American Journal of Gastroenterology




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Prescribing Colonoscopy Bowel Preparations: Tips for Maximizing Outcomes.

Oldfield, Edward C. IV MD 1; Johnson, David A. MD, MACG, FASGE, MACP 1; Rex, Douglas K. MD, MACG, MASGE, MACP 2,3

doi : 10.14309/ajg.0000000000002110

Volume 118(5) pgs. 761-913 May 2023

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Socioenvironmental Stressors, Gut Microbes, and Colorectal Cancer Inequities: A Chicago Perspective.

Wolf, Patricia G. PhD, RD 1; Kim, Sage PhD 2; Tussing-Humphreys, Lisa PhD, MS, RD 3

doi : 10.14309/ajg.0000000000002131

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Madame Bouveret: Duodenal Obstruction due to a Large Isoattenuating Gallstone.

Nahoum, Luiza MD 1; Carpentieri-Primo, Pedro MD 1; Parente, Daniella Braz MD, PhD 1,2

doi : 10.14309/ajg.0000000000002101

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Hemorrhagic Acute Cholecystitis Causing Mirizzi Syndrome.

Shirata, Chikara MD 1; Demartines, Nicolas MD, FACS, FRCS 1; Matter, Maurice MD 1; Joliat, Gaetan-Romain MD 1

doi : 10.14309/ajg.0000000000002169

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Sessile Serrated Lesion of the Rectum in Ulcerative Colitis Observed by Image-Enhanced Endoscopy.

Kawasaki, Keisuke MD 1; Kawatoko, Shinichiro MD 1,2; Yamamoto, Hidetaka MD 2; Torisu, Takehiro MD 1

doi : 10.14309/ajg.0000000000002175

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Long-term Major Papilla Metastasis From Lobular Breast Cancer Mimicking Ampullary Neoplasm: An Endoscopic Ultrasound Diagnosis.

Mazza, Stefano MD 1; Drago, Andrea MD 1; Tanzi, Giulia MD 2; Soro, Sara MD 1; Verga, Maria Chiara MD 1; Elvo, Biagio MD 1; Laurenza, Carmen MD 1; di Luna, Imma MD 1; Grassia, Roberto MD 1

doi : 10.14309/ajg.0000000000002231

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Odynophagia Secondary to Mpox-Associated Esophageal Ulceration.

Chittajallu, Vibhu MD 1; Vozzo, Catherine DO 1; Friedman, Kenneth MD 2; Glessing, Brooke MD 1; Nguyen, Vu MD 1

doi : 10.14309/ajg.0000000000002095

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Endoscopic Resection of a Complex Rectosigmoid Lesion Using Novel Technology to Prevent Long-Term Luminal Stricture.

Tsiamoulos, Zacharias P. MBBS, MD(Res), PhD 1; Basit, Rizwan MBBS, BSc (Hons), FRCR 2; Vega, Roser LMC, PhD 3; Beintaris, Iosif MBBS 4; Ramchandani, Mohan MD, PhD 5; Sebastian, Joseph MBBS, MS, MRCS, FRCS 6; Saunders, Brian P. MBBS, MD, FRCP, FRCS 7

doi : 10.14309/ajg.0000000000002150

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Continuing Medical Education Questions: May 2023.

Holzwanger, Erik A. MD

doi : 10.14309/ajg.0000000000002271

AB Article Title: Reduced Adenoma Miss Rate with 9-Minute vs 6-Minute Withdrawal Times for Screening Colonoscopy: A Multicenter Randomized Tandem Trial (C) The American College of Gastroenterology 2023. All Rights Reserved.

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Continuing Medical Education Questions: May 2023.

Khan, Zubair MD

doi : 10.14309/ajg.0000000000002272

AB Article Title: Linaclotide Reduced Response Time for Irritable Bowel Syndrome with Constipation Symptoms: Analysis of Four Randomized Controlled Trials (C) The American College of Gastroenterology 2023. All Rights Reserved.

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Strategies for the Use of Dupilumab in Eosinophilic Esophagitis.

