177
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2307–2319
ART has allowed the extracorporeal observation of early human development. Time-lapse technology (TLT) has revealed the complexity of the morphokinetic changes underpinning fertilization and the importance of this process for the genetic and cellular integrity of the embryo.
Removal of a well-palpable one-rod subdermal contraceptive implant using a dedicated hand-held device or standard technique: a randomized, open-label, non-inferiority trial
David Hubacher, Josaphat Byamugisha, Othman Kakaire, Hadija Nalubwama, Karin Emtell Iwarsson, Marte Bratlie, Pai-Lien Chen, Kristina Gemzell-Danielsson
doi : 10.1093/humrep/deac179
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2320–2333
An easy-to-use device for removing a subdermal contraceptive implant may be helpful in settings where skilled providers are in short supply. Prior to this study, the only report on the world’s first hand-held, mechanical device with build-in incisor was a Swedish study using earlier versions of the product.
Single-cell sequencing reveals novel cellular heterogeneity in uterine leiomyomas
Jyoti Goad, Joshua Rudolph, Mehrdad Zandigohar, Matthew Tae, Yang Dai, Jian-Jun Wei, Serdar E Bulun, Debabrata Chakravarti, Aleksandar Rajkovic
doi : 10.1093/humrep/deac183
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2334–2349
Previous studies have shown the presence of SMCs, fibroblasts, endothelial cells and immune cells in myometrium and leiomyomas. However, there is no information on the cellular heterogeneity in these tissues and the transcriptomic differences at the single-cell level between these tissues.
Pregnancy outcomes in women with endometriosis and/or ART use: a population-based cohort study
Ibinabo Ibiebele, Tanya Nippita, Rodney Baber, Siranda Torvaldsen
doi : 10.1093/humrep/deac186
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2350–2358
There are contradictory findings on the association between endometriosis and adverse pregnancy outcomes, and many large studies have not considered the effect of ART use.
Comparison of #Enzian classification and revised American Society for Reproductive Medicine stages for the description of disease extent in women with deep endometriosis
Eliana Montanari, Attila Bokor, Gábor Szabó, William Kondo, Carlos Henrique Trippia, Mario Malzoni, Alessandra Di Giovanni, Hans-Rudolf Tinneberg, Anna Oberstein, Rodrigo Manieri Rocha, Mathew Leonardi, George Condous, Hanan Alsalem, Joerg Keckstein, Gernot Hudelist
doi : 10.1093/humrep/deac187
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2359–2365
Endometriotic lesions can be accurately described regarding their localization and severity by sonography as well as during surgery using the recently updated #Enzian classification for endometriosis.
Progesterone supplementation in natural cycles improves live birth rates after embryo transfer of frozen-thawed embryos—a randomized controlled trial
K WÃ¥nggren, M Dahlgren Granbom, S I Iliadis, J Gudmundsson, A Stavreus-Evers
doi : 10.1093/humrep/deac181
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2366–2374
Progesterone supplementation during luteal phase and early pregnancy may improve the number of live births after frozen-thawed embryo transfer. However, due to the limited number of previous studies, being mainly retrospective, evidence is still limited.
microRNA-based signatures obtained from endometrial fluid identify implantative endometrium
Jone Ibañez-Perez, MarÃa DÃaz-Nuñez, Marc Clos-GarcÃa, LucÃa Lainz, MarÃa Iglesias, Miren DÃez-Zapirain, Aintzane Rabanal, Laura Bárcena, Monika González, Juan J Lozano, Urko M Marigorta, Esperanza González, Félix Royo, Ana M Aransay, Nerea Subiran, Roberto Matorras, Juan Manuel Falcón-Pérez
doi : 10.1093/humrep/deac184
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2375–2391
miRNAs and extracellular vesicles (EVs) from EF have been described as mediators of the embryo–endometrium crosstalk. Therefore, the analysis of miRNA from this fluid could become a non-invasive technique for recognizing implantative endometrium. This analysis could potentially help improve the implantation rates in ART.
The number and rate of euploid blastocysts in women undergoing IVF/ICSI cycles are strongly dependent on ovarian reserve and female age
Antonio La Marca, Martina Capuzzo, Maria Longo, Maria Giovanna Imbrogno, Giorgio Alfredo Spedicato, Francesco Fiorentino, Francesca Spinella, Pierfrancesco Greco, Maria Giulia Minasi, Ermanno Greco
doi : 10.1093/humrep/deac191
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2392–2401
The blastocyst euploidy rate among women undergoing ART has already been shown to significantly decrease with increasing female age, and the total number of euploid embryos is dependent on the blastocyst cohort size. However, the vast majority of published studies are based on retrospective analysis of data.
