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Should any use of artificial cycle regimen for frozen-thawed embryo transfer in women capable of ovulation be abandoned: yes, but what’s next for FET cycle practice and research?
Frauke von Versen-Höynck, Georg Griesinger
doi : 10.1093/humrep/deac125
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1697–1703
Over the past decade, the use of frozen-thawed embryo transfer (FET) treatment cycles has increased substantially.
Fertilization signatures as biomarkers of embryo quality
Giovanni Coticchio, Andrea Borini, Carlotta Zacà , Evangelos Makrakis, Ioannis Sfontouris
doi : 10.1093/humrep/deac123
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1704–1711
Fertilization underpins the vital transition from gametic meiosis to embryonic mitosis. For decades, in human IVF, microscopic observation at a single time point has limited our appreciation of the morphokinetic complexity of this process.
Histone H4 acetylation is dysregulated in active seminiferous tubules adjacent to testicular tumours
Ferran Barrachina, Alberto de la Iglesia, Meritxell Jodar, Ada Soler-Ventura, Carme Mallofré, Leonardo Rodriguez-Carunchio, Afsaneh Goudarzi, Juan Manuel Corral, Josep LluÃs Ballescà , Judit Castillo, Rafael Oliva
doi : 10.1093/humrep/deac130
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1712–1726
Altered H4ac levels have been associated with a variety of testicular pathological conditions. However, no information has been available regarding potential alterations in the spermatogenic cells adjacent to the neoplasia in testicular tumour patients.
Diurnal rhythm of human semen quality: analysis of large-scale human sperm bank data and timing-controlled laboratory study
Kun Liu, Tianqing Meng, Qing Chen, Guizhong Hou, Xiaogang Wang, Siheng Hu, Xiuli Gu, Honggang Li, Yuyan Li, Chengliang Xiong, Jia Cao
doi : 10.1093/humrep/deac135
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1727–1738
A circadian clock appears to regulate different physiological functions in various organs, but it remains controversial whether diurnal rhythms occur in human semen parameters.
Pregnancy complications and placental histology following embryo transfer with a thinner endometrium
Hadas Ganer Herman, Alexander Volodarsky-Perel, Tuyet Nhung Ton Nu, Alexandre Machado-Gedeon, Yiming Cui, Jonathan Shaul, Michael H Dahan
doi : 10.1093/humrep/deac148
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1739–1745
Past studies have noted a higher rate of adverse outcomes on deliveries following IVF with a thinner endometrium, mainly placental-associated complications. However, no study to date has investigated placental histopathology in such cases.
Development of an artificial intelligence model for predicting the likelihood of human embryo euploidy based on blastocyst images from multiple imaging systems during IVF
S M Diakiw, J M M Hall, M D VerMilyea, J Amin, J Aizpurua, L Giardini, Y G Briones, A Y X Lim, M A Dakka, T V Nguyen, D Perugini, M Perugini
doi : 10.1093/humrep/deac131
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1746–1759
Euploid embryos displaying the normal human chromosomal complement of 46 chromosomes are preferentially selected for transfer over aneuploid embryos (abnormal complement), as they are associated with improved clinical outcomes.
TEAD4 regulates trophectoderm differentiation upstream of CDX2 in a GATA3-independent manner in the human preimplantation embryo
P Stamatiadis, G Cosemans, A Boel, B Menten, P De Sutter, D Stoop, S M Chuva de Sousa Lopes, F Lluis, P Coucke, B Heindryckx
doi : 10.1093/humrep/deac138
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1760–1773
Tead4 is one of the earliest transcription factors expressed during mouse embryo preimplantation development and is required for the expression of TE-associated genes.
Recalculating the staff required to run a modern assisted reproductive technology laboratory
E Veiga, C Olmedo, L Sánchez, M Fernández, A Mauri, E Ferrer, N Ortiz
doi : 10.1093/humrep/deac121
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1774–1785
In today’s modern ART laboratories, the amount of time required to perform increasingly complicated processes has more than doubled, with a downward trend in the amount of work an embryologist can do. Different workload unit values have been used to evaluate each workload task and efficiency in a particular ART laboratory, as well as to occasionally compare one laboratory with another.
