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Balancing embryo donation and double gamete donation
Guido Pennings
doi : 10.1093/humrep/deab273
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 389–392
Huele and colleagues started a debate on the comparison between embryo donation and double donation. Although I largely agree with their final conclusion, I believe that the perspective of the recipients needs to be added to get a more complete picture.
External validation of a frequently used prediction model for ongoing pregnancy in couples with unexplained recurrent pregnancy loss
A Youssef, M L P van der Hoorn, M Dongen, J Visser, K Bloemenkamp, J van Lith, N van Geloven, E E L O Lashley
doi : 10.1093/humrep/deab264
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 393–399
In 50–75% of couples with RPL, no risk factor or cause can be determined and RPL remains unexplained. Clinical management in RPL is primarily focused on providing supportive care, in which counselling on prognosis is a main pillar.
Fluorescence lifetime imaging microscopy (FLIM) detects differences in metabolic signatures between euploid and aneuploid human blastocysts
Jaimin S Shah, Marta Venturas, Tim H Sanchez, Alan S Penzias, Daniel J Needleman, Denny Sakkas
doi : 10.1093/humrep/deac016
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 400–410
Prior studies have demonstrated that FLIM can detect metabolic differences in mouse oocytes and embryos and in discarded human blastocysts.
Metabolic state of human blastocysts measured by fluorescence lifetime imaging microscopy
Marta Venturas, Jaimin S Shah, Xingbo Yang, Tim H Sanchez, William Conway, Denny Sakkas, Dan J Needleman
doi : 10.1093/humrep/deab283
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 411–427
Mammalian embryos undergo large changes in metabolism over the course of preimplantation development.
Impact of uterine malformations on pregnancy and neonatal outcomes of IVF/ICSI–frozen embryo transfer
Jiaxin Qiu, Tong Du, Chen Chen, Qifeng Lyu, Ben W Mol, Ming Zhao, Yanping Kuang
doi : 10.1093/humrep/deac003
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 428–446
Several studies have investigated the negative effects of uterine malformations on pregnancy outcomes. However, an all-round and definitive conclusion has not been reached yet owing to the relatively low incidence of the disease and the heterogeneity of study populations, especially among women undergoing ART.
The extracellular vesicular pseudogene LGMNP1 induces M2-like macrophage polarization by upregulating LGMN and serves as a novel promising predictive biomarker for ovarian endometriosis recurrence
S G Sun, J J Guo, X Y Qu, X Y Tang, Y Y Lin, K Q Hua, J J Qiu
doi : 10.1093/humrep/deab266
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 447–465
Extracellular vesicles (EVs) can mediate cell-to-cell crosstalk to promote disease progression via cargo molecule transport. Recently, LGMNP1, a newly identified pseudogene of LGMN, has been reported to promote cancer progression by upregulating LGMN. LGMN is a well-studied protein that can induce M2-like polarization.
Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform
Franz S Gruber, Zoe C Johnston, Neil R Norcross, Irene Georgiou, Caroline Wilson, Kevin D Read, Ian H Gilbert, Jason R Swedlow, Sarah Martins da Silva, Christopher L R Barratt
doi : 10.1093/humrep/deac007
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 466–475,
Several efforts to find small molecules modulating sperm function have been performed but none have used high-throughput technology.
Elective freezing of embryos versus fresh embryo transfer in IVF: a multicentre randomized controlled trial in the UK (E-Freeze)
Abha Maheshwari, Jennifer L Bell, Priya Bhide, Daniel Brison, Tim Child, Huey Yi Chong, Ying Cheong, Christina Cole, Arri Coomarasamy, Rachel Cutting, Pollyanna Hardy, Haitham Hamoda, Edmund Juszczak, Yacoub Khalaf, Jennifer J Kurinczuk, Stuart Lavery, Louise Linsell, Nick Macklon, Raj Mathur, Jyotsna Pundir, Nick Raine-Fenning, Madhurima Rajkohwa, Graham Scotland, Kayleigh Stanbury, Stephen Troup, Siladitya Bhattacharya
doi : 10.1093/humrep/deab279
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 476–487
The policy of freezing all embryos followed by frozen embryo transfer is associated with a higher live birth rate for high responders but a similar/lower live birth after first embryo transfer and cumulative live birth rate for normal responders.
