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Role of HIF-1α in pathogenic mechanisms of keloids
Zi-kai Qiu MD, Ming-zi Zhang MD, Wen-chao Zhang MD, Zhi-jin Li MD, Lou-bin Si MD, Xiao Long MD, Nan-ze Yu MD, Xiao-jun Wang MD
doi : 10.1111/jocd.15601
Keloids are defined as overrepairing products that develop after skin lesions. Keloids are characterized by the proliferation of fibroblasts and the overaccumulation of extracellular matrix components (mainly collagen), leading to a locally hypoxic microenvironment. Hence, this article was aimed to review hypoxia in pathogenesis of keloids.
Idiopathic hirsutism and dyslipidemia: A systematic review, meta-analysis, and meta-regressions
Mina Amiri PhD, Leila Mahmoudieh MD, Ali Sheidaei PhD, Fahimeh Ramezani Tehrani MD
doi : 10.1111/jocd.15608
Despite existing several kinds of studies on idiopathic hirsutism (IH) and its association with metabolic disturbances, a limited number of studies have assessed lipid profiles in patients with IH with conflicting and inconclusive results.
An umbrella review of the use of platelet-rich plasma in the treatment of androgenetic alopecia
Caihong Li MD, Lingfeng Pan MD, Liehao Yang MD, Jiao Kong MD, Lianbo Zhang MD
doi : 10.1111/jocd.15617
To evaluate the efficacy of platelet-rich plasma (PRP) in the treatment of androgenetic alopecia, as well as establish an effective treatment protocol and optimal PRP preparation procedure.
Facial fat necrosis after autologous fat transfer possibly associated with SARS-CoV-2 vaccine
Cristina N. Brau-Javier MD, Andrea Paola Caro-Muniz MD, Orlando Canizares MD
doi : 10.1111/jocd.15635
A 52-year-old female patient developed facial fat necrosis presenting with cutaneous induration three weeks after minimal access cranial suspension (MACS) lift with autologous fat grafting from the abdomen.
Intralesional injection of platelet-rich plasma versus steroid in the treatment of oral lichen planus
Mohamed Ibrahim ElGhareeb MD, Soheir Ghoneimy MD, Asmaa Elsayed MS
doi : 10.1111/jocd.15622
Oral licen planus (OLP) is a chronic inflammatory disease and may have immunological background. Both intralesional injection of PRP and steroids succeeded in treating and decreasing recurrence of the disease.
The efficacy and safety of the high-intensity parallel beam ultrasound device at the depth of 1.5 mm for skin tightening
Wichai Hongcharu MD, Kanjana Boonchoo MD, MSc, Michael H. Gold MD
doi : 10.1111/jocd.15672
High-intensity parallel beam ultrasound (US) is a novel device equipped with Synchronous Ultrasound Parallel Beam (SUPERB) technology applied in anti-aging treatment. The system is aimed at pathways stimulating neocollagenesis and neoelastinogenesis in the dermis leading to skin tightening and rejuvenation.
Characterization of an ablative fractional CO2 laser-induced wound-healing model based on in vitro 3D reconstructed skin
Chunyan He MS, Wei Zhang MD, Yidong Tu PhD, Lingyan Zhong BS, Ranran Wang MS, Yao Teng PhD, I-Chien Liao PhD, Chunmei Ding PhD
doi : 10.1111/jocd.15597
This study describes the development and characterization of a novel in vitro wound-healing model based on a full-thickness reconstructed skin by exposing the tissue to fractional ablative laser treatment.
Clinical and histological evaluation of microneedle fractional radiofrequency treatment on facial fine lines and skin laxity in Koreans
Dong Hye Suh MD, Minah Cho MD, Hyeong Seob Kim MD, Sang Jun Lee MD, Kye Yong Song MD, PhD, Hei Sung Kim MD, PhD
doi : 10.1111/jocd.15614
Facial wrinkles and sagging are the most visible signs of aging and can cause profound distress. Microneedle fractional radiofrequency (MFR) is a minimally invasive procedure, which utilizes both microneedling and radiofrequency energy to rejuvenate the skin.
