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THE ANGIOPOIETIN/TIE PATHWAY IN RETINAL VASCULAR DISEASES
Heier, Jeffrey S. MD*; Singh, Rishi P. MD†; Wykoff, Charles C. MD, PHD‡; Csaky, Karl G. MD, PHD§; Lai, Timothy Y.Y. MD, FRCS, FRCOPHTH¶; Loewenstein, Anat MD**; Schlottmann, Patricio G. MD††; Paris, Liliana P. MD, PHD‡‡; Westenskow, Peter D. PHD‡‡; Quezada-Ruiz, Carlos MD§§,¶¶
doi : 10.1097/IAE.0000000000003003
Retina: January 2021 - Volume 41 - Issue 1 - p 1-19
To provide a concise overview for ophthalmologists and practicing retina specialists of available clinical evidence of manipulating the angiopoietin/tyrosine kinase with immunoglobulin-like and endothelial growth factor–like domains (Tie) pathway and its potential as a therapeutic target in retinal vascular diseases.
EARLY AND LATE MACULAR CHANGES AFTER THE INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE FOR A FULL-THICKNESS MACULAR HOLE
Tsui, Mei-Chi MD*; Yang, Chung-May MD*,†
doi : 10.1097/IAE.0000000000002796
Retina: January 2021 - Volume 41 - Issue 1 - p 20-28
To describe the anatomic evolution of full-thickness macular hole closure after the inverted internal limiting membrane (ILM) flap technique.
ASSESSING THE ABILITY OF PREOPERATIVE QUANTITATIVE SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY CHARACTERISTICS TO PREDICT VISUAL OUTCOME IN IDIOPATHIC MACULAR HOLE SURGERY
Mehta, Nitish MD*; Lavinsky, Fabio MD*; Larochelle, Ryan MS*; Rebhun, Carl MD†; Mehta, Nihaal B. BA†; Yanovsky, Rebecca L. BS†; Cohen, Michael N. MD†; Lee, Gregory D. MD*; Dedania, Vaidehi MD*; Ishikawa, Hiroshi MD*; Wollstein, Gadi MD*; Schuman, Joel S. MD*; Waheed, Nadia MD, MPH†; Modi, Yasha MD*
doi : 10.1097/IAE.0000000000002797
Retina: January 2021 - Volume 41 - Issue 1 - p 29-36
To determine which spectral domain optical coherence tomography biomarkers of idiopathic macular hole (MH) correlate with the postoperative best-corrected visual acuity (BCVA) in anatomically closed MH.
COMPARISON OF THE INTERNAL LIMITING MEMBRANE INSERTION TECHNIQUE AND THE INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE WITH VITRECTOMY TO TREAT MACULAR HOLE–ASSOCIATED RETINAL DETACHMENT
Zhu, Ke MD*,†,‡; Lei, Boya MD*,†,‡; Wong, Wenghang MD*,†,‡; Zhang, Juan PhD*,†,‡; Guo, Yue PhD*,†,‡; Chen, Han PhD*,†,‡; Song, Fang BN*; Chang, Qing PhD*,†,‡; Xu, Gezhi PhD*,†,‡; Zhang, Yanqiong PhD*,†,‡
doi : 10.1097/IAE.0000000000002804
Retina: January 2021 - Volume 41 - Issue 1 - p 37-44
To compare the anatomical and functional outcomes of macular hole (MH)-associated retinal detachment after vitrectomy with the internal limiting membrane (ILM) insertion technique or the inverted ILM flap technique.
RETINAL SENSITIVITY AND VESSEL DENSITY AFTER MACULAR HOLE SURGERY WITH THE SUPERIOR INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE
Kunikata, Hiroshi MD, PhD*,†; Yasuda, Masayuki MD, PhD*; Aizawa, Naoko MD, PhD*; Osada, Urara MD*; Nishiguchi, Koji M. MD, PhD‡; Abe, Toshiaki MD, PhD§; Nakazawa, Toru MD, PhD*,†,‡,¶
doi : 10.1097/IAE.0000000000002839
Retina: January 2021 - Volume 41 - Issue 1 - p 45-53
To evaluate retinal vessel density and retinal sensitivity (RS) after macular hole surgery with the superior inverted internal limiting membrane flap technique.
