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Novel Insights Into Immunohistochemical Analysis For Acinar Cell Neoplasm of The Pancreas: Carboxypeptidase A2, Carboxypeptidase A1, and Glycoprotein 2.
Ishimoto-Namiki, Utako MD *,+,++,[S]; Ino, Yoshinori PhD *,+; Esaki, Minoru MD, PhD [//]; Shimada, Kazuaki MD, PhD [//]; Saruta, Masayuki MD, PhD [S]; Hiraoka, Nobuyoshi MD, PhD *,+,++,[P]
doi : 10.1097/PAS.0000000000002024
Volume 47(5) pgs. 525-633 May 2023
AB Acinar cell carcinoma (ACC) is a rare and highly malignant pancreatic tumor. Owing to histologic similarity, ACC is often difficult to distinguish from other solid medullary pancreatic tumors, particularly neuroendocrine neoplasm (NEN) and intraductal tubulopapillary neoplasm (ITPN).
A Clinicopathologic and Molecular Characterization of Uterine Sarcomas Classified as Malignant PEComa.
Anderson, William J. MBChB; Dong, Fei MD; Fletcher, Christopher D.M. MD; Hirsch, Michelle S. MD, PhD; Nucci, Marisa R. MD
doi : 10.1097/PAS.0000000000002028
AB Perivascular epithelioid cell tumors (PEComas) are a distinctive group of mesenchymal neoplasms that demonstrate features of smooth muscle and melanocytic differentiation.
CYP1A1 Is a Useful Diagnostic Marker for Angiofibroma of Soft Tissue.
Uemura, Kotaro MD *,+; Komatsu, Masato MD, PhD *; Hara, Shigeo MD, PhD ++; Kawamoto, Teruya MD, PhD [S],[//]; Bitoh, Yuko MD, PhD +; Itoh, Tomoo MD, PhD *; Hirose, Takanori MD, PhD [P],#
doi : 10.1097/PAS.0000000000002029
AB Angiofibroma of soft tissue (AFST) is a recently described benign fibroblastic neoplasm composed of uniform bland spindle cell proliferation in fibrous and fibromyxoid stroma with prominent thin-walled small branching vessels.
L1-CAM in Mucinous Ovarian Carcinomas and Borderline Tumors: Impact on Tumor Recurrence and Potential Role in Tumor Progression.
Wiedenhoefer, Rebekka *; Schmoeckel, Elisa MD +; Grube, Marcel MD ++; Sulyok, Mihaly MD, PhD *; Pasternak, Iana MD ++; Beschorner, Christine *; Greif, Karen *; Brucker, Sara MD ++; Mayr, Doris MD +; Kommoss, Stefan MD ++; Fend, Falko MD *; Staebler, Annette MD *; Fischer, Anna K. MD *
doi : 10.1097/PAS.0000000000002027
AB Mucinous ovarian carcinoma (MOC) is a rare histotype of primary ovarian carcinoma. Frequent pathogenic molecular alterations include mutations in KRAS, TP53, and overexpression of human epidermal growth factor receptor 2, but without having prognostic relevance.
Morphologic Features in Congenital Pulmonary Airway Malformations and Pulmonary Sequestrations Correlate With Mutation Status: A Mechanistic Approach to Classification.
Nelson, Nya D. MD, PhD *,+; Xu, Feng PhD *; Peranteau, William H. MD ++; Li, Marilyn MD *; Pogoriler, Jennifer MD, PhD *
doi : 10.1097/PAS.0000000000002025
AB Congenital pulmonary airway malformations (CPAMs) have a range of morphologies with varying cyst sizes and histologic features (types 1 to 3). Evidence suggested they arise secondary to bronchial atresia, however, we recently showed that cases with type 1 and 3 morphology are driven by mosaic KRAS mutations
HER2 IHC Expression and Gene Amplification in p53-aberrant High-grade Endometrial Endometrioid Carcinoma Suggests That This Population May Benefit From HER2 Testing and Targeted Therapy.
