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Aiming for Burst Suppression in Treating Refractory Status Epilepticus: Probably Not.
Young, G. Bryan MD *; Drislane, Frank W. MD *
doi : 10.1212/WNL.0000000000207290
Volume 100(19) pgs. 889-936,e1955-e2044 May 9, 2023
Maximal Care After Intracerebral Hemorrhage: Giving Patients a Chance.
Jaffa, Matthew N. DO; Morris, Nicholas A. MD
Bridging the Gap Between Hypertensive Disorders of Pregnancy and Cognitive Decline in Older Women.
Prodan, Calin I. MD
Association Between Induced Burst Suppression and Clinical Outcomes in Patients With Refractory Status Epilepticus: A 9-Year Cohort Study.
Fisch, Urs MD, PhD *; Junger, Anja L. MD *; Baumann, Sira M. MD; Semmlack, Saskia MD; De Marchis, Gian Marco MD, MSc; Hunziker, Sabina MD, MPH; Ruegg, Stephan MD, FAES; Marsch, Stephan MD, DPhil; Sutter, Raoul MD
doi : 10.1212/WNL.0000000000207129
To investigate the frequency of induced EEG burst suppression pattern during continuous IV anesthesia (IVAD) and associated outcomes in adult patients treated for refractory status epilepticus (RSE).
Association of Posttraumatic Epilepsy With Long-term Functional Outcomes in Individuals With Severe Traumatic Brain Injury.
Pease, Matthew MD; Mallela, Arka N. MD; Elmer, Jonathan MS, MD; Okonkwo, David O. MD, PhD; Shutter, Lori MD; Barot, Niravkumar MD; Gonzalez-Martinez, Jorge MD, PhD; Castellano, James F. MD, PhD
doi : 10.1212/WNL.0000000000207183
Nearly one-third of patients with severe traumatic brain injury (TBI) develop posttraumatic epilepsy (PTE). The relationship between PTE and long-term outcomes is unknown.
Seizure Burden and Neurologic Outcomes After Neonatal Encephalopathy.
Alharbi, Huda M. MD; Pinchefsky, Elana F. MDCM, MSc, FRCPC; Tran, My-An MD; Salazar Cerda, Carlos Ivan MD; Parokaran Varghese, Jessy PhD; Kamino, Daphne MS; Widjaja, Elysa MD, MPH; Mamak, Eva PhD, CPsych, ABPP-CN; Ly, Linh MD, FRCPC; Nevalainen, Paivi MD, PhD; Hahn, Cecil D. MD, MPH, FRCPC *; Tam, Emily W.Y. MDCM, MAS *
doi : 10.1212/WNL.0000000000207202
Seizures are common during neonatal encephalopathy (NE), but the contribution of seizure burden (SB) to outcomes remains controversial.
Functional Outcomes and Mortality in Patients With Intracerebral Hemorrhage After Intensive Medical and Surgical Support.
Abulhasan, Yasser B. MBChB, FRCPC; Teitelbaum, Jeanne MD, FRCPC; Al-Ramadhani, Khalsa MD, DABR-NR; Morrison, Kathryn T. PhD, AStat; Angle, Mark R. MD
doi : 10.1212/WNL.0000000000207132
Despite decades of increasingly sophisticated neurocritical care, patient outcomes after spontaneous intracerebral hemorrhage (ICH) remain dismal. Whether this reflects therapeutic nihilism or the effects of the primary injury has been questioned.
Association of Tirofiban With Functional Outcomes After Thrombectomy in Acute Ischemic Stroke Due to Intracranial Atherosclerotic Disease.
Sang, Hongfei MD *; Xie, Dongjing MS *; Tian, Yan MS *; Nguyen, Thanh N. MD, FRCPC; Saver, Jeffrey L. MD; Nogueira, Raul G. MD; Wu, Junxiong MS; Long, Chen MS; Tian, Zhenxuan MS; Hu, Zhizhou MS; Wang, Tao MS; Li, Rongzong MS; Ke, Yingbing MS; Zhu, Xiurong MS; Peng, Daizhou MS; Chang, Mingze MS; Li, Lingfei MD; Ruan, Jie MS; Wu, Deping MD; Zi, Wenjie MD; Yang, Qingwu MD; Li, Fengli MD +; Qiu, Zhongming MD +
doi : 10.1212/WNL.0000000000207194
To investigate the efficacy and safety of IV infusion of tirofiban before endovascular thrombectomy for patients with large vessel occlusion due to intracranial atherosclerotic disease.
Apathy in Patients With Cerebral Amyloid Angiopathy: A Multimodal Neuroimaging Study.