QUANTITATIVE ASSESSMENT OF THE FOVEAL AVASCULAR ZONE USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY BEFORE AND AFTER SURGERY FOR IDIOPATHIC EPIRETINAL MEMBRANE
Ersoz, M. Giray MD; Hocaoglu, Mumin MD, FEBO; Sayman Muslubas, Isil MD, FEBO; Arf, Serra MD; Karacorlu, Murat MD, MSc, FEBO
doi : 10.1097/IAE.0000000000002794
Retina: January 2021 - Volume 41 - Issue 1 - p 54-59
To investigate, using optical coherence tomography angiography, the foveal avascular zone (FAZar), the FAZ perimeter (FAZp), the acircularity index of the FAZ (FAZai), and the density of vessels surrounding the FAZ (FAZvd) before and after idiopathic epiretinal membrane surgery, and associations of these parameters with postoperative best-corrected visual acuity, letter score gain, and central foveal thickness.
EPIDEMIOLOGY OF VITREOMACULAR INTERFACE ABNORMALITIES USING MACULAR SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY IN AN ELDERLY POPULATION (THE MONTRACHET STUDY)
Ben Ghezala, Inès MD*,†; Seydou, Alassane PhD†,‡; Gabrielle, Pierre-Henry MD*,‡; Bouche-Pillon, Jacques MD*; Binquet, Christine MD, PhD†; Delcourt, Cécile PhD§; Daien, Vincent MD, PhD¶,**; Bron, Alain M. MD*,‡; Creuzot-Garcher, Catherine MD, PhD*,‡
doi : 10.1097/IAE.0000000000002802
Retina: January 2021 - Volume 41 - Issue 1 - p 60-67
The aim of this study was to investigate the prevalence of vitreomacular interface abnormalities (VMIAs) and to identify associated factors in an elderly population in Europe.
OUTCOMES OF COMBINED PHACOEMULSIFICATION AND PARS PLANA VITRECTOMY FOR RHEGMATOGENOUS RETINAL DETACHMENT
Tan, Alexia MD; Bertrand-Boiché, Mathilde MD; Angioi-Duprez, Karine MD, PhD; Berrod, Jean-Paul MD; Conart, Jean-Baptiste MD, PhD
doi : 10.1097/IAE.0000000000002803
Retina: January 2021 - Volume 41 - Issue 1 - p 68-74
To evaluate and to compare the anatomical and functional results of phacovitrectomy and pars plana vitrectomy (PPV) alone for phakic rhegmatogenous retinal detachment.
THE EFFECT OF ELECTIVE CATARACT EXTRACTION BY PHACOEMULSIFICATION IN EYES WITH VITREOMACULAR TRACTION SYNDROME
Mantopoulos, Dimosthenis MD, PhD*,†; Prenner, Jonathan L. MD*; Patel, Vishal K. MD*; Roth, Daniel B. MD*; Shah, Sumit P. MD*; Tsavaris, Onoufrios MD‡; Fine, Howard F. MD, MHSc*; Wheatley, H. Matthew MD*
doi : 10.1097/IAE.0000000000002785
Retina: January 2021 - Volume 41 - Issue 1 - p 75-81
To evaluate the effect of cataract extraction (CE) by phacoemulsification on the vitreomacular interface (VMI) of eyes with preexisting vitreomacular traction (VMT).
INTRARETINAL HYPERREFLECTIVE LINES
Amoroso, Francesca MD*; Mrejen, Sarah MD†; Pedinielli, Alexandre MD*; Tabary, Sandrine†; Souied, Eric H. MD, PhD*; Gaudric, Alain MD†,‡; Cohen, Salomon Y. MD, PhD*,†
doi : 10.1097/IAE.0000000000002806
Retina: January 2021 - Volume 41 - Issue 1 - p 82-92
To report intraretinal hyperreflective lines related to various macular conditions.
QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF INACTIVE MACULAR NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION
Serra, Rita MD*,†,‡; Coscas, Florence MD‡,§; Pinna, Antonio MD¶; Cabral, Diogo MD**; Coscas, Gabriel MD‡,§; Souied, Eric H. MD, PhD§
doi : 10.1097/IAE.0000000000002807
Retina: January 2021 - Volume 41 - Issue 1 - p 93-102
To compare quantitative optical coherence tomography angiography parameters between treatment-naïve quiescent macular neovascularizations (MNVs) and previously treated nonexudative Type 1 MNVs, in patients with age-related macular degeneration.