Talking about possible IVF/ICSI failure and need for multiple cycles in treatment planning: qualitative investigation of multi-cycle planning and its acceptability to patients and staff
C Harrison, J Boivin, S Gameiro
doi : 10.1093/humrep/deab278
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 488–498
Many patients need more than one round of IVF/ICSI stimulation to achieve their parenthood goals. About 60% of patients are willing to plan for multiple cycles of treatment in advance of treatment engagement.
Parent–child relationship quality and child psychological adjustment in families created using egg donation: children’s perspectives at age 5 years
S Imrie, J Lysons, V Jadva, K Shaw, J Grimmel, S Golombok
doi : 10.1093/humrep/deab265
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 499–509
Little is known about how children in families created through egg donation view their family relationships and their own psychological well-being.
National survey of donor-conceived individuals who requested information about their sperm donor—experiences from 17 years of identity releases in Sweden
Claudia Lampic, Agneta Skoog Svanberg, Johannes Gudmundsson, Pia Leandersson, Nils-Gunnar Solensten, Ann Thurin-Kjellberg, Kjell Wånggren, Gunilla Sydsjö
doi : 10.1093/humrep/deab275
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 510–521
In 1985, Sweden was the first country worldwide to enact legislation that gave DC individuals the right to obtain identifying information about their donor. Since then, identity-release gamete donation has become available in many countries but there is limited knowledge about the individuals who request donor information.
Quantification of residual cryoprotectants and cytotoxicity in thawed bovine ovarian tissues after slow freezing or vitrification
Yodo Sugishita, Lingbo Meng, Yuki Suzuki-Takahashi, Sandy Nishimura, Sayako Furuyama, Atsushi Uekawa, Akiko Tozawa-Ono, Junko Migitaka-Igarashi, Tomoe Koizumi, Hibiki Seino, Yasunori Natsuki, Manabu Kubota, Junki Koike, Keisuke Edashige, Nao Suzuki
doi : 10.1093/humrep/deab274
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 522–533
Ovarian tissue cryopreservation (OTC) by slow freezing has been the conventional method; while the vitrification method has gained popularity for its practicality. The main concern about vitrification is how much potentially toxic residual cryoprotectant remains in the warmed tissues at the time of transplantation.
The effect of Covid-19 mRNA vaccine on serum anti-Müllerian hormone levels
A Mohr-Sasson, J Haas, S Abuhasira, M Sivan, H Doitch Amdurski, T Dadon, S Blumenfeld, E Derazne, R Hemi, R Orvieto, A Afek, J Rabinovici
doi : 10.1093/humrep/deab282
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 534–541
A possible impact of SARS-CoV-2 infection or vaccination through an interaction between the oocyte and the somatic cells could not be ruled out, however, data are limited.
Effect of acupuncture and metformin on insulin sensitivity in women with polycystic ovary syndrome and insulin resistance: a three-armed randomized controlled trial
Qidan Wen, Min Hu, Maohua Lai, Juan Li, Zhenxing Hu, Kewei Quan, Jia Liu, Hua Liu, Yanbing Meng, Suling Wang, Xiaohui Wen, Chuyi Yu, Shuna Li, Shiya Huang, Yanhua Zheng, Han Lin, Xingyan Liang, Lingjing Lu, Zhefen Mai, Chunren Zhang, Taixiang Wu, Ernest H Y Ng, Elisabet Stener-Victorin, Hongxia Ma
doi : 10.1093/humrep/deab272
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 542–552
Uncontrolled trials have shown that acupuncture improved insulin sensitivity with fewer side effects compared with metformin in women with PCOS and IR. However, data from randomized trials between acupuncture and metformin or sham acupuncture are lacking.
Association of severity of menstrual dysfunction with hyperinsulinemia and dysglycemia in polycystic ovary syndrome
U Ezeh, M D Pisarska, R Azziz
doi : 10.1093/humrep/deac001
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 553–564
PCOS is associated with metabolic dysregulation including insulin resistance (IR) and hyperinsulinemia, risk factors for type 2 diabetes mellitus (T2DM) and other vascular-metabolic morbidities. Although the severity of menstrual cyclicity is associated with IR in PCOS, it is unclear whether, and to what extent, it is related to hyperinsulinemia and glycemic abnormalities.