The efficacy of adding topical 5-fluorouracil to micro-needling in the treatment of vitiligo: A randomized controlled trial
Nader Pazyar MD, Mohammad Hatami MD, Reza Yaghoobi MD, Seyedeh Yasamin Parvar MD, Mohammad Radmanesh MD, Maryam Hadibarhaghtalab MD, MPH
doi : 10.1111/jocd.15616
Vitiligo is an autoimmune skin disorder characterized by circumscribed depigmented macules and patches caused by the loss of functional melanocytes. Although there is no definitive treatment for vitiligo, several treatment options have been associated with relative satisfactory outcomes. The purpose of this study was to compare the efficacy of micro-needling in conjunction with topical 5-fluorouracil (5-FU) versus topical tacrolimus ointment in treating vitiligo patches.
Efficacy of topical vitamin D combined with microneedling in the treatment of vitiligo: A comparative study
Maha Wafic Salem MBBS of General Medicine and Surgery, Amira Adel Abd El Azim MD, MRCP (UK), Sara Ahmed Galal MD
doi : 10.1111/jocd.15621
Vitiligo is a depigmenting disorder caused by the destruction of melanocytes by various mechanisms which affect melanocyte function and survival. Different therapeutic approaches for vitiligo include nonsurgical and surgical methods but effective therapy is still challenging.
Effect of fractional laser alone or in combination on alopecia areata: A systematic review and meta-analysis
Yuqing Shen MD, Jiayi Sun MD, Yuqi Zhu MD, Yi Chen MD, Yebei Hu MD, Haixin Luo MD, Xiuzu Song PhD
doi : 10.1111/jocd.15630
Alopecia areata (AA) is characterized by limited non-scarring patchy alopecia, which appears as round or oval patches and is prone to recurrence, causing severe psychological burdens to patients.
Effectiveness of combination therapy of broadband light and intradermal injection of tranexamic acid in the treatment of chloasma
Zou Jia MD, Kai Tian MD, Yuanyuan Zhong BM, Xiaoyun Wang BM, Suyue Gao MD, Wushuang Xu MD, Ke Li PhD, Lijun Wu PhD
doi : 10.1111/jocd.15632
To investigate the efficacy and safety of broadband light (BBL) combined with intradermal injection of tranexamic acid for treating melasma.
Safety and effectiveness of nano-pulse stimulationâ„¢ technology to treat acne vulgaris of the back
Bruce E. Katz MD, Mark S. Nestor MD, PhD, Richard Nuccitelli PhD, Lauren Jauregui Johnston BS, William A. Knape BS
doi : 10.1111/jocd.15633
This feasibility study describes the effects of Nano-pulse stimulationâ„¢ (NPSâ„¢) technology using the CellFXâ„¢ System on acne vulgaris of the back with the objectives of demonstrating safety and effectiveness.
Facial psoriasis in the etiology of prolonged erythema following medium-depth chemical peels for severe photodamage
Liang Joo Leow MPH&TM, FACD, FACMS, Nicolas Zubrzycki BSc
doi : 10.1111/jocd.15620
Chemical peeling is the controlled wounding of the epidermis and dermis for skin rejuvenation, involving the application of ablative agents to induce keratolysis and regeneration of damaged cell layers. Prolonged erythema is one complication of this procedure. We report the prevalence and probable etiology of prolonged facial erythema in a cohort of patients treated with medium-depth chemical peels.
Objective, measurable assessment of the elasticity of the skin around the eyes following the carboxytherapy treatment
Anna KoÅ‚odziejczak PhD, Helena Rotsztejn PhD
doi : 10.1111/jocd.15599
Carboxytherapy is one of the most popular procedures used in dermatology. The treatments are known to be minimally invasive and highly effective for various skin disorders. Therefore, the research carried out in the paper is purposeful and addresses an important area of aesthetic therapies.
Aesthetic considerations for treating the Middle Eastern patient: Thriving in Diversity international roundtable series
Sabrina Guillen Fabi MD, FAAD, FAACS, Hassan Galadari MD, FAAD, Nabil Fakih-Gomez MD, MSc, Sheila Nazarian Mobin MD, Ofir Artzi MD, Steve Dayan MD
doi : 10.1111/jocd.15640
The Middle East has a significant influence on the global aesthetic market. Within the United States and globally, patients with Middle Eastern heritage have a wide range of ethnic and cultural backgrounds that affect their perceptions of beauty and motivations to seek cosmetic treatment.
