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Routine double-ovarian-stimulation (DuoStim) in poor responders lacks rationale, evidence, and follow-up
Angelo Tocci, David Barad, Krzysztof �ukaszuk, Raoul Orvieto International Do No Harm Group in IVF (IDNHG-IVF)
doi : 10.1093/humrep/dead002
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 329–333
The emerging role of extracellular vesicles in the testis
Yi Ma, Qin-Wen Ma, Yun Sun, Xiang-Feng Chen
doi : 10.1093/humrep/dead015
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 334–351
Extracellular vesicles (EVs) are nano-sized membrane-bounded particles, released by all cells and capable of transporting bioactive cargoes, proteins, lipids, and nucleic acids, to regulate a variety of biological functions. Seminal plasma is enriched in EVs, and extensive evidence has revealed the role of EVs (e.g. prostasomes and epididymosomes) in the male genital tract.
An analysis of the outcome of 11Â 712 men applying to be sperm donors in Denmark and the USA
Allan A Pacey, Guido Pennings, Edgar Mocanu, Janne Rothmar, Anja Pinborg, Stine Willum Adrian, Corey Burke, Anne-Bine Skytte
doi : 10.1093/humrep/deac264
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 352–358
The successful recruitment of sperm donors is essential to provide a range of medically assisted reproduction (MAR) procedures, which rely upon donor sperm.
Childhood cancer and hematological disorders negatively affect spermatogonial quantity at diagnosis: a retrospective study of a male fertility preservation cohort
Ieva Masliukaite, Elissavet Ntemou, Elizabeth A M Feijen, Marianne van de Wetering, Andreas Meissner, Alexandre T Soufan, Sjoerd Repping, Leontien M C Kremer, Kirsi Jahnukainen, Ellen Goossens, Ans M M van Pelt
doi : 10.1093/humrep/dead004
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 359–370
Fertility preservation in pediatric male patients is considered based on the gonadotoxicity of selected treatments. Although treatment effects on germ cells have been extensively investigated, limited data are available on the effect of the disease on the prepubertal male gonad. Of the few studies investigating the effects of cancer or hematologic disorders on testicular function and germ cell quantity in prepuberty, the results are inconsistent.
Condensation and protamination of sperm chromatin affect ICSI outcomes when gametes from healthy individuals are used
Jordi Ribas-Maynou, Sergi Novo, Albert Salas-Huetos, Sergi Rovira, Marta Antich, Marc Yeste
doi : 10.1093/humrep/deac261
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 371–386
Previous data on how sperm chromatin damage affects ICSI outcomes are inconsistent. Revealing which sperm factors influence embryo development is necessary to understand the male contribution to ICSI success and to develop novel sperm selection techniques or male-based treatments.
Maternal age affects pronuclear and chromatin dynamics, morula compaction and cell polarity, and blastulation of human embryos
Kenji Ezoe, Tetsuya Miki, Hikari Akaike, Kiyoe Shimazaki, Tsubasa Takahashi, Yuko Tanimura, Ayumi Amagai, Ayano Sawado, Mai Mogi, Shigeru Kaneko, Satoshi Ueno, Giovanni Coticchio, Danilo Cimadomo, Andrea Borini, Laura Rienzi, Keiichi Kato
doi : 10.1093/humrep/dead001
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 387–399
In ART, advanced maternal age (AMA) affects oocyte yield, fertilization, and overall developmental competence. However, with the exception of chromosome segregation errors occurring during oocyte meiosis, the molecular and biochemical mechanisms responsible for AMA-related subfertility and reduced embryo developmental competence remain unclear
Sperm cryopreservation does not affect live birth rate in normozoospermic men: analysis of 7969 oocyte donation cycles
M Torra-Massana, R Vassena, A RodrÃguez
doi : 10.1093/humrep/dead005
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 400–407
Sperm cryopreservation by slow freezing is a common practice in ART. While frozen-thawed semen typically presents reduced motility and vitality, its use for ICSI is generally considered adequate in terms of reproductive outcomes.
Impact of first chemotherapy exposure on follicle activation and survival in human cryopreserved ovarian tissue
Melody Devos, Paula Diaz Vidal, Jason Bouziotis, Ellen Anckaert, Marie-Madeleine Dolmans, Isabelle Demeestere
doi : 10.1093/humrep/dead013
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 408–420
OTC is currently the only available fertility preservation procedure for children and for patients who have already started their treatment.
Long-term outcomes of switching to gonadotrophins versus continuing with clomiphene citrate, with or without intrauterine insemination, in women with normogonadotropic anovulation and clomiphene failure: follow-up study of a factorial randomized clinical trial
E M Bordewijk, T I Jannink, N S Weiss, T de Vries, M Nahuis, A Hoek, M Goddijn, B W Mol, M van Wely, M-ovin study group
doi : 10.1093/humrep/deac268
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 421–429
CC has long been used as first line treatment for ovulation induction in women with normogonadotropic anovulation.
