Cornea




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New Endothelial Corneal Dystrophy in a Chinese Family.

Ye, Minjie MD *; Lu, Qinyi MD, PhD *; Zhao, Duran MD, PhD *; Zhao, Bingying MD *; Zhang, Shengquan PhD +; Liao, Yi PhD ++; Liao, Rongfeng MD, PhD *

doi : 10.1097/ICO.0000000000003209

Volume 42(5) pgs. 529-661,e7-e8 May 2023

The aim of this study was to characterize the clinical presentation of atypical endothelial corneal dystrophy (ECD) and to identify possible associated genetic variants in a Chinese family.

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Long-Term Clinical Outcomes of Keratolimbal Allograft Alone or in Combination With Keratoplasty in Chronic and Delayed-Onset Mustard Gas Keratopathy.

Karimian, Farid MD; Jafarinasab, Mohammad-Reza MD; Feizi, Sepehr MD, MSc; Javadi, Mohammadali MD; Ansari, Mohammad-Hassan MD; Hassanpour, Kiana MD

doi : 10.1097/ICO.0000000000003066

The purpose of this study was to investigate the long-term clinical outcome of keratolimbal allograft (KLAL) alone or in combination with keratoplasty, in the management of patients with chronic and delayed-onset mustard gas keratopathy (MGK).

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Transferability of an Artificial Intelligence Algorithm Predicting Rebubblings After Descemet Membrane Endothelial Keratoplasty.

Hayashi, Takahiko MD, PhD *; Iliasian, Rosa M. +; Matthaei, Mario MD, PhD +; Schrittenlocher, Silvia MD +; Masumoto, Hiroki MD ++; Tanabe, Mao MD [S]; Tabuchi, Hitoshi MD, PhD, EMBA [P]; Siggel, Robert MD ||; Bachmann, Bjorn MD, PhD +; Cursiefen, Claus MD, PhD +; Siebelmann, Sebastian MD, PhD, MHBA +,**,++

doi : 10.1097/ICO.0000000000003049

To develop an artificial intelligence (AI) algorithm enabling corneal surgeons to predict the probability of rebubbling after Descemet membrane endothelial keratoplasty (DMEK) from images obtained using optical coherence tomography (OCT).

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Graft Survival, Graft Rejection, and Glaucoma in a Consecutive Series of Descemet Stripping Endothelial Keratoplasty.

Patel, Sanjay V. MD, FRCOphth *; Hodge, David O. MS +; Winkler, Nelson S. MD *; Maguire, Leo J. MD *; Baratz, Keith H. MD *

doi : 10.1097/ICO.0000000000003050

The goal of this study was to compare outcomes of Descemet stripping endothelial keratoplasty (DSEK) in eyes with glaucoma and abnormal anatomy to eyes with Fuchs endothelial corneal dystrophy (FECD).

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Elevated Neuropeptides in Dry Eye Disease and Their Clinical Correlations.

Yang, Tingting MSc *,+; Zhou, Yifan PhD +; Ma, Baikai PhD +; Duan, Hongyu MD *,+; Liu, Rongjun MD +; Zhao, Lu MD +; Qi, Hong MD, PhD *,+

doi : 10.1097/ICO.0000000000003069

The goal of this study was to assess neuropeptide levels in patients with dry eye disease (DED) and investigate their correlations with clinical characteristics.

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A 10-Year Review of the Management of Ocular Mucous Membrane Pemphigoid: A Private Practice Experience.

Johnson, Kasey B. BS *; Rosenbaum, James T. MD +,++; Yarter, Jason T. BS [S]; Broadbent, Talmage MD [P]; Michels, Kevin S. MD *,[P]

doi : 10.1097/ICO.0000000000003071

Ocular mucous membrane pemphigoid (OcMMP) is a rare and potentially blinding condition for which consensus treatment guidelines do not exist. The purpose of this study was to assess the effectiveness and safety of various immunomodulatory agents in the treatment of OcMMP in a private practice setting.

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Epidemiology of Contact Lens-Related Emergency Department Visits: Data From Nationwide Emergency Department Sample.

Usmani, Bushra MD *; Dayananda, Sanjana MD +; Shah, Syed MD *; Jhanji, Vishal MD *

doi : 10.1097/ICO.0000000000003092

The purpose of this retrospective longitudinal cohort study was to determine the epidemiology of contact lens-related visits to the emergency department at a national level and identify high-risk groups.

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Clinical Characteristics and Therapeutic Outcomes of Pediatric Blepharokeratoconjunctivitis.

