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Low-Density Lipoprotein Cholesterol Is Predominantly Associated With Atherosclerotic Cardiovascular Disease Events in Patients With Evidence of Coronary Atherosclerosis: The Western Denmark Heart Registry.
Mortensen, Martin Bodtker MD, PhD ,,*; Dzaye, Omar MD, MPH, PhD ,*; Botker, Hans Erik MD, DMSc; Jensen, Jesper Moller MD, PhD; Maeng, Michael MD, PhD; Bentzon, Jacob Fog MD, PhD; Kanstrup, Helle MD, PhD; Sorensen, Henrik Toft MD, DMSc; Leipsic, Jonathon MD; Blankstein, Ron MD; Nasir, Khurram MD, MPH; Blaha, Michael J. MD, MPH; Norgaard, Bjarne Linde MD, PhD
doi : 10.1161/CIRCULATIONAHA.122.061010
Low-density lipoprotein cholesterol (LDL-C) is an important causal risk factor for atherosclerotic cardiovascular disease (ASCVD). However, a sizable proportion of middle-aged individuals with elevated LDL-C level have not developed coronary atherosclerosis as assessed by coronary artery calcification (CAC).
Cholesterol, Coronary Calcification, and Cardiovascular Prevention: Lessons We Can Learn From the Western Denmark Heart Registry.
Akl, Elie MD; Sniderman, Allan D. MD
Patient Characteristics, Outcomes, and Effects of Dapagliflozin According to the Duration of Heart Failure: A Prespecified Analysis of the DELIVER Trial.
Kondo, Toru MD, PhD ,,*; Jering, Karola S. MD ,*; Borleffs, C. Jan Willem MD; de Boer, Rudolf A. MD; Claggett, Brian L. PhD; Desai, Akshay S. MD, MPH; Dobreanu, Dan MD; Inzucchi, Silvio E. MD; Hernandez, Adrian F. MD, MHS; Janssens, Stefan P. MD; Jhund, Pardeep S. MB ChB, MSc, PhD; Kosiborod, Mikhail N. MD; Lam, Carolyn S.P. MBBS, PhD; Langkilde, Anna Maria MD, MPH, PhD; Martinez, Felipe A. MD; Petersson, Magnus MD, PhD; Vinh, Pham Nguyen MD; Vaduganathan, Muthiah MD, MPH; Solomon, Scott D. MD; McMurray, John J.V. MD
doi : 10.1161/CIRCULATIONAHA.122.062918
How patient characteristics and outcomes vary according to the duration of heart failure (HF) is unknown in individuals with mildly reduced or preserved ejection fraction.
Gut Microbiota-Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms.
Benson, Tyler W. PhD ,,*; Conrad, Kelsey A. PhD ,,,*; Li, Xinmin S. PhD; Wang, Zeneng PhD; Helsley, Robert N. PhD; Schugar, Rebecca C. PhD; Coughlin, Taylor M. BS; Wadding-Lee, Caris BS; Fleifil, Salma BS; Russell, Hannah M. PhD; Stone, Timothy PhD; Brooks, Michael BS; Buffa, Jennifer A. MS; Mani, Kevin MD, PhD; Bjorck, Martin MD, PhD; Wanhainen, Anders MD, PhD; Sangwan, Naseer PhD; Biddinger, Sudha MD; Bhandari, Rohan MD; Ademoya, Akiirayi BS; Pascual, Crystal BS; Tang, W.H. Wilson MD; Tranter, Michael PhD; Cameron, Scott J. MD, PhD; Brown, J. Mark PhD; Hazen, Stanley L. MD, PhD; Owens, A. Phillip III PhD
Genetic Risk of Primary Aldosteronism and Its Contribution to Hypertension: A Cross-Ancestry Meta-Analysis of Genome-Wide Association Studies.
Naito, Tatsuhiko MD, PhD; Inoue, Kosuke MD, PhD; Sonehara, Kyuto MD, PhD; Baba, Ryuta MD, PhD; Kodama, Takaya MD; Otagaki, Yu MD; Okada, Akira MD; Itcho, Kiyotaka MD, PhD; Kobuke, Kazuhiro MD, PhD; Kishimoto, Shinji MD, PhD; Yamamoto, Kenichi MD, PhD; BioBank Japan; Morisaki, Takayuki MD, PhD; Higashi, Yukihito MD, PhD; Hinata, Nobuyuki MD, PhD; Arihiro, Koji MD, PhD; Hattori, Noboru MD, PhD; Okada, Yukinori MD, PhD ,,,,,,*; Oki, Kenji MD, PhD ,*
doi : 10.1161/CIRCULATIONAHA.122.062349
Hypertension imposes substantial health and economic burden worldwide. Primary aldosteronism (PA) is one of the most common causes of secondary hypertension, causing cardiovascular events at higher risk compared with essential hypertension.
Decoding Hypertension Through Primary Aldosteronism.
Mitchell, Braxton D. PhD, MPH; Whitlatch, Hilary B. MD
Association Between Concussion Burden During Professional American-Style Football and Postcareer Hypertension.
Grashow, Rachel PhD, MS; Tan, Can Ozan PhD; Izzy, Saef MD; Taylor, Herman A. Jr MD, MPH; Weisskopf, Marc G. PhD, ScD; Wasfy, Meagan M. MD; Whittington, Alicia J. PhD, MPH; Speizer, Frank MD; Zafonte, Ross DO; Baggish, Aaron L. MD
Economic Adversity and Health Care: Synopsis of American Heart Association Presidential Address.
Albert, Michelle A. MD, MPH
Letter by Wong and Demers Regarding Article, "Efficacy and Safety of Dapagliflozin According to Frailty in Patients With Heart Failure: A Prespecified Analysis of the DELIVER Trial".
Wong, Eric K.C. MD; Demers, Catherine MD, MSc
Response by Butt et al to Letter Regarding Article, "Efficacy and Safety of Dapagliflozin According to Frailty in Patients With Heart Failure: A Prespecified Analysis of the DELIVER Trial".
Butt, Jawad H. MD; Solomon, Scott D. MD; McMurray, John J.V. MD
Correction to: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
Expression of Concern: c-Cbl Inhibition Improves Cardiac Function and Survival in Response to Myocardial Ischemia.