Qualitative evaluation of the acceptability and feasibility among healthcare professionals and patients of an ART multi-cycle treatment planning and continuation intervention prototype
C Harrison, S Gameiro, J Boivin
doi : 10.1093/humrep/deac272
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 430–443
People discontinue ART due to its psychological burden. Digital tools to support people undergoing ART are available but typically focus only on practical support rather than psychological support.
Spatio-temporal remodelling of the composition and architecture of the human ovarian cortical extracellular matrix during in vitro culture
Johanne Grosbois, Emily C Bailie, Tom W Kelsey, Richard A Anderson, Evelyn E Telfer
doi : 10.1093/humrep/dead008
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 444–458
The ovarian ECM is the scaffold within which follicles and stromal cells are organized. Its composition and structural properties constantly evolve to accommodate follicle development and expansion.
Obesity is associated with alterations in antral follicle dynamics in eumenorrheic women
Alexis L Oldfield, Heidi Vanden Brink, Faith E Carter, Brittany Y Jarrett, Marla E Lujan
doi : 10.1093/humrep/dead007
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 459–470
Ovarian antral follicle development is a dynamic process involving distinct follicular and endocrine events that are critical for the occurrence of regular monthly ovulations.
Association between body mass index, weight loss and the chance of pregnancy in women with polycystic ovary syndrome and overweight or obesity: a retrospective cohort study in the UK
Christiane Lundegaard Haase, Anette Varbo, Peter Nørkjær Laursen, Volker Schnecke, Adam H Balen
doi : 10.1093/humrep/deac267
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 471–481
Two studies in large cohorts of Danish women with the intention to become pregnant showed a decline in fecundability ratios with higher BMI. Furthermore, a meta-analysis found that overweight/obesity significantly worsened metabolic and reproductive outcomes in women with PCOS.
Management of testosterone around ovarian stimulation in transmasculine patients: challenging common practices to meet patient needs—2 case reports
Molly B Moravek, Marjorie Dixon, Samantha M Pena, Juno Obedin-Maliver
doi : 10.1093/humrep/dead003
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 482–488
Approximately 50% of transmasculine people use testosterone for gender affirmation, yet very little is known about the effects of testosterone on future reproductive capacity.
Live birth rate after female fertility preservation for cancer or haematopoietic stem cell transplantation: a systematic review and meta-analysis of the three main techniques; embryo, oocyte and ovarian tissue cryopreservation
E Fraison, S Huberlant, E Labrune, M Cavalieri, M Montagut, F Brugnon, B Courbiere
doi : 10.1093/humrep/deac249
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 489–502
Currently, fertility preservation (FP) has become a major public health issue as diagnostic and therapeutic progress has made it possible to achieve an 80% survival rate in children, adolescents and young adults with cancer.
Social disparities in the use of ART treatment: a national register-based cross-sectional study among women in Denmark
Louise Ayoe Sparvath Brautsch, Ida Voss, Lone Schmidt, Ditte Vassard
doi : 10.1093/humrep/deac247
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 503–510
Infertility is common in populations worldwide, and the approach to this issue differs between societies and healthcare systems. In the public Danish healthcare system, ART treatment is free of charge, and the direct cost for patients is therefore low.
Preclinical workup using long-read amplicon sequencing provides families with de novo pathogenic variants access to universal preimplantation genetic testing
Olga Tsuiko, Yasmine El Ayeb, Tatjana Jatsenko, Joke Allemeersch, Cindy Melotte, Jia Ding, Sophie Debrock, Karen Peeraer, Arne Vanhie, Anne De Leener, Céline Pirard, Candice Kluyskens, Ellen Denayer, Eric Legius, Joris Robert Vermeesch, Hilde Brems, Eftychia Dimitriadou
doi : 10.1093/humrep/deac273
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 511–519
Universal PGT combines genome-wide haplotyping and copy number profiling to select embryos devoid of both familial pathogenic variants and aneuploidies.
Better late than never: the clinical value of Day 7 blastocysts
Juan J Fraire-Zamora, Munevver Serdarogullari, Kashish Sharma, Omar Farhan Ammar, Mina Mincheva, Nick Macklon, Aïda Pujol, Antonio Capalbo, Marcos Meseguer, George Liperis
doi : 10.1093/humrep/deac269
Human Reproduction, Volume 38, Issue 3, March 2023, Pages 520–524
Correction: Investigation of the effects of heparin and low molecular weight heparin on E-cadherin and laminin expressions in rat pregnancy by immunohistochemistry
doi : 10.1093/humrep/dead022
Human Reproduction, Volume 38, Issue 3, March 2023, Page 525