Moon, Jayoon MD *,+; Lee, Junseok MD *,++; Kim, Mee Kum MD, PhD *,+; Hyon, Joon Young MD, PhD *,++; Jeon, Hyun Sun MD *,++; Oh, Joo Youn MD, PhD *,+

doi : 10.1097/ICO.0000000000003120

The purpose of this study was to determine the clinical characteristics, disease course, therapeutic outcomes, and prognostic factors for pediatric patients with blepharokeratoconjunctivitis (BKC).

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Graft Outcomes After Temporary Keratoprosthesis in Combined Penetrating Keratoplasty and Vitreoretinal Surgery.

Yu, Julia BS *,+; Shalaby, Wesam Shamseldin MD ++; Shiuey, Eric J. MS *,+; Rapuano, Christopher J. MD *,+; Yonekawa, Yoshihiro MD *,[S]; Hammersmith, Kristin M. MD *,+; Nagra, Parveen K. MD *,+; Syed, Zeba A. MD *,+

doi : 10.1097/ICO.0000000000003207

Corneal pathology can obstruct the visualization required for surgical management of coexisting posterior segment diseases, and use of a temporary keratoprosthesis (TKP) permits combined penetrating keratoplasty (PK) and vitreoretinal surgery.

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Patient-Reported Outcomes in Keratoconus: A Save Sight Keratoconus Registry Study.

Kandel, Himal PhD *; Pesudovs, Konrad PhD +; Nguyen, Vuong PhD *; Chen, Jern Yee MBBS, MMed ++; Poon, Alexander MBBS [S]; Mills, Richard MBBS, PhD ++; Watson, Stephanie L. MBBS, PhD *

doi : 10.1097/ICO.0000000000003119

The aim of this study was to evaluate the quality-of-life (QoL) status in keratoconus severity subgroups using the Keratoconus Outcomes Research Questionnaire (KORQ) and to determine the relationship between the QoL scores and the standard clinical variables.

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Etiology-Specific Comparison of the Long-Term Clinical Outcome of Repeat Deep Anterior Lamellar Keratoplasty for Optical Indications.

Yasu-Mimura, Ririko MD *; Hirayama, Masatoshi MD, PhD *,+; Kasamatsu, Hirotsugu MD, PhD *,++; Yamaguchi, Takefumi MD, PhD *; Shimazaki, Jun MD, PhD *

doi : 10.1097/ICO.0000000000003189

The aim of this study was to evaluate the etiology-specific clinical outcomes and complications of repeat deep anterior lamellar keratoplasty (DALK) after failed DALK.

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Leukocyte Immunoglobulin-like Receptor A5 Deletion Aggravates the Pathogenesis of Pseudomonas aeruginosa Keratitis by Promoting Proinflammatory Cytokines.

Shang, Yuqi *,+; Liu, Xi MD *,+; Wei, Liwen *,+; Liang, Siping +; Zou, Zhengyu +; Wu, Minhao PhD *,+; Xia, Jinyu MMed *,+

doi : 10.1097/ICO.0000000000003205

The purpose of this study was to assess the role of leukocyte immunoglobulin-like receptor A5 (LILRA5) in regulating bacterial infection and corneal inflammation.

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Comparative In Vitro Activity of New Lipoglycopeptides and Vancomycin Against Ocular Staphylococci and Their Toxicity on the Human Corneal Epithelium.

Andre, Camille PharmD *,+; Islam, Mohammad Mirazul PhD *,++; Paschalis, Eleftherios PhD *,++; Bispo, Paulo J. M. PhD *,+

doi : 10.1097/ICO.0000000000003197

The purpose of this study was to assess the potential of new lipoglycopeptides as novel topical therapies for improved treatment of recalcitrant ocular infections.

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Susceptibility of the Intact and Traumatized Feline Cornea to In Vitro Binding and Invasion by Acanthamoeba castellanii.

Ledbetter, Eric C. DVM, DACVO *; Dong, Longying PhD +

doi : 10.1097/ICO.0000000000003220

Acanthamoeba castellanii (A. castellanii) displays host specificity at the level of the ocular surface. This study determined the susceptibility of the intact and traumatized feline cornea to A.

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Prospective In Vitro Comparison of Kerasave and Optisol-GS Corneal Storage Solutions.

Tran, Khoa D. PhD *; Ellison, Mark BS *; Straiko, Megan M. W. PhD *; Giurgola, Laura MSc +; Gatto, Claudio MSc +; Galloway, Joshua D. CEBT *; Ragazzi, Eugenio MD ++; D'Amato Tothova, Jana PhD +

doi : 10.1097/ICO.0000000000003201

The aim of this study was to compare the performance of Kerasave and Optisol-GS for hypothermic corneal storage for 14 days. Methods: This study was a prospective laboratory investigation.

