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Navigating Through the Recent Diagnostic Criteria for MOGAD: Challenges and Practicalities.
Ciccarelli, Olga PhD, FRCP; Toosy, Ahmed T. PhD, FRCP; Thompson, Alan MD, FRCP; Hacohen, Yael PhD, MRCPCH
doi : 10.1212/WNL.0000000000207238
Volume 100(15) pgs. 689-738,e1529-e1642 April 11, 2023
On the Track of [alpha]-Synuclein in the Body: Skin Biopsies for Diagnosing Synucleinopathies?.
Parnetti, Lucilla MD, PhD; Bellomo, Giovanni PhD
Polygenic Risk Scores in the Clinic: A Case for Stroke Survivors.
Georgakis, Marios K. MD, PhD; Anderson, Christopher D. MD, MMSc
Cutaneous [alpha]-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease.
Gibbons, Christopher MD, MMSc *; Wang, Ningshan PhD *; Rajan, Sharika MD; Kern, Drew MD; Palma, Jose-Alberto; Kaufmann, Horacio MD; Freeman, Roy MD
doi : 10.1212/WNL.0000000000206772
Multiple system atrophy (MSA) is a progressive neurodegenerative disorder caused by the abnormal accumulation of [alpha]-synuclein in the nervous system.
DMD Genotypes and Motor Function in Duchenne Muscular Dystrophy: A Multi-institution Meta-analysis With Implications for Clinical Trials.
Muntoni, Francesco MD; Signorovitch, James PhD; Sajeev, Gautam ScD; Lane, Henry BA; Jenkins, Madeline BSc; Dieye, Ibrahima BA; Ward, Susan J. PhD; McDonald, Craig MD; Goemans, Nathalie MD; Niks, Erik H. MD, PhD; Wong, Brenda MD; Servais, Laurent PhD; Straub, Volker MD, PhD; Guglieri, Michela MD; de Groot, Imelda J.M. PhD; Chesshyre, Mary MBBS, MA; Tian, Cuixia MD; Manzur, Adnan Y. MD; Mercuri, Eugenio MD; Aartsma-Rus, Annemieke PhD; Association Francaise Contre Les Myopathies; on behalf of Universitaire Ziekenhuizen Leuven Group, PRO-DMD-01, The UK NorthStar Clinical Network, CCHMC, and The DMD Italian Group
doi : 10.1212/WNL.0000000000201626
Clinical trials of genotype-targeted treatments in Duchenne muscular dystrophy (DMD) traditionally compare treated patients with untreated patients with the same DMD genotype class.
Changing Trends in Demographics, Risk Factors, and Clinical Features of Patients With Infective Endocarditis-Related Stroke, 2005-2015.
Ridha, Mohamed MD; Flaherty, Mathew L. MD; Aziz, Yasmin MD; Ades, Laura MD; Alwell, Kathleen BSN; Khoury, Jane C. PhD; Woo, Daniel MD; Ferioli, Simona MD; Adeoye, Opeolu MD; Khatri, Pooja MD; De Los Rios La Rosa, Felipe MD, FAHA; Mistry, Eva A. MD; Demel, Stacie L. MD; Mackey, Jason MD, MS; Martini, Sharyl MD, PhD; Coleman, Elisheva MD; Jasne, Adam MD; Slavin, Sabreena MD; Walsh, Kyle MD; Star, Michael MD; Haverbusch, Mary BSN; Madsen, Tracy E. MD, PhD; Broderick, Joseph P. MD PhD; Kissela, Brett MD, MS; Kleindorfer, Dawn O. MD
doi : 10.1212/WNL.0000000000206865
There is a rising incidence of infective endocarditis-related stroke (IERS) in the United States attributed to the opioid epidemic. A contemporary epidemiologic description is necessary to understand the impact of the opioid epidemic on clinical characteristics of IERS.
Patient Relevance of the Modified Rankin Scale in Subarachnoid Hemorrhage Research: An International Cross-sectional Survey.
