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Modelling futility in the setting of fertility treatment
Alex Polyakov, Christopher Gyngel, Julian Savulescu
doi : 10.1093/humrep/deac051
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 877–883
When is a fertility treatment futile? This question has great practical importance, given the role futility plays in ethical, legal and clinical discussions. Here, we outline a novel method of determining futility for IVF treatments.
Evaluation of marketing authorization and clinical implementation of ulipristal acetate for uterine fibroids
Mei-An Middelkoop, Maria E de Lange, T Justin Clark, Ben Willem J Mol, Pierre M Bet, Judith A F Huirne, Wouter J K Hehenkamp
doi : 10.1093/humrep/deac009
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 884–894
Ulipristal acetate (UPA) is a medical treatment for uterine fibroids and was authorized for surgical pre-treatment in 2012 after the conduct of the PEARL I and II randomized controlled trials and for intermittent treatment after the observational PEARL III and IV trials.
Are we leaving money on the table in infertility RCTs? Trialists should statistically adjust for prespecified, prognostic covariates to increase power
J Wilkinson, M Showell, V P Taxiarchi, S Lensen
doi : 10.1093/humrep/deac030
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 895–901
Infertility randomized controlled trials (RCTs) are often too small to detect realistic treatment effects. Large observational studies have been proposed as a solution. However, this strategy threatens to weaken the evidence base further, because non-random assignment to treatments makes it impossible to distinguish effects of treatment from confounding factors.
Exploring the causes of semen quality changes post-bariatric surgery: a focus on endocrine-disrupting chemicals
Danielly P Magalhaes, Shruthi Mahalingaiah, Melissa J Perry
doi : 10.1093/humrep/deac039
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 902–921
Rapid weight loss promoted by bariatric surgery (BS) can release accumulated lipophilic endocrine-disrupting chemicals (EDCs), making these chemicals systemically available.
Human sperm cells can form paracetamol metabolite AM404 that directly interferes with sperm calcium signalling and function through a CatSper-dependent mechanism
A Rehfeld, H Frederiksen, R H Rasmussen, A David, J Chaker, B S Nielsen, J E Nielsen, A Juul, N E Skakkebæk, D M Kristensen
doi : 10.1093/humrep/deac042
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 922–935,
While APAP itself does not interact with Ca2+-signalling in human sperm, its metabolite N-arachidonoyl phenolamine (AM404), produced via fatty acid amide hydrolase (FAAH), interferes with human sperm Ca2+-signalling and function through a suggested CatSper channel-dependent action.
Predicting the likelihood of successful medical treatment of early pregnancy loss: development and internal validation of a clinical prediction model
C C Hamel, P Vart, F P H A Vandenbussche, D D M Braat, M P L M Snijders, S F P J Coppus
doi : 10.1093/humrep/deac048
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 936–946
Success rates of medical treatment for EPL vary strongly, between but also within different treatment regimens. Up until now, although some predictors have been identified, no clinical prediction model has been developed yet.
IVF under COVID-19: treatment outcomes of fresh ART cycles
Michal Youngster, Sarit Avraham, Odelia Yaakov, Moran Landau Rabbi, Itai Gat, Gil Yerushalmi, Rachael Sverdlove, Micha Baum, Ettie Maman, Ariel Hourvitz, Alon Kedem
doi : 10.1093/humrep/deac043
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 947–953
A single previous study suggested no evidence that a history of asymptomatic or mild SARS-CoV-2 infection in females caused impairment of fresh ART treatment outcomes.
