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Novel insights into reproductive ageing and menopause from genomics
Arunika Das, Aspasia Destouni
doi : 10.1093/humrep/deac256
Human Reproduction, Volume 38, Issue 2, February 2023, Pages 195–203
The post-reproductive phase or menopause in females is triggered by a physiological timer that depends on a threshold of follicle number in the ovary.
Separating the chaff from the wheat: antibody-based removal of DNA-fragmented sperm
L B Belardin, M P Antoniassi, M Camargo, P Intasqui, R P Bertolla
doi : 10.1093/humrep/deac260
Human Reproduction, Volume 38, Issue 2, February 2023, Pages 204–215
In bovines, ELSPBP1 is bound to dead spermatozoa. Human ejaculates with high SDF have increased detected levels of sperm ELSPBP1 when compared to ejaculates with low native SDF.
Testicular torsion and subsequent testicular function in young men from the general population
A H Hansen, L Priskorn, L S Hansen, E Carlsen, U N Joensen, F M Jacobsen, C F S Jensen, N Jørgensen
doi : 10.1093/humrep/deac271
Human Reproduction, Volume 38, Issue 2, February 2023, Pages 216–224
Testicular function may be impaired after testicular torsion, but knowledge is sparse and based on studies with small sample sizes and no control group or a less than ideal control group.
A drop in serum progesterone from oocyte pick-up +3 days to +5 days in fresh blastocyst transfer, using hCG-trigger and standard luteal support, is associated with lower ongoing pregnancy rates
Esra Uyanik, Sezcan Mumusoglu, Mehtap Polat, Irem Yarali Ozbek, Sandro C Esteves, Peter Humaidan, Hakan Yarali
doi : 10.1093/humrep/deac255
Human Reproduction, Volume 38, Issue 2, February 2023, Pages 225–236
In fresh embryo transfer cycles, significant inter-individual variation occurs in serum P4 levels during the luteal phase, possibly due to differences in endogenous P4 production after hCG trigger and/or differences in bioavailability of exogenously administered progesterone (P) via different routes.
Thin endometrial lining: is it more prevalent in patients utilizing preimplantation genetic testing for monogenic disease (PGT-M) and related to prior hormonal contraceptive use?
I Homminga, A F ter Meer, H Groen, A E P Cantineau, A Hoek
doi : 10.1093/humrep/deac258
Human Reproduction, Volume 38, Issue 2, February 2023, Pages 237–246
Thin endometrial lining has been associated with lower pregnancy rates in IVF/ICSI cycles and increased chances of miscarriage and low birth weight. Endometrial thinning and atrophy occur during hormonal contraceptive use.
COVID-19-related uncertainty: fertility staff experiences of its sources, processing, responses, and consequences
Sofia Gameiro, Kiri Armstrong, Natasha Carluke, Giuliana Baccino, Fernando Zegers-Hochschild, Jacky Boivin
doi : 10.1093/humrep/deac262
Human Reproduction, Volume 38, Issue 2, February 2023, Pages 247–255
COVID-19 created significant disruption in fertility care delivery, including temporary clinic closure and treatment delay. Patients experienced significant distress, including concerns regarding the impact of COVID-19 and its vaccine on fertility and pregnancy.
A mouse model mimicking gender-affirming treatment with pubertal suppression followed by testosterone in transmasculine youth
Cynthia Dela Cruz, Hadrian M Kinnear, Prianka H Hashim, Abigail Wandoff, Likitha Nimmagadda, Faith L Chang, Vasantha Padmanabhan, Ariella Shikanov, Molly B Moravek
doi : 10.1093/humrep/deac257
Human Reproduction, Volume 38, Issue 2, February 2023, Pages 256–265
There is limited knowledge available in transgender medicine to provide evidence-based fertility care, with the current guidelines being based on the assumption of fertility loss.