Sauer, Bryan G. MD, MSc, FACG 1; Barnes, Barrett H. MD 2; McGowan, Emily C. MD, PhD 3

doi : 10.14309/ajg.0000000000002206

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The Liver in Celiac Disease: A Strong 2-Way Talk!

Jansson-Knodell, Claire L. MD 1; Rubio-Tapia, Alberto MD 1

doi : 10.14309/ajg.0000000000002144

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Esophageal Hypervigilance and Visceral Anxiety Contribute to Symptom Severity of Laryngopharyngeal Reflux.

Wong, Ming-Wun MD, PhD 1,2; Hsiao, Shih-Hsuan MD 3; Wang, Jen-Hung PhD 4; Yi, Chih-Hsun MD 1; Liu, Tso-Tsai MD 1; Lei, Wei-Yi MD, PhD 1; Hung, Jui-Sheng MD 1; Liang, Shu-Wei MD 1; Lin, Lin MD 1; Gyawali, Chandra Prakash MD 5; Chen, Peir-Rong MD 3; Chen, Chien-Lin MD, PhD 1,6

doi : 10.14309/ajg.0000000000002151

Laryngopharyngeal reflux (LPR) is a clinical conundrum without a diagnostic gold standard. The Esophageal Hypervigilance and Anxiety Scale (EHAS) is a questionnaire designed for cognitive-affective evaluation of visceral sensitivity.

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Ambulatory pH-Impedance Findings Confirm That Grade B Esophagitis Provides Objective Diagnosis of Gastroesophageal Reflux Disease.

Visaggi, Pierfrancesco MD 1,2; Del Corso, Giulio MD 3; Gyawali, C. Prakash MD 4; Ghisa, Matteo MD 5; Baiano Svizzero, Federica MD 1; Stefani Donati, Delio MD 1; Venturini, Arianna MD 1; Savarino, Vincenzo MD 6; Penagini, Roberto MD 7; Zeki, Sebastian MD, PhD 2,8; Bellini, Massimo MD 1; Savarino, Edoardo V. MD, PhD 5,*; de Bortoli, Nicola MD 1,*

doi : 10.14309/ajg.0000000000002173

The Lyon Consensus designates Los Angeles (LA) grade C/D esophagitis or acid exposure time (AET) >6% on impedance-pH monitoring (MII-pH) as conclusive for gastroesophageal reflux disease (GERD).

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Reduced Adenoma Miss Rate With 9-Minute vs 6-Minute Withdrawal Times for Screening Colonoscopy: A Multicenter Randomized Tandem Trial.

Zhao, Shengbing MD 1,*; Song, Yihang MD 1,*; Wang, Shuling MD 1,*; Wang, Rong MD 2,*; Feng, Zhijie MD 3,*; Gong, Aixia MD 4,*; Yang, Xia MD 5,*; Pan, Peng MD 1; Yao, Dongmei MD 3; Zhang, Jingwen MD 4; Zhu, Yaqin MD 5; Li, Tao MD 2; Bi, Junhua MD 2; Ren, Xu MD 6; Tang, Xiufen MD 6; Li, Qiang MD 6; Yu, Dan MD 6; Zheng, Jinghua MD 7; Song, Bo MD 7; Wang, Ping MD 7; Chen, Weigang MD 8; Shang, Guochen MD 8; Xu, Yanqiu MD 8; Xu, Ping MD 9; Lai, Yuexing MD 9; Xu, Huanhai MD 10; Yang, Xiaomin MD 10; Sheng, Jianqiu MD 11; Tao, Yurong MD 11; Li, Xinghua MD 12; Zhu, Yangbei MD 12; Zhang, Xiaofeng MD 13; Shen, Hongzhang MD 13; Ma, Yingcai MD 14; Wang, Fangyu MD 15; Wu, Lin MD 15; Wang, Xianfei MD 16; Li, Zhaoshen MD, PhD 1; Bai, Yu MD, PhD 1

doi : 10.14309/ajg.0000000000002055

Although the 9-minute mean withdrawal time (m-WT) is often reported to be associated with the optimal adenoma detection rate (ADR), no randomized trials of screening colonoscopy have confirmed the impact of a 9-minute m-WT on adenoma miss rate (AMR) and ADR.

