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Why double ovarian stimulation in an in vitro fertilization cycle is potentially unsafe
Angelo Tocci
doi : 10.1093/humrep/deab259
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 199–202
The occurrence of two antral follicle recruitment waves in a single inter-ovulatory interval has been detected in ovaries of normal women.
Peritoneal fluid progesterone and progesterone resistance in superficial endometriosis lesions
Philippe R Koninckx, Anastasia Ussia, Leila Adamyan, Victor Gomel, Dan C Martin
doi : 10.1093/humrep/deab258
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 203–211
Peritoneal fluid in ovulatory women is an ovarian exudate with higher estrogen and progesterone concentrations than in plasma. In the follicular phase, progesterone concentrations are as high as plasma concentrations in the luteal phase.
Characterization and comparison of commercial oils used for human embryo culture
E Mestres, Q Matia-Algué, A Villamar, A Casals, M Acacio, M GarcÃa-Jiménez, A MartÃnez-Casado, C Castelló, G Calderón, N Costa-Borges
doi : 10.1093/humrep/deab245
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 212–225
Mineral oil is a critical component of the human culture system due to its protective and stabilizing roles during in vitro embryo development. Many different oils are available on the market, with differences in their viscosity, density and overall quality.
Aneuploidy rates and morphokinetic parameters of embryos cultured in distinct culture media: a sibling oocyte study
Molly M Quinn, Philip Marsh, Salustiano Ribeiro, Rhodel K Simbulan, Cristina Hickman, Jørgen Berntsen, Mitchell P Rosen
doi : 10.1093/humrep/deab253
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 226–234
Studies on the effect of commercially available embryo culture media systems have demonstrated inconsistent impact on human embryonic development, morphokinetics, aneuploidy rates and clinical outcomes.
Risk of contamination of semen, vaginal secretions, follicular fluid and ovarian medulla with SARS-CoV-2 in patients undergoing ART
K Kteily, D Pening, P Diaz Vidal, M Devos, J Dechene, A Op de Beeck, A Botteaux, S Janssens, E Van den Abbeel, O Goldrat, A Delbaere, I Demeestere
doi : 10.1093/humrep/deab255
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 235–241
The SARS-CoV-2 pandemic had a huge impact on the activities of fertility clinics. Although some studies reported the presence of SARS-CoV-2 mRNA in the reproductive system during or after acute COVID-19 symptomatic infections, uncertainties remain regarding the presence of viral mRNA in the reproductive material and follicular fluid of asymptomatic patients undergoing ART.
In vitro maturation without gonadotropins versus in vitro fertilization with hyperstimulation in women with polycystic ovary syndrome: a non-inferiority randomized controlled trial
Xiaoying Zheng, Wei Guo, Lin Zeng, Danni Zheng, Shuo Yang, Yalan Xu, Lina Wang, Rui Wang, Ben Willem Mol, Rong Li, Jie Qiao
doi : 10.1093/humrep/deab243
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 242–253
IVM is an emerging alternative treatment for women with PCOS who need assisted reproductive technology. Since a minimal or even zero dose of gonadotropins are required in the IVM procedure, the occurrence of ovarian hyperstimulation syndrome (OHSS) is eliminated.
Economic evaluation of endometrial scratching before the second IVF/ICSI treatment: a cost-effectiveness analysis of a randomized controlled trial (SCRaTCH trial)
N E van Hoogenhuijze, R van Eekelen, F Mol, I Schipper, E R Groenewoud, M A F Traas, C A H Janssen, G Teklenburg, J P de Bruin, R H F van Oppenraaij, J W M Maas, E Moll, K Fleischer, M H A van Hooff, C H de Koning, A E P Cantineau, C B Lambalk, M Verberg, A M van Heusden, A P Manger, M M E van Rumste, L F van der Voet, Q D Pieterse, J Visser, E A Brinkhuis, J E den Hartog, M W Glas, N F Klijn, M van der Zanden, M L Bandell, J C Boxmeer, J van Disseldorp, J Smeenk, M van Wely, M J C Eijkemans, H L Torrance, F J M Broekmans
doi : 10.1093/humrep/deab261
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 254–263
Endometrial scratching is thought to improve the chances of success in couples with previously failed embryo implantation in IVF/ICSI treatment.
Predictors of self-compassion in endometriosis: the role of psychological health and endometriosis symptom burden
L Van Niekerk, L Johnstone, M Matthewson
doi : 10.1093/humrep/deab257
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 264–273
Existing research indicates that endometriosis is associated with reduced psychological health and varied endometriosis-related symptom profiles.
Striving for motherhood after uterus transplantation: a qualitative study concerning pregnancy attempts, and the first years of parenthood after transplantation
Stina Järvholm, Hans Bokström, Anders Enskog, Catrina Hammarling, Pernilla Dahm-Kähler, Mats Brännström
doi : 10.1093/humrep/deab260
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 274–283
UTx has proven to be a successful treatment for absolute uterine factor infertility (AUFI). Although UTx seems to have a positive effect on self-image there is a lack of knowledge about how women who have received uterine grafts experience pregnancy attempts, pregnancy itself and the first years of motherhood.
