One-year access to more than 500 world journals available in the system
-
http://medilib.ir
- Duration of Time : 365 Day
Price : 300$- Special Price : 100$
Lipid-Based Nanocarriers in the Treatment of Glioblastoma Multiforme (GBM): Challenges and Opportunities
Tanisha Gupta, Rakesh K. Sahoo, Himani Singh, Sumeet Katke, Akash Chaurasiya & Umesh Gupta
doi : 10.1208/s12249-023-02555-2
Volume 24, issue 4, April 2023
Glioblastoma multiforme (also known as glioblastoma; GBM) is one of the most malignant types of brain tumors that occurs in the CNS. Treatment strategies for glioblastoma are majorly comprised of surgical resection, radiotherapy, and chemotherapy along with combination therapy.
PEGylated Erlotinib HCl Injectable Nanoformulation for Improved Bioavailability
PEGylated Erlotinib HCl Injectable Nanoformulation for Improved Bioavailability
doi : 10.1208/s12249-023-02560-5
The present study was undertaken to synthesize PEGylated monomethoxy poly (ethylene glycol)-poly (ε-Caprolactone) (mPEG-PCL) block copolymer and formulate Erlotinib HCl–loaded mPEG-PCL nanoparticles for enhancing the bioavailability of the drug.
Inclusion Complex of Ibuprofen-β-Cyclodextrin Incorporated in Gel for Mucosal Delivery: Optimization Using an Experimental Design
Chandraprabha Upadhyay, Anisha D’Souza, Pratikkumar Patel, Vivek Verma, Kamal Kumar Upadhayay & Meenakshi Bharkatiya
doi : 10.1208/s12249-023-02534-7
β-Cyclodextrin/ibuprofen inclusion complex was synthesized by freeze-drying method and characterized for phase solubility profiles, infrared spectra, thermal analysis, and X-ray powder diffractograms.
A Novel Alginate Film Based on Nanocoating Approach for Enteric-Release Tablets
Bao Ngoc Tran, Khanh-Ly Tran, Thach-Tung Nguyen, Lan-Phuong T. Bui & Chien Ngoc Nguyen
doi : 10.1208/s12249-023-02557-0
The objective of this study was to propose a new coating film for biodegradable polymers and environmentally friendly processing.
Inhalable Nanoparticle-based Dry Powder Formulations for Respiratory Diseases: Challenges and Strategies for Translational Research
Ho Wan Chan, Stephanie Chow, Xinyue Zhang, Yayi Zhao, Henry Hoi Yee Tong & Shing Fung Chow
doi : 10.1208/s12249-023-02559-y
The emergence of novel respiratory infections (e.g., COVID-19) and expeditious development of nanoparticle-based COVID-19 vaccines have recently reignited considerable interest in designing inhalable nanoparticle-based drug delivery systems as next-generation respiratory therapeutics.
Development of Photoprotective Formulations: Influence of Formulation Composition on the SPF and Mechanical Properties
Gabriela Maria D’Angelo Costa & PatrÃcia Maria Berardo Gonçalves Maia Campos
doi : 10.1208/s12249-023-02558-z
The evaluation of the vehicle formulation is important during the development of sunscreens, as it influences their efficacy.
Best Practices and Guidelines (2022) for Scale-up and Technology Transfer in Freeze Drying Based on Case Studies. Part 2: Past Practices, Current Best Practices, and Recommendations
Serguei Tchessalov, Evgenyi Shalaev, Bakul Bhatnagar, Steven Nail, Alina Alexeenko, Feroz Jameel, Jayasree Srinivasan, Michael Dekner, Ekneet Sahni, Stefan Schneid, Petr Kazarin, Orla McGarvey, Bert Van Meervenne, Vaibhav Kshirsagar, Paritosh Pande, Jens Philipp, Greg Sacha, Ke Wu, Joseph Azzarella, Gayathri Shivkumar, Shreyas Bhatt & Shyam B. Mehta
doi : 10.1208/s12249-023-02553-4
Scale-up and transfer of lyophilization processes remain very challenging tasks considering the technical challenges and the high cost of the process itself.