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Periprocedural Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant Undergoing a Digestive Endoscopy.

Hansen-Barkun, Christopher BKin 1; Martel, Myriam MSc 1; Douketis, James MD 2; Abraham, Neena S. MD, MSc (Epi), MACG 3; Liederman, Zachary MD 4; Kaplovitch, Eric MD 5; Schulman, Sam MD, PhD 6,7; Spyropoulos, Alex C. MD 8,9; Majid, Almadi MD, MSc 10; Barkun, Alan N. MD 11

doi : 10.14309/ajg.0000000000002076

The periprocedural management of patients with atrial fibrillation (AF) using a direct oral anticoagulant (DOAC) undergoing elective gastrointestinal (GI) endoscopic procedure remains uncertain.

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Prevalence of Celiac Disease in Patients With Liver Diseases: A Systematic Review and Meta-Analyses.

Yoosuf, Shakira MD 1,2; Singh, Prashant MD 3; Khaitan, Ashank MBBS 1; Strand, Tor A. MD 4; Ahuja, Vineet MD, DM 1; Makharia, Govind K. MD, DM, DNB 1

doi : 10.14309/ajg.0000000000002123

A subset of patients with celiac disease (CeD) has liver involvement in the form of hypertransaminasemia, liver cirrhosis, and autoimmune hepatitis. We conducted a systematic review with meta-analyses to determine the pooled prevalence of CeD in patients with cryptogenic cirrhosis, all-cause cirrhosis, cryptogenic hypertransaminasemia, and all-cause hypertransaminasemia.

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Assessing the Risk of Further Decompensation and Survival in Patients With Cirrhosis With Variceal Bleeding as Their First Decompensation Event.

Gupta, Anany MD 1,*; Rana, Randeep MD 1,*; Agarwal, Samagra MD, DM 1,*; Sharma, Sanchit MD, DM 1,2,**; Gopi, Srikanth MD, DM 1; Mohta, Srikant MD, DM 1; Gunjan, Deepak MD, DM 1; Saraya, Anoop MD, DM, DNB 1,**

doi : 10.14309/ajg.0000000000002018

Limited data exist on long-term outcomes of patients with compensated cirrhosis presenting with acute variceal bleeding (AVB) as an index and lone decompensating event.

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A Reappraisal of the Diagnostic Performance of B-Mode Ultrasonography for Mild Liver Steatosis.

Lee, Chul-min MD, PhD 1,*; Yoon, Eileen L. MD, PhD 2,*; Nakajima, Atsushi MD, PhD 3; Yoneda, Masato MD, PhD 3; Toyoda, Hidenori MD, PhD 4; Yasuda, Satoshi MD, PhD 4; Lee, Jonghyun PhD 5; Kim, Mimi MD, PhD 1; Kang, Bo-Kyeong MD, PhD 1; Nguyen, Mindie H. MD, PhD 6; Jun, Dae Won MD, PhD 2,5; Sumida, Yoshio MD, PhD 7

doi : 10.14309/ajg.0000000000002020

Previous studies have shown that ultrasonography has high specificity (80%-100%) but low sensitivity (50%-70%) in diagnosing fatty liver; sensitivity is especially low for mild steatosis. In this study, we aimed to reappraise the diagnostic performance of B-mode ultrasonography (B-USG) for fatty liver disease.

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Increased Proportion of Colorectal Cancer in Patients With Ulcerative Colitis Undergoing Surgery in the Netherlands.

Heuthorst, Lianne MD 1; Harbech, Houda BSc 1; Snijder, Harmanna J. MD 1,2,3,4; Mookhoek, Aart MD, PhD 5; D'Haens, Geert R. MD, PhD 2; Vermeire, Severine MD, PhD 3; D'Hoore, Andre MD, PhD 4; Bemelman, Willem A. MD, PhD 1; Buskens, Christianne J. MD, PhD 1

doi : 10.14309/ajg.0000000000002099

The aim of the current study was to assess whether there is an indication shift for surgery in patients with ulcerative colitis (UC) from refractory disease to malignant degeneration over the past 3 decades.