Fertility preservation for women with breast cancer: a multicentre randomized controlled trial on various ovarian stimulation protocols
Eva M E Balkenende, Taghride Dahhan, Catharina C M Beerendonk, Kathrin Fleischer, Dominic Stoop, Annelies M E Bos, Cornelis B Lambalk, Roel Schats, Jesper M J Smeenk, Leonie A Louwé, Astrid E P Cantineau, Jan Peter de Bruin, Sabine C Linn, Fulco van der Veen, Madelon van Wely, Mariëtte Goddijn
doi : 10.1093/humrep/deac145
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1786–1794,
Alternative ovarian stimulation protocols have been introduced for women with breast cancer who opt for fertility preservation by means of banking of oocytes or embryos. How these ovarian stimulation protocols compare to standard ovarian stimulation in terms of COC yield is unknown.
Ovulation triggering with hCG alone, GnRH agonist alone or in combination? A randomized controlled trial in advanced-age women undergoing IVF/ICSI cycles
Chengliang Zhou, Xinyue Yang, Yong Wang, Ji Xi, Hong Pan, Min Wang, Yuzhong Zhou, Yu Xiao
doi : 10.1093/humrep/deac114
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1795–1805
Many studies have demonstrated that a dual trigger has positive impact on oocyte maturation, retrieval rate and pregnancy rate without increasing the risk of ovarian hyperstimulation syndrome (OHSS) in some groups of IVF patients, when compared with single hCG trigger.
Increased versus standard gonadotrophin dosing in predicted poor responders of IVF: an open-label randomized controlled trial
Xitong Liu, Wen Wen, Tao Wang, Li Tian, Na Li, Ting Sun, Ting Wang, Hanying Zhou, Na Zhang, Pengfei Qu, Ben W Mol, Wentao Li, Juanzi Shi
doi : 10.1093/humrep/deac113
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1806–1815
Poor ovarian reserve leads to worse IVF outcomes owing to the low number and quality of oocytes. Clinicians often individualize the FSH dose using ovarian reserve tests, including antral follicle count (AFC), and basal plasma FSH or anti-Müllerian hormone level. However, the evidence that increased FSH dosing improves fertility outcomes in women with an expected poor response is lacking.
Endometrial HLA-F expression is influenced by genotypes and correlates differently with immune cell infiltration in IVF and recurrent implantation failure patients
Henrieta Papúchová, Malene Hviid Saxtorph, Trine Hallager, Ida E Jepsen, Jens O Eriksen, Gry Persson, Tina Funck, Iben Weisdorf, Nicholas S Macklon, Lise Grupe Larsen, Thomas Vauvert F Hviid
doi : 10.1093/humrep/deac118
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1816–1834
The immunomodulatory HLA class Ib molecules HLA-G and HLA-F are expressed on the extravillous trophoblast cells and interact with receptors on maternal immune cells.
Derailed peripheral circadian genes in polycystic ovary syndrome patients alters peripheral conversion of androgens synthesis
Betcy Susan Johnson, Meera B Krishna, Renjini A Padmanabhan, Sathy M Pillai, K Jayakrishnan, Malini Laloraya
doi : 10.1093/humrep/deac139
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1835–1855
PCOS patients exhibit features of metabolic syndrome. Circadian rhythm disruption is involved in the development of metabolic diseases and subfertility. An association between shift work and the incidence of PCOS in females was recently reported.
Idiopathic early ovarian ageing: risk of miscarriage and chance of delivery following ART in a nationwide cohort study
M W Christensen, H J Ingerslev, K Kirkegaard, U S Kesmodel
doi : 10.1093/humrep/deac093
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1856–1870
Normal ovarian ageing is described as a concomitant decline in oocyte quantity and quality with increasing age. Conflicting results exist with regard to whether a similar decline in oocyte quality also follows an accelerated loss of follicles in young women.
Development of children born from IVM versus IVF: 2-year follow-up of a randomized controlled trial
Lan N Vuong, Minh H N Nguyen, Nghia A Nguyen, Trung T Ly, Van T T Tran, Nam T Nguyen, Hieu L T Hoang, Xuyên T H Le, Toan D Pham, Johan E J Smitz, Ben W Mol, Robert J Norman, Tuong M Ho
doi : 10.1093/humrep/deac115
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1871–1879
IVM has been shown to be a feasible alternative to conventional IVF in women with a high antral follicle count (AFC). In addition to live birth rate, childhood development is also a relevant metric to compare between the two approaches to ART and there are currently no data on this.