Editor’s Choice: Modelling chance of pregnancy in the general population
Cornelis (Nils) Lambalk
doi : 10.1093/humrep/deac037
Human Reproduction, Volume 37, Issue 3, March 2022, Page e1
Predictive models of pregnancy based on data from a preconception cohort study
Jennifer J Yland, Taiyao Wang, Zahra Zad, Sydney K Willis, Tanran R Wang, Amelia K Wesselink, Tammy Jiang, Elizabeth E Hatch, Lauren A Wise, Ioannis Ch Paschalidis
doi : 10.1093/humrep/deab280
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 565–576
Earlier work has focused primarily on identifying individual risk factors for infertility. Several predictive models have been developed in subfertile populations, with relatively low discrimination (AUC: 59–64%).
Ovarian stimulation for fertility treatments and risk of breast cancer: a matched cohort study
R Machtinger, N Fallach, I Goldstein, G Chodick, E Schiff, R Orvieto, R Mashiach
doi : 10.1093/humrep/deab270
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 577–585
Studies investigating breast cancer risk in women who have undergone fertility treatments have provided conflicting results.
Pre-eclampsia in pregnancies resulting from oocyte donation, natural conception or IVF: a systematic review and meta-analysis
A Keukens, M van Wely, C van der Meulen, M H Mochtar
doi : 10.1093/humrep/deab267
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 586–599
The indication for OD is expanding to lesbian women requesting shared lesbian motherhood. Previous reviews have shown that the risk of PE is higher in pregnancies after OD than after NC and after IVF with AO.
Cardiovascular function in 8- to 9-year-old singletons born after ART with frozen and fresh embryo transfer
I Mizrak, L L Asserhøj, M A V Lund, L R Kielstrup, G Greisen, T D Clausen, K M Main, R B Jensen, N G Vejlstrup, P L Madsen, A Pinborg
doi : 10.1093/humrep/deab284
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 600–611
ART has been suggested to influence cardiovascular risk factors (i.e. endothelial dysfunction, increased arterial blood pressure and insulin resistance). It is not known if ART procedures alter arterial stiffness in singletons.
Bi-allelic mutations in MOS cause female infertility characterized by preimplantation embryonic arrest
Yang Zeng, Juanzi Shi, Shiru Xu, Rong Shi, Tonghua Wu, Hongyan Li, Xia Xue, Yuanchang Zhu, Biaobang Chen, Qing Sang, Lei Wang
doi : 10.1093/humrep/deab281
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 612–620
MOS, an activator of mitogen-activated protein kinase, mediates germinal vesicle breakdown and metaphase II arrest. Female MOS knockout mice are viable but sterile. Thus, MOS seems to be an important part of the mammalian cell cycle mechanism that regulates female meiosis.
A single cut-off value of anti-Müllerian hormone should not be used for the diagnosis of PCOS in all reproductive-aged women
Fatemeh Mahboobifard, Maryam Rahmati, Fahimeh Ramezani Tehrani
doi : 10.1093/humrep/deac012
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 621–622,
The utilization of accurate body mass index classification is imperative for grouping based on BMI
Xuzhi Liang, Jiangtao Fan
doi : 10.1093/humrep/deab276
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 622–623
Reply: A single cut-off value of anti-Mullerian hormone should not be used for the diagnosis of PCOS in all reproductive-aged women
Robin J Bell, Rakibul M Islam, Marina A Skiba, Susan R Davis
doi : 10.1093/humrep/deac013
Human Reproduction, Volume 37, Issue 3, March 2022, Page 622
Reply: The utilization of accurate body mass index classification is imperative for grouping based on BMI
�lvaro Hernáez, Maria Christine Magnus
doi : 10.1093/humrep/deab277
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 623–624
#ESHREjc report: Catch 22—is PGT a number game? Efficacy of PGT and the importance of counselling
Juan J Fraire-Zamora, Munevver Serdarogullari, Florian Kohlhepp, Kashish Sharma, Mina Popovic, Aïda Pujol, George Liperis
doi : 10.1093/humrep/deab286
Human Reproduction, Volume 37, Issue 3, March 2022, Pages 625–627
