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Out of step societal and Darwinian adaptation during evolution is the cause of multiple women’s health issues
Zhenle Pei, Wenhan Lu, Yi Feng, Congjian Xu, Aaron J W Hsueh
doi : 10.1093/humrep/deac156
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 1959–1969
During human evolution, major changes in our societal conditions and environment took place without sufficient time for concomitant genetic alterations, leading to out of step adaptation and diseases in women.
Age-related fertility decline: is there a role for elective ovarian tissue cryopreservation?
Lorraine S Kasaven, Srdjan Saso, Natalie Getreu, Helen O’Neill, Timothy Bracewell-Milnes, Fevzi Shakir, Joseph Yazbek, Meen-Yau Thum, James Nicopoullos, Jara Ben Nagi, Paul Hardiman, Cesar Diaz-Garcia, Benjamin P Jones
doi : 10.1093/humrep/deac144
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 1970–1979
Age-related fertility decline (ARFD) is a prevalent concern amongst western cultures due to the increasing age of first-time motherhood
A propensity score-based, comparative study assessing humid and dry time-lapse incubation, with single-step medium, on embryo development and clinical outcomes
MarÃa Ã�ngeles Valera, Carmela Albert, Julián Marcos, Zaloa Larreategui, Lorena Bori, Marcos Meseguer
doi : 10.1093/humrep/deac165
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 1980–1993
The use of a humid atmosphere inside incubators can reduce changes in culture media osmolality, which has been reported to have a significant effect on embryo quality and morphokinetics. Studies assessing the effect of humid culture (HC) in clinical outcomes are, however, scarce and inconclusive, mostly due to a high variability in culture conditions and reduced sample size.
β-hydroxybutyrate reduces blastocyst viability via trophectoderm-mediated metabolic aberrations in mice
Emma G Whatley, Thi T Truong, Dagmar Wilhelm, Alexandra J Harvey, David K Gardner
doi : 10.1093/humrep/deac153
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 1994–2011
A maternal KD in humans elevates gamete and offspring βOHB exposure during conception and gestation, and in rodents is associated with an increased time to pregnancy, and altered offspring organogenesis, post-natal growth and behaviour, suggesting a developmental programming effect.
Development of a core outcome set and outcome definitions for studies on uterus-sparing treatments of adenomyosis (COSAR): an international multistakeholder-modified Delphi consensus study
T Tellum, J Naftalin, C Chapron, M Dueholm, S -W Guo, M Hirsch, E R Larby, M G Munro, E Saridogan, Z M van der Spuy, D Jurkovic
doi : 10.1093/humrep/deac166
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2012–2031
Research reporting adenomyosis treatment is not patient-centred and shows wide variation in outcome selection, definition, reporting and measurement of quality.
Assessing the experience of dyspareunia in the endometriosis population: the Subjective Impact of Dyspareunia Inventory (SIDI)
F Facchin, G Barbara, L Buggio, D Dridi, A Frassineti, P Vercellini
doi : 10.1093/humrep/deac141
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2032–2041
In the endometriosis population, dyspareunia has a tremendous negative impact on psychological health, overall sexual function and couple relationships. However, there is a paucity of tools that can be effectively used in either research or clinical practice to assess the subjective components of the dyspareunia experience, including coping strategies to deal with the pain.
Circulating proteomic profiles associated with endometriosis in adolescents and young adults
Naoko Sasamoto, Long Ngo, Allison F Vitonis, Simon T Dillon, Stacey A Missmer, Towia A Libermann, Kathryn L Terry
doi : 10.1093/humrep/deac146
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2042–2053
Little is known about the pathophysiology of adolescent endometriosis despite the fact that over 50% of adults with endometriosis report onset of severe pelvic pain during adolescence.
Inactivated COVID-19 vaccination does not affect in vitro fertilization outcomes in women
Yixuan Wu, Mingzhu Cao, Yanshan Lin, Zijin Xu, Zhu Liang, Qing Huang, Sichen Li, Lei Li, Yaming Meng, Chunyan An, Haiying Liu, Jianqiao Liu
doi : 10.1093/humrep/deac160
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2054–2062
Limited studies have reported that COVID-19 vaccines do not affect ovarian function, embryo development or pregnancy outcomes.