Identifying and optimizing human endometrial gene expression signatures for endometrial dating
P Diaz-Gimeno, P Sebastian-Leon, J M Sanchez-Reyes, K Spath, A Aleman, C Vidal, A Devesa-Peiro, E Labarta, I Sánchez-Ribas, M Ferrando, G Kohls, J A GarcÃa-Velasco, E Seli, D Wells, A Pellicer
doi : 10.1093/humrep/deab262
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 284–296
Among the new generation of transcriptomic endometrial dating (TED) tools developed in the last decade, there exists variation in the technology used for measuring gene expression, the gene makeup and the prediction model design.
Histological study on the influence of puberty suppression and hormonal treatment on developing germ cells in transgender women
I de Nie, C L Mulder, A Meißner, Y Schut, E M Holleman, W B van der Sluis, S E Hannema, M den Heijer, J Huirne, A M M van Pelt, N M van Mello
doi : 10.1093/humrep/deab240
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 297–308
Gender affirming treatment (i.e. puberty suppression, hormonal treatment, and subsequent orchiectomy) impairs reproductive function in transgender women.
Impact of letrozole co-treatment during ovarian stimulation with gonadotrophins for IVF: a multicentre, randomized, double-blinded placebo-controlled trial
Nathalie Søderhamn Bülow, Sven Olaf Skouby, Agnieszka Katarzyna Warzecha, Hanne Udengaard, Claus Yding Andersen, Marianne Dreyer Holt, Marie Louise Grøndahl, Anders Nyboe Andersen, Negjyp Sopa, Anne Lis Englund Mikkelsen, Anja Pinborg, Nicholas Stephen Macklon
doi : 10.1093/humrep/deab249
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 309–321
IVF creates multiple follicles with supraphysiological levels of sex steroids interrupting the endocrine milieu and affects the window of implantation. Letrozole is an effective aromatase inhibitor, normalizing serum oestradiol, thereby ameliorating some of the detrimental effects of IVF treatment.
The association between miscarriage and fecundability: the Norwegian Mother, Father and Child Cohort Study
Lise A Arge, Siri E Håberg, Allen J Wilcox, Øyvind Næss, Olga Basso, Maria C Magnus
doi : 10.1093/humrep/deab252
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 322–332
Although miscarriage and low fecundability share common risk factors, prior studies have reported both lower and higher fecundability after miscarriage.
The relation of number of childbirths with age at natural menopause: a population study of 310 147 women in Norway
Marthe S Gottschalk, Anne Eskild, Solveig Hofvind, Elisabeth K Bjelland
doi : 10.1093/humrep/deab246
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 333–340
Pregnancies interrupt ovulation, and a high number of pregnancies have therefore been assumed to delay menopause.
Menstrual cycle characteristics and incident cancer: a prospective cohort study
Siwen Wang, Yi-Xin Wang, Helena Sandoval-Insausti, Leslie V Farland, Jan L Shifren, Dan Zhang, JoAnn E Manson, Brenda M Birmann, Walter C Willett, Edward L Giovannucci, Stacey A Missmer, Jorge E Chavarro
doi : 10.1093/humrep/deab251
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 341–351
Long and irregular menstrual cycles have been associated with lower risk of pre-menopausal breast cancer and higher risk of endometrial cancer, but associations with other malignancies are less clear.
Leveraging Northern European population history: novel low-frequency variants for polycystic ovary syndrome
Jaakko S Tyrmi, Riikka K Arffman, Natà lia Pujol-Gualdo, Venla Kurra, Laure Morin-Papunen, Eeva Sliz, FinnGen Consortium, Estonian Biobank Research Team, Terhi T Piltonen, Triin Laisk, Johannes Kettunen, Hannele Laivuori
doi : 10.1093/humrep/deab250
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 352–365
PCOS is a common, complex disorder with unknown aetiology. While previous genome-wide association studies (GWAS) have mapped several loci associated with PCOS, the analysis of populations with unique population history and genetic makeup has the potential to uncover new low-frequency variants with larger effects.
Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways
E O Adewuyi, D Mehta, International Endogene Consortium (IEC) , 23andMe Research Team , D R Nyholt
doi : 10.1093/humrep/deab254
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 366–383
Role of platelets in female reproduction
József Bódis
doi : 10.1093/humrep/deab268
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 384–385
Reply: Is there a role for platelets in female reproduction
Roger Sturmey, Lloyd Atkinson, Francesa Martin
doi : 10.1093/humrep/deab269
Human Reproduction, Volume 37, Issue 2, February 2022, Page 385
#ESHREjc report: trick or treatment—evidence based use of add-ons in ART and patient perspectives
George Liperis, Juan J Fraire-Zamora, Sofia Makieva, Claudia Massarotti, Zoya Enakshi Ali, Florian Kohlhepp, Omar Farhan Ammar, Raj Mathur, Christos Venetis, Anita Fincham, Munevver Serdarogullari
doi : 10.1093/humrep/deab271
Human Reproduction, Volume 37, Issue 2, February 2022, Pages 386–388
