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A Novel Computational Biomechanics Framework to Model Vascular Mechanopropagation in Deep Bone Marrow (Adv. Healthcare Mater. 8/2023)
Yunduo Charles Zhao, Yingqi Zhang, Fengtao Jiang, Chi Wu, Boyang Wan, Ruhma Syeda, Qing Li, Bo Shen, Lining Arnold Ju
doi : 10.1002/adhm.202370035
Volume 12, Issue 8
From Conventional to Microfluidic: Progress in Extracellular Vesicle Separation and Individual Characterization (Adv. Healthcare Mater. 8/2023)
Mingrui Chen, Shujing Lin, Cheng Zhou, Daxiang Cui, Hossam Haick, Ning Tang
doi : 10.1002/adhm.202370036
Profiling of Tumor Cell-Delivered Exosome by Surface Enhanced Raman Spectroscopy-Based Biosensor for Evaluation of Nasopharyngeal Cancer Radioresistance (Adv. Healthcare Mater. 8/2023)
Qiong Wu, Qin Ding, Wanzun Lin, Youliang Weng, Shangyuan Feng, Rong Chen, Chuanben Chen, Sufang Qiu, Duo Lin
doi : 10.1002/adhm.202370039
Engineered Sandwich-Structured Composite Wound Dressings with Unidirectional Drainage and Anti-Adhesion Supporting Accelerated Wound Healing (Adv. Healthcare Mater. 8/2023)
Haipeng Wang, Wu Duan, Zhongjing Ren, Xinxin Li, Wenjie Ma, Yingchun Guan, Fuqiang Liu, Li Chen, Peng Yan, Xinguo Hou
doi : 10.1002/adhm.202370040
From Conventional to Microfluidic: Progress in Extracellular Vesicle Separation and Individual Characterization
Mingrui Chen, Shujing Lin, Cheng Zhou, Daxiang Cui, Hossam Haick, Ning Tang
doi : 10.1002/adhm.202202437
Extracellular vesicles (EVs) are nanoscale membrane vesicles, which contain a wide variety of cargo such as proteins, miRNAs, and lipids.
Smart Nanoparticle-Based Platforms for Regulating Tumor Microenvironment and Cancer Immunotherapy
Ruoyu Cheng, Hélder A. Santos
doi : 10.1002/adhm.202202063
A Novel Computational Biomechanics Framework to Model Vascular Mechanopropagation in Deep Bone Marrow
Yunduo Charles Zhao, Yingqi Zhang, Fengtao Jiang, Chi Wu, Boyang Wan, Ruhma Syeda, Qing Li, Bo Shen, Lining Arnold Ju
doi : 10.1002/adhm.202201830
The mechanical stimuli generated by body exercise can be transmitted from cortical bone into the deep bone marrow (mechanopropagation). Excitingly, a mechanosensitive perivascular stem cell niche is recently identified within the bone marrow for osteogenesis and lymphopoiesis.
Profiling of Tumor Cell-Delivered Exosome by Surface Enhanced Raman Spectroscopy-Based Biosensor for Evaluation of Nasopharyngeal Cancer Radioresistance
Qiong Wu, Qin Ding, Wanzun Lin, Youliang Weng, Shangyuan Feng, Rong Chen, Chuanben Chen, Sufang Qiu, Duo Lin
doi : 10.1002/adhm.202202482
Although the advancement of radiotherapy significantly improves the survival of nasopharyngeal cancer (NPC), radioresistance associated with recurrence and poor outcomes still remains a daunting challenge in the clinical scenario.
Engineered Sandwich-Structured Composite Wound Dressings with Unidirectional Drainage and Anti-Adhesion Supporting Accelerated Wound Healing
Haipeng Wang, Wu Duan, Zhongjing Ren, Xinxin Li, Wenjie Ma, Yingchun Guan, Fuqiang Liu, Li Chen, Peng Yan, Xinguo Hou
doi : 10.1002/adhm.202202685
Proper management of exudate is of great clinical value for reducing wound infection and promoting wound healing, thus various dressings have been studied to address this widespread medical challenge.