Associations between epigenetic age acceleration and infertility
Yunsung Lee, Jon Bohlin, Christian M Page, Haakon E Nustad, Jennifer R Harris, Per Magnus, Astanand Jugessur, Maria C Magnus, Siri E HÃ¥berg, Hans I Hanevik
doi : 10.1093/humrep/deac147
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2063–2074
Among mothers who used ART, epigenetic age acceleration may be associated with low oocyte yield and poor ovarian response. However, the difference in epigenetic age acceleration between non-ART and ART mothers (or even fathers) has not been examined.
Predicting cumulative live birth for couples beginning their second complete cycle of in vitro fertilization treatment
Mariam B Ratna, Siladitya Bhattacharya, N van Geloven, David J McLernon
doi : 10.1093/humrep/deac152
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2075–2086
After the completion of a first complete cycle of IVF, couples who are unsuccessful may choose to undergo further treatment to have their first child, while those who have had a live birth may decide to have more children.
Are donor-conceived people willing to use donors themselves? Insights from individuals conceived via donor-assisted reproduction
D R Siegel, J Sheeder, W Kramer, C Roeca
doi : 10.1093/humrep/deac169
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2087–2094,
DCP view their donor conception as an important part of their self-identity and many desire contact with genetically related individuals. Additionally, many believe that sperm donation should only be practiced if identifying information on the donor is provided.
Metabolic transitions define spermatogonial stem cell maturation
A L Voigt, R Dardari, L Su, N L M Lara, S Sinha, A Jaffer, S K Munyoki, W Alpaugh, A Dufour, J Biernaskie, K E Orwig, I Dobrinski
doi : 10.1093/humrep/deac157
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2095–2112
Maintenance of both mouse and human adult SSCs relies on glycolysis, while embryonic SSC precursors, primordial germ cells (PGCs), exhibit an elevated dependence on OXPHOS. Neonatal porcine SSC precursors reportedly initiate a transition to an adult SSC metabolic phenotype at 2 months of development. However, when and if such a metabolic transition occurs in humans is ambiguous.
Early childhood respiratory tract infections according to parental subfertility and conception by assisted reproductive technologies
V R Mitter, S E HÃ¥berg, M C Magnus
doi : 10.1093/humrep/deac162
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2113–2125
Some studies report increased risks of infections in children conceived by ART. Results for URTIs and LRTIs are inconclusive, and the contribution of underlying parental subfertility remains unclear.
Attention-deficit hyperactivity disorder in children born to mothers with infertility: a population-based cohort study
Alexa Fine, Natalie Dayan, Maya Djerboua, Jessica Pudwell, Deshayne B Fell, Simone N Vigod, Joel G Ray, Maria P Velez
doi : 10.1093/humrep/deac129
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2126–2134
Infertility, and use of fertility treatment, is common. The long-term neurodevelopmental outcome of a child born to a mother with infertility, including the risk of ADHD, remains unclear.
Association of PCOS with offspring morbidity: a longitudinal cohort study
Shu Qin Wei, Marianne Bilodeau-Bertrand, Nathalie Auger
doi : 10.1093/humrep/deac154
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2135–2142
PCOS is associated with higher rates of gestational diabetes, pre-eclampsia and preterm delivery, but the long-term impact on child health is poorly understood.
The influence of regulation of medically assisted reproduction on the risk of hospitalization in the first 2Â years of life
Olga Basso, Gabriel D Shapiro, Sarah E Twardowski, Patricia Monnier, William Buckett, Robyn Tamblyn
doi : 10.1093/humrep/deac158
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2143–2153
Previous studies reported lower NICU admission rates among children conceived with ART after the 2010 law; however, children conceived without ART by parents with infertility were not considered.
Associations of maternal anthropometrics with newborn anogenital distance and the 2:4 digit ratio
Maria E Kloboves, Diana C Pacyga, Joseph C Gardiner, Jodi A Flaws, Susan L Schantz, Rita S Strakovsky
doi : 10.1093/humrep/deac143
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2154–2166
Excessive maternal weight or adiposity before or in early pregnancy may impact child reproductive, and other hormonally mediated, development. AGD and 2:4D are proposed markers of in utero reproductive development.