CLINICAL OUTCOMES OF DIFFERENT SUBTYPES OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION DURING AFLIBERCEPT TREATMENT
Rezar-Dreindl, Sandra MD, PhD; Eibenberger, Katharina MD, PhD; Buehl, Wolf MD; Maccora, Katia; Waldstein, Sebastian MD, PhD; Baratsits, Magdalena; Schmidt-Erfurth, Ursula MD; Sacu, Stefan MD
doi : 10.1097/IAE.0000000000002786
Retina: January 2021 - Volume 41 - Issue 1 - p 103-110
To prospectively evaluate the outcomes of different subtypes of neovascular age-related macular degeneration during intravitreal aflibercept monotherapy.
THE CORRELATION BETWEEN AQUEOUS VASCULAR ENDOTHELIAL GROWTH FACTOR LEVEL AND CLINICAL ACTIVITY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
Ichiyama, Yusuke MD; Sawada, Tomoko MD; Sawada, Osamu MD; Ito, Yuka MD; Kakinoki, Masashi MD; Obata, Shumpei MD; Saishin, Yoshitsugu MD; Ohji, Masahito MD
doi : 10.1097/IAE.0000000000002790
Retina: January 2021 - Volume 41 - Issue 1 - p 111-117
The aim of the current study was to investigate the correlation between the pretreatment aqueous level of vascular endothelial growth factor (VEGF) and clinical activity in neovascular age-related macular degeneration.
FIVE-YEAR INCIDENCE AND VISUAL ACUITY OUTCOMES FOR INTRAVITREAL THERAPY IN BILATERAL NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
Cornish, Elisa E. MBBS GradDipMed(OphthalSc), PhD*; Teo, Kelvin Y. MBBS MMed(Ophth)*,†,‡; Nguyen, Vuong PhD*; Squirrel, David MBChB MBBS§; Young, Stephanie MBBS¶; Gillies, Mark C. MBBS, PhD*; Barthelmes, Daniel MD, PhD*,**
doi : 10.1097/IAE.0000000000002798
Retina: January 2021 - Volume 41 - Issue 1 - p 118-124
To compare treatment intensity and mean visual acuity gains for first- and second-affected eyes with age-related macular degeneration nAMD over 5 years of treatment. The cumulative incidence of second-eye involvement was assessed.
BETA-PERIPAPILLARY ATROPHY AND GEOGRAPHIC ATROPHY IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENTS TRIALS
Kolomeyer, Anton M. MD, PhD; Smith, Eli BA; Daniel, Ebenezer MBBS, PhD; Ying, Gui-Shuang MD; Pan, Wei MA; Pistilli, Max MA; Grunwald, Juan MD; Maguire, Maureen G. PhD; Kim, Benjamin J. MD; for the CATT Research Group
doi : 10.1097/IAE.0000000000002825
Retina: January 2021 - Volume 41 - Issue 1 - p 125-134
To determine associations between beta-peripapillary atrophy (B-PPA) and incidence and growth of geographic atrophy (GA) in eyes treated with anti–vascular endothelial growth factor agents in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT).
SUB-RETINAL PIGMENT EPITHELIUM MULTILAMINAR HYPERREFLECTIVITY AT THE ONSET OF TYPE 3 MACULAR NEOVASCULARIZATION
Miere, Alexandra MD, MSc*; Sacconi, Riccardo MD, FEBO†; Amoroso, Francesca MD*; Capuano, Vittorio MD*,†; Jung, Camille MD, PhD*; Bandello, Francesco MD, FEBO†; Souied, Eric H. MD, PhD*; Querques, Giuseppe MD, PhD*,†
doi : 10.1097/IAE.0000000000002815
Retina: January 2021 - Volume 41 - Issue 1 - p 135-143
To report the prevalence and treatment outcomes of eyes with sub-retinal pigment epithelium (sub-RPE) multilaminar hyperreflectivity at the onset/clinical detection of Type 3 macular neovascularization (MNV) secondary to exudative age-related macular degeneration.
PHASE 2 STUDY OF THE SAFETY AND EFFICACY OF BRIMONIDINE DRUG DELIVERY SYSTEM (BRIMO DDS) GENERATION 1 IN PATIENTS WITH GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION
Kuppermann, Baruch D. MD, PhD*; Patel, Sunil S. MD, PhD†; Boyer, David S. MD‡; Augustin, Albert J. MD§; Freeman, William R. MD¶; Kerr, Kevin J. PharmD**; Guo, Qiang PhD**; Schneider, Susan MD**; L?pez, Francisco J. MD, PhD**, on behalf of the Brimo DDS Gen 1 Study Group
doi : 10.1097/IAE.0000000000002789
Retina: January 2021 - Volume 41 - Issue 1 - p 144-155
To evaluate the safety and efficacy of Brimonidine Drug Delivery System (Brimo DDS), a biodegradable intravitreal implant, in the treatment of geographic atrophy (GA) secondary to age-related macular degeneration.
