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An ounce of prevention is worth a pound of cure: time to focus on preconception workplace reproductive health
Carmen Messerlian, Yu Zhang, Yang Sun, Yixin Wang, Vicente Mustieles
doi : 10.1093/humrep/deab263
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 1–4
Effects of COVID-19 and mRNA vaccines on human fertility
Fei Chen, Shiheng Zhu, Zhiqing Dai, Lanting Hao, Chun Luan, Qi Guo, Chaofan Meng, Yankun Zhang
doi : 10.1093/humrep/deab238
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 5–13
The coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has precipitated a global health crisis of unprecedented proportions.
Non-invasive, label-free optical analysis to detect aneuploidy within the inner cell mass of the preimplantation embryo
Tiffany C Y Tan, Saabah B Mahbub, Jared M Campbell, Abbas Habibalahi, Carl A Campugan, Ryan D Rose, Darren J X Chow, Sanam Mustafa, Ewa M Goldys, Kylie R Dunning
doi : 10.1093/humrep/deab233
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 14–29
Euploid/aneuploid mosaicism affects up to 17.3% of human blastocyst embryos with trophectoderm biopsy or spent media currently utilized to diagnose aneuploidy and mosaicism in clinical in vitro fertilization.
Positive effects of amphiregulin on human oocyte maturation and its molecular drivers in patients with polycystic ovary syndrome
Nazli Akin, Anh H Le, Uyen D T Ha, Sergio Romero, Flor Sanchez, Toan D Pham, Minh H N Nguyen, Ellen Anckaert, Tuong M Ho, Johan Smitz, Lan N Vuong
doi : 10.1093/humrep/deab237
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 30–43
Amphiregulin concentration in follicular fluid is correlated with human oocyte developmental competence. Amphiregulin added to the meiotic trigger has been shown to improve outcomes of IVM in a range of mammalian species.
Fertility status among long-term childhood acute lymphoblastic leukaemia survivors enrolled between 1971 and 1998 in EORTC CLG studies: results of the 58 Late Adverse Effects study
Giovanna Rossi, Michal Kicinski, Stefan Suciu, Els Vandecruys, Geneviève Plat, Anne Uyttebroeck, Catherine Paillard, Mélissa Barbati, Marie-Françoise Dresse, Pauline Simon, Odile Minckes, Claire Pluchart, Alina Ferster, Claire Freycon, Frederic Millot, Jutte van der Werff ten Bosch, Christophe Chantrain, Robert Paulus, Teresa de Rojas, Gaetan de Schaetzen, Pierre Rohrlich, Yves Benoit, Caroline Piette
doi : 10.1093/humrep/deab236
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 44–53
Survival after childhood ALL is currently >90% and fertility impairments are among the main concerns of the long-term survivors.
Association of mode of delivery with offspring pubertal development in Project Viva: a prospective pre-birth cohort study in the USA
Izzuddin M Aris, Sheryl L Rifas-Shiman, Lidia MÃnguez-Alarcón, Joanne E Sordillo, Marie-France Hivert, Emily Oken, Jorge E Chavarro
doi : 10.1093/humrep/deab235
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 54–65
Cesarean delivery is posited to have long-term effects on health outcomes. However, few studies have examined whether mode of delivery is related to pubertal development.
Extensive analysis of mitochondrial DNA quantity and sequence variation in human cumulus cells and assisted reproduction outcomes
Kishlay Kumar, Marta Venturas, Daniel J Needleman, Catherine Racowsky, Dagan Wells
doi : 10.1093/humrep/deab231
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 66–79
CCs fulfil a vital role in the support of oocyte developmental competence. As with other cell types, appropriate cellular function is likely to rely upon adequate energy production, which in turn depends on the quantity and genetic competence of the mitochondria.
The impact of maternal age on gene expression during the GV to MII transition in euploid human oocytes
P Ntostis, D Iles, G Kokkali, T Vaxevanoglou, E Kanavakis, A Pantou, J Huntriss, K Pantos, H M Picton
doi : 10.1093/humrep/deab226
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 80–92
Early embryonic development is dependent on maternal transcripts accumulated and stored within the oocyte during oogenesis. Transcriptional activity of the oocyte, which dictates its ultimate developmental potential, may be influenced by age and explain the reduced competence of advanced maternal age (AMA) oocytes compared with the young maternal age (YMA).
Scribble downregulation in adenomyosis compromises endometrial stromal decidualization by decreasing FOXO1 expression
Yaoming Peng, Xiaoxia Liu, Zhixing Jin, Haiou Liu, Congjian Xu
doi : 10.1093/humrep/deab234
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 93–108
Stromal SCRIB is required for primary decidual zone formation and pregnancy success in mice. In our previous studies, decidualization was dampened in ESC isolated from adenomyosis patients, yet the underlying molecular mechanisms remain elusive.