Thyroid-on-a-Chip: An Organoid Platform for In Vitro Assessment of Endocrine Disruption (Adv. Healthcare Mater. 8/2023)
Daniel J. Carvalho, Anna M. Kip, MÃÂrian Romitti, Marta Nazzari, Andreas Tegel, Matthias Stich, Christian Krause, Florian Caiment, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
doi : 10.1002/adhm.202370038
Thyroid-on-a-Chip: An Organoid Platform for In Vitro Assessment of Endocrine Disruption
Daniel J. Carvalho, Anna M. Kip, MÃÂrian Romitti, Marta Nazzari, Andreas Tegel, Matthias Stich, Christian Krause, Florian Caiment, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
doi : 10.1002/adhm.202201555
Thyroid is a glandular tissue in the human body in which the function can be severely affected by endocrine disrupting chemicals (EDCs). Current in vitro assays to test endocrine disruption by chemical compounds are largely based on 2DÂ thyroid cell cultures, which often fail to precisely evaluate the safety of these compounds
In Situ Hydrogelation of Cellular Monolayers Enables Conformal Biomembrane Functionalization for Xeno-Free Feeder Substrate Engineering
Chen-Ying Chien, Jung-Chen Lin, Ching-Ying Huang, Chung-Yao Hsu, Kai-Chieh Yang, Saborni Chattopadhyay, Nicolas Nikoloutsos, Patrick Ching-Ho Hsieh, Che-Ming Jack Hu
doi : 10.1002/adhm.202201708
Cell Behavior Changes and Enzymatic Biodegradation of Hybrid Electrospun Poly(3-hydroxybutyrate)-Based Scaffolds with an Enhanced Piezoresponse after the Addition of Reduced Graphene Oxide
Roman V. Chernozem, Igor Pariy, Maria A. Surmeneva, Vladimir V. Shvartsman, Guillaume Planckaert, Joost Verduijn, Stef Ghysels, Anatolii Abalymov, Bogdan V. Parakhonskiy, Eric Gracey, Amanda Gonçalves, Sanjay Mathur, Frederik Ronsse, Diederik Depla, Doru C. Lupascu, Dirk Elewaut, Roman A. Surmenev, Andre G. Skirtach
doi : 10.1002/adhm.202201726
This is the first comprehensive study of the impact of biodegradation on the structure, surface potential, mechanical and piezoelectric properties of poly(3-hydroxybutyrate) (PHB) scaffolds supplemented with reduced graphene oxide (rGO) as well as cell behavior under static and dynamic mechanical conditions.
Correlation between Fibrin Fibrillation Kinetics and the Resulting Fibrin Network Microstructure
Katja Pietsch, Lisa Storm-Johannsen, Antonia Schmidt-Thomée, Tilo Pompe
doi : 10.1002/adhm.202202231
Fibrin, the prominent extracellular matrix in early wound tissue, is discussed to influence immune cells and healing.
High-Yield Production of Extracellular Vesicle Subpopulations with Constant Quality Using Batch-Refeed Cultures
Carolina Paganini, Hannah Boyce, Gabriela Libort, Paolo Arosio
doi : 10.1002/adhm.202202232
The conventional manufacturing of extracellular vesicles (EVs) is characterized by low yields and batch-to-batch variability, hampering fundamental research on EVs and their practical applications. Perfusion operations have huge potential to address these limitations and increase the productivity and quality of EVs.
Bioinspired MoS2 Nanosheet-Modified Carbon Fibers for Synergetic Bacterial Elimination and Wound Disinfection
Yanan Tang, Zhen Qin, Yinghui Zhong, Xianqiang Yan, Liang Kong, Xiangyu Yang, Shengyan Yin, Mo Li, Zhenning Liu, Hang Sun
doi : 10.1002/adhm.202202270
Bacterial infection is one of the most frequent wound complications and has become a major public health concern.
A Novel Signal-On Electrochemiluminescence Immunosensor for the Detection of NSCLC Antigen Biomarker Based on New Co-Reaction Accelerators
Lei Guo, Zhaode Mu, Min Qing, Jing Zhou, Huizhen Li, Lulu Wang, Muyue Zhong, Lijuan Bai
doi : 10.1002/adhm.202202287
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer with substantial morbidity and mortality.
GDNF-Loaded Polydopamine Nanoparticles-Based Anisotropic Scaffolds Promote Spinal Cord Repair by Modulating Inhibitory Microenvironment
Jinjin Ma, Jiaying Li, Xingran Wang, Meimei Li, Wenwen Teng, Zihan Tao, Jile Xie, Yanxia Ma, Qin Shi, Bin Li, Saijilafu
doi : 10.1002/adhm.202202377
Spinal cord injury (SCI) is a devastating injury that causes permanent loss of sensation and motor function. SCI repair is a significant challenge due to the limited regenerating ability of adult neurons and the complex inflammatory microenvironment.
Monoclonal Antibody-Guided Tumor-Targeted Hollow Virus-Like Cerium Oxide with Oxygen Self-Supply for Intensifying Photodynamic Therapy
Mengqi Li, Jiajing Liu, Xian Luo, Zhiyu Zhao, Shengyu Wang, Zongjunlin Liu, Tingting Li, Dong Yang, Yang Li, Peiyuan Wang, Fanghong Luo, Jianghua Yan
doi : 10.1002/adhm.202202418
The hypoxic character of tumors and the poor targeting ability of photosensitizers often limit the efficacy of photodynamic therapy (PDT).
Functionalized Collagen/Elastin-like Polypeptide Hydrogels for Craniofacial Bone Regeneration
Pallabi Pal, Michelle A. Tucci, Lir-Wan Fan, Ratna Bollavarapu, Jonathan W. Lee, Susana M. Salazar Marocho, Amol V. Janorkar
doi : 10.1002/adhm.202202477
Critical-sized cranial bone defects fail to re-ossify and require the surgical intervention of cranioplasty.
Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract
Cagatay M. Oral, Martina Ussia, Mario Urso, Jiri Salat, Adam Novobilsky, Michal Stefanik, Daniel Ruzek, Martin Pumera
doi : 10.1002/adhm.202202682
Magnetic nanorobots offer wireless navigation capability in hard-to-reach areas of the human body for targeted therapy and diagnosis.