Chokesuwattanaskul, Anthipa MD; Zanon Zotin, Maria Clara MD; Schoemaker, Dorothee PhD; Sveikata, Lukas MD; Gurol, M. Edip MD MSc; Greenberg, Steven M. MD, PhD; Viswanathan, Anand MD PhD
doi : 10.1212/WNL.0000000000207200
To analyze the prevalence and associated clinical characteristics of apathy in sporadic cerebral amyloid angiopathy and investigate whether apathy was associated with disease burden and disconnections of key structures in the reward circuit through a structural and functional multimodal neuroimaging approach.
Association of Hypertensive Disorders of Pregnancy With Cognition in Later Life.
Mielke, Michelle M. PhD; Frank, Ryan D. MS; Christenson, Luke R. BS; Fields, Julie A. PhD; Rocca, Walter A. MD, MPH; Garovic, Vesna D. MD, PhD
doi : 10.1212/WNL.0000000000207134
Studies of hypertensive disorders of pregnancy (HDP), including gestational or chronic hypertension (GH/CH) and preeclampsia/eclampsia (PE/E), suggest associations with early-life and mid-life cognition but have been limited by self-report or use of diagnostic codes, exclusion of nulliparous women, and lack of measurement of cognition in later life.
Cognitive and Clinical Characteristics of Patients With Limbic-Predominant Age-Related TDP-43 Encephalopathy.
Butler Pagnotti, Rachel M. PsyD; Pudumjee, Shehroo B. PhD; Cross, Chad L. PhD, MFT, PStat(R), C-MDI; Miller, Justin B. PhD, ABPP-CN
doi : 10.1212/WNL.0000000000207159
Limbic-predominant age-related TDP-43 encephalopathy (LATE) affects similar neuroanatomical networks as Alzheimer disease (AD) and is often comorbid with AD, though frequently missed in clinical diagnosis.
Phenotypes Associated With the Val122Ile, Leu58His, and Late-Onset Val30Met Variants in Patients With Hereditary Transthyretin Amyloidosis.
Zampino, Serena; Sheikh, Farooq H. MD; Vaishnav, Joban MD; Judge, Daniel MD; Pan, Baohan MD, PhD; Daniel, Amrita MD; Brown, Emily MGC, CGC; Ebenezer, Gigi MBBS, MD; Polydefkis, Michael MD, MHS
doi : 10.1212/WNL.0000000000207158
Hereditary transthyretin amyloidosis (hATTR) is a rare autosomal dominant systemic disease with variable penetrance and heterogeneous clinical presentation.
Dysphagia and Lung Disease in Children With Spinal Muscular Atrophy Treated With Disease-Modifying Agents.
Chacko, Archana MBBS, FRACP; Marshall, Jeanne BSpPath, PhD; Taylor, Olivia BSpPath, MPhil; McEniery, Jane MBBS, FRCR; Sly, Peter D. MBBS, FRACP, MD, DSc; Gauld, Leanne M. MBBS, FRACP, MD
doi : 10.1212/WNL.0000000000206826
Disease-modifying agents (DMAs) for the treatment of spinal muscular atrophy (SMA) have evolved the SMA phenotype with improved survival. Ongoing oropharyngeal dysphagia and respiratory complications are reported.
Clinical Reasoning: A 49-Year-Old Woman With Isolated Sinus Intracranial Dural Arteriovenous Fistula With Perimedullary Drainage.
Lu, Hui MD; Ma, Yong-jie MD; Liu, Heng MD; Li, Hai-Feng MD, PhD
doi : 10.1212/WNL.0000000000206824
AB While demyelination is the most common etiology of longitudinally extensive myelopathy, other causes are important to recognize. In this study, we present the case of a longitudinal cervical lesion with a very rare cause.
Clinical Reasoning: New-Onset Diplopia and Headache in a Patient With Metastatic Breast Cancer.
Rizzo, Skylar A. BS; Flanagan, Eoin P. MBBCh; Trejo-Lopez, Jorge A. MD; Toledano, Michel MD *; Chia, Nicholas H. MBBS *
Teaching NeuroImage: Bilateral Internal Carotid Artery Stenosis Due to Aggressive Giant Cell Arteritis.
Doncel-Moriano Cubero, Antonio MD; Espigol, Georgina MD, PhD; Renu, Arturo MD, PhD
Reader Response: Association Between Dietary Habits in Midlife With Dementia Incidence Over a 20-Year Period.
Brenner, Steven
Editors' Note: Association Between Dietary Habits in Midlife With Dementia Incidence Over a 20-Year Period.
Siegler, James E. MD; Galetta, Steven MD
Reader Response: Association Between Dietary Habits in Midlife With Dementia Incidence Over a 20-Year Period.
Smith, Anthony David; Refsum, Helga
Increased Dystrophin Production With Golodirsen in Patients With Duchenne Muscular Dystrophy.