Substituting serum anti-Müllerian hormone for polycystic ovary morphology increases the number of women diagnosed with polycystic ovary syndrome: a community-based cross-sectional study
Robin J Bell, Rakibul M Islam, Marina A Skiba, Dilinie Herbert, Alejandra Martinez Garcia, Susan R Davis
doi : 10.1093/humrep/deab232
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 109–118
AMH has been proposed as an alternative to PCOM as a diagnostic component of PCOS. Previous studies are limited by poorly defining PCOS, use of infertile women as comparators, measurement of hormones by immunoassay that lack precision in the female range, low-resolution ovarian ultrasound and inconsistent handling and storage of serum samples.
Developmental stage and morphology of the competent blastocyst are associated with sex of the child but not with other obstetric outcomes: a multicenter cohort study
M B Borgstrøm, U S Kesmodel, T W Klausen, A K Danielsen, T Thomsen, A Gabrielsen, A L M Englund, A Zedeler, B B Povlsen, B Troest, G J Almind, J Fedder, J Kirk, J Hindkjær, J G Lemmen, K Petersen, K Haahr, M R Petersen, S Laursen, U B Knudsen, U Bentin-Ley, T Larsen, M I Grøndahl
doi : 10.1093/humrep/deab242
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 119–128
The association between blastocyst assessment scores and obstetric outcomes have been reported in small single-center studies and the results are conflicting.
Weight gain and lifestyle factors in women with and without polycystic ovary syndrome
Mamaru Ayenew Awoke, Arul Earnest, Anju E Joham, Allison M Hodge, Helena J Teede, Wendy J Brown, Lisa J Moran
doi : 10.1093/humrep/deab239
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 129–141
Women with PCOS have a higher prevalence of overweight/obesity and greater weight gain than women without PCOS. The association of lifestyle factors with weight change in PCOS is not known.
Maternal occupational exposure to endocrine-disrupting chemicals and urogenital anomalies in the offspring
N Spinder, J E H Bergman, M van Tongeren, H M Boezen, H Kromhout, H E K de Walle
doi : 10.1093/humrep/deab205
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 142–151
Previous studies showed an association between maternal occupational exposure to EDCs and hypospadias. However, little is known about the effect of these chemicals on the development of CAKUT, especially subgroups of urinary tract anomalies.
Whole-exome sequencing of a cohort of infertile men reveals novel causative genes in teratozoospermia that are chiefly related to sperm head defects
Yaqian Li, Yan Wang, Yuting Wen, Tao Zhang, Xiaodong Wang, Chuan Jiang, Rui Zheng, Fan Zhou, Daijuan Chen, Yihong Yang, Ying Shen
doi : 10.1093/humrep/deab229
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 152–177
Teratozoospermia is one of the most common factors causing male infertility. Owing to high phenotypic variability, currently known genetic causes of teratozoospermia can only explain a rather minor component for patients with anomalous sperm-head shapes, and the agents responsible for atypical sperm head shapes remain largely unknown.
Bi-allelic variants in DNA mismatch repair proteins MutS Homolog MSH4 and MSH5 cause infertility in both sexes
M J Wyrwoll, E S van Walree, G Hamer, N Rotte, M M Motazacker, H Meijers-Heijboer, M Alders, A Meißner, E Kaminsky, M Wöste, C Krallmann, S Kliesch, T J Hunt, A T Clark, S Silber, B Stallmeyer, C Friedrich, A M M van Pelt, I B Mathijssen, F Tüttelmann
doi : 10.1093/humrep/deab230
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 178–189
MSH4 and MSH5 form a heterodimer, which is required for prophase of meiosis I. One variant in MSH5 and two variants in MSH4 have been described as causal for premature ovarian insufficiency (POI) in a total of five women, resulting in infertility.
Antithrombotic therapy for live birth in women with recurrent pregnancy loss: do not confound available high-level evidence
Luuk J J Scheres, Saskia Middeldorp, Mariëtte Goddijn
doi : 10.1093/humrep/deab247
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 190–191
Reply: The pathway to the ‘truth’ in the study of recurrent pregnancy loss and thrombophilia
Elvira Grandone, Gregory Piazza
doi : 10.1093/humrep/deab248
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 191–193
Comment on the grouping of patients with polycystic ovary syndrome based on body mass index
Jie Wei
doi : 10.1093/humrep/deab244
Human Reproduction, Volume 37, Issue 1, January 2022, Page 193
Reply: Association of maternal polycystic ovary syndrome or anovulatory infertility with obesity and diabetes in offspring: a population-based cohort study
Xinxia Chen, Emilia Koivuaho, Terhi T Piltonen, Mika Gissler, Catharina Lavebratt
doi : 10.1093/humrep/deab256
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 193–194
#ESHREjc live edition report: ‘the forgotten Y’—advanced paternal age from a global health perspective
Claudia Massarotti, Julia Uraji, Zoya Enakshi Ali, Munevver Serdarogullari, Sofia Makieva, George Liperis, Florian Kohlhepp, Juan J Fraire-Zamora, Omar Farhan Ammar, Christopher Barratt, Sarah Martins da Silva, Mina Mincheva
doi : 10.1093/humrep/deab241
Human Reproduction, Volume 37, Issue 1, January 2022, Pages 195–197