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@MondayNightIBD and the Expanding Gastroenterology Twitterverse: A Study on Continuing Medical Education on #GITwitter.

Goldowsky, Alexander MD 1; Billings, Wade MD 2; Kickel, Allison BS 3; Charabaty, Aline MD 4

doi : 10.14309/ajg.0000000000002103

MondayNightIBD provides weekly continuing medical education (CME) activities focused on inflammatory bowel diseases to clinicians on Twitter. Given its novelty, we assessed whether @MondayNightIBD improves learner knowledge and leads to practice change.

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REMIT-UC: Real-World Effectiveness and Safety of Tofacitinib for Moderate-to-Severely Active Ulcerative Colitis: A Canadian IBD Research Consortium Multicenter National Cohort Study.

Ma, Christopher MD, MPH 1,2,3; Panaccione, Remo MD 1; Xiao, Yasi MD 4; Khandelwal, Yuvan BSc 5; Murthy, Sanjay K. MD, MSc 6,7; Wong, Emily C.L. BHSc 8; Narula, Neeraj MD, MPH 8; Tsai, Catherine MD 9; Peerani, Farhad MD 9; Reise-Filteau, Marica MD 10; Bressler, Brian MD, MS 10; Starkey, Samantha Y. BSc 11; Loomes, Dustin MD 12; Sedano, Rocio MD 3; Jairath, Vipul MBChB, DPhil, MRCP 3,13,14; Bessissow, Talat MDCM, MSc 15

doi : 10.14309/ajg.0000000000002129

We aimed to evaluate the real-world effectiveness and safety of tofacitinib for the treatment of ulcerative colitis (UC). METHODS: REMIT-UC is a Canadian multicenter cohort study.

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Linaclotide Reduced Response Time for Irritable Bowel Syndrome With Constipation Symptoms: Analysis of 4 Randomized Controlled Trials.

Brenner, Darren M. MD 1; Lacy, Brian E. MD, PhD 2; Ford, Alexander C. MD 3,4; Bartolini, Wilmin PhD 5,6; Wu, James PhD 5; Shea, Elizabeth P. PhD 5,7; Bochenek, Wieslaw MD, PhD 8; Boinpally, Ramesh PhD 8; Almansa, Cristina MD, PhD 5,9

doi : 10.14309/ajg.0000000000002064

These post hoc analyses provide clinically relevant data concerning time to response for individual irritable bowel syndrome with constipation (IBS-C) symptoms after linaclotide use.

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Short-term and Long-term Outcomes of a Disruption and Disconnection of the Pancreatic Duct in Necrotizing Pancreatitis: A Multicenter Cohort Study in 896 Patients.

Timmerhuis, Hester C. MD 1,2; van Dijk, Sven M. MD, PhD 3,4; Hollemans, Robbert A. MD 5; Sperna Weiland, Christina J. MD, PhD 6; Umans, Devica S. MD 4,7; Boxhoorn, Lotte MD, PhD 4,7; Hallensleben, Nora H. MD 8; van der Sluijs, Rogier MD, PhD 9; Brouwer, Lieke MD, PhD 10; van Duijvendijk, Peter MD, PhD 11; Kager, Liesbeth MD, PhD 12; Kuiken, Sjoerd MD, PhD 13; Poley, Jan-Werner MD, PhD 14; de Ridder, Rogier MD 14; Romkens, Tessa E.H. MD, PhD 15; Quispel, Rutger MD, PhD 16; Schwartz, Matthijs P. MD, PhD 17; Tan, Adriaan C.I.T.L. MD, PhD 18; Venneman, Niels G. MD, PhD 19; Vleggaar, Frank P. MD, PhD 20; van Wanrooij, Roy L.J. MD, PhD 4,21; Witteman, Ben J. MD, PhD 22; van Geenen, Erwin J. MD, PhD 6; Molenaar, I. Quintus MD, PhD 5; Bruno, Marco J. MD, PhD 8; van Hooft, Jeanin E. MD, PhD, MBA 23; Besselink, Marc G. MD, PhD 3,4; Voermans, Rogier P. MD, PhD 4,7; Bollen, Thomas L. MD, PhD 24; Verdonk, Robert C. MD, PhD 20,25,*; van Santvoort, Hjalmar C. MD, PhD 2,5,*; for the Dutch Pancreatitis Study Group