Niznick, Naomi MD; Saigle, Victoria MSc; Marti, Maria Luisa; Laframboise, Josephine; Zha, Xiaohui PhD; Andersen, Chris MD; Presseau, Justin PhD; Chasse, Michael MD, PhD; McIntyre, Lauralyn MD, MSc; Fergusson, Dean MHA, PhD; Turgeon, Alexis F. MD, MSc; Lauzier, Francois MD, MSc; Mayer, Stephan A. MD; Lahiri, Shouri MD; Ramsay, Tim PhD; English, Shane MD, MSc; for the APOC Investigators and the Canadian Critical Care Trials Group; Delaney, Anthony MBBS, MSc, PhD, FACEM, FCICM; Finfer, Simon MBBS, FRCP, FRCA, FCICM, FAHMS, DrMed; Marshall, John MD, FRCSC, FACS, FCAHS; Muscedere, John MD, FRCPC; Griesdale, Donald MD, MPH, FRCPC; Marshall, Shawn MD, FRCPC; Thavorn, Kednapa BPharm, MPharm, PhD; Brehaut, Jamie PhD; Tugwell, Peter OC, MD, FRCPC; Graham, Ian PhD, FCAHS, FNYAM, FRSC
doi : 10.1212/WNL.0000000000206879
There is significant heterogeneity in the reporting of outcome measures in aneurysmal subarachnoid hemorrhage (aSAH) research.
Lifetime Cumulative Effect of Reproductive Factors on Stroke and Its Subtypes in Postmenopausal Chinese Women: A Prospective Cohort Study.
Hou, Leying MD; Li, Shuting MPH; Zhu, Siyu MPH; Yi, Qian MPH; Liu, Wen MPH; Wu, You PhD; Wu, Feitong PhD; Ji, Yuelong PhD; Song, Peige PhD; Rahimi, Kazem PhD
doi : 10.1212/WNL.0000000000206863
Multiple reproductive factors are associated with stroke. Little is known about the cumulative effects of reproductive factors during a reproductive life course on stroke and its subtypes, especially among female Chinese individuals.
Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors.
Acosta, Julian N. MD; Both, Cameron P. BS; Demarais, Zachariah S. BS; Conlon, Carolyn J. BS; Leasure, Audrey C. BS; Torres-Lopez, Victor M. MA; de Havenon, Adam MD; Petersen, Nils H. MD; Gill, Thomas M. MD; Sansing, Lauren H. MD, MS; Sheth, Kevin N. MD; Falcone, Guido J. MD, ScD, MPH
doi : 10.1212/WNL.0000000000206763
Blood pressure (BP) is often not at goal in stroke survivors, leaving individuals vulnerable to additional vascular events. Given that BP is a highly heritable trait, we hypothesize that a higher polygenic susceptibility to hypertension (PSH) leads to worse BP control in stroke survivors.
Disease Course and Long-term Outcomes in Pregnant Women With Idiopathic Intracranial Hypertension: The IIH Prospective Maternal Health Study.
Thaller, Mark MBBCh, MRCP; Homer, Victoria MSc; Mollan, Susan P. MBcHB; Sinclair, Alexandra Jean PhD
doi : 10.1212/WNL.0000000000206854
Idiopathic intracranial hypertension (IIH) most typically occurs in women of childbearing age with increased weight as a key risk factor for development or exacerbation of the disease.
Risk Factors and Prognosis of Epilepsy Following Brain Abscess: A Nationwide Population-Based Cohort Study.
Bodilsen, Jacob MD, PhD; Duerlund, Laerke Storgaard MD; Mariager, Theis MD; Brandt, Christian Thomas MD, DMSc; Wiese, Lothar MD, PhD; Petersen, Pelle Trier MD; Larsen, Lykke MD, PhD; Hansen, Birgitte Ronde MD; Omland, Lars Haukali MD, PhD, DMSc; Tetens, Malte Mose MD; Jorgensen, Rasmus Langelund MD; Leth, Steffen MD, PhD; Nielsen, Henrik MD, DMSc; for DASGIB; Storgaard, Merete MD, PhD; Ostergaard, Christian MD, DMSc; Helweg-Larsen, Jannik MD, DMSc; von Luttichau, Hans Rudolf MD, DMSc
doi : 10.1212/WNL.0000000000206866
Epilepsy in patients with brain abscess is frequent, but risk factors and prognosis remain undetermined. This study examined risk factors of epilepsy among survivors of brain abscess and associated prognosis.
Contribution of White Matter Fiber Bundle Damage to Language Change After Surgery for Temporal Lobe Epilepsy.