Safety of fertility preservation techniques before and after anticancer treatments in young women with breast cancer: a systematic review and meta-analysis
L Arecco, E Blondeaux, M Bruzzone, M Ceppi, M M Latocca, C Marrocco, A Boutros, F Spagnolo, M G Razeti, D Favero, S Spinaci, M Condorelli, C Massarotti, O Goldrat, L Del Mastro, I Demeestere, M Lambertini
doi : 10.1093/humrep/deac035
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 954–968
COS for oocyte/embryo cryopreservation before starting chemotherapy is standard of care for young women with breast cancer wishing to preserve fertility
Can hysterosalpingo-foam sonography replace hysterosalpingography as first-choice tubal patency test? A randomized non-inferiority trial
Nienke van Welie, Joukje van Rijswijk, Kim Dreyer, Machiel H A van Hooff, Jan Peter de Bruin, Harold R Verhoeve, Femke Mol, Wilhelmina M van Baal, Maaike A F Traas, Arno M van Peperstraten, Arentje P Manger, Judith Gianotten, Cornelia H de Koning, Aafke M H Koning, Neriman Bayram, David P van der Ham, Francisca P J M Vrouenraets, Michaela Kalafusova, Bob I G van de Laar, Jeroen Kaijser, Arjon F Lambeek, Wouter J Meijer, Frank J M Broekmans, Olivier Valkenburg, Lucy F van der Voet, Jeroen van Disseldorp, Marieke J Lambers, Rachel Tros, Cornelis B Lambalk, Jaap Stoker, Madelon van Wely, Patrick M M Bossuyt, Ben Willem J Mol, Velja Mijatovic
doi : 10.1093/humrep/deac034
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 969–979
Traditionally, tubal patency testing during fertility work-up is performed by HSG. HyFoSy is an alternative imaging technique lacking ionizing radiation and iodinated contrast medium exposure which is less expensive than HSG. Globally, there is a shift towards the use of office-based diagnostic methods, such as HyFoSy.
Endometrial compaction does not predict live birth in single euploid frozen embryo transfers: a prospective study
Jaimin S Shah, Denis A Vaughan, Laura E Dodge, Angela Leung, Ann Korkidakis, Denny Sakkas, David A Ryley, Alan S Penzias, Thomas L Toth
doi : 10.1093/humrep/deac060
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 980–987
There has been increasing interest in the correlation between endometrial compaction and clinical outcomes but there has been conflicting evidence from prior investigations.
The ABC of reproductive intentions: a mixed-methods study exploring the spectrum of attitudes towards family building
B Grace, J Shawe, S Johnson, N O Usman, J Stephenson
doi : 10.1093/humrep/deac036
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 988–996
Several studies have highlighted poor fertility awareness across men and women of reproductive age. As the average age of first-time parents continues to rise, there has been a concerted effort from educators, healthcare professionals, charities, reproductive health groups and government policymakers, to improve fertility awareness.
Great expectations of IVF patients: the role of gender, dispositional optimism and shared IVF prognoses
J Devroe, K Peeraer, T M D’Hooghe, J Boivin, A Laenen, J Vriens, E A F Dancet
doi : 10.1093/humrep/deac038
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 997–1006
Female patients undergoing IVF are known to have unrealistic expectations of the success of their own IVF cycle. The available evidence suggests women expect above average performance of their fertility clinic and (family) reproductive systems.
Development, implementation and initial feasibility testing of the MediEmo mobile application to provide support during medically assisted reproduction
I Robertson, C Harrison, K Y B Ng, N Macklon, Y Cheong, J Boivin
doi : 10.1093/humrep/deac046
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 1007–1017
Digital tools are increasingly popular to provide practical, administrative and psychological support alongside medical treatments. Apps and other digital tools have been developed for use alongside MAR but there is very limited research on the development or acceptability and feasibility of these tools.
High-intensity training elicits greater improvements in cardio-metabolic and reproductive outcomes than moderate-intensity training in women with polycystic ovary syndrome: a randomized clinical trial
Rhiannon K Patten, Luke C McIlvenna, Itamar Levinger, Andrew P Garnham, Soulmaz Shorakae, Alexandra G Parker, Andrew J McAinch, Raymond J Rodgers, Danielle Hiam, Alba Moreno-Asso, Nigel K Stepto
doi : 10.1093/humrep/deac047
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 1018–1029
Exercise training is recognized to improve clinical outcomes in women with PCOS, but little is known about whether HIIT results in greater health outcomes compared to standard MICT.
Incidence and familial risk of premature ovarian insufficiency in the Finnish female population
H Silvén, S M Savukoski, P Pesonen, E Pukkala, M Gissler, E Suvanto, M Niinimäki
doi : 10.1093/humrep/deac014
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 1030–1036
So far, there has been no good quality, nationwide studies of the incidence of POI. Early menopause has been associated with the elevated risk of early menopause among relatives, but the knowledge of the familial risk of POI is scarce. Lower socioeconomic status has been associated with lower age at natural menopause.