REDUCED VASCULAR DENSITY IN THE CHOROID AFTER TREATMENT WITH PHOTODYNAMIC THERAPY COMBINED WITH AFLIBERCEPT IN PATIENTS WITH POLYPOIDAL CHOROIDAL VASCULOPATHY
Mukai, Ryo MD, PhD; Matsumoto, Hidetaka MD, PhD; Miyakubo, Tomoko MD; Akiyama, Hideo MD, PhD
doi : 10.1097/IAE.0000000000002793
Retina: January 2021 - Volume 41 - Issue 1 - p 156-161
To investigate changes of vascular density in the choroid of patients with polypoidal choroidal vasculopathy treated with photodynamic therapy (PDT) combined with intravitreal aflibercept.
ANATOMICAL CHANGES ON SEQUENTIAL MULTIMODAL IMAGING IN PERIFOVEAL EXUDATIVE VASCULAR ANOMALOUS COMPLEX
Verhoekx, Jennifer S. N. MD, PhD*; Smid, Lisette M. MSc†; Vermeer, Koenraad A. PhD†; Martinez Ciriano, José P. MD*; Yzer, Suzanne MD, PhD*
doi : 10.1097/IAE.0000000000002809
Retina: January 2021 - Volume 41 - Issue 1 - p 162-169
To report a series of 21 patients with perifoveal exudative vascular anomalous complex (PEVAC) and to investigate the anatomical changes over time.
INTRAOCULAR AND INTEROCULAR DIFFERENCES IN PARAFOVEAL VASCULAR DENSITY IN DIABETIC PATIENTS WITHOUT DIABETIC RETINOPATHY
Kim, Yong-Kyu MD; An, Yerim MD; Park, Sung Pyo MD, PhD
doi : 10.1097/IAE.0000000000002781
Retina: January 2021 - Volume 41 - Issue 1 - p 170-180
To evaluate the associations among optical coherence tomography angiography–measured vascular density (VD), intraocular and interocular VD differences, and clinical factors in diabetic patients without diabetic retinopathy.
REVISED CLASSIFICATION OF THE OPTICAL COHERENCE TOMOGRAPHY OUTER RETINAL BANDS BASED ON CENTRAL SEROUS CHORIORETINOPATHY ANALYSIS
Bloom, Steven M. MD; Singal, Inder P. MD
doi : 10.1097/IAE.0000000000002792
Retina: January 2021 - Volume 41 - Issue 1 - p 181-188
To evaluate the optical coherence tomography (OCT) imaging findings in recent onset neurosensory retinal detachments induced by central serous chorioretinopathy and to attempt to corroborate these findings with proposed anatomical correlates.
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY-GUIDED PHOTODYNAMIC THERAPY FOR ACUTE CENTRAL SEROUS CHORIORETINOPATHY
Hu, Jie MD; Qu, Jinfeng MD; Li, Mengyang MD; Sun, Guosheng MD; Piao, Zhenyu MD; Liang, Zhiqiao MD; Yao, Yuou MD; Sadda, SriniVas MD; Zhao, Mingwei MD
doi : 10.1097/IAE.0000000000002795
Retina: January 2021 - Volume 41 - Issue 1 - p 189-198
To compare the anatomic results of optical coherence tomography angiography (OCTA)-guided half-dose photodynamic therapy (PDT) versus indocyanine green angiography (ICGA)-guided PDT in eyes with acute central serous chorioretinopathy.
CLINICAL FEATURES OF FLAT IRREGULAR PIGMENT EPITHELIAL DETACHMENT ASSOCIATED WITH CHOROIDAL NEOVASCULARIZATION IN CHRONIC CENTRAL SEROUS CHORIORETINOPATHY
Guo, Jingli MD, PHD*; Tang, Wenyi MD*; Liu, Wei MD, PHD*; Chang, Qing MD, PHD*; Xu, Gezhi MD, PHD*,†
doi : 10.1097/IAE.0000000000002791
Retina: January 2021 - Volume 41 - Issue 1 - p 199-207
To describe the multimodal imaging characteristics of flat irregular pigment epithelial detachment (FIPED) in patients with chronic central serous chorioretinopathy and determine the risk factors for vascularized FIPED and to explore the activity of vascularized FIPED before and after half-dose photodynamic therapy.