Exposure to corticosteroids in the first trimester is associated with an increased risk of urogenital congenital anomalies
V Thalluri, R J Woodman, B Vollenhoven, K Tremellen, D Zander-Fox
doi : 10.1093/humrep/deac142
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2167–2174
Maternal exposure to corticosteroids may increase the risk of congenital anomalies such as cleft palate and neural tube defects. However, the existing studies have conflicting outcomes, are underpowered, and do not study a population undergoing IVF/ICSI, a group known to be at increased risk of abnormalities.
Menopause, hysterectomy, menopausal hormone therapy and cause-specific mortality: cohort study of UK Biobank participants
Zhiwei Xu, Hsin-Fang Chung, Annette J Dobson, Louise F Wilson, Martha Hickey, Gita D Mishra
doi : 10.1093/humrep/deac137
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2175–2185
Evidence from the Women’s Health Initiative randomized controlled trials showed that the use of estrogen alone is not associated with the risk of cardiovascular mortality and is associated with a lower risk of breast cancer mortality, but evidence from the Million Women Study showed that use of estrogen alone is associated with a higher risk of breast cancer mortality.
Endometriosis and irritable bowel syndrome: similarities and differences in the spectrum of comorbidities
M Peters, I Mikeltadze, H Karro, M Saare, Estonian Biobank Research Team , A Salumets, R Mägi, T Laisk
doi : 10.1093/humrep/deac140
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2186–2196
Endometriosis and IBS both have several similar unspecific symptoms, such as recurrent abdominal pain, cramping and anxiety, and both diseases affect young women and are associated with a number of comorbidities causing a poor quality of life. However, a detailed study, revealing the full spectrum of endometriosis and IBS comorbidities in the same study population, is lacking.
Genome-wide causal mediation analysis identifies genetic loci associated with uterine fibroids mediated by age at menarche
An-Shun Tai, Ro-Ting Lin, Yi-Chun Lin, Chung-Hsing Wang, Sheng-Hsuan Lin, Seiya Imoto
doi : 10.1093/humrep/deac136
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2197–2212
Uterine fibroids are common benign tumors developing from uterine smooth muscle. Genome-wide association studies (GWASs) have identified over 30 genetic loci associated with uterine fibroids in different ethnic populations.
Avoid mixing apples and oranges: blastocysts diagnosed with uniform whole chromosome aneuploidies are reproductively incompetent and their transfer is harmful
Antonio Capalbo, Danilo Cimadomo, Laura Rienzi, Juan Antonio Garcìa-Velasco, Carlos Simòn, Filippo Maria Ubaldi
doi : 10.1093/humrep/deac149
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2213–2214
Correct assessment and interpretation of results determines the accuracy of any diagnostic test, and PGT-A is no exception
Baris Ata, Mina Popovic, Human Fatemi
doi : 10.1093/humrep/deac150
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2214–2216
In science truth ultimately wins, and PGT-A is no exception
D H Barad, D F Albertini, N Gleicher
doi : 10.1093/humrep/deac151
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2216–2218
#ESHREjc report: diagnosing endometriosis loosens the Gordian knot of infertility treatment
Sofia Makieva, Kashish Sharma, Munevver Serdarogullari, Julia Uraji, Zoya E Ali, George Liperis, Omar F Ammar, Thomas D’Hooghe, M Louise Hull, Mathew Leonardi, Paola Vigano’, Claudia Massarotti
doi : 10.1093/humrep/deac134
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2219–2223
#ESHREjc report: renewing the old: novel stem cell research for unsolved ART problems
Kashish Sharma, Julia Uraji, Omar Farhan Ammar, Zoya E Ali, George Liperis, Deepak Modi, Samuel Ojosnegros, Marta N Shahbazi, Juan J Fraire-Zamora
doi : 10.1093/humrep/deac163
Human Reproduction, Volume 37, Issue 9, September 2022, Pages 2224–2227
Correction to: Correct assessment and interpretation of results determines the accuracy of any diagnostic test, and PGT-A is no exception
doi : 10.1093/humrep/deac176
Human Reproduction, Volume 37, Issue 9, September 2022, Page 2228