doi : 10.14309/ajg.0000000000002157

Necrotizing pancreatitis may result in a disrupted or disconnected pancreatic duct (DPD) with the potential for long-lasting negative impact on a patient's clinical outcome.

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A Randomized Controlled Trial of Fibrin Glue to Prevent Bleeding After Gastric Endoscopic Submucosal Dissection.

Lee, Hyun Deok MD 1; Lee, Eunwoo MD 1; Kim, Sang Gyun MD, PhD 1; Shin, Cheol Min MD, PhD 2; Park, Jun Chul MD, PhD 3; Choi, Kee Don MD, PhD 4; Hahn, Seokyung PhD 5; Cho, Soo-Jeong MD, PhD 1

doi : 10.14309/ajg.0000000000002172

This study evaluated the efficacy of fibrin glue for preventing postendoscopic submucosal dissection (ESD) bleeding in high-risk patients for bleeding (expected iatrogenic ulcer size >=40 mm or receiving antithrombotic therapy).

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Wide Variability in Dysplasia Detection Rate and Adherence to Seattle Protocol and Surveillance Recommendations in Barrett's Esophagus: A Population-Based Analysis Using the GIQuIC National Quality Benchmarking Registry.

Kolb, Jennifer M. MD, MS 1; Davis, Christian MD 2; Williams, J. Lucas MPH 3; Holub, Jennifer MPH 3; Shaheen, Nicholas MD, MPH 4; Wani, Sachin MD 5

doi : 10.14309/ajg.0000000000002102

Variability in adherence rates to the Seattle protocol and to surveillance interval recommendations, established quality indicators (QIs) in Barrett's esophagus (BE), is unknown.

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Pentosan Polysulfate-Associated Dysplasia in Patients With Inflammatory Bowel Disease: A Case Series.

Anderson, Jenna MD 1; Frost, Spencer MD 2; Keyashian, Kian MD 2; Modiano, Nir MD, PhD 1

doi : 10.14309/ajg.0000000000002137

This study evaluates the potential association of pentosan polysulfate (PPS) with inflammatory bowel disease (IBD) or dysplasia. METHODS: We searched electronic medical records to identify patients with IBD using PPS.

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The Neglected Portal Intrahepatic Shunts.

Zhang, Heng MD 1; Jiang, Bin PhD 1; Meng, Zhong-ji PhD 1

doi : 10.14309/ajg.0000000000002177

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Response to Zhang et al.

Dhakre, Vijay Waman MS, FHPB, FMAS 1; Shah, Preet MBBS, DNB 2; Nagral, Sanjay S. MS, FACS 3; Nagral, Aabha S. MD, DNB 4

doi : 10.14309/ajg.0000000000002246

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Intrapancreatic Fat Deposition: Cause or Consequence of First Acute Pancreatitis Attack?.

Schepis, Tommaso MD 1,2; Tringali, Andrea MD, PhD 1,2; Spada, Cristiano MD, PhD 1,2; Costamagna, Guido MD, FACG, FJGES 1,2; Boskoski, Ivo MD, PhD 1,2

doi : 10.14309/ajg.0000000000002221

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Duodenal Biopsies: Individual or Multiple Samples?.

Rettally, Carlos MD 1

doi : 10.14309/ajg.0000000000002229

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Calendar of Courses, Symposiums and Conferences.

doi : 10.14309/ajg.0000000000002273

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