Structural Changes in Liposomal Vesicles in Association with Sodium Taurodeoxycholate
Deepak Kumar, Abhishek Suna, Debes Ray, Vinod K. Aswal, Pratap Bahadur & Sanjay Tiwari
doi : 10.1208/s12249-023-02550-7
Liposomes composed of soy lecithin (SL) have been studied widely for drug delivery applications.
Designing Optimum Drug Delivery Systems Using Machine Learning Approaches: a Prototype Study of Niosomes
Aliasgar F. Shahiwala, Samar Salam Qawoogha & Nuruzzaman Faruqui
doi : 10.1208/s12249-023-02547-2
This study demonstrates a machine learning approach in designing optimized drug formulations.
The Effect of Design and Size of the Fluid-Bed Equipment on the Particle Size-Dependent Trend of Particle Coating Thickness and Drug Prolonged-Release Profile
Teja Brezovar, Grega Hudovornik, Matjaž Perpar, Matevž Luštrik & Rok Dreu
doi : 10.1208/s12249-023-02540-9
The focus of the current work is to study and demonstrate the impact of the design, the scale, and settings of fluid-bed coating equipment on the differences in pellet coating thickness, which in case of prolonged-release pellets dictates the drug release.
Loteprednol-Loaded Nanoformulations for Corneal Delivery by Quality-by-Design Concepts: Optimization, Characterization, and Anti-inflammatory Activity
Burcu Uner, Samet Ozdemir, Cetin Tas, Melike Uner & Yildiz Ozsoy
doi : 10.1208/s12249-023-02551-6
Loteprednol etabonate (LE) is a topical corticosteroid that uses inflammatory conditions of the eye.
Assessment of Tribo-charging and Continuous Feeding Performance of Direct Compression Grades of Isomalt and Mannitol Powders
Michela Beretta, Julia Kruisz, Theresa R. Hörmann-Kincses, Viktoria Magosi, Meishan Guo, Majid Naderi, Sarah Heupl, Johann Kastner, Martin Spoerk & Amrit Paudel
doi : 10.1208/s12249-023-02552-5
Tribo-charging is often a root cause of mass flow deviations and powder adhesion during continuous feeding. Thus, it may critically impact product quality.
Self-Double-Emulsifying Drug Delivery System Enteric-Coated Capsules: A Novel Approach to Improve Oral Bioavailability and Anti-inflammatory Activity of Panax notoginseng Saponins
Yaru Wang, Yunxia Shang, Fengyu Tang, Kun Qiu, Xiaohui Wei & Zhengtao Wang
doi : 10.1208/s12249-023-02549-0
In this work, self-double-emulsifying drug delivery system enteric-coated capsules (PNS-SDE-ECC) were used to enhance the oral bioavailability and anti-inflammatory effects of Panax notoginseng saponins (PNS), which are rapidly biodegradable, poorly membrane permeable, and highly water-soluble compounds.
Evaluation of In-Die Compression Data for a Deeper Understanding of Altered Excipient Properties upon Temperature Rise
Hanna Dorothea Grumann, Stefan Klinken & Peter Kleinebudde
doi : 10.1208/s12249-023-02554-3
The thermodynamic analysis of tablet formation includes the thermal and mechanical analysis during compression.
Development of 3D DLP Printed Sustained Release Ibuprofen Tablets and Their Pharmacokinetic Evaluation in Rats
Keb Mosley-Kellum, Arvind Bagde, Shawn Spencer, Satyanarayan Dev & Mandip Singh
doi : 10.1208/s12249-023-02544-5
The objective of the present study was to develop digital light processing (DLP) 3D printed sustained release ibuprofen (IBU) tablets using 3D DLP printers for evaluation in in vitro release and in vivo pharmacokinetic studies with their in vitro–in vivo correlation.
