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Clinical milestones as triggers for palliative care intervention in progressive Supranuclear palsy and multiple system atrophy
Robin Bessemer a, Alla Iansavichene b, Mary E. Jenkins a, Elizabeth Finger a, Teneille E. Gofton
doi : 10.1016/j.jns.2023.120614
Volume 448, 15 May 2023, 120614
Participation by patients from low- and middle-income countries (LMICs) in trial evidence supporting secondary stroke prevention guideline recommendations
Priscilla Abrafi Opare-Addo a, Fred Stephen Sarfo a,b,*, Patrick Opoku Berchie a, Minas Aikins a, Bruce Ovbiagele
doi : 10.1016/j.jns.2023.120641
Volume 448, 15 May 2023, 120641
One out of every four strokes is a highly preventable recurrent stroke. However, while low-and-middle-income countries (LMICs) experience a disproportionate global burden of stroke, individuals in these regions seldomly participate in pivotal clinical trials, which form the basis for international expert consensus guideline recommendations.
Plasma growth differentiation factor − 8 / Myostatin level as prognostic biomarker of patients with ischemic stroke and acute revascularization therapy. PARADISE study
Pauline Jakubina a,b, Alexandre Meloux b, Gauthier Duloquin a,b, Serge Aho c, Catherine Vergely b, Yannick B �ejot
doi : 10.1016/j.jns.2023.120611
Volume 448, 15 May 2023, 120611
Identifying biological markers of ischemic stroke (IS) is an important research approach to develop innovative therapeutic strategies. This study aimed to assess the association between plasma Growth Differentiation Factor-8 (GDF-8)/Myostatin levels and outcome of IS patients.
Cortical atrophy and leukoaraiosis, imaging markers of cerebrovascular small vessel disease, are associated with driving behavior changes among cognitively normal older adults
Ganesh M. Babulal a,b,c,d,*, Ling Chen e, David B. Carr f, Ann M. Johnson g, Joshua S. Shimony h, Jason Doherty a, Samantha Murphy a, Alexis Walker a, Hailee Domash a, Russ Hornbeck h, Sarah Keefe h, Shaney Flores h, Cyrus A. Raji a,h, John C. Morris a,b,i, Beau M. Ances a,h,i, Tammie L.S. Benzinger
doi : 10.1016/j.jns.2023.120616
Volume 448, 15 May 2023, 120616
Cerebral small vessel disease (CSVD) as measured by cortical atrophy and white matter hyperintensities [leukoaraiosis], captured via magnetic resonance imaging (MRI) are increasing in prevalence due to the growth of the aging population and an increase in cardiovascular risk factors in the population. CSVD impacts cognitive function and mobility, but it is unclear if it affects complex, functional activities like driving.
Altered visual conscious awareness in patients with vestibular dysfunctions; a cross-sectional observation study
Mishaal Sharif a,1, Yougan Saman a,b,1, Rose Burling a, Oliver Rea a, Rakesh Patel c, Douglas J.K. Barrett a, Peter Rea b, Amir Kheradmand d,e,*,1, Qadeer Arshad
doi : 10.1016/j.jns.2023.120617
Volume 448, 15 May 2023, 120617
Clinical, radiological, and molecular analyses of neuronal intranuclear inclusion disease with polyglycine inclusions
Minori Furuta a, Masayuki Sato a, Hiroo Kasahara a, Setsuki Tsukagoshi a, Kimitoshi Hirayanagi a,b, Yukio Fujita a, Eriko Takai a, Yuko Aihara c, Koichi Okamoto d, Yoshio Ikeda
doi : 10.1016/j.jns.2023.120618
Volume 448, 15 May 2023, 120618
Neuronal intranuclear inclusion disease (NIID) is a clinically complex neurological disorder that appears sporadically or autosomally. Expansions of intronic GGC trinucleotide repeats in the NOTCH2 N-terminal-like C (NOTCH2NLC) gene cause NIID.
Digital health metrics reveal upper limb impairment profiles in ARSACS
Christoph M. Kanzler a,b,*, Isabelle Lessard c, Roger Gassert a,b, Bernard Brais d, Cynthia Gagnon c,e,1, Olivier Lambercy
doi : 10.1016/j.jns.2023.120621
Volume 448, 15 May 2023, 120621
Adults with autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) often present with reduced upper limb coordination affecting their independence in daily life. Previous studies in ARSACS identified reduced performance in clinical assessments requiring fine and gross dexterity as well as prehension.
Risk factors for developing dyskinesia among Parkinson's disease patients with wearing-off: J-FIRST
Takayasu Mishima a, Shih-Wei Chiu b, Hidemoto Saiki c,1, Takuhiro Yamaguchi b, Yasushi Shimo d,2, Tetsuya Maeda e,3, Hirohisa Watanabe f,4, Kenichi Kashihara g,5, Masahiro Nomoto h,6, Nobutaka Hattori d, Yoshio Tsuboi a,*, on behalf of the J-FIRST Group
doi : 10.1016/j.jns.2023.120619
Volume 448, 15 May 2023, 120619
Dyskinesia frequently occurs during long-term treatment with levodopa in patients with Parkinson's disease (PD) and impacts quality of life. Few studies have examined risk factors for developing dyskinesia in PD patients exhibiting wearing-off. Therefore, we investigated the risk factors and impact of dyskinesia in PD patients exhibiting wearing-off.