Analysis of pathogen distribution and antimicrobial resistance at infected sites in plastic surgery
Fengli Jiang MMD, Xueshang Su MM, Yuduo Dai MD, Hang Shen MM, Jintian Hu MD, Lingsong Wu MBBS, Yuanyuan Wu MM, Sien Zhan MD
doi : 10.1111/jocd.15600
By analyzing the distribution and drug resistance of common pathogen in different sites in plastic surgery to provide reference for clinicians to choose the best antibacterial treatment plan.
An improved human skin explant culture method for testing and assessing personal care products
Linli Zhou PhD, Wei Ji MS, Teresa Dicolandrea PhD, Deborah Finlay PhD, Dorothy Supp PhD, Steven Boyce PhD, Karl Wei PhD, Ana Luisa Kadekaro PhD, Yuhang Zhang PhD
doi : 10.1111/jocd.15607
Cultured human skin models have been widely used in the evaluation of dermato-cosmetic products as alternatives to animal testing and expensive clinical testing. The most common in vitro skin culture approach is to maintain skin biopsies in an airlifted condition at the interface of the supporting culture medium and the air phase.
Validation of the Cardiff acne disability index and the impact of educational materials in a Romanian cultural adaptation context
Stefana Cretu MD, Mihai Dascalu PhD, Carmen-Maria Salavastru MD, PhD
doi : 10.1111/jocd.15609
Acne has a high impact on patients being a chronic, common, and visible skin condition. Knowledge regarding treatment improves outcomes. The Cardiff Acne Disability Index (CADI) is commonly used in clinical practice for quality-of-life assessment. It has been validated in many languages, however, not in Romanian.
Morinda officinalis extract exhibits protective effects against atopic dermatitis by regulating the MALAT1/miR-590-5p/CCR7 axis
Huan-Huan Yu MM, Wei Zhao MD, Bu-Xin Zhang MD, Ying Wang MM, Jie Li BD, Yu-Fu Fang MM
doi : 10.1111/jocd.15610
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a genetic predisposition, and the traditional Chinese medicine Morinda officinalis and its roots are characterized with anti-inflammatory effects and have been used for the treatment of various disease. However, it is still largely unknown whether Morinda officinalis extract (MOE) can be used for the treatment of AD.
Microwave-assisted and chemically tailored chlorogenic acid-functionalized silver nanoparticles of Citrus sinensis in gel matrix aiding QbD design for the treatment of acne
Aftab Alam M. Pharm, PhD, Ahmed I. Foudah B. Pharm, PhD, Mohammed H. Alqarni B. Pharm, PhD, Hasan S. Yusufoglu M. Pharm, PhD
doi : 10.1111/jocd.15611
Numerous studies have shown that various products of Citrus sinensis, for example, crude extracts, essential oil, and purified components, possess anti-acne properties. However, the development of chlorogenic acid-functionalized silver nanoparticles of C. sinensis in gel matrix aiding QbD design has not been evaluated for acne treatment.
Profiling of phytochemicals using LC-ESI-MS2, in vitro, in vivo characterization and cosmeceutical effects of Alpinia galanga (wild) extract loaded emulgel
Muhammad Shahzad khan PhD, Qazi Adnan PhD, Naveed Akhtar PhD
doi : 10.1111/jocd.15623
The potential as a depigmenting agent, sun protection, and healthy benefits is indicated by the sun protection factor, radical scavenging, and tyrosinase inhibitory activities of Alpinia galanga (wild).
The vitamin D receptor gene polymorphism rs1544410 T/T genotype as a predictor of factor vitamin D thresholds deficiency in patients with psoriasis vulgaris�A preliminary study
Ahmed Ibrahim AbdElneam PhD, Mohammed Saleh Al-Dhubaibi MD, Saleh Salem Bahaj PhD, Ghada Farouk Mohammed MD
doi : 10.1111/jocd.15625
Many clinical features of psoriasis include a rash with itchy, scaly patches, most frequently on the knees, elbows, trunk, and scalp. By studying genes involved with psoriasis receptivity, the pathologic pathways of psoriasis become clearer and more understood.
Topical niacinamide (Nicotinamide) treatment for discoid lupus erythematosus (DLE): A prospective pilot study
Ahmed H. Nouh MD, Ahmed R. Elshahid MD, Ahmed S. Kadah MD, Youssef A. Zeyada MbBch
doi : 10.1111/jocd.15628
Cutaneous lupus erythematosus is an umbrella term for a group of autoimmune connective tissue disorders affecting the skin. Discoid lupus erythematosus (DLE) is the chronic condition and most common form of cutaneous lupus erythematosus.