TOXICITY AND EFFICACY OF INTRAVITREAL MELPHALAN FOR RETINOBLASTOMA
Liao, Albert MD, MS*,†; Hsieh, Terry MD, PhD*,‡; Francis, Jasmine H. MD*,§; Lavery, Jessica A. MS¶; Mauguen, Audrey PhD¶; Brodie, Scott E. MD, PhD**; Abramson, David H. MD, FACS*,§
doi : 10.1097/IAE.0000000000002782
Retina: January 2021 - Volume 41 - Issue 1 - p 208-212
To compare retinal toxicity as measured by electroretinogram, ocular, and patient survival in retinoblastoma treated with intravitreal melphalan at two concentrations (25 vs. 30 µg).
CLINICAL CHARACTERISTICS AND NATURAL HISTORY OF RHO-ASSOCIATED RETINITIS PIGMENTOSA
Nguyen, Xuan-Thanh-An MD*; Talib, Mays MD*; van Cauwenbergh, Caroline PhD†; van Schooneveld, Mary J. MD, PhD‡; Fiocco, Marta PhD§,¶; Wijnholds, Jan PhD*; ten Brink, Jacoline B. BAS**; Florijn, Ralph J. PhD**; Schalij-Delfos, Nicoline E. MD, PhD*; Dagnelie, Gislin PhD††; van Genderen, Maria M. MD, PhD‡‡,§§; de Baere, Elfride MD, PhD†; Meester-Smoor, Magda A. PhD¶¶; De Zaeytijd, Julie MD†; Balikova, Irina MD, PhD†; Thiadens, Alberta A. MD, PhD¶¶; Hoyng, Carel B. MD, PhD***; Klaver, Caroline C. MD, PhD¶¶,***,†††; van den Born, L. Ingeborgh MD, PhD‡‡‡; Bergen, Arthur A. PhD**,§§§; Leroy, Bart P. MD, PhD†,¶¶¶; Boon, Camiel J.F. MD, PhD*,‡
doi : 10.1097/IAE.0000000000002808
Retina: January 2021 - Volume 41 - Issue 1 - p 213-223
To investigate the natural history of RHO-associated retinitis pigmentosa (RP).
Diagnostic and Therapeutic Challenges
Chen, Ling Drs.; Xu, Gezhi; Vavvas, Demetrios G.
doi : 10.1097/IAE.0000000000002658
Retina: January 2021 - Volume 41 - Issue 1 - p 224-227
MODIFIED PORTABLE CAMERA ENDOSCOPE FOR POSTERIOR SEGMENT SURGERY
Sturzeneker, Guilherme MD, MSc*,†; Pereira, Rafael R. MD*,†; Nakaghi, Ricardo O. MD†; Maia, André MD, PhD*,†
doi : 10.1097/IAE.0000000000002973
Retina: January 2021 - Volume 41 - Issue 1 - p 228-229
Multimodal Imaging of Acute Siderotic Maculopathy
Ramtohul, Prithvi MD; Gascon, Pierre MD; Comet, Alban MD; Denis, Danièle MD, PhD
doi : 10.1097/IAE.0000000000002975
Retina: January 2021 - Volume 41 - Issue 1 - p e1-e2
Correspondence
Gioia, Marco MD*; De Bernardo, Maddalena MD, PhD*; Luigi, Capasso MD, PhD†; Rosa, Nicola MD*
doi : 10.1097/IAE.0000000000003020
Retina: January 2021 - Volume 41 - Issue 1 - p e3
Reply
Sakurada, Yoichi MD, PhD*; Fragiotta, Serena MD†; Leong, Belinda C. S. MD‡; Parikh, Ravi MD, MPH§; Hussnain, S. Amal MD¶; Freund, K. Bailey MD§,**
doi : 10.1097/IAE.0000000000003021
Retina: January 2021 - Volume 41 - Issue 1 - p e3-e4
Retina, The Journal of Retinal and Vitreous Diseases 2020 Scientific Reviewers
Author Information
doi : 10.1097/IAE.0000000000003019
Retina: January 2021 - Volume 41 - Issue 1 - p e5-e9
