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STRONG-HF and Implementing Heart Failure Therapies: Godspeed [horizontal ellipsis] With Care.
Butler, Javed MD, MPH, MBA; Talha, Khawaja M. MBBS; Fonarow, Gregg C. MD
doi : 10.1161/CIRCULATIONAHA.122.063811
Volume 147(16) pgs. 1189-1259,e699-e716 April 18, 2023
Association Between Achieved Low-Density Lipoprotein Cholesterol Levels and Long-Term Cardiovascular and Safety Outcomes: An Analysis of FOURIER-OLE.
Gaba, Prakriti MD; O'Donoghue, Michelle L. MD, MPH; Park, Jeong-Gun PhD; Wiviott, Stephen D. MD; Atar, Dan MD; Kuder, Julia F. MA; Im, KyungAh PhD; Murphy, Sabina A. MPH; De Ferrari, Gaetano M. MD; Gaciong, Zbigniew A. MD; Toth, Kalman MD, PhD; Gouni-Berthold, Ioanna MD; Lopez-Miranda, Jose MD; Schiele, Francois MD; Mach, Francois MD; Flores-Arredondo, Jose H. MD; Lopez, J. Antonio G. MD; Elliott-Davey, Mary MSc; Wang, Bei PhD; Monsalvo, Maria Laura MD; Abbasi, Siddique MD; Giugliano, Robert P. MD, SM; Sabatine, Marc S. MD, MPH
doi : 10.1161/CIRCULATIONAHA.122.063399
Low-density lipoprotein cholesterol (LDL-C) is a well-established risk factor for atherosclerotic cardiovascular disease. However, the optimal achieved LDL-C level with regard to efficacy and safety in the long term remains unknown.
How Low Can You Go? New Evidence Supports No Lower Bound to Low-Density Lipoprotein Cholesterol Level in Secondary Prevention.
Rodriguez, Fatima MD, MPH; Khera, Amit MD, MSc
Mechanical Thrombectomy Global Access For Stroke (MT-GLASS): A Mission Thrombectomy (MT-2020 Plus) Study.
Asif, Kaiz S. MD; Otite, Fadar O. MD; Desai, Shashvat M. MD; Herial, Nabeel MD, MPH; Inoa, Violiza MD; Al-Mufti, Fawaz MD; Jadhav, Ashutosh P. MD, PhD; Dmytriw, Adam A. MD, MPH, MSc; Castonguay, Alicia PhD; Khandelwal, Priyank MD; Potter-Vig, Jennifer PhD; Szeder, Viktor MD, PhD; Kulman, Tanzila MD; Urrutia, Victor MD; Masoud, Hesham MD; Toth, Gabor MD; Limaye, Kaustubh MD;
doi : 10.1161/CIRCULATIONAHA.122.063366
Despite the well-established potent benefit of mechanical thrombectomy (MT) for large vessel occlusion (LVO) stroke, access to MT has not been studied globally.
Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure.
Skogestad, Jonas MD, PhD ,*; Albert, Ingrid MSc ,*; Hougen, Karina MD, PhD; Lothe, Gustav B. MD; Lunde, Marianne MSc; Eken, Olav Sovik MD; Veras, Ioanni MSc; Huynh, Ngoc Trang Thi MSc; Borstad, Mira MSc; Marshall, Serena PhD; Shen, Xin PhD; Louch, William E. PhD; Robinson, Emma Louise PhD; Cleveland, Joseph C. Jr MD; Ambardekar, Amrut V. MD; Schwisow, Jessica A. BSc; Jonas, Eric BSc; Calejo, Ana I. PhD; Morth, Jens Preben PhD; Tasken, Kjetil MD, PhD; Melleby, Arne Olav PhD; Lunde, Per Kristian PhD; Sjaastad, Ivar MD, PhD; Carlson, Cathrine Rein PhD; Aronsen, Jan Magnus MD, PhD
doi : 10.1161/CIRCULATIONAHA.121.054168
Increasing SERCA2 (sarco[endo]-plasmic reticulum Ca2+ ATPase 2) activity is suggested to be beneficial in chronic heart failure, but no selective SERCA2-activating drugs are available.
Unloading the Left Ventricle in Venoarterial ECMO: In Whom, When, and How?.
Ezad, Saad M. MD; Ryan, Matthew MD, PhD; Donker, Dirk W. MD, PhD; Pappalardo, Federico MD; Barrett, Nicholas MD; Camporota, Luigi MD, PhD; Price, Susanna MD, PhD; Kapur, Navin K. MD; Perera, Divaka MD
doi : 10.1161/CIRCULATIONAHA.122.062371
AB Venoarterial extracorporeal membrane oxygenation provides cardiorespiratory support to patients in cardiogenic shock. This comes at the cost of increased left ventricle (LV) afterload that can be partly ascribed to retrograde aortic flow, causing LV distension, and leads to complications including cardiac thrombi, arrhythmias, and pulmonary edema.
Prevalence of Diabetes and Cardiovascular Risk in the Middle East and Africa: Primary Results of the PACT-MEA Study.
Verma, Subodh MD, PhD; Alamuddin, Naji MD; Alawadi, Fatheya MD; Alkandari, Hessa MD; Almahmeed, Wael MD; Assaad-Khalil, Samir H. MD, PhD; Haddad, Jihad MD, PhD; Husemoen, Lise Lotte N. MSc, PhD; Lombard, Landman MBChB, MMed; Malik, Rayaz A. MBChB, PhD; Mashaki Ceyhan, Emel PharmD, PhD; Sabbour, Hani MD; Tombak, Gamze MD; Yadav, Gourav MD; Salek, Sam PhD
Letter by Zhou et al Regarding Article, "Long-Term Evolocumab in Patients With Established Atherosclerotic Cardiovascular Disease".
Zhou, Xin MD, PhD; Sun, Pengfei MD, PhD; Yang, Qing MD, PhD
Response by O'Donoghue et al to Letter Regarding Article, "Long-Term Evolocumab in Patients With Established Atherosclerotic Cardiovascular Disease".
O'Donoghue, Michelle L. MD, MPH; Giugliano, Robert P. MD, SM; Sabatine, Marc S. MD, MPH
Supervised Exercise Training for Chronic Heart Failure With Preserved Ejection Fraction: A Scientific Statement From the American Heart Association and American College of Cardiology.
Sachdev, Vandana MD, Chair *,+; Sharma, Kavita MD, Vice Chair; Keteyian, Steven J. PhD; Alcain, Charina F. DNP, ACNP-BC; Desvigne-Nickens, Patrice MD +; Fleg, Jerome L. MD, FAHA +; Florea, Viorel G. MD, PhD; Franklin, Barry A. PhD, FAHA; Guglin, Maya MD, PhD; Halle, Martin MD; Leifer, Eric S. PhD +; Panjrath, Gurusher MD, FAHA; Tinsley, Emily A. PhD +; Wong, Renee P. PhD +; Kitzman, Dalane W. MD, FAHA *; on behalf of the American Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology; Council on Arteriosclerosis, Thrombosis and Vascular Biology; and American College of Cardiology
doi : 10.1161/CIR.0000000000001122
AB Heart failure with preserved ejection fraction (HFpEF) is one of the most common forms of heart failure; its prevalence is increasing, and outcomes are worsening. Affected patients often experience severe exertional dyspnea and debilitating fatigue, as well as poor quality of life, frequent hospitalizations, and a high mortality rate.
Correction to: Mechanical Thrombectomy Global Access For Stroke (MT-GLASS): A Mission Thrombectomy (MT-2020 Plus) Study.