Comparison of the cardiometabolic profiles of adolescents conceived through ART with those of a non-ART cohort
L A Wijs, D A Doherty, J A Keelan, P Burton, J L Yovich, L Beilin, T A Mori, R C Huang, L A Adams, J K Olynyk, O T Ayonrinde, B Penova-Veselinovic, R J Hart
doi : 10.1093/humrep/deac122
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1880–1895
It has been proposed that the cardiometabolic health of offspring conceived with ART may be unfavourable compared to that of their counterparts conceived without ART.
Parents’ age at birth and daughters’ time to pregnancy: a study within the Norwegian Mother, Father and Child Cohort
Olga Basso, Maria C Magnus, Lise A Arge, Siri E HÃ¥berg
doi : 10.1093/humrep/deac086
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1896–1906
Two recent studies reported lower fecundability in women born to mothers <20 years, which may be partly due to daughters of young mothers being less likely to plan their pregnancies.
Fertility intentions to have a second or third child under China’s three-child policy: a national cross-sectional study
Wenzhan Jing, Jue Liu, Qiuyue Ma, Shikun Zhang, Yuanyuan Li, Min Liu
doi : 10.1093/humrep/deac101
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1907–1918
The Chinese government announced the three-child policy on 31 May 2021, allowing all couples to have up to three children. At present, there is a lack of national surveys on the fertility intentions of women and men to have a second or third child under the three-child policy in China.
Prevalence, incidence and years lived with disability due to polycystic ovary syndrome in 204 countries and territories, 1990–2019
Saeid Safiri, Maryam Noori, Seyed Aria Nejadghaderi, Nahid Karamzad, Kristin Carson-Chahhoud, Mark J M Sullman, Gary S Collins, Ali-Asghar Kolahi, Jodie Avery
doi : 10.1093/humrep/deac091
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1919–1931
Data from the Global Burden of Disease (GBD) study 2017 showed that the global age-standardized PCOS incidence rate increased 1.45% over the period 1990–2017.
Biallelic variants in MOS cause large polar body in oocyte and human female infertility
Yin-Li Zhang, Wei Zheng, Peipei Ren, Jiamin Jin, Zhanhong Hu, Qing Liu, Heng-Yu Fan, Fei Gong, Guang-Xiu Lu, Ge Lin, Songying Zhang, Xiaomei Tong
doi : 10.1093/humrep/deac120
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1932–1944
MOS, an oocyte-specific gene, encodes a serine/threonine-protein kinase that directly phosphorylates mitogen-activated protein kinase (MAPK) kinase (MEK) to activate MAPK (also called extracellular-signal-regulated kinase (ERK)) signal cascade in the oocyte.
In response to: why double ovarian stimulation in an in vitro fertilization cycle is potentially unsafe?
Ozgur Oktem
doi : 10.1093/humrep/deac127
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1945–1947
Reply: In response to: why double ovarian stimulation in an in vitro fertilization cycle is potentially unsafe?
doi : 10.1093/humrep/deac128
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1947–1949
Neither rationale nor scientific evidence exist to support that double stimulation is potentially unsafe
Livio Casarini, Alberto Vaiarelli, Danilo Cimadomo, Daniele Santi, Manuela Simoni, Juan Antonio Garcìa-Velasco, Carlo Alviggi, Antonio La Marca, Laura Rienzi, Filippo Maria Ubaldi
doi : 10.1093/humrep/deac064
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1949–1950
Reply to: Neither rationale nor scientific evidence exist to support that double stimulation is potentially unsafe
Angelo Tocci
doi : 10.1093/humrep/deac065
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1951–1952
‘One-stop shop’ ultrasound evaluation of an infertile patient: doing less is no longer an option
Yaakov Melcer, Ron Maymon
doi : 10.1093/humrep/deac132
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1952–1953
Reply: ‘One-stop shop’ ultrasound evaluation of an infertile patient: doing less is no longer an option
Nienke van Welie, Joukje van Rijswijk, Kim Dreyer, Ben Willem Mol, Velja Mijatovic
doi : 10.1093/humrep/deac133
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1953–1954
#ESHREjc report: on the road to preconception and personalized counselling with machine learning models
doi : 10.1093/humrep/deac111
Human Reproduction, Volume 37, Issue 8, August 2022, Pages 1955–1957