Joehlin-Price, Amy S. MD *; Komforti, Miglena K. MD +; Ladwig, Nicholas R. MD ++; Devine, Patrick MD, PhD ++; Hoyle, Carrie BA, CG (ASCP) *; McCoy, Lauren BS *; Sprague, Cathy BA *; Astbury, Caroline PhD, FACMG *; Hoda, Raza MD *; Chen, Yunn-Yi MD, PhD ++; Garg, Karuna MD *
doi : 10.1097/PAS.0000000000002030
AB Among gynecologic cancers, uterine serous carcinoma (USC) has been shown to be human epidermal growth factor receptor 2 (HER2) amplified and trastuzumab has been included in the recent National Comprehensive Cancer Network (NCCN) guidelines for treatment of advanced stage or recurrent USC with HER2 overexpression/amplification.
Endometrial Carcinomas With Subclonal Loss of Mismatch Repair Proteins: A Clinicopathologic and Genomic Study.
Mendoza, Rachelle P. MD *; Wang, Peng MD, PhD *; Schulte, Jefree J. MD *,+; Tjota, Melissa Y. MD, PhD *; Jani, Ina MD ++; Martinez, Anna C. *,++; Haridas, Rishikesh MS *; Wanjari, Pankhuri MS *; Steinhardt, George PhD *; Brown, Noah MD [S]; Betz, Bryan L. PhD [S]; Chapel, David B. MD [S]; Kertowidjojo, Elizabeth MD, PhD *; Yamada, S.D. MD ++; Bennett, Jennifer A. MD *
doi : 10.1097/PAS.0000000000002031
AB Subclonal loss of mismatch repair (MMR) proteins has been described in a small subset of endometrial carcinomas (ECs), but the genomic basis for this phenomenon has received limited attention.
PRAME Expression in Mucosal Melanoma of the Head and Neck Region.
Ricci, Costantino MD *,+; Altavilla, Maria V. MD ++,[S]; Corti, Barbara MD ++; Pasquini, Ernesto MD [//]; Presutti, Livo MD [P]; Baietti, Anna M. MD #; Amorosa, Luca MD **; Balbi, Tiziana MD ++; Baldovini, Chiara MD, PhD ++; Ambrosi, Francesca MD *,+; Grillini, Marco BSc ++; D'Errico, Antonia MD, PhD +,++; Fiorentino, Michelangelo MD, PhD *,+; Foschini, Maria P. MD ++
doi : 10.1097/PAS.0000000000002032
AB PRAME (PReferentially expressed Antigen in MElanoma), a cancer-testis antigen expressed in normal and neoplastic tissues with several functions, proved to be a useful diagnostic tool in the differential diagnosis between benign and malignant melanocytic lesions.
Mesothelioma In Situ Mimicking Well-differentiated Papillary Mesothelial Tumor.
Galateau-Salle, Francoise MD *; Hamilton, Trevor MD, MSc +; MacNeill, Andrea MD +; Hofman, Veronique MD, PhD ++; Sequeiros, Ruth MSc [S]; Sagan, Christine MD [//]; Le Stang, Nolwenn PhD [P]; Churg, Andrew MD #
doi : 10.1097/PAS.0000000000002033
AB We have previously hypothesized that well-differentiated papillary mesothelial tumor (WDPMT) consists of 2 morphologically identical lesions, one of which is true WDPMT, while the other is a form of mesothelioma in situ.
[beta]-catenin, Pax2, and Pten Panel Identifies Precancers Among Histologically Subdiagnostic Endometrial Lesions.
Aguilar, Mitzi BS *; Chen, Hao MD, PhD *; Sahoo, Subhransu S. PhD *; Zheng, Wenxin MD *,+,++; Grubman, Jessica MD, MAS +; SoRelle, Jeffrey A. MD *,[S]; Lucas, Elena MD *,++; Castrillon, Diego H. MD, PhD *,+,++
doi : 10.1097/PAS.0000000000002034
AB Despite refinements in histologic criteria for the diagnosis of endometrioid precancers, many challenging cases are encountered in daily practice, creating diagnostic uncertainty and suboptimal patient management.
Crohn Disease in Granulomatous Appendicitis Revisited: And Yersinia infection?.
Graber, Anne PhD; Koike, Jacqueline BMA; Cathomas, Gieri MD
Splenic Lesions and Other Findings in Kaposiform Lymphangiomatosis.
Suarez-Vilela, Dimas MD *; Izquierdo, Francisco M. MD, PhD +; Honrado, Emiliano MD, PhD +; Diez-Tascon, Cristina PhD +