Puberty disorders among ART-conceived singletons: a Nordic register study from the CoNARTaS group
R Klemetti, B Perry, A K Aaris Henningsen, A Lærke Spangmose, A Pinborg, S Opdahl, L Bente Romundstad, C Bergh, U B Wennerholm, A Tiitinen, M Gissler
doi : 10.1093/humrep/deac192
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2402–2411
Some physiological differences in growth and metabolism have been reported for ART-conceived children compared to non-ART-conceived children. Knowledge on pubertal development and disorders in ART-conceived children is limited.
Feasibility randomized controlled trial of a self-guided online intervention to promote psychosocial adjustment to unmet parenthood goals
B Rowbottom, A Galhardo, E Donovan, S Gameiro
doi : 10.1093/humrep/deac168
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2412–2425
Self-identifying as having a UPG, defined as being unable to have children or as many as desired, is associated with impaired well-being and mental health.
‘I’m the only mum she knows’: parents’ understanding of, and feelings about, identity-release egg donation
J Lysons, S Imrie, V Jadva, S Golombok
doi : 10.1093/humrep/deac174
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2426–2437
Identity-release egg donation has been the only treatment option available to patients wishing to pursue this route to parenthood in the UK since 2005. However, little is known about how well parents understand this legislation, and how they feel about potential donor–child contact.
Markers of ovarian reserve are associated with reproductive age acceleration in granulosa cells from IVF patients
A K Knight, H S Hipp, S Abhari, S A Gerkowicz, Q S Katler, L J McKenzie, W Shang, A K Smith, J B Spencer
doi : 10.1093/humrep/deac178
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2438–2445
The rate of reproductive aging varies among women of the same age. DNA methylation can be used to predict epigenetic age in a variety of tissues.
The FIGO Ovulatory Disorders Classification Systemâ€
Malcolm G Munro, Adam H Balen, SiHyun Cho, Hilary O D Critchley, Ivonne DÃaz, Rui Ferriani, Laurie Henry, Edgar Mocanu, Zephne M van der Spuy, FIGO Committee on Menstrual Disorders and Related Health Impacts, and FIGO Committee on Reproductive Medicine, Endocrinology, and Infertility
doi : 10.1093/humrep/deac180
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2446–2464
Ovulatory disorders are common causes of amenorrhea, abnormal uterine bleeding and infertility and are frequent manifestations of polycystic ovary syndrome (PCOS).
Preconception vitamin D and miscarriage in a prospective cohort study
A Subramanian, A Z Steiner, C R Weinberg, G L Doss, A M Z Jukic
doi : 10.1093/humrep/deac155
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2465–2473
In humans, low vitamin D has been associated with prolonged menstrual cycles, delayed ovulation and a lower probability of conception. Animal and in vitro data indicate that vitamin D may affect implantation.
Outcomes of in-vitro fertilization after bariatric surgery: a national register-based case–control study
E Nilsson-Condori, K Mattsson, A Thurin-Kjellberg, J L Hedenbro, B Friberg
doi : 10.1093/humrep/deac164
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2474–2481
Because of the perinatal risks of obesity to mother and infant as well as impaired outcomes of IVF, obese women are advised to reduce their weight, but it is not clear whether previous BS could affect IVF results.
The impact of embryo vitrification on placental histopathology features and perinatal outcome in singleton live births
A Volodarsky-Perel, T N Ton Nu, R Orvieto, R Mashiach, A Machado-Gedeon, Y Cui, J Shaul, M H Dahan
doi : 10.1093/humrep/deac167
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2482–2491
Obstetrical and perinatal outcomes differ between live births resulting from fresh and frozen embryo transfers. The effect of embryo vitrification on the placental histopathology features associated with the development of perinatal complications remains unclear.
#ESHREjc report: are sperm selection techniques a panacea? Indications for the use of physiological intracytoplasmic sperm injection (PICSI) in medically assisted reproduction
George Liperis, Kashish Sharma, Omar Farhan Ammar, Juan J Fraire-Zamora, Sarah Martins da Silva, Andrew Thomson, Taylor Pini, Mina Mincheva
doi : 10.1093/humrep/deac182
Human Reproduction, Volume 37, Issue 10, October 2022, Pages 2492–2496