Regulation of epidermal proliferation and hair follicle cycling by synthetic photostable retinoid EC23
Arto Määttä PhD, Rebecca Nixon Bsc (hons), Neil Robinson BSc (hons), Carrie A. Ambler PhD, Kirsty Goncalves PhD, Victoria Maltman PhD, Stefan Przyborski PhD
doi : 10.1111/jocd.15629
Retinoid signaling is an important regulator of the epidermis and skin appendages. Therefore, synthetic retinoids have been developed for therapeutic use for skin disorders such as psoriasis and acne.
Sodium alginate/gelatin hydrogels loaded with adipose-derived mesenchymal stem cells promote wound healing in diabetic rats
Wei Sheng MSc, Qi Song PhD, XiangZheng Su PhD, Yao Lu MSc, YuZhe Bai MSc, FengKun Ji MSc, Li Zhang PhD, RunGong Yang MSc, Xiaobing Fu PhD
doi : 10.1111/jocd.15631
Chronic refractory wounds are a common complication in diabetic patients. Adipose-derived mesenchymal stem cells (ASCs) have been shown to play an essential role in diabetic wound repair.
Recurrence and risk factors in cured patients with vitiligo: AÂ real-life single-center retrospective study
Wei Xu, Zhijin Qiu, Chaolan Li, Yuyi Wang, Mao Lin, Yi Liu, Yating Wen, Wenhao Zheng
doi : 10.1111/jocd.15637
The risk of recurrence after successful repigmentation in vitiligo has attracted attention from both patients and clinicians.
Effect of silver-containing hydrofiber dressing on burn wound healing: A meta-analysis and systematic review
Juan-juan Wu BD, Fan Zhang MS, Jing Liu BD, Hui-jun Yao BD, Yan Wang BD
doi : 10.1111/jocd.15639
Silver sulfadiazine is commonly used to treat local burn wounds. Aquacel-Ag is a hydrogen fiber dressing containing ionic silver that reduces burn wound infection and promotes antimicrobial activity. It is necessary to compare the efficacy of the two in the healing of burns.
Strategic use of virtual and face-to-face visits for optimal care of dermatologic disease
Julianne M. Falotico BA, Lilly Gu BS, Shari R. Lipner MD, PhD
doi : 10.1111/jocd.15604
Foreign body reaction to polyacrylamide filler (Aquafilling®) injected nine years previously: A complication of SARS-CoV-2 infection or merely a coincidence?
Pinar Incel Uysal MD, Burak Ozkan MD, Suleyman Savran MD, Pelin Borcek MD, Ahmet Cagri Uysal MD, PhD
doi : 10.1111/jocd.15615
Bilateral second branchial cleft fistulae coexisting with bilateral cleft lip and bilateral supra-auricular fissures
Rekik Mariem DR, Sellami Khadija PhD, Hableni Hanen PhD, Baklouti Massara DR, Karray Fathi PR, Abdelmoula Mohamed PR, Turki Hamida PR
doi : 10.1111/jocd.15619
Platelet-rich plasma injection versus combined fractional carbon dioxide laser with platelet-rich plasma in treatment of vitiligo: A comparative study
Shaymaa El-Mongy El-Mongy MD, Bothaina Mahrous Ghanem MD, Yasmen Mohamed Mohamed Ebrahiem El-Shrbeny MBBCh
doi : 10.1111/jocd.15594
Early-stage volume effect difference between injectable poly-l-lactic acid and injectable poly-d,l-lactic acid
Jui-Yu Lin MD, Ju-Peng Fu MD, Nai-Jen Hsu MD, Chuan-Yuan Lin MD
doi : 10.1111/jocd.15595
Keloid scar after herpes zoster ophthalmicus
Rym Maamouri MD, Anissa Zaouak MD, Amri Ali MD, Refka Frioui MD, Monia Cheour MD
doi : 10.1111/jocd.15636
Industry collaboration with dermatology education during medical school
Sean E. Mangion BHlthSc(Adv), BBiomedRes(Hons), GradCert(Innov&Enterp), Sarah A.L. Hughes AssocDegAppHlthSc
doi : 10.1111/jocd.15627
Fan-Dotting injection technique: A simple method for infraorbital rejuvenation using injectable Poly-D,L-lactic acid
Jui-Yu Lin MD, Chuan-Yuan Lin MD
doi : 10.1111/jocd.15624