Construction of Imatinib Controlled Release Film-Forming System Based on Drug Ion-Pair and Oligomeric Ionic Liquids for the Long Local Therapy of Cutaneous Melanoma
Junzhu Wang, Han Sun, Wenxuan Jia, Yilin Song, Peng Quan, Liang Fang & Chao Liu
doi : 10.1208/s12249-023-02546-3
An imatinib controlled release film-forming system (FFS) was developed based on the drug ion-pair and newly designed oligomeric ionic liquids (OILs) for the topical therapy of cutaneous melanoma, which avoided the systemic side-effect of oral administration and maintained a long local therapy effect.
Folic Acid–Chitosan Oligosaccharide Conjugates Decorated Nanodiamond as Potential Carriers for the Oral Delivery of Doxorubicin
Dandan Liu, Yupei Su, Jixuan Chen, Hao Pan & Weisan Pan
doi : 10.1208/s12249-023-02545-4
Oral administration of doxorubicin (DOX) is preferred but challenged owing to poor permeability in the gastrointestinal tract (GIT), efflux of P-glycoprotein, short residence time in the intestine, and rapid hydrolysis
Enhanced Optimal Parameter-Based Nebulizer Design for Flow Analysis of Fluticasone Propionate
Vinoth N & Bhaskara Rao Lokavarapu
doi : 10.1208/s12249-023-02548-1
A jet nebulizer sprays a fine mist or aerosol directly into the lungs to reduce inflammation, expand airways, and make breathing easier for respiratory patients.
Evaluation and Screening of Biopharmaceuticals using Multi-Angle Dynamic Light Scattering
Ashutosh Sharma, Jason Beirne, Dikshitkumar Khamar, Ciaran Maguire, Ambrose Hayden & Helen Hughes
doi : 10.1208/s12249-023-02529-4
Biopharmaceuticals are large, complex and labile therapeutic molecules prone to instability due to various factors during manufacturing.
Long Acting Ionically Paired Pamoate-based Suspension of Lurasidone: An exploration of Size Effects on in vitro Dissolution and in vivo Pharmacokinetic Behaviors
Shuo Li, Ying He, Dianjun Sun, Zhaomeng Wang, Jiang Yu, Jianying Ye, Zhonggui He & Yongjun Wang
doi : 10.1208/s12249-023-02541-8
Latuda® is an oral tablet approved by the US Food and Drug Administration (FDA) for the treatment of schizophrenia.
Microfluidic Generation of Near-Infrared Photothermal Vitexin/ICG Liposome with Amplified Photodynamic Therapy
Xia Cao, Qi Liu, Michael Adu-Frimpong, Wenwan Shi, Kai liu, Tianwen Deng, Hui Yuan, Xuedi Weng, Yihong Gao, Qingtong Yu, Wenwen Deng, Jiangnan Yu, Qilong Wang, Gao Xiao & Ximing Xu
doi : 10.1208/s12249-023-02539-2
Glioma, in which a malignant tumor cell occurs in neural mesenchymal cells, has a rapid progression and poor prognosis, which is still far from desirable in clinical treatments.
Correction to: PhysioCell®—a Novel, Bio-relevant Dissolution Apparatus: Hydrodynamic Conditions and Factors Influencing the Dissolution Dynamics
Marcela Staniszewska, Michał Romański, Justyna Dobosz, Bartosz Kołodziej, Uladzimir Lipski, Grzegorz Garbacz & Dorota Danielak
Estimating Shelf Life Through Tolerance Intervals Extended to Nonlinear Response Trends
James Schwenke, Walter Stroup, Michelle Quinlan & Patrick Forenzo
doi : 10.1208/s12249-023-02532-9
Methods for estimating pharmaceutical shelf life based on tolerance intervals are proposed by Schwenke, et al.