Omega-3 fatty acid supplementation and fecundability
J Stanhiser, A M Z Jukic, D R McConnaughey, A Z Steiner
doi : 10.1093/humrep/deac027
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 1037–1046
In infertile women, omega-3 fatty acid intake has been associated with increased probability of pregnancy following IVF. In natural fertility, studies are conflicting, and no study of natural fertility has evaluated omega-3 fatty acid supplementation and fecundity.
Editor’s Choice: Delayed childbearing and medically assisted reproduction
Cornelis (Nils) Lambalk
doi : 10.1093/humrep/deac090
Human Reproduction, Volume 37, Issue 5, May 2022, Page e1
Population-wide contribution of medically assisted reproductive technologies to overall births in Australia: temporal trends and parental characteristics
Stephanie K Y Choi, Christos Venetis, William Ledger, Alys Havard, Katie Harris, Robert J Norman, Louisa R Jorm, Georgina M Chambers
doi : 10.1093/humrep/deac032
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 1047–1058
There is considerable global variation in utilization rates of ART despite a similar infertility prevalence worldwide. While the overall contribution of ART to national births is known in many countries because of ART registries, very little is known about the contribution of OI/IUI treatment or the socio-demographic characteristics of the parents.
Reproductive factors, hormone use, and incidence of melanoma in a cohort of US Radiologic Technologists
Jim Z Mai, Rui Zhang, Michael R Sargen, Mark P Little, Bruce H Alexander, Margaret A Tucker, Cari M Kitahara, Elizabeth K Cahoon
doi : 10.1093/humrep/deac029
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 1059–1068
Although estrogens have been recognized as photosensitizing, previous studies have reported inconsistent findings for the association of melanoma with estrogen-related factors. Most have not collected detailed skin cancer risk factors and have not thoroughly investigated effect modification by ambient UVR and sun sensitivity.
Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women
Renée M G Verdiesen, Yvonne T van der Schouw, Carla H van Gils, W M Monique Verschuren, Frank J M Broekmans, Maria C Borges, Ana L Gonçalves Soares, Deborah A Lawlor, A Heather Eliassen, Peter Kraft, Dale P Sandler, Siobán D Harlow, Jennifer A Smith, Nanette Santoro, Minouk J Schoemaker, Anthony J Swerdlow, Anna Murray, Katherine S Ruth, N Charlotte Onland-Moret
doi : 10.1093/humrep/deac028
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 1069–1082
AMH is expressed by antral stage ovarian follicles in women, and variation in age-specific circulating AMH levels has been associated with disease outcomes. However, the physiological mechanisms underlying these AMH-disease associations are largely unknown.
Reduced cardiovascular risks in women with endometriosis or polycystic ovary syndrome carrying a common functional IGF1R variant
Mark J Powell, Sophia Fuller, Erica P Gunderson, Christopher C Benz
doi : 10.1093/humrep/deac059
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 1083–1094
Women with endometriosis or PCOS have been shown to have an increased future risk of CVD and associated risk factors with limited predictive ability.
Risk of contamination with SARS-CoV-2 in ART
Gábor Vajta, Catello Scarica, Lodovico Parmegiani
doi : 10.1093/humrep/deac053
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 1095–1096
Reply: Risk of contamination with SARS-CoV-2 in ART
I Demeestere, E Van den Abbeel, A Delbaere
doi : 10.1093/humrep/deac054
Human Reproduction, Volume 37, Issue 5, May 2022, Page 1096
Large randomized controlled trials in reproductive medicine: another battle won by biases and confounders?
Stefano Palomba
doi : 10.1093/humrep/deac055
Human Reproduction, Volume 37, Issue 5, May 2022, Page 1097
Acupuncture for insulin sensitivity in women with polycystic ovary syndrome
Hongxia Ma, Min Hu, Qidan Wen, Elisabet Stener-Victorin
doi : 10.1093/humrep/deac056
Human Reproduction, Volume 37, Issue 5, May 2022, Pages 1098–1100