Binding, Lawrence Peter BSc, MSc; Dasgupta, Debayan MB, BS, MA(Cantab), MRCS (Eng); Taylor, Peter Neal PhD; Thompson, Pamela Jane PhD; O'Keeffe, Aidan G. PhD; de Tisi, Jane BA; McEvoy, Andrew William FRCS (SN); Miserocchi, Anna FRCS (SN); Winston, Gavin P. BM BCh, PhD, FRCP; Duncan, John S. FRCP, FMedSci; Vos, Sjoerd B. PhD
doi : 10.1212/WNL.0000000000206862
In medically refractory temporal lobe epilepsy (TLE), 30%-50% of patients experience substantial language decline after resection in the language-dominant hemisphere.
Respiratory Strength Training in Amyotrophic Lateral Sclerosis: A Double-Blind, Randomized, Multicenter, Sham-Controlled Trial.
Plowman, Emily K. PhD; Gray, Lauren T. PhD; Chapin, Jennifer MS; Anderson, Amber MS; Vasilopoulos, Terrie PhD; Gooch, Clifton MD; Vu, Tuan MD; Wymer, James P. MD, PhD
doi : 10.1212/WNL.0000000000206830
The objective of this study was to evaluate the short-term physiologic effect and one-year functional effect of a 12-week inspiratory and expiratory respiratory strength training (RST) program in individuals with amyotrophic lateral sclerosis (ALS).
Microembolism and Other Links Between Migraine and Stroke: Clinical and Pathophysiologic Update.
Sacco, Simona MD; Harriott, Andrea M. MD, PhD; Ayata, Cenk MD, PhD; Ornello, Raffaele MD, PhD; Bagur, Rodrigo MD; Jimenez-Ruiz, Amado MD; Sposato, Luciano A. MD, MBA, FRCPC
doi : 10.1212/WNL.0000000000201699
AB Migraine and stroke are highly prevalent diseases with a high effect on quality of life, with multiple epidemiologic, pathophysiologic, clinical, and prognostic areas of overlap. Migraine is a risk factor for stroke.
Pearls & Oy-sters: Status Epilepticus and Cerebral Edema From Hyperammonemia Due to Disseminated Ureaplasma and Mycoplasma Species.
Bharath, Suman Preet MD; Pang, Haoming MD; Kaderi, Tamana MD; Rampolla, Reinaldo MD; Chen, Timothy MD; Gezalian, Michael MD; Lahiri, Shouri MD; Toossi, Shahed MD; Ayodele, Maranatha MD
doi : 10.1212/WNL.0000000000206778
AB Nonhepatic hyperammonemia syndrome is a rare cause of neurologic dysfunction and cerebral edema and has most commonly been reported in posttransplant patients.
Right Brain: Cogwheels and Crystals.
Sastry, Amita ScB
doi : 10.1212/WNL.0000000000206798
AB "Cogwheels and Crystals" is a reflection on how difficult it was to see a patient with Parkinson disease in the office as the daughter of a man with the same diagnosis.
Teaching Video NeuroImage: Bilateral Eyelid Opening Apraxia in a Patient With Top of the Basilar Syndrome.
Cimmino, Angelo Tiziano MD; Vitali, Francesca MD; Iorio, Raffaele MD, PhD
Editors' Note: Effect of Cholinesterase Inhibitors on Mortality in Patients With Dementia: A Systematic Review of Randomized and Nonrandomized Trials.
Siegler, James E M.D; Galetta, Steven MD
Reader Response: Effect of Cholinesterase Inhibitors on Mortality in Patients With Dementia: A Systematic Review of Randomized and Nonrandomized Trials.
Watt, Jennifer A.; Veroniki, Areti-Angeliki; Goodarzi, Zahra; Straus, Sharon E.
Author Response: Effect of Cholinesterase Inhibitors on Mortality in Patients With Dementia: A Systematic Review of Randomized and Nonrandomized Trials.
Lafuente-Lafuente, Carmelo; Truong, Celine; Recto, Caryn; Lafont, Charlotte; Canoui-Poitrine, Florence; Belmin, Joel
Surveillance of Unruptured Intracranial Aneurysms: Cost-Effectiveness Analysis for 3 Countries.