Combining metabolomics and machine learning models as a tool to distinguish non-classic 21-hydroxylase deficiency from polycystic ovary syndrome without adrenocorticotropic hormone testing
Guillaume Bachelot, Anne Bachelot, Marion Bonnier, Joe-Elie Salem, Dominique Farabos, Severine Trabado, Charlotte Dupont, Peter Kamenicky, Muriel Houang, Jean Fiet, Yves Le Bouc, Jacques Young, Antonin Lamazière
doi : 10.1093/humrep/deac254
Human Reproduction, Volume 38, Issue 2, February 2023, Pages 266–276
The clinical presentation of patients with NC21OHD is similar with that for other disorders of androgen excess. Currently, cosyntropin stimulation remains the gold standard diagnosis of NC21OHD.
Associations between maternal urinary isoflavone concentrations and anogenital distance of offspring throughout infancy: a prospective cohort study
Yao Chen, Hong Liang, Honglei Ji, Xiaowei Sun, Gengsheng He, Yan Wang, Wentao Dai, Maohua Miao, Wei Yuan
doi : 10.1093/humrep/deac234
Human Reproduction, Volume 38, Issue 2, February 2023, Pages 277–292
Evidence of the association of prenatal exposure to ISO with offspring’s AGD is mainly derived from animal studies, which used different study designs and had inconsistent results.
Selection bias in a male-offspring cohort investigating fecundity: is there reason for concern?
Anne Gaml-Sørensen, Nis Brix, Sandra Søgaard Tøttenborg, Karin Sørig Hougaard, Katia Keglberg Hærvig, Jens Peter Ellekilde Bonde, Tine Brink Henriksen, Gunnar Toft, Cecilia Høst Ramlau-Hansen
doi : 10.1093/humrep/deac241
Human Reproduction, Volume 38, Issue 2, February 2023, Pages 293–305
Participation rates in studies relying on volunteers to provide a semen sample are often very low. Many risk factors for poor male fecundity are associated with participation status, and as men with low fecundity may be more inclined to participate in studies of semen quality, a risk of selection bias exists.
A biallelic loss of function variant in HORMAD1 within a large consanguineous Turkish family is associated with spermatogenic arrest
Ozlem Okutman, Manon Boivin, Jean Muller, Nicolas Charlet-Berguerand, Stéphane Viville
doi : 10.1093/humrep/deac259
Human Reproduction, Volume 38, Issue 2, February 2023, Pages 306–314
Studying patient cohorts in small or large consanguineous families using high-throughput sequencing allows the identification of genetic causes of different pathologies, including infertility.
Two clinical case reports of embryonic mosaicism identified with PGT-A persisting during pregnancy as true fetal mosaicism
Ermanno Greco, Pavel Yakovlev, Nikolay Kornilov, Svetlana Vyatkina, Daria Bogdanova, Marina Ermakova, Yulia Tarasova, Andrei Tikhonov, Anna Pendina, Anil Biricik, Maria Teresa Sessa, Ilaria Listorti, Carlo Ronsini, Pier Francesco Greco, Andrea Victor, Frank Barnes, Christo Zouves, Francesca Spinella, Manuel Viotti
doi : 10.1093/humrep/deac263
Human Reproduction, Volume 38, Issue 2, February 2023, Pages 315–323
The health risks associated with transferring embryos classified as mosaic by preimplantation genetic testing for aneuploidies (PGT-A) are currently unknown.
#ESHREjc report: failed fertilization: is genetic incompatibility the elephant in the room?
Sofia Makieva, Juan J Fraire-Zamora, Mina Mincheva, Julia Uraji, Zoya E Ali, Omar F Ammar, George Liperis, Munevver Serdarogullari, Enrica Bianchi, Jonathan Pettitt, Karen Sermon, Siladitya Bhattacharya, Claudia Massarotti
doi : 10.1093/humrep/deac265
Human Reproduction, Volume 38, Issue 2, February 2023, Pages 324–327
Correction to: P-497 Men’s attitude towards two fertility education interventions and preferences for future fertility awareness initiatives
doi : 10.1093/humrep/deac270
Human Reproduction, Volume 38, Issue 2, February 2023, Page 328