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Corneal Plana-Like Phenotype With Peripheral Scleralization Associated With a Pathogenic Variant of PITX2: A Case Report.

Franco, Elena MD, PhD *,+,++; Scanga, Hannah L. MS, CGC *; Nischal, Ken K. MD, FAAP, FRCOphth *,[S],[P]

doi : 10.1097/ICO.0000000000003208

The aim of this study was to report a case of corneal plana-like phenotype with bilateral peripheral scleralization associated with a PITX2 pathogenic variant. Methods: Clinical findings were obtained by ophthalmologic examination.

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Monkeypox-Associated Disciform Keratitis.

Alsarhani, Waleed K. MD *; Chan, Clara C. MD *,+; Boyd, Shelley R. BSc, MD *,+,++; Hasso, Maan MD ++,[S]; Almeer, Ahmed MD *; Tan, Darrell H. S. MD, PhD [P],||,**

doi : 10.1097/ICO.0000000000003171

The purpose of this study was to describe a case of monkeypox (MPX)-associated disciform keratitis. Methods: This is a case report.

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Recurrent Lisch Epithelial Corneal Dystrophy Treated With 5-Fluorouracil: A Case Report and Review of the Literature.

Amer, Mona M. BA *; Arze, Karen BS *; Galor, Anat MD, MSPH *,+; Sayegh, Yoseph MD *; Dubovy, Sander S. MD *; Karp, Carol L. MD *

doi : 10.1097/ICO.0000000000003211

The aim of the study was to describe a case of Lisch epithelial corneal dystrophy (LECD), review its clinical and histopathological features and diagnostic imaging, and introduce a novel treatment approach using topical 5-fluorouracil (5-FU).

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Acute Fibrinous Anterior Uveitis in a Patient Treated With Topical Interferon-[alpha]2b for Ocular Surface Squamous Neoplasia With Uveitis Susceptibility.

del-Pinal, Miguel MD *; Klein-Burgos, Claudia MD *; Martin-Ucero, Ana M. MD *; Larranaga-Cores, Maria MD *; de la Hoz, Adriana MD +,++; Lopez-Vazquez, Ana MD *; Fernandez-Gutierrez, Eva MD *

doi : 10.1097/ICO.0000000000003254

To report a case of fibrinous acute anterior uveitis associated with topical interferon-[alpha]2b (IFN-[alpha]2b) treatment for ocular surface squamous neoplasia in a patient with HLA-B27 uveitis predisposition.

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Descemet Membrane Endothelial Patching: Selective Endothelial Replacement in Eyes With Localized Endothelial Dysfunction.

Garcia-Onrubia, Luis MD; Stanojcic, Nick MD, FRCOphth, MCOptom; Bhogal, Maninder PhD, FRCOphth, FEBOS-CR

doi : 10.1097/ICO.0000000000003243

AB Descemet membrane (DM) endothelial keratoplasty is considered the gold standard for treating corneal endothelial decompensation and is a true like-for-like replacement. Not all causes of endothelial dysfunction are global, with conditions such as viral endotheliitis affecting discrete populations of endothelial cells.

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En Bloc Keratolimbal Allograft and Central Penetrating Keratoplasty: A Novel Surgical Technique in Severe Limbal Stem Cell Deficiency.

Karimian, Farid MD, MBA *,+; Hassanpour, Kiana MD, MPH *,+

doi : 10.1097/ICO.0000000000003199

The purpose of this study was to present a novel surgical technique combining 360-degree keratolimbal allograft (KLAL) and simultaneous central keratoplasty termed en bloc KLAL with the central penetrating keratoplasty (PKP) performed in those cases with total limbal stem cell deficiency (LSCD) and corneal scars. Methods: Nine eyes of 9 patients underwent en bloc KLAL and central PKP between 2014 and 2016.

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Letter Regrading Comparison of Graft Outcomes Reusing Original Intermediate-Term Cold Storage Solution for Entire Corneal Donor Storage Period With Exchanged Fresh Storage Solution After Donor Preparation in the Cornea Preservation Time Study.

Kaufman, Stephen C. MD, PhD

doi : 10.1097/ICO.0000000000003249

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Paraproteinemic Keratopathy in a Patient With Previous LASIK Procedure Mimicking Lattice Corneal Dystrophy: Erratum.

doi : 10.1097/ICO.0000000000003277

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