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Putting the "Big" in Big Data: Learning to Be Just as (Un)certain as a Clinician at EEG.
Kaestner, Erik PhD; Stacey, William MD, PhD
doi : 10.1212/WNL.0000000000207224
Volume 100(17) pgs. 799-844,e1737-e1848 April 25, 2023
Seizures and Status Epilepticus in the Intensive Care Unit: Some Paradoxes and Insights.
Young, G. Bryan MD
Pioglitazone and Lower Risk of Dementia: Will This Change Practice?.
Maxwell, Colleen J. PhD; Alkabbani, Wajd MSc; Yasar, Sevil MD, PhD
Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs.
Jing, Jin PhD; Ge, Wendong PhD; Struck, Aaron F. MD; Fernandes, Marta Bento PhD; Hong, Shenda PhD; An, Sungtae; Fatima, Safoora MD; Herlopian, Aline MD; Karakis, Ioannis MD, PhD, MSc; Halford, Jonathan J. MD; Ng, Marcus C. MD; Johnson, Emily L. MD; Appavu, Brian L. MD; Sarkis, Rani A. MD, MSc; Osman, Gamaleldin MD, MS; Kaplan, Peter W. MBBS, FRCP; Dhakar, Monica B. MD, MS; Jayagopal, Lakshman Arcot MD; Sheikh, Zubeda MD, MS; Taraschenko, Olga MD, PhD; Schmitt, Sarah MD; Haider, Hiba A. MD; Kim, Jennifer A. MD, PhD; Swisher, Christa B. MD; Gaspard, Nicolas MD, PhD; Cervenka, Mackenzie C. MD; Rodriguez Ruiz, Andres A. MD; Lee, Jong Woo MD, PhD; Tabaeizadeh, Mohammad MD; Gilmore, Emily J. MD; Nordstrom, Kristy AS; Yoo, Ji Yeoun MD; Holmes, Manisha G. MD; Herman, Susan T. MD; Williams, Jennifer A. MB, BAO, BchFRCPI; Pathmanathan, Jay MD, PhD; Nascimento, Fabio A. MS; Fan, Ziwei MS; Nasiri, Samaneh PhD; Shafi, Mouhsin M. MD, PhD; Cash, Sydney S. MD, PhD; Hoch, Daniel B. MD, PhD; Cole, Andrew J. MD; Rosenthal, Eric S. MD; Zafar, Sahar F. MD; Sun, Jimeng PhD; Westover, M. Brandon MD, PhD
doi : 10.1212/WNL.0000000000201670
The validity of brain monitoring using electroencephalography (EEG), particularly to guide care in patients with acute or critical illness, requires that experts can reliably identify seizures and other potentially harmful rhythmic and periodic brain activity, collectively referred to as "ictal-interictal-injury continuum" (IIIC).
Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation.
Jing, Jin PhD *; Ge, Wendong PhD *; Hong, Shenda PhD; Fernandes, Marta Bento PhD; Lin, Zhen; Yang, Chaoqi; An, Sungtae; Struck, Aaron F. MD; Herlopian, Aline MD; Karakis, Ioannis MD, PhD, MSc; Halford, Jonathan J. MD; Ng, Marcus C. MD; Johnson, Emily L. MD; Appavu, Brian L. MD; Sarkis, Rani A. MD, MSc; Osman, Gamaleldin MD, MS; Kaplan, Peter W. MBBS, FRCP; Dhakar, Monica B. MD, MS; Arcot Jayagopal, Lakshman MD; Sheikh, Zubeda MD, MS; Taraschenko, Olga MD, PhD; Schmitt, Sarah MD; Haider, Hiba A. MD; Kim, Jennifer A. MD, PhD; Swisher, Christa B. MD; Gaspard, Nicolas MD, PhD; Cervenka, Mackenzie C. MD; Rodriguez Ruiz, Andres A. MD; Lee, Jong Woo MD, PhD; Tabaeizadeh, Mohammad MD; Gilmore, Emily J. MD; Nordstrom, Kristy AS; Yoo, Ji Yeoun MD; Holmes, Manisha G. MD; Herman, Susan T. MD; Williams, Jennifer A. MB, BAO, Bch, FRCPI; Pathmanathan, Jay MD, PhD; Nascimento, Fabio A. MD; Fan, Ziwei MS; Nasiri, Samaneh PhD; Shafi, Mouhsin M. MD, PhD; Cash, Sydney S. MD, PhD; Hoch, Daniel B. MD, PhD; Cole, Andrew J. MD; Rosenthal, Eric S. MD; Zafar, Sahar F. MD; Sun, Jimeng PhD +; Westover, M. Brandon MD, PhD +
doi : 10.1212/WNL.0000000000207127
Seizures (SZs) and other SZ-like patterns of brain activity can harm the brain and contribute to in-hospital death, particularly when prolonged. However, experts qualified to interpret EEG data are scarce.
