Clinical and Translational Gastroenterology




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Small Intestinal Bacterial Overgrowths and Intestinal Methanogen Overgrowths Breath Testing in a Real-Life French Cohort.

Plauzolles, Anne PhD 1; Uras, Stella Master degree 1,2; Penaranda, Guillaume PhD 1; Bonnet, Marion PharmD, PhD 1; Dukan, Patrick MD 3; Retornaz, Frederique MD 3,*; Halfon, Philippe MD, PharmD, PhD 1,3,*

doi : 10.14309/ctg.0000000000000556

Volume 14(4) pgs. e00556-e00570 April 2023

Breath testing has become a widely used tool to diagnose small intestinal bacterial overgrowths (SIBOs) and intestinal methanogen overgrowths (IMOs) in clinical settings.

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Understanding Our Tests: Hydrogen-Methane Breath Testing to Diagnose Small Intestinal Bacterial Overgrowth.

Tansel, Aylin MD, MPH 1; Levinthal, David J. MD, PhD 1

doi : 10.14309/ctg.0000000000000567

AB There is increasing appreciation that small intestinal bacterial overgrowth (SIBO) drives many common gastrointestinal symptoms, including diarrhea, bloating, and abdominal pain.

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ABX464 (Obefazimod) Upregulates miR-124 to Reduce Proinflammatory Markers in Inflammatory Bowel Diseases.

Apolit, Cecile PhD 1,*; Campos, Noelie PhD 1,*; Vautrin, Audrey PhD 1; Begon-Pescia, Christina PhD 2; Lapasset, Laure PhD 1; Scherrer, Didier PhD 1; Gineste, Paul PharmD 3; Ehrlich, Hartmut MD 3; Garcel, Aude PharmD, PhD 1; Santo, Julien PhD 1; Tazi, Jamal PhD 1,3

doi : 10.14309/ctg.0000000000000560

AB Advanced therapies have transformed the treatment of inflammatory bowel disease; however, many patients fail to respond, highlighting the need for therapies tailored to the underlying cell and molecular disease drivers.

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The Slender Esophagus: Unrecognized Esophageal Narrowing in Eosinophilic Esophagitis.

Lynch, Kristle L. MD 1; Benitez, Alain J. MD 2; Godwin, Bridget MD 2; Klein, Jeremy BS 2; Savant, Deepika MD 3; Wilkins, Benjamin J. MD PhD 4; Menard-Katcher, Calies MD 5; Gluckman, Craig MD 1; Falk, Gary W. MD, MS 1; Muir, Amanda MD 2

doi : 10.14309/ctg.0000000000000564

Inflammation in eosinophilic esophagitis (EoE) often leads to esophageal strictures. Evaluating esophageal narrowing is clinically challenging.

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Adverse Events Related to SARS-CoV-2 Vaccine in a Nationwide Cohort of Patients With Inflammatory Bowel Disease.

Mahmud, Nadim MD, MS, MPH, MSCE 1,2,*; Reinisch, Walter MD 3,*; Patel, Manthankumar MS 1; Sundararajan, Ramaswamy MBBS 1; Khan, Nabeel MD 1,2

doi : 10.14309/ctg.0000000000000554

There are limited data on the safety profile of the severe acute respiratory syndrome coronavirus-2 vaccine among patients taking immunosuppressive medications.

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Digital Therapeutics: Emerging New Therapy for Nonalcoholic Fatty Liver Disease.

Zhou, Run MSN *,1; Gu, Yunpeng PhD *,2; Zhang, Binbin PhD 3,4; Kong, Tingting MSN 1; Zhang, Wei PhD 2; Li, Jie MD, PhD 5,6; Shi, Junping MD, PhD 7,8

doi : 10.14309/ctg.0000000000000575

AB The increased prevalence of nonalcoholic fatty liver disease (NAFLD) worldwide is particularly worrisome, as no medication has been approved to treat the disease.

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Acute Liver Failure: Biomarkers Evaluated by the Acute Liver Failure Study Group.

Rakela, Jorge L. MD 1; Karvellas, Constantine J. MD, SM, FRCPC 2; Koch, David G. MD, MSCR 3; Vegunta, Suneela MD 4; Lee, William M. MD 5

doi : 10.14309/ctg.0000000000000565

AB There has been a growing interest in identifying prognostic biomarkers that alone or with available prognostic models (King's College Criteria, KCC; MELD and ALFSG Prognostic Index) would improve prognosis in acute liver failure (ALF) patients being assessed for liver transplantation.

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