Vitamin K antagonists but not non-vitamin K antagonists in addition on antiplatelet therapy should be associated with increase of hematoma volume and mortality in patients with intracerebral hemorrhage: A sub-analysis of PASTA registry study
Koichi Nomura a,b,*, Satoshi Suda a, Arata Abe c, Yasuyuki Iguchi d, Yoshiki Yagita e, Takao Kanzawa f,g, Seiji Okubo h, Shigeru Fujimoto i, Kazumi Kimura a, on behalf of the PASTA study group
doi : 10.1016/j.jns.2023.120643
Volume 448, 15 May 2023, 120643
Prior concomitant use of vitamin K antagonists (VKAs) and antiplatelet (AP) therapy increase the hematoma volume and mortality compared with VKA monotherapy in patients with intracranial hemorrhage (ICH). However, the prior concomitant use of non-vitamin K oral antagonists (NOACs) and AP has not been clarified.
Development of a stroke risk score with MRI asymptomatic brain lesions attributes to evaluate prognostic vascular events
Kenichi Iwasa a,*, Keiichi Onoda b, Masahiro Takamura a, Hiroyuki Takayoshi c, Shingo Mitaki a, Shuhei Yamaguchi c, Atsushi Nagai
doi : 10.1016/j.jns.2023.120642
Volume 448, 15 May 2023, 120642
The use of a combination of stroke predictors, such as clinical factors and asymptomatic lesions on brain magnetic resonance imaging (MRI), may improve the accuracy of stroke risk prediction. Therefore, we attempted to develop a stroke risk score for healthy individuals.
Safety of recanalization therapy in patients with acute ischemic stroke on direct oral anticoagulants: A sub-analysis of PASTA registry study
Satoshi Suda a,*, Arata Abe b,c, Yasuyuki Iguchi d, Yoshiki Yagita e, Takao Kanzawa f,g, Seiji Okubo c, Shigeru Fujimoto h, Yu Kono i, Kazumi Kimura a, on behalf of PASTA Investigators
doi : 10.1016/j.jns.2023.120639
Volume 448, 15 May 2023, 120639
The safety of intravenous recombinant tissue plasminogen activator (rtPA) and mechanical thrombectomy (MT) in patients treated with direct oral anticoagulants (DOACs) before stroke has not been fully investigated. Therefore, we aimed to investigate the safety of recanalization therapy in patients receiving DOACs.
The influence of scene tilt on saccade directions is amplitude dependent
Stephanie M. Reeves a, Jorge Otero-Millan
doi : 10.1016/j.jns.2023.120635
Volume 448, 15 May 2023, 120635
When exploring a visual scene, humans make more saccades in the horizontal direction than any other direction. While many have shown that the horizontal saccade bias rotates in response to scene tilt, it is unclear whether this effect depends on saccade amplitude.
Clinical spectrum and genotype-phenotype associations in Finnish patients with Wilson's disease
Jussi O.T. Sipil ̈a a,b,*, Laura Kyt ̈ovuori c,d, Valtteri Kaasinen a,e
doi : 10.1016/j.jns.2023.120620
Volume 448, 15 May 2023, 120620
Genotype-phenotype correlation data covering all ages of Wilson's disease onset in Caucasian patients are limited. We therefore analyzed genotype-phenotype correlations in a retrospective cohort of Finnish patients.
An autopsy case of copper deficiency myelopathy and selenium deficiency-associated central nervous system disorder after total parenteral nutrition
Ryuichi Koizumia,b,*, Hideki Katoc, Akio Akagia, Yuichi Rikua, Jun Sonea, Hiroaki Miyaharaa, Takuya Oguric, Hiroyuki Yuasac, Fumiaki Tanakab, Mari Yoshidaa, Yasushi Iwasaki
doi : 10.1016/j.jns.2023.120636
Volume 448, 15 May 2023, 120636
Restricted access in the emergency department prevents MRI from being the workhorse for ischemic stroke care
Mukesh Kumara,*, Sherry Hub, Steven Beyeac,d, Noreen Kamala,b,e a Department of Industrial Engineering, Dalhousie University, Halifax, Canada
doi : 10.1016/j.jns.2023.120637
Volume 448, 15 May 2023, 120637
Computed tomography versus short sequence magnetic resonance imaging in acute ischaemic stroke
Ho Lun Wonga,*, Ashraf Nasima,b, Amit K.J. Mandala, Robert Daviesc, Constantinos G. Missouris
doi : 10.1016/j.jns.2023.120638
Volume 448, 15 May 2023, 120638
Lamotrigine and risk of arrhythmias: A global pharmacovigilance analysis
Lisa Ortsa,b, Clara Flumiana,b, François Montastruc
doi : 10.1016/j.jns.2023.120644
Volume 448, 15 May 2023, 120644
Multimodal evaluation of carpal tunnel syndrome in a pre-symptomatic TTR mutation carrier
A. Salvalaggioa,b, M. Cacciavillanic, C. Tiengod, A. Ciprianie, L. Frizzierof, M. Fedrigog, S. Rizzog, A. Angelinig, R. Gasparottih, C. Briania,
doi : 10.1016/j.jns.2023.120596
Volume 448, 15 May 2023, 120596
Antiphospholipid syndrome mimicking posterior cortical atrophy and the “railroad track� sign on brain fluorodeoxyglucose-positron emission tomography
Arenn F. Carlosa, Jonathan Graff-Radforda, Brian A. Cruma, Mary M. Machuldab, Nha Trang Thu Phamc, Val J. Lowec, Jennifer L. Whitwellc, Keith A. Josephs
doi : 10.1016/j.jns.2023.120615
Volume 448, 15 May 2023, 120615