Comparing Patients With Isolated Seizures and Status Epilepticus in Intensive Care Units: An Observational Cohort Study.
Wagner, Anna S. MD *; Baumann, Sira M. MD *; Semmlack, Saskia MD; Frei, Anja I.; Ruegg, Stephan MD, FAES; Hunziker, Sabina MD, MPH; Marsch, Stephan MD, DPhil; Sutter, Raoul MD
doi : 10.1212/WNL.0000000000206838
To assess the frequency of status epilepticus (SE) among seizing critically ill adult patients and to determine clinical differences between patients with isolated seizures and patients with SE in the intensive care unit (ICU).
Association Between Neighborhood Socioeconomic Status and 30-Day Mortality and Readmission for Patients With Common Neurologic Conditions.
Lusk, Jay B. BSc; Hoffman, Molly N. MPH; Clark, Amy G. PhD; Bae, Jonathan MD; Luedke, Matthew W. MD; Hammill, Bradley G. DrPH
doi : 10.1212/WNL.0000000000207094
Patients of low individual socioeconomic status (SES) are at a greater risk of unfavorable health outcomes. However, the association between neighborhood socioeconomic deprivation and health outcomes for patients with neurologic disorders has not been studied at the population level
Depressive Symptoms and Risk of Acute Stroke: INTERSTROKE Case-Control Study.
Murphy, Robert P. MB; Reddin, Catriona MB; Rosengren, Annika MD; Judge, Conor PhD; Hankey, Graeme J. MBBS, MD, FRACP; Ferguson, John PhD; Alvarez-Iglesias, Alberto PhD; Oveisgharan, Shahram MD; Wasay, Mohammad MD; McDermott, Clodagh MB BCh, BAO, MSc; Iversen, Helle Klingenberg MD; Lanas, Fernando MD; Al-Hussain, Fawaz MD; Czlonkowska, Anna MD, PhD; Oguz, Aytekin MD; Ogunniyi, Adesola MD; Damasceno, Albertino MD; Xavier, Denis MD; Avezum, Alvaro MD; Wang, Xingyu PhD; Langhorne, Peter PhD; Yusuf, Salim DPhil; O'Donnell, Martin PhD; for the INTERSTROKE investigators
doi : 10.1212/WNL.0000000000207093
Depression has been reported to be a risk factor of acute stroke, based largely on studies in high-income countries. In the INTERSTROKE study, we explored the contribution of depressive symptoms to acute stroke risk and 1-month outcome across regions of the world, within subpopulations and by stroke type.
Pioglitazone Use and Reduced Risk of Dementia in Patients With Diabetes Mellitus With a History of Ischemic Stroke.
Ha, Junghee MD, PhD *; Choi, Dong-Woo PhD *; Kim, Kwang Joon MD, PhD; Kim, Keun You MD; Nam, Chung Mo PhD; Kim, Eosu MD, PhD
doi : 10.1212/WNL.0000000000207069
Previous studies have reported the protective effect of pioglitazone on dementia in patients with type 2 diabetes mellitus (DM).
Associations Between CSF Markers of Inflammation, White Matter Lesions, and Cognitive Decline in Individuals Without Dementia.
Gertje, Eske Christiane MD; Janelidze, Shorena PhD; van Westen, Danielle MD, PhD; Cullen, Nicholas BS; Stomrud, Erik MD, PhD; Palmqvist, Sebastian MD, PhD; Hansson, Oskar MD, PhD *; Mattsson-Carlgren, Niklas MD, PhD *
doi : 10.1212/WNL.0000000000207113
Small vessel disease (SVD) and neuroinflammation both occur in Alzheimer disease (AD) and other neurodegenerative diseases.
Sex Hormones and Calcitonin Gene-Related Peptide in Women With Migraine: A Cross-sectional, Matched Cohort Study.
Raffaelli, Bianca MD; Storch, Elisabeth; Overeem, Lucas Hendrik MSc; Terhart, Maria; Fitzek, Mira Pauline MD; Lange, Kristin Sophie MD; Reuter, Uwe MD
doi : 10.1212/WNL.0000000000207114
Sex hormones may modulate calcitonin gene-related peptide (CGRP) release in the trigeminovascular system. We studied CGRP concentrations in plasma and tear fluid in female participants with episodic migraine (EM) and a regular menstrual cycle (RMC), female participants with EM and combined oral contraception (COC), and female participants with EM in the postmenopause.
"Glass Eel" Sign in Chikungunya Myelopathy.
Nobrega, Paulo Ribeiro MD, MSc; Junior, Pedro Helder MD; Galdino, Gabriela Studart MD, MSc; Dias, Daniel Aguiar MD; Castro, Jose Daniel Vieira MD, PhD
Clinical Reasoning: A Teenager With Chronic Meningitis-Does Occam's Razor Apply?.
Pavuluri, Harini MD, DM; KV, Vysakha MD, DM; Thomas, Bejoy MD; Vilanilam, George C. MS, MCh; Nair, Prakash MS, MCh; Narasimhaiah, Deepti A. MD; Poyuran, Rajalakshmi MD; Menon, Ramshekhar N. MD, DM
doi : 10.1212/WNL.0000000000206783
AB A 14-year-old girl presented with subacute onset headache, fever, and vomiting and was managed initially with antibiotics for suspected bacterial meningitis. Her symptoms further evolved over the next few weeks with systemic signs and symptoms favoring chronic meningitis with raised intracranial pressure.
Child Neurology: Infantile Biotin Thiamine Responsive Basal Ganglia Disease: Case Report and Brief Review.
Maney, Kayli MD; Pizoli, Carolyn MD, PhD; Russ, Jeffrey B. MD, PhD
doi : 10.1212/WNL.0000000000206832
AB Biotin thiamine responsive basal ganglia disease (BTRBGD) is an inherited autosomal recessive disorder that results from the inability of thiamine to cross the blood-brain barrier. It is considered a treatable condition if vitamin supplementation, most commonly with thiamine and biotin, is initiated early.
Teaching NeuroImage: ROBO3 Mutation Causing Horizontal Gaze Palsy and Brainstem Malformation.
Chanda, Geetha MD Pediatrics; Reddy, Nihaal MD; Konanki, Ramesh MD, DM; Boltshauser, Eugen MD; Lingappa, Lokesh MD, DM
Migraine and Hormones: A Complex Interaction.
Karceski, Steven MD
Editors' Note: Hyperacute Perfusion Imaging Before Pediatric Thrombectomy: Analysis of the Save ChildS Study.
Lewis, Ariane MD; Galetta, Steven MD
Reader Response: Hyperacute Perfusion Imaging Before Pediatric Thrombectomy: Analysis of the Save ChildS Study.
Siegler, James E.; Nguyen, Thanh N.
Author Response: Hyperacute Perfusion Imaging Before Pediatric Thrombectomy: Analysis of the Save ChildS Study.
Lee, Sarah
Association of Endovascular Thrombectomy With Functional Outcome in Patients With Acute Stroke With a Large Ischemic Core.
Association Between Dietary Habits in Midlife With Dementia Incidence Over a 20-Year Period.
Normobaric Hyperoxia Combined With Endovascular Treatment for Patients With Acute Ischemic Stroke: A Randomized Controlled Clinical Trial.
Baseline Clinical and Blood Biomarkers in Patients With Preataxic and Early-Stage Disease Spinocerebellar Ataxia 1 and 3.
Tezenas du Montcel, Sophie MD, PhD; Petit, Emilien MSc; Olubajo, Titilayo MD; Faber, Jennifer MD; Lallemant-Dudek, Pauline MD; Bushara, Khalaf MD; Perlman, Susan MD; Subramony, Sub H. MD; Morgan, David PhD; Jackman, Brianna MS; Paulson, Henry Lauris MD; Oz, Gulin PhD; Klockgether, Thomas MD; Durr, Alexandra PhD *; Ashizawa, Tetsuo MD *; for the READISCA Consortium Collaborators
doi : 10.1212/WNL.0000000000207088
In spinocerebellar ataxia, ataxia onset can be preceded by mild clinical manifestation, cerebellar and/or brainstem alterations, or biomarker modifications